Fulvio Mavilio Center for Genome Research, Department of Life Sciences University of Modena and Reggio Emilia Biography Publications Institution JoVE Articles Fulvio Mavilio has not added a biography. If you are Fulvio Mavilio and would like to personalize this page please email our Author Liaison for assistance. Publications Systemic AAV8-Mediated Gene Therapy Drives Whole-Body Correction of Myotubular Myopathy in Dogs Molecular Therapy : the Journal of the American Society of Gene Therapy. Apr, 2017 | Pubmed ID: 28237839 Efficacy and Biodistribution Analysis of Intracerebroventricular Administration of an Optimized ScAAV9-SMN1 Vector in a Mouse Model of Spinal Muscular Atrophy Molecular Therapy. Methods & Clinical Development. 2016 | Pubmed ID: 27652289 Transcriptional, Epigenetic and Retroviral Signatures Identify Regulatory Regions Involved in Hematopoietic Lineage Commitment Scientific Reports. Apr, 2016 | Pubmed ID: 27095295 Dynamic Transcriptional and Epigenetic Regulation of Human Epidermal Keratinocyte Differentiation Stem Cell Reports. Apr, 2016 | Pubmed ID: 27050947 Genome-Wide Definition of Promoter and Enhancer Usage During Neural Induction of Human Embryonic Stem Cells PloS One. 2015 | Pubmed ID: 25978676 Outcomes Following Gene Therapy in Patients with Severe Wiskott-Aldrich Syndrome JAMA. Apr, 2015 | Pubmed ID: 25898053 Nuclear Architecture Dictates HIV-1 Integration Site Selection Nature. May, 2015 | Pubmed ID: 25731161 A Single Epidermal Stem Cell Strategy for Safe Ex Vivo Gene Therapy EMBO Molecular Medicine. Apr, 2015 | Pubmed ID: 25724200 Perspectives on Best Practices for Gene Therapy Programs Human Gene Therapy. Mar, 2015 | Pubmed ID: 25654329 Genomic Analysis of Sleeping Beauty Transposon Integration in Human Somatic Cells PloS One. 2014 | Pubmed ID: 25390293 Genome-wide Analysis of Alpharetroviral Integration in Human Hematopoietic Stem/progenitor Cells Genes. May, 2014 | Pubmed ID: 24840152 Repairing Without Cutting: a Safer Alternative to Gene Correction? Molecular Therapy : the Journal of the American Society of Gene Therapy. Apr, 2014 | Pubmed ID: 24691177 Gene Therapy Prolongs Survival and Restores Function in Murine and Canine Models of Myotubular Myopathy Science Translational Medicine. Jan, 2014 | Pubmed ID: 24452262 RD2-MolPack-Chim3, a Packaging Cell Line for Stable Production of Lentiviral Vectors for Anti-HIV Gene Therapy Human Gene Therapy Methods. Aug, 2013 | Pubmed ID: 23767932 Targeted Gene Addition in Human Epithelial Stem Cells by Zinc-finger Nuclease-mediated Homologous Recombination Molecular Therapy : the Journal of the American Society of Gene Therapy. Sep, 2013 | Pubmed ID: 23760447 Genotoxic Signature in Cord Blood Cells of Newborns Exposed in Utero to a Zidovudine-based Antiretroviral Combination The Journal of Infectious Diseases. Jul, 2013 | Pubmed ID: 23559464 Nup153 and Nup98 Bind the HIV-1 Core and Contribute to the Early Steps of HIV-1 Replication Virology. May, 2013 | Pubmed ID: 23523133 Deletion of the LTR Enhancer/promoter Has No Impact on the Integration Profile of MLV Vectors in Human Hematopoietic Progenitors PloS One. 2013 | Pubmed ID: 23383272 Traducir La Revolución Genómica: La Necesidad De Un Consorcio De Terapia De Gene Internacional Para Enfermedades Monogénicas Molecular Therapy : the Journal of the American Society of Gene Therapy. Feb, 2013 | Pubmed ID: 23369965 Mechanisms of Retroviral Integration and Mutagenesis Human Gene Therapy. Feb, 2013 | Pubmed ID: 23330935 IL-7 and IL-15 Instruct the Generation of Human Memory Stem T Cells from Naive Precursors Blood. Jan, 2013 | Pubmed ID: 23160470 Gene Therapies Need New Development Models Nature. Oct, 2012 | Pubmed ID: 23038429 Lentiviral Vector Integration in the Human Genome Induces Alternative Splicing and Generates Aberrant Transcripts The Journal of Clinical Investigation. May, 2012 | Pubmed ID: 22523069 Alternative Splicing Caused by Lentiviral Integration in the Human Genome Methods in Enzymology. 2012 | Pubmed ID: 22365773 Gene Therapy of Skin Adhesion Disorders (mini Review) Current Pharmaceutical Biotechnology. Aug, 2012 | Pubmed ID: 22250710 Preclinical Corrective Gene Transfer in Xeroderma Pigmentosum Human Skin Stem Cells Molecular Therapy : the Journal of the American Society of Gene Therapy. Apr, 2012 | Pubmed ID: 22068429 The GATA1-HS2 Enhancer Allows Persistent and Position-independent Expression of a β-globin Transgene PloS One. 2011 | Pubmed ID: 22164220 Estimated Comparative Integration Hotspots Identify Different Behaviors of Retroviral Gene Transfer Vectors PLoS Computational Biology. Dec, 2011 | Pubmed ID: 22144885 Insertion Sites in Engrafted Cells Cluster Within a Limited Repertoire of Genomic Areas After Gammaretroviral Vector Gene Therapy Molecular Therapy : the Journal of the American Society of Gene Therapy. Nov, 2011 | Pubmed ID: 21862999 Site-specific Integration by the Adeno-associated Virus Rep Protein Current Gene Therapy. Oct, 2011 | Pubmed ID: 21827397 Correction of Murine SCID-X1 by Lentiviral Gene Therapy Using a Codon-optimized IL2RG Gene and Minimal Pretransplant Conditioning Molecular Therapy : the Journal of the American Society of Gene Therapy. Oct, 2011 | Pubmed ID: 21750532 High-definition Mapping of Retroviral Integration Sites Defines the Fate of Allogeneic T Cells After Donor Lymphocyte Infusion PloS One. 2010 | Pubmed ID: 21203516 High-definition Mapping of Retroviral Integration Sites Identifies Active Regulatory Elements in Human Multipotent Hematopoietic Progenitors Blood. Dec, 2010 | Pubmed ID: 20864581 Correction of Beta-thalassemia Major by Gene Transfer in Haematopoietic Progenitors of Pediatric Patients EMBO Molecular Medicine. Aug, 2010 | Pubmed ID: 20665635 Gene Therapy: Back on Track? EMBO Reports. Feb, 2010 | Pubmed ID: 20118988 Comprehensive Genomic Access to Vector Integration in Clinical Gene Therapy Nature Medicine. Dec, 2009 | Pubmed ID: 19966782 Integration of Retroviral Vectors Induces Minor Changes in the Transcriptional Activity of T Cells from ADA-SCID Patients Treated with Gene Therapy Blood. Oct, 2009 | Pubmed ID: 19652199 Transcriptional Enhancers Induce Insertional Gene Deregulation Independently from the Vector Type and Design Molecular Therapy : the Journal of the American Society of Gene Therapy. May, 2009 | Pubmed ID: 19293778 Transcription Factor Binding Sites Are Genetic Determinants of Retroviral Integration in the Human Genome PloS One. 2009 | Pubmed ID: 19238208 Tracking Gene-modified T Cells in Vivo Methods in Molecular Biology (Clifton, N.J.). 2009 | Pubmed ID: 19110640 PPARdelta is a Ligand-dependent Negative Regulator of Vitamin D3-induced Monocyte Differentiation Carcinogenesis. Feb, 2009 | Pubmed ID: 19056929 Correction of Laminin-5 Deficiency in Human Epidermal Stem Cells by Transcriptionally Targeted Lentiviral Vectors Molecular Therapy : the Journal of the American Society of Gene Therapy. Dec, 2008 | Pubmed ID: 18813277 Genetic Modification of Somatic Stem Cells. The Progress, Problems and Prospects of a New Therapeutic Technology EMBO Reports. Jul, 2008 | Pubmed ID: 18578029 Role of CD34 Antigen in Myeloid Differentiation of Human Hematopoietic Progenitor Cells Stem Cells (Dayton, Ohio). Apr, 2008 | Pubmed ID: 18192237 Multilineage Hematopoietic Reconstitution Without Clonal Selection in ADA-SCID Patients Treated with Stem Cell Gene Therapy The Journal of Clinical Investigation. Aug, 2007 | Pubmed ID: 17671653 Long-term Engraftment of Single Genetically Modified Human Epidermal Holoclones Enables Safety Pre-assessment of Cutaneous Gene Therapy Molecular Therapy : the Journal of the American Society of Gene Therapy. Sep, 2007 | Pubmed ID: 17579576 C/EBPdelta Regulates Cell Cycle and Self-renewal of Human Limbal Stem Cells The Journal of Cell Biology. Jun, 2007 | Pubmed ID: 17562792 Hot Spots of Retroviral Integration in Human CD34+ Hematopoietic Cells Blood. Sep, 2007 | Pubmed ID: 17507662 Towards a Gene Therapy Clinical Trial for Epidermolysis Bullosa Reviews on Recent Clinical Trials. May, 2006 | Pubmed ID: 18473966 Correction of Junctional Epidermolysis Bullosa by Transplantation of Genetically Modified Epidermal Stem Cells Nature Medicine. Dec, 2006 | Pubmed ID: 17115047 Site-specific Integration into the Human Genome: Ready for Clinical Application? Rejuvenation Research. 2006 | Pubmed ID: 17105384 Gene Therapy in Combination with Tissue Engineering to Treat Epidermolysis Bullosa Expert Opinion on Biological Therapy. Apr, 2006 | Pubmed ID: 16548763 Retroviral Vector Integration Deregulates Gene Expression but Has No Consequence on the Biology and Function of Transplanted T Cells Proceedings of the National Academy of Sciences of the United States of America. Jan, 2006 | Pubmed ID: 16432223 T Lymphocytes Transduced with a Lentiviral Vector Expressing F12-Vif Are Protected from HIV-1 Infection in an APOBEC3G-independent Manner Molecular Therapy : the Journal of the American Society of Gene Therapy. Oct, 2005 | Pubmed ID: 16039909 Gene Therapy Approaches for Epidermolysis Bullosa Clinics in Dermatology. Jul-Aug, 2005 | Pubmed ID: 16023940 Competitive Engraftment of Hematopoietic Stem Cells Genetically Modified with a Truncated Erythropoietin Receptor Human Gene Therapy. May, 2005 | Pubmed ID: 15916484 Stem Cell Plasticity: Time for a Reappraisal? Haematologica. Mar, 2005 | Pubmed ID: 15749669 Site-specific Integration of Functional Transgenes into the Human Genome by Adeno/AAV Hybrid Vectors Molecular Therapy : the Journal of the American Society of Gene Therapy. Oct, 2004 | Pubmed ID: 15451450 The Future of Gene Therapy Nature. Feb, 2004 | Pubmed ID: 14985734 The Choice of a Suitable Lentivirus Vector: Transcriptional Targeting Methods in Molecular Biology (Clifton, N.J.). 2003 | Pubmed ID: 12824618 Myogenic Stem Cells from the Bone Marrow: a Therapeutic Alternative for Muscular Dystrophy? Neuromuscular Disorders : NMD. Oct, 2002 | Pubmed ID: 12206789 Transcriptional Targeting of Lentiviral Vectors by Long Terminal Repeat Enhancer Replacement Journal of Virology. Apr, 2002 | Pubmed ID: 11907239 Células Madre Hematopoyéticas Derivado Del Músculo Son Hematopoyéticas En Origen Proceedings of the National Academy of Sciences of the United States of America. Feb, 2002 | Pubmed ID: 11830662 Escaneo Retroviral: Mapeo de sitios de integración MLV para definir regiones reguladoras específicas de células Oriana Romano1,2, Ingrid Cifola3, Valentina Poletti4, Marco Severgnini3, Clelia Peano3, Gianluca De Bellis3, Fulvio Mavilio1,4, Annarita Miccio1,2,4,5 1Center for Genome Research, Department of Life Sciences, University of Modena and Reggio Emilia, 2Laboratory of Chromatin and Gene Regulation During Development, Imagine Institute, 3Institute for Biomedical Technologies, CNR, 4Généthon, 5Sorbonne Paris Cité - Université Paris Descartes JoVE 55919 Genetics
Escaneo Retroviral: Mapeo de sitios de integración MLV para definir regiones reguladoras específicas de células Oriana Romano1,2, Ingrid Cifola3, Valentina Poletti4, Marco Severgnini3, Clelia Peano3, Gianluca De Bellis3, Fulvio Mavilio1,4, Annarita Miccio1,2,4,5 1Center for Genome Research, Department of Life Sciences, University of Modena and Reggio Emilia, 2Laboratory of Chromatin and Gene Regulation During Development, Imagine Institute, 3Institute for Biomedical Technologies, CNR, 4Généthon, 5Sorbonne Paris Cité - Université Paris Descartes JoVE 55919 Genetics
