Gabriela Chiosis Molecular Pharmacology and Chemistry Program Memorial Sloan Kettering Cancer Center Biography Publications Institution JoVE Articles Gabriela Chiosis has not added a biography. If you are Gabriela Chiosis and would like to personalize this page please email our Author Liaison for assistance. Publications Affinity Purification Probes of Potential Use to Investigate the Endogenous Hsp70 Interactome in Cancer ACS Chemical Biology. Aug, 2014 | Pubmed ID: 24934503 Protein Chaperones: a Composition of Matter Review (2008 - 2013) Expert Opinion on Therapeutic Patents. May, 2014 | Pubmed ID: 24742089 Heat Shock Protein 90 Inhibitors in the Treatment of Cancer: Current Status and Future Directions Expert Opinion on Investigational Drugs. May, 2014 | Pubmed ID: 24669860 Environment-responsive Nanophores for Therapy and Treatment Monitoring Via Molecular MRI Quenching Nature Communications. 2014 | Pubmed ID: 24594970 Heat Shock Protein 70 Inhibitors. 2. 2,5'-thiodipyrimidines, 5-(phenylthio)pyrimidines, 2-(pyridin-3-ylthio)pyrimidines, and 3-(phenylthio)pyridines As Reversible Binders to an Allosteric Site on Heat Shock Protein 70 Journal of Medicinal Chemistry. Feb, 2014 | Pubmed ID: 24548239 Heat Shock Protein 70 Inhibitors. 1. 2,5'-thiodipyrimidine and 5-(phenylthio)pyrimidine Acrylamides As Irreversible Binders to an Allosteric Site on Heat Shock Protein 70 Journal of Medicinal Chemistry. Feb, 2014 | Pubmed ID: 24548207 Improved Targeting of JAK2 Leads to Increased Therapeutic Efficacy in Myeloproliferative Neoplasms Blood. Mar, 2014 | Pubmed ID: 24470592 Pre-clinical Efficacy of PU-H71, a Novel HSP90 Inhibitor, Alone and in Combination with Bortezomib in Ewing Sarcoma Molecular Oncology. Mar, 2014 | Pubmed ID: 24388362 Regulatory Chaperone Complexes in Neurodegenerative Diseases: a Perspective on Therapeutic Intervention Current Alzheimer Research. Jan, 2014 | Pubmed ID: 24251390 Chaperone-dependent Neurodegeneration: A Molecular Perspective on Therapeutic Intervention Journal of Alzheimer's Disease & Parkinsonism. Apr, 2013 | Pubmed ID: 25258700 Identification of an Allosteric Pocket on Human Hsp70 Reveals a Mode of Inhibition of This Therapeutically Important Protein Chemistry & Biology. Dec, 2013 | Pubmed ID: 24239008 A Purine Analog Synergizes with Chloroquine (CQ) by Targeting Plasmodium Falciparum Hsp90 (PfHsp90) PloS One. 2013 | Pubmed ID: 24098696 Molecular Chaperone Gp96 is a Novel Therapeutic Target of Multiple Myeloma Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Nov, 2013 | Pubmed ID: 24077352 Paralog-selective Hsp90 Inhibitors Define Tumor-specific Regulation of HER2 Nature Chemical Biology. Nov, 2013 | Pubmed ID: 23995768 Experimental and Structural Testing Module to Analyze Paralogue-Specificity and Affinity in the Hsp90 Inhibitors Series Journal of Medicinal Chemistry. Aug, 2013 | Pubmed ID: 23965125 Targeting the Hsp90-associated Viral Oncoproteome in Gammaherpesvirus-associated Malignancies Blood. Oct, 2013 | Pubmed ID: 23943653 Posttranslational Modification and Conformational State of Heat Shock Protein 90 Differentially Affect Binding of Chemically Diverse Small Molecule Inhibitors Oncotarget. Jul, 2013 | Pubmed ID: 23867252 α7 Helix Region of αI Domain is Crucial for Integrin Binding to Endoplasmic Reticulum Chaperone Gp96: a Potential Therapeutic Target for Cancer Metastasis The Journal of Biological Chemistry. Jun, 2013 | Pubmed ID: 23671277 Synthesis and Evaluation of Cell-permeable Biotinylated PU-H71 Derivatives As Tumor Hsp90 Probes Beilstein Journal of Organic Chemistry. 2013 | Pubmed ID: 23616796 Monitoring Afatinib Treatment in HER2-positive Gastric Cancer with 18F-FDG and 89Zr-trastuzumab PET Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. Jun, 2013 | Pubmed ID: 23578997 A Global View of Hsp90 Functions Nature Structural & Molecular Biology. Jan, 2013 | Pubmed ID: 23288357 The Novel HSP90 Inhibitor, PU-H71, Suppresses Glial Cell Activation but Weakly Affects Clinical Signs of EAE Journal of Neuroimmunology. Feb, 2013 | Pubmed ID: 23123171 Discovery and Validation of Small-molecule Heat-shock Protein 90 Inhibitors Through Multimodality Molecular Imaging in Living Subjects Proceedings of the National Academy of Sciences of the United States of America. Sep, 2012 | Pubmed ID: 22895790 Heterodimeric JAK-STAT Activation As a Mechanism of Persistence to JAK2 Inhibitor Therapy Nature. Sep, 2012 | Pubmed ID: 22820254 Heat Shock Protein Gp96 Regulates Toll-like Receptor 9 Proteolytic Processing and Conformational Stability Biochemical and Biophysical Research Communications. May, 2012 | Pubmed ID: 22554506 Targeting of KRAS Mutant Tumors by HSP90 Inhibitors Involves Degradation of STK33 The Journal of Experimental Medicine. Apr, 2012 | Pubmed ID: 22451720 Advances in the Clinical Development of Heat Shock Protein 90 (Hsp90) Inhibitors in Cancers Biochimica Et Biophysica Acta. Mar, 2012 | Pubmed ID: 22062686 Advances in the Discovery and Development of Heat-shock Protein 90 Inhibitors for Cancer Treatment Expert Opinion on Drug Discovery. May, 2011 | Pubmed ID: 22400044 HSP90 Inhibitors As Therapy for Multiple Myeloma Clinical Lymphoma, Myeloma & Leukemia. Jun, 2011 | Pubmed ID: 22035754 Affinity-based Proteomics Reveal Cancer-specific Networks Coordinated by Hsp90 Nature Chemical Biology. Nov, 2011 | Pubmed ID: 21946277 Synthesis of Purine-scaffold Fluorescent Probes for Heat Shock Protein 90 with Use in Flow Cytometry and Fluorescence Microscopy Bioorganic & Medicinal Chemistry Letters. Sep, 2011 | Pubmed ID: 21802945 Design, Synthesis, and Evaluation of Small Molecule Hsp90 Probes Bioorganic & Medicinal Chemistry. Apr, 2011 | Pubmed ID: 21459002 Heat Shock Protein 90-sheltered Overexpression of Insulin-like Growth Factor 1 Receptor Contributes to Malignancy of Thymic Epithelial Tumors Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Apr, 2011 | Pubmed ID: 21372220 Design of a Flexible Cell-based Assay for the Evaluation of Heat Shock Protein 70 Expression Modulators Assay and Drug Development Technologies. Jun, 2011 | Pubmed ID: 21133677 BCL6 Repression of EP300 in Human Diffuse Large B Cell Lymphoma Cells Provides a Basis for Rational Combinatorial Therapy The Journal of Clinical Investigation. Nov, 2010 | Pubmed ID: 21041953 The Anti-myeloma Activity of a Novel Purine Scaffold HSP90 Inhibitor PU-H71 is Via Inhibition of Both HSP90A and HSP90B1 Journal of Hematology & Oncology. 2010 | Pubmed ID: 20977755 HSP90 is a Therapeutic Target in JAK2-dependent Myeloproliferative Neoplasms in Mice and Humans The Journal of Clinical Investigation. Oct, 2010 | Pubmed ID: 20852385 Assay Strategies for the Discovery and Validation of Therapeutics Targeting Brugia Pahangi Hsp90 PLoS Neglected Tropical Diseases. 2010 | Pubmed ID: 20559560 Heat Shock Protein 90 in Neurodegenerative Diseases Molecular Neurodegeneration. 2010 | Pubmed ID: 20525284 Synthesis of Reblastatin, Autolytimycin, and Non-benzoquinone Analogues: Potent Inhibitors of Heat Shock Protein 90 The Journal of Organic Chemistry. May, 2010 | Pubmed ID: 20392070 Measuring the Pharmacodynamic Effects of a Novel Hsp90 Inhibitor on HER2/neu Expression in Mice Using Zr-DFO-trastuzumab PloS One. 2010 | Pubmed ID: 20111600 A Purine Scaffold Hsp90 Inhibitor Destabilizes BCL-6 and Has Specific Antitumor Activity in BCL-6-dependent B Cell Lymphomas Nature Medicine. Dec, 2009 | Pubmed ID: 19966776 Purine-scaffold Hsp90 Inhibitors Current Topics in Medicinal Chemistry. 2009 | Pubmed ID: 19860732 Targeting Heat Shock Protein 90 with Non-quinone Inhibitors: a Novel Chemotherapeutic Approach in Human Hepatocellular Carcinoma Hepatology (Baltimore, Md.). Jul, 2009 | Pubmed ID: 19441108 Hsp90 Inhibitor PU-H71, a Multimodal Inhibitor of Malignancy, Induces Complete Responses in Triple-negative Breast Cancer Models Proceedings of the National Academy of Sciences of the United States of America. May, 2009 | Pubmed ID: 19416831 Assay for Isolation of Inhibitors of Her2-kinase Expression Methods in Molecular Biology (Clifton, N.J.). 2009 | Pubmed ID: 19347621 Microwave-assisted One Step Synthesis of 8-arylmethyl-9H-purin-6-amines Bioorganic & Medicinal Chemistry Letters. Jan, 2009 | Pubmed ID: 19058963 Discovery and Development of Heat Shock Protein 90 Inhibitors Bioorganic & Medicinal Chemistry. Mar, 2009 | Pubmed ID: 19017562 Discovery and Development of Purine-scaffold Hsp90 Inhibitors Expert Opinion on Drug Discovery. Jan, 2008 | Pubmed ID: 23480142 Heat Shock Protein 90: Translation from Cancer to Alzheimer's Disease Treatment? BMC Neuroscience. 2008 | Pubmed ID: 19090995 Kaiso Contributes to DNA Methylation-dependent Silencing of Tumor Suppressor Genes in Colon Cancer Cell Lines Cancer Research. Sep, 2008 | Pubmed ID: 18794111 Targeting Hsp90: Small-molecule Inhibitors and Their Clinical Development Current Opinion in Pharmacology. Aug, 2008 | Pubmed ID: 18644253 Discovery of Aminoquinolines As a New Class of Potent Inhibitors of Heat Shock Protein 90 (Hsp90): Synthesis, Biology, and Molecular Modeling Bioorganic & Medicinal Chemistry. Jul, 2008 | Pubmed ID: 18571929 The Yeast Hsp110, Sse1p, Exhibits High-affinity Peptide Binding FEBS Letters. Jul, 2008 | Pubmed ID: 18539149 Design of a Fluorescence Polarization Assay Platform for the Study of Human Hsp70 Bioorganic & Medicinal Chemistry Letters. Jul, 2008 | Pubmed ID: 18515098 The Chaperone Activity of Heat Shock Protein 90 is Critical for Maintaining the Stability of Leucine-rich Repeat Kinase 2 The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Mar, 2008 | Pubmed ID: 18367605 Development and Application of Hsp90 Inhibitors Drug Discovery Today. Jan, 2008 | Pubmed ID: 18190862 Molecular Imaging of the Efficacy of Heat Shock Protein 90 Inhibitors in Living Subjects Cancer Research. Jan, 2008 | Pubmed ID: 18172314 Anti-cancer Therapeutic Approaches Based on Intracellular and Extracellular Heat Shock Proteins Current Medicinal Chemistry. 2007 | Pubmed ID: 18045130 High-throughput Screening Fluorescence Polarization Assay for Tumor-specific Hsp90 Journal of Biomolecular Screening. Oct, 2007 | Pubmed ID: 17942784 Selective Compounds Define Hsp90 As a Major Inhibitor of Apoptosis in Small-cell Lung Cancer Nature Chemical Biology. Aug, 2007 | Pubmed ID: 17603540 Roles of Heat-shock Protein 90 in Maintaining and Facilitating the Neurodegenerative Phenotype in Tauopathies Proceedings of the National Academy of Sciences of the United States of America. May, 2007 | Pubmed ID: 17517623 Tumor Selectivity of Hsp90 Inhibitors: the Explanation Remains Elusive ACS Chemical Biology. Jun, 2006 | Pubmed ID: 17163756 Purine-scaffold Hsp90 Inhibitors IDrugs : the Investigational Drugs Journal. Nov, 2006 | Pubmed ID: 17096299 Gene Expression Signature-based Chemical Genomic Prediction Identifies a Novel Class of HSP90 Pathway Modulators Cancer Cell. Oct, 2006 | Pubmed ID: 17010675 Structural and Quantum Chemical Studies of 8-aryl-sulfanyl Adenine Class Hsp90 Inhibitors Journal of Medicinal Chemistry. Aug, 2006 | Pubmed ID: 16884307 Hsp70 Molecular Chaperones: Emerging Roles in Human Disease and Identification of Small Molecule Modulators Current Topics in Medicinal Chemistry. 2006 | Pubmed ID: 16842158 Discovery and Development of Purine-scaffold Hsp90 Inhibitors Current Topics in Medicinal Chemistry. 2006 | Pubmed ID: 16842155 Synthesis of a Red-shifted Fluorescence Polarization Probe for Hsp90 Bioorganic & Medicinal Chemistry Letters. Sep, 2006 | Pubmed ID: 16797988 Heat Shock Protein-90 Inhibitors: a Chronicle from Geldanamycin to Today's Agents Current Opinion in Investigational Drugs (London, England : 2000). Jun, 2006 | Pubmed ID: 16784024 Identification of Novel Quaternary Domain Interactions in the Hsp90 Chaperone, GRP94 Protein Science : a Publication of the Protein Society. Jun, 2006 | Pubmed ID: 16731965 Synthesis of Hsp90 Dimerization Modulators Bioorganic & Medicinal Chemistry Letters. Jul, 2006 | Pubmed ID: 16621545 New Arylthioindoles: Potent Inhibitors of Tubulin Polymerization. 2. Structure-activity Relationships and Molecular Modeling Studies Journal of Medicinal Chemistry. Feb, 2006 | Pubmed ID: 16451061 Targeting Chaperones in Transformed Systems--a Focus on Hsp90 and Cancer Expert Opinion on Therapeutic Targets. Feb, 2006 | Pubmed ID: 16441227 Identification of Potent Water Soluble Purine-scaffold Inhibitors of the Heat Shock Protein 90 Journal of Medicinal Chemistry. Jan, 2006 | Pubmed ID: 16392823 Small Molecule Microarrays: from Proteins to Mammalian Cells - Are We There Yet? Trends in Biotechnology. Jun, 2005 | Pubmed ID: 15922078 Evaluation of 8-arylsulfanyl, 8-arylsulfoxyl, and 8-arylsulfonyl Adenine Derivatives As Inhibitors of the Heat Shock Protein 90 Journal of Medicinal Chemistry. Apr, 2005 | Pubmed ID: 15828828 Hsp90: the Vulnerable Chaperone Drug Discovery Today. Oct, 2004 | Pubmed ID: 15475321 Development of a Fluorescence Polarization Assay for the Molecular Chaperone Hsp90 Journal of Biomolecular Screening. Aug, 2004 | Pubmed ID: 15296636 Targeting Wide-range Oncogenic Transformation Via PU24FCl, a Specific Inhibitor of Tumor Hsp90 Chemistry & Biology. Jun, 2004 | Pubmed ID: 15217612 General Method for the Synthesis of 8-arylsulfanyl Adenine Derivatives The Journal of Organic Chemistry. Apr, 2004 | Pubmed ID: 15104473 Synthesis of Novel Fluorescent Probes for the Molecular Chaperone Hsp90 Bioorganic & Medicinal Chemistry Letters. Nov, 2003 | Pubmed ID: 14592488 Development of Purine-scaffold Small Molecule Inhibitors of Hsp90 Current Cancer Drug Targets. Oct, 2003 | Pubmed ID: 14529388 Microtiter Cell-based Assay for Detection of Agents That Alter Cellular Levels of Her2 and EGFR Chemistry & Biology. Jul, 2003 | Pubmed ID: 12890536 Vancomycin Resistance: Occurrence, Mechanisms and Strategies to Combat It Expert Opinion on Therapeutic Targets. Jun, 2003 | Pubmed ID: 12783569 Total Synthesis As a Resource in the Discovery of Potentially Valuable Antitumor Agents: Cycloproparadicicol Angewandte Chemie (International Ed. in English). Mar, 2003 | Pubmed ID: 12645064 17AAG: Low Target Binding Affinity and Potent Cell Activity--finding an Explanation Molecular Cancer Therapeutics. Feb, 2003 | Pubmed ID: 12589029 BCR-ABL Point Mutants Isolated from Patients with Imatinib Mesylate-resistant Chronic Myeloid Leukemia Remain Sensitive to Inhibitors of the BCR-ABL Chaperone Heat Shock Protein 90 Blood. Oct, 2002 | Pubmed ID: 12351420 Development of a Purine-scaffold Novel Class of Hsp90 Binders That Inhibit the Proliferation of Cancer Cells and Induce the Degradation of Her2 Tyrosine Kinase Bioorganic & Medicinal Chemistry. Nov, 2002 | Pubmed ID: 12213470 Akt Forms an Intracellular Complex with Heat Shock Protein 90 (Hsp90) and Cdc37 and is Destabilized by Inhibitors of Hsp90 Function The Journal of Biological Chemistry. Oct, 2002 | Pubmed ID: 12176997 Ex Vivo Treatment Response of Primary Tumors and/or Associated Metastases for Preclinical and Clinical Development of Therapeutics Adriana D. Corben*1, Mohammad M. Uddin*2, Brooke Crawford3, Mohammad Farooq4, Shanu Modi5, John Gerecitano5, Gabriela Chiosis2, Mary L. Alpaugh6 1Department of Pathology, Memorial Sloan Kettering Cancer Center, 2Molecular Pharmacology and Chemistry Program, Memorial Sloan Kettering Cancer Center, 3Department of Radiology, Weill Cornell Medical College, 4Department of Medicine, Memorial Sloan Kettering Cancer Center, 5Department of Oncology, Memorial Sloan Kettering Cancer Center, 6Department of Surgery, Memorial Sloan Kettering Cancer Center JoVE 52157 Medicine
Ex Vivo Treatment Response of Primary Tumors and/or Associated Metastases for Preclinical and Clinical Development of Therapeutics Adriana D. Corben*1, Mohammad M. Uddin*2, Brooke Crawford3, Mohammad Farooq4, Shanu Modi5, John Gerecitano5, Gabriela Chiosis2, Mary L. Alpaugh6 1Department of Pathology, Memorial Sloan Kettering Cancer Center, 2Molecular Pharmacology and Chemistry Program, Memorial Sloan Kettering Cancer Center, 3Department of Radiology, Weill Cornell Medical College, 4Department of Medicine, Memorial Sloan Kettering Cancer Center, 5Department of Oncology, Memorial Sloan Kettering Cancer Center, 6Department of Surgery, Memorial Sloan Kettering Cancer Center JoVE 52157 Medicine
