Frank Reimann Metabolic Research Laboratories and MRC Metabolic Diseases Unit Wellcome Trust-MRC Institute of Metabolic Science, University of Cambridge Biography Publications Institution JoVE Articles Frank Reimann has not added a biography. If you are Frank Reimann and would like to personalize this page please email our Author Liaison for assistance. Publications Signalling in the Gut Endocrine Axis Physiology & Behavior. Feb, 2017 | Pubmed ID: 28257936 Glucagon-Like Peptide 1 and Its Analogs Act in the Dorsal Raphe and Modulate Central Serotonin to Reduce Appetite and Body Weight Diabetes. Apr, 2017 | Pubmed ID: 28057699 Scaling It Down: New in Vitro Tools to Get the Balance Right The Biochemical Journal. Jan, 2017 | Pubmed ID: 28008090 Gut Hormone Regulation and Secretion Via FFA1 and FFA4 Handbook of Experimental Pharmacology. 2017 | Pubmed ID: 27873089 Functional and Molecular Adaptations of Enteroendocrine L-Cells in Male Obese Mice Are Associated With Preservation of Pancreatic α-Cell Function and Prevention of Hyperglycemia Endocrinology. Oct, 2016 | Pubmed ID: 27547850 Angiotensin II Type 1 Receptor-Dependent GLP-1 and PYY Secretion in Mice and Humans Endocrinology. Oct, 2016 | Pubmed ID: 27447725 Transcriptomic Profiling of Pancreatic Alpha, Beta and Delta Cell Populations Identifies Delta Cells As a Principal Target for Ghrelin in Mouse Islets Diabetologia. Oct, 2016 | Pubmed ID: 27390011 Mechanisms Underlying Glucose-dependent Insulinotropic Polypeptide and Glucagon-like Peptide-1 Secretion Journal of Diabetes Investigation. Apr, 2016 | Pubmed ID: 27186350 Preproglucagon Neurons in the Hindbrain Have IL-6 Receptor-α and Show Ca2+ Influx in Response to IL-6 American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. Jul, 2016 | Pubmed ID: 27097661 Role of Enteroendocrine L-cells in Arginine Vasopressin-mediated Inhibition of Colonic Anion Secretion The Journal of Physiology. Sep, 2016 | Pubmed ID: 27037495 Proglucagon Promoter Cre-Mediated AMPK Deletion in Mice Increases Circulating GLP-1 Levels and Oral Glucose Tolerance PloS One. 2016 | Pubmed ID: 27010458 The Incretin Hormone Glucagon-like Peptide 1 Increases Mitral Cell Excitability by Decreasing Conductance of a Voltage-dependent Potassium Channel The Journal of Physiology. May, 2016 | Pubmed ID: 26931093 Stimulation of Incretin Secreting Cells Therapeutic Advances in Endocrinology and Metabolism. Feb, 2016 | Pubmed ID: 26885360 Peptide Production and Secretion in GLUTag, NCI-H716, and STC-1 Cells: a Comparison to Native L-cells Journal of Molecular Endocrinology. Apr, 2016 | Pubmed ID: 26819328 G Protein-coupled Receptors As New Therapeutic Targets for Type 2 Diabetes Diabetologia. Feb, 2016 | Pubmed ID: 26661410 Galanin Inhibits GLP-1 and GIP Secretion Via the GAL1 Receptor in Enteroendocrine L and K Cells British Journal of Pharmacology. Mar, 2016 | Pubmed ID: 26661062 The Effect of Encapsulated Glutamine on Gut Peptide Secretion in Human Volunteers Peptides. Mar, 2016 | Pubmed ID: 26541888 GLP1- and GIP-producing Cells Rarely Overlap and Differ by Bombesin Receptor-2 Expression and Responsiveness The Journal of Endocrinology. Jan, 2016 | Pubmed ID: 26483393 Enteroendocrine Cells: Chemosensors in the Intestinal Epithelium Annual Review of Physiology. 2016 | Pubmed ID: 26442437 The Effect of Bariatric Surgery on Gastrointestinal and Pancreatic Peptide Hormones Peptides. Mar, 2016 | Pubmed ID: 26344355 Signalling Pathways Involved in the Detection of Peptones by Murine Small Intestinal Enteroendocrine L-cells Peptides. Mar, 2016 | Pubmed ID: 26215048 High Fat Diet Impairs the Function of Glucagon-like Peptide-1 Producing L-cells Peptides. Mar, 2016 | Pubmed ID: 26145551 Lipid Derivatives Activate GPR119 and Trigger GLP-1 Secretion in Primary Murine L-cells Peptides. Mar, 2016 | Pubmed ID: 26144594 Distribution and Characterisation of Glucagon-like Peptide-1 Receptor Expressing Cells in the Mouse Brain Molecular Metabolism. Oct, 2015 | Pubmed ID: 26500843 Limited Impact on Glucose Homeostasis of Leptin Receptor Deletion from Insulin- or Proglucagon-expressing Cells Molecular Metabolism. Sep, 2015 | Pubmed ID: 26413468 Can Encapsulated Glutamine Increase GLP-1 Secretion, Improve Glucose Tolerance, and Reduce Meal Size in Healthy Volunteers? A Randomised, Placebo-controlled, Cross-over Trial Lancet (London, England). Feb, 2015 | Pubmed ID: 26312890 Bile Acids Trigger GLP-1 Release Predominantly by Accessing Basolaterally Located G Protein-Coupled Bile Acid Receptors Endocrinology. Nov, 2015 | Pubmed ID: 26280129 A Transcriptome-Led Exploration of Molecular Mechanisms Regulating Somatostatin-Producing D-Cells in the Gastric Epithelium Endocrinology. Nov, 2015 | Pubmed ID: 26241122 Corrigendum: Transcriptional Regulator PRDM12 is Essential for Human Pain Perception Nature Genetics. Aug, 2015 | Pubmed ID: 26220135 Farnesoid X Receptor Inhibits Glucagon-like Peptide-1 Production by Enteroendocrine L Cells Nature Communications. Jul, 2015 | Pubmed ID: 26134028 Effect of Reducing Portion Size at a Compulsory Meal on Later Energy Intake, Gut Hormones, and Appetite in Overweight Adults Obesity (Silver Spring, Md.). Jul, 2015 | Pubmed ID: 26054049 Transcriptional Regulator PRDM12 is Essential for Human Pain Perception Nature Genetics. Jul, 2015 | Pubmed ID: 26005867 Novel SCN9A Mutations Underlying Extreme Pain Phenotypes: Unexpected Electrophysiological and Clinical Phenotype Correlations The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. May, 2015 | Pubmed ID: 25995458 Submembrane ATP and Ca2+ Kinetics in α-cells: Unexpected Signaling for Glucagon Secretion FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Aug, 2015 | Pubmed ID: 25911612 LKB1 and AMPKα1 Are Required in Pancreatic Alpha Cells for the Normal Regulation of Glucagon Secretion and Responses to Hypoglycemia Molecular Metabolism. Apr, 2015 | Pubmed ID: 25830091 Activation of the GLP-1 Receptors in the Nucleus of the Solitary Tract Reduces Food Reward Behavior and Targets the Mesolimbic System PloS One. 2015 | Pubmed ID: 25793511 Inhibition of the Malate-aspartate Shuttle in Mouse Pancreatic Islets Abolishes Glucagon Secretion Without Affecting Insulin Secretion The Biochemical Journal. May, 2015 | Pubmed ID: 25731850 Gut Chemosensing Mechanisms The Journal of Clinical Investigation. Mar, 2015 | Pubmed ID: 25664852 Targeting Development of Incretin-producing Cells Increases Insulin Secretion The Journal of Clinical Investigation. Jan, 2015 | Pubmed ID: 25500886 Stimulation of GLP-1 Secretion Downstream of the Ligand-gated Ion Channel TRPA1 Diabetes. Apr, 2015 | Pubmed ID: 25325736 Bacterial Metabolite Indole Modulates Incretin Secretion from Intestinal Enteroendocrine L Cells Cell Reports. Nov, 2014 | Pubmed ID: 25456122 The Melanocortin-4 Receptor is Expressed in Enteroendocrine L Cells and Regulates the Release of Peptide YY and Glucagon-like Peptide 1 in Vivo Cell Metabolism. Dec, 2014 | Pubmed ID: 25453189 Clocking Up GLP-1: Considering Intestinal Rhythms in the Incretin Effect Diabetes. Nov, 2014 | Pubmed ID: 25342730 The Role of Gut Endocrine Cells in Control of Metabolism and Appetite Experimental Physiology. Sep, 2014 | Pubmed ID: 25210110 The Peutz-Jeghers Kinase LKB1 Suppresses Polyp Growth from Intestinal Cells of a Proglucagon-expressing Lineage in Mice Disease Models & Mechanisms. Nov, 2014 | Pubmed ID: 25190708 Na+ Current Properties in Islet α- and β-cells Reflect Cell-specific Scn3a and Scn9a Expression The Journal of Physiology. Nov, 2014 | Pubmed ID: 25172946 Reversible Changes in Pancreatic Islet Structure and Function Produced by Elevated Blood Glucose Nature Communications. Aug, 2014 | Pubmed ID: 25145789 Diabetes Recovery by Age-dependent Conversion of Pancreatic δ-cells into Insulin Producers Nature. Oct, 2014 | Pubmed ID: 25141178 GLP-1 Receptor Stimulation of the Lateral Parabrachial Nucleus Reduces Food Intake: Neuroanatomical, Electrophysiological, and Behavioral Evidence Endocrinology. Nov, 2014 | Pubmed ID: 25116706 LKB1 and AMPK Differentially Regulate Pancreatic β-cell Identity FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Nov, 2014 | Pubmed ID: 25070369 Insulin-like Peptide 5 is an Orexigenic Gastrointestinal Hormone Proceedings of the National Academy of Sciences of the United States of America. Jul, 2014 | Pubmed ID: 25028498 Fructose Stimulates GLP-1 but Not GIP Secretion in Mice, Rats, and Humans American Journal of Physiology. Gastrointestinal and Liver Physiology. Apr, 2014 | Pubmed ID: 24525020 Identification and Characterization of GLP-1 Receptor-expressing Cells Using a New Transgenic Mouse Model Diabetes. Apr, 2014 | Pubmed ID: 24296712 Generation of L Cells in Mouse and Human Small Intestine Organoids Diabetes. Feb, 2014 | Pubmed ID: 24130334 Role of KATP Channels in Glucose-regulated Glucagon Secretion and Impaired Counterregulation in Type 2 Diabetes Cell Metabolism. Dec, 2013 | Pubmed ID: 24315372 Towards the Harnessing of Gut Feelings Current Opinion in Pharmacology. Dec, 2013 | Pubmed ID: 24140240 A Tag to Track Short Chain Fatty Acid Sensors Endocrinology. Oct, 2013 | Pubmed ID: 24058154 Oligopeptides Stimulate Glucagon-like Peptide-1 Secretion in Mice Through Proton-coupled Uptake and the Calcium-sensing Receptor Diabetologia. Dec, 2013 | Pubmed ID: 24045836 Molecular Mechanisms of Incretin Hormone Secretion Current Opinion in Pharmacology. Dec, 2013 | Pubmed ID: 24035446 The G Protein-coupled Receptor Family C Group 6 Subtype A (GPRC6A) Receptor is Involved in Amino Acid-induced Glucagon-like Peptide-1 Secretion from GLUTag Cells The Journal of Biological Chemistry. Feb, 2013 | Pubmed ID: 23269670 PPARβ/δ Affects Pancreatic β Cell Mass and Insulin Secretion in Mice The Journal of Clinical Investigation. Nov, 2012 | Pubmed ID: 23093780 Neurochemical Characterization of Body Weight-regulating Leptin Receptor Neurons in the Nucleus of the Solitary Tract Endocrinology. Oct, 2012 | Pubmed ID: 22869346 Overlap of Endocrine Hormone Expression in the Mouse Intestine Revealed by Transcriptional Profiling and Flow Cytometry Endocrinology. Jul, 2012 | Pubmed ID: 22685263 G-protein-coupled Receptors in Intestinal Chemosensation Cell Metabolism. Apr, 2012 | Pubmed ID: 22482725 Intestinal Sensing of Nutrients Handbook of Experimental Pharmacology. 2012 | Pubmed ID: 22249821 Short-chain Fatty Acids Stimulate Glucagon-like Peptide-1 Secretion Via the G-protein-coupled Receptor FFAR2 Diabetes. Feb, 2012 | Pubmed ID: 22190648 Nutrient Detection by Incretin Hormone Secreting Cells Physiology & Behavior. Jun, 2012 | Pubmed ID: 22182802 Na(+)-D-glucose Cotransporter SGLT1 is Pivotal for Intestinal Glucose Absorption and Glucose-dependent Incretin Secretion Diabetes. Jan, 2012 | Pubmed ID: 22124465 Interleukin-6 Enhances Insulin Secretion by Increasing Glucagon-like Peptide-1 Secretion from L Cells and Alpha Cells Nature Medicine. Oct, 2011 | Pubmed ID: 22037645 CCK Stimulation of GLP-1 Neurons Involves α1-adrenoceptor-mediated Increase in Glutamatergic Synaptic Inputs Diabetes. Nov, 2011 | Pubmed ID: 21885869 Glutamine Triggers and Potentiates Glucagon-like Peptide-1 Secretion by Raising Cytosolic Ca2+ and CAMP Endocrinology. Feb, 2011 | Pubmed ID: 21209017 Role of Phosphodiesterase and Adenylate Cyclase Isozymes in Murine Colonic Glucagon-like Peptide 1 Secreting Cells British Journal of Pharmacology. May, 2011 | Pubmed ID: 21054345 Congenital Insensitivity to Pain: Novel SCN9A Missense and In-frame Deletion Mutations Human Mutation. Sep, 2010 | Pubmed ID: 20635406 Leptin Directly Depolarizes Preproglucagon Neurons in the Nucleus Tractus Solitarius: Electrical Properties of Glucagon-like Peptide 1 Neurons Diabetes. Aug, 2010 | Pubmed ID: 20522593 GLP-1 Inhibits and Adrenaline Stimulates Glucagon Release by Differential Modulation of N- and L-type Ca2+ Channel-dependent Exocytosis Cell Metabolism. Jun, 2010 | Pubmed ID: 20519125 Pain Perception is Altered by a Nucleotide Polymorphism in SCN9A Proceedings of the National Academy of Sciences of the United States of America. Mar, 2010 | Pubmed ID: 20212137 Molecular Mechanisms Underlying Nutrient Detection by Incretin-secreting Cells International Dairy Journal. Apr, 2010 | Pubmed ID: 20204054 Increased Liver Stiffness in Alcoholic Liver Disease: Differentiating Fibrosis from Steatohepatitis World Journal of Gastroenterology. Feb, 2010 | Pubmed ID: 20180235 Molecular Mechanisms Underlying Nutrient-stimulated Incretin Secretion Expert Reviews in Molecular Medicine. Jan, 2010 | Pubmed ID: 20047700 Hypogonadotropic Hypogonadism Due to a Novel Missense Mutation in the First Extracellular Loop of the Neurokinin B Receptor The Journal of Clinical Endocrinology and Metabolism. Oct, 2009 | Pubmed ID: 19755480 Insulin Storage and Glucose Homeostasis in Mice Null for the Granule Zinc Transporter ZnT8 and Studies of the Type 2 Diabetes-associated Variants Diabetes. Sep, 2009 | Pubmed ID: 19542200 TAC3 and TACR3 Mutations in Familial Hypogonadotropic Hypogonadism Reveal a Key Role for Neurokinin B in the Central Control of Reproduction Nature Genetics. Mar, 2009 | Pubmed ID: 19079066 Oral Glutamine Increases Circulating Glucagon-like Peptide 1, Glucagon, and Insulin Concentrations in Lean, Obese, and Type 2 Diabetic Subjects The American Journal of Clinical Nutrition. Jan, 2009 | Pubmed ID: 19056578 Nutritional Regulation of Glucagon-like Peptide-1 Secretion The Journal of Physiology. Jan, 2009 | Pubmed ID: 19001044 Dissociation Between Sensing and Metabolism of Glucose in Sugar Sensing Neurones The Journal of Physiology. Jan, 2009 | Pubmed ID: 18981030 Glucose Sensing in L Cells: a Primary Cell Study Cell Metabolism. Dec, 2008 | Pubmed ID: 19041768 Extrahepatic Cholestasis Increases Liver Stiffness (FibroScan) Irrespective of Fibrosis Hepatology (Baltimore, Md.). Nov, 2008 | Pubmed ID: 18836992 No Differences in Mortality Between Users of Pancreatic-specific and Non-pancreatic-specific Sulphonylureas: a Cohort Analysis Diabetes, Obesity & Metabolism. Apr, 2008 | Pubmed ID: 18093208 An SCN9A Channelopathy Causes Congenital Inability to Experience Pain Nature. Dec, 2006 | Pubmed ID: 17167479 Sodium-coupled Glucose Cotransporters Contribute to Hypothalamic Glucose Sensing Diabetes. Dec, 2006 | Pubmed ID: 17130483 Mucolipin-1 is a Lysosomal Membrane Protein Required for Intracellular Lactosylceramide Traffic Traffic (Copenhagen, Denmark). Oct, 2006 | Pubmed ID: 16978393 Relapsing Diabetes Can Result from Moderately Activating Mutations in KCNJ11 Human Molecular Genetics. Apr, 2005 | Pubmed ID: 15718250 Constitutive Ras Activity Induces Hippocampal Hypertrophy and Remodeling of Pyramidal Neurons in SynRas Mice Journal of Neuroscience Research. Sep, 2004 | Pubmed ID: 15352209 Open to Control--new Hope for Patients with Neonatal Diabetes The New England Journal of Medicine. Apr, 2004 | Pubmed ID: 15115828 A Novel Missense Mutation in AE1 Causing Autosomal Dominant Distal Renal Tubular Acidosis Retains Normal Transport Function but is Mistargeted in Polarized Epithelial Cells The Journal of Biological Chemistry. Apr, 2004 | Pubmed ID: 14734552 A Novel Glucose-sensing Mechanism Contributing to Glucagon-like Peptide-1 Secretion from the GLUTag Cell Line Diabetes. May, 2003 | Pubmed ID: 12716745 Differential Selectivity of Insulin Secretagogues: Mechanisms, Clinical Implications, and Drug Interactions Journal of Diabetes and Its Complications. Mar-Apr, 2003 | Pubmed ID: 12623163 Analysis of the Differential Modulation of Sulphonylurea Block of Beta-cell and Cardiac ATP-sensitive K+ (K(ATP)) Channels by Mg-nucleotides The Journal of Physiology. Feb, 2003 | Pubmed ID: 12562963 A New Subtype of Autosomal Dominant Diabetes Attributable to a Mutation in the Gene for Sulfonylurea Receptor 1 Lancet (London, England). Jan, 2003 | Pubmed ID: 12559865 Sulfonylurea Stimulation of Insulin Secretion Diabetes. Dec, 2002 | Pubmed ID: 12475777 Glucose-sensing in Glucagon-like Peptide-1-secreting Cells Diabetes. Sep, 2002 | Pubmed ID: 12196469 Смешанные первичные культуры мышиных тонкой кишки, предназначенные для изучения Gut Гормон Секреции и живых изображений клеток из клеток энтероэндокринных Arianna Psichas*1, Gwen Tolhurst*1, Cheryl A. Brighton1, Fiona M. Gribble1, Frank Reimann1 1Metabolic Research Laboratories and MRC Metabolic Diseases Unit, Wellcome Trust-MRC Institute of Metabolic Science, University of Cambridge JoVE 55687 Biology
Смешанные первичные культуры мышиных тонкой кишки, предназначенные для изучения Gut Гормон Секреции и живых изображений клеток из клеток энтероэндокринных Arianna Psichas*1, Gwen Tolhurst*1, Cheryl A. Brighton1, Fiona M. Gribble1, Frank Reimann1 1Metabolic Research Laboratories and MRC Metabolic Diseases Unit, Wellcome Trust-MRC Institute of Metabolic Science, University of Cambridge JoVE 55687 Biology