Gail V.W. Johnson

Publications

• Metabolic State Determines Sensitivity to Cellular Stress in Huntington Disease: Normalization by Activation of PPARγ
  PloS One. 2012  |   Pubmed ID: 22276192
• Complete Transglutaminase 2 Ablation Results in Reduced Stroke Volumes and Astrocytes That Exhibit Increased Survival in Response to Ischemia
  Neurobiology of Disease. Mar, 2012  |   Pubmed ID: 22198379
• Transglutaminase 2: A Molecular Swiss Army Knife
  Biochimica Et Biophysica Acta. Feb, 2012  |   Pubmed ID: 22015769
• Truncated Tau and Aβ Cooperatively Impair Mitochondria in Primary Neurons
  Neurobiology of Aging. Mar, 2012  |   Pubmed ID: 21450370
• Decreases in Valosin-containing Protein Result in Increased Levels of Tau Phosphorylated at Ser262/356
  FEBS Letters. Nov, 2011  |   Pubmed ID: 21983102
• Transglutaminase 2 and Its Role in Pulmonary Fibrosis
  American Journal of Respiratory and Critical Care Medicine. Sep, 2011  |   Pubmed ID: 21700912
• The Toxicity of Tau in Alzheimer Disease: Turnover, Targets and Potential Therapeutics
  Journal of Cellular and Molecular Medicine. Aug, 2011  |   Pubmed ID: 21348938
• Cytosolic Guanine Nucledotide Binding Deficient Form of Transglutaminase 2 (R580a) Potentiates Cell Death in Oxygen Glucose Deprivation
  PloS One. 2011  |   Pubmed ID: 21304968
• Split GFP Complementation Assay for Quantitative Measurement of Tau Aggregation in Situ
  Methods in Molecular Biology (Clifton, N.J.). 2011  |   Pubmed ID: 20967587
• AES/GRG5: More Than Just a Dominant-negative TLE/GRG Family Member
  Developmental Dynamics : an Official Publication of the American Association of Anatomists. Nov, 2010  |   Pubmed ID: 20925119
• The Role of Tau Kinases in Alzheimer's Disease
  Current Opinion in Drug Discovery & Development. Sep, 2010  |   Pubmed ID: 20812151
• Differential Modulation of TCF/LEF-1 Activity by the Soluble LRP6-ICD
  PloS One. 2010  |   Pubmed ID: 20676368
• The Interrelationship Between Mitochondrial Dysfunction and Transcriptional Dysregulation in Huntington Disease
  Journal of Bioenergetics and Biomembranes. Jun, 2010  |   Pubmed ID: 20556492
• A Caspase Cleaved Form of Tau is Preferentially Degraded Through the Autophagy Pathway
  The Journal of Biological Chemistry. Jul, 2010  |   Pubmed ID: 20466727
• Phosphorylation of PPP(S/T)P Motif of the Free LRP6 Intracellular Domain is Not Required to Activate the Wnt/beta-catenin Pathway and Attenuate GSK3beta Activity
  Journal of Cellular Biochemistry. Nov, 2009  |   Pubmed ID: 19711366
• Role of Mitochondrial Dysfunction in the Pathogenesis of Huntington's Disease
  Brain Research Bulletin. Oct, 2009  |   Pubmed ID: 19622387
• Intracellular Localization and Conformational State of Transglutaminase 2: Implications for Cell Death
  PloS One. 2009  |   Pubmed ID: 19568436
• Caspase-cleaved Tau Expression Induces Mitochondrial Dysfunction in Immortalized Cortical Neurons: Implications for the Pathogenesis of Alzheimer Disease
  The Journal of Biological Chemistry. Jul, 2009  |   Pubmed ID: 19389700
• Increased Expression of Bim Contributes to the Potentiation of Serum Deprivation-induced Apoptotic Cell Death in Huntington's Disease Knock-in Striatal Cell Line
  Neurological Research. Feb, 2009  |   Pubmed ID: 18691453
• Immortalized Cortical Neurons Expressing Caspase-cleaved Tau Are Sensitized to Endoplasmic Reticulum Stress Induced Cell Death
  Brain Research. Oct, 2008  |   Pubmed ID: 18718455
• The Last Tangle of Tau
  Journal of Alzheimer's Disease : JAD. Aug, 2008  |   Pubmed ID: 18688096
• Rosiglitazone Treatment Prevents Mitochondrial Dysfunction in Mutant Huntingtin-expressing Cells: Possible Role of Peroxisome Proliferator-activated Receptor-gamma (PPARgamma) in the Pathogenesis of Huntington Disease
  The Journal of Biological Chemistry. Sep, 2008  |   Pubmed ID: 18640979
• Histone Deacetylase 6 Interacts with the Microtubule-associated Protein Tau
  Journal of Neurochemistry. Sep, 2008  |   Pubmed ID: 18636984
• New Application of Beta-galactosidase Complementation to Monitor Tau Self-association
  Journal of Neurochemistry. Aug, 2008  |   Pubmed ID: 18498442
• Transglutaminase 2 Protects Against Ischemic Insult, Interacts with HIF1beta, and Attenuates HIF1 Signaling
  FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Aug, 2008  |   Pubmed ID: 18375543
• Split GFP Complementation Assay: a Novel Approach to Quantitatively Measure Aggregation of Tau in Situ: Effects of GSK3beta Activation and Caspase 3 Cleavage
  Journal of Neurochemistry. Dec, 2007  |   Pubmed ID: 17908237
• Activation of Glycogen Synthase Kinase 3beta Promotes the Intermolecular Association of Tau. The Use of Fluorescence Resonance Energy Transfer Microscopy
  The Journal of Biological Chemistry. Aug, 2007  |   Pubmed ID: 17565981
• Ubiquitin-proteasome System Alterations in a Striatal Cell Model of Huntington's Disease
  Journal of Neuroscience Research. Jun, 2007  |   Pubmed ID: 17455294
• Type 2 Transglutaminase Differentially Modulates Striatal Cell Death in the Presence of Wild Type or Mutant Huntingtin
  Journal of Neurochemistry. Jul, 2007  |   Pubmed ID: 17403029
• Mitochondrial-targeted Active Akt Protects SH-SY5Y Neuroblastoma Cells from Staurosporine-induced Apoptotic Cell Death
  Journal of Cellular Biochemistry. Sep, 2007  |   Pubmed ID: 17340627
• Regulated Proteolytic Processing of LRP6 Results in Release of Its Intracellular Domain
  Journal of Neurochemistry. Apr, 2007  |   Pubmed ID: 17326769
• Transglutaminase 2 in Neurodegenerative Disorders
  Frontiers in Bioscience : a Journal and Virtual Library. 2007  |   Pubmed ID: 17127346
• The Role of Tau Phosphorylation and Cleavage in Neuronal Cell Death
  Frontiers in Bioscience : a Journal and Virtual Library. 2007  |   Pubmed ID: 17127334
• The Role of Tau Phosphorylation in the Pathogenesis of Alzheimer's Disease
  Current Alzheimer Research. Dec, 2006  |   Pubmed ID: 17168644
• Tau is Hyperphosphorylated at Multiple Sites in Mouse Brain in Vivo After Streptozotocin-induced Insulin Deficiency
  Diabetes. Dec, 2006  |   Pubmed ID: 17130475
• Mutant Huntingtin Expression Induces Mitochondrial Calcium Handling Defects in Clonal Striatal Cells: Functional Consequences
  The Journal of Biological Chemistry. Nov, 2006  |   Pubmed ID: 16973623
• Tau Phosphorylation and Proteolysis: Insights and Perspectives
  Journal of Alzheimer's Disease : JAD. 2006  |   Pubmed ID: 16914862
• Site-specific Phosphorylation and Caspase Cleavage Differentially Impact Tau-microtubule Interactions and Tau Aggregation
  The Journal of Biological Chemistry. Jul, 2006  |   Pubmed ID: 16687396
• Tissue Transglutaminase Overexpression in the Brain Potentiates Calcium-induced Hippocampal Damage
  Journal of Neurochemistry. Apr, 2006  |   Pubmed ID: 16539654
• The Low Density Lipoprotein Receptor-related Protein 6 Interacts with Glycogen Synthase Kinase 3 and Attenuates Activity
  The Journal of Biological Chemistry. Feb, 2006  |   Pubmed ID: 16365045
• The Protective Effects of Cystamine in the R6/2 Huntington's Disease Mouse Involve Mechanisms Other Than the Inhibition of Tissue Transglutaminase
  Neurobiology of Aging. Jun, 2006  |   Pubmed ID: 15896882
• Cystamine Treatment is Neuroprotective in the YAC128 Mouse Model of Huntington Disease
  Journal of Neurochemistry. Oct, 2005  |   Pubmed ID: 16181425
• Increased Glutathione Levels in Cortical and Striatal Mitochondria of the R6/2 Huntington's Disease Mouse Model
  Neuroscience Letters. Sep, 2005  |   Pubmed ID: 15993538
• Mitochondrial Respiration and ATP Production Are Significantly Impaired in Striatal Cells Expressing Mutant Huntingtin
  The Journal of Biological Chemistry. Sep, 2005  |   Pubmed ID: 15983033
• 14-3-3Zeta Does Not Increase GSK3beta-mediated Tau Phosphorylation in Cell Culture Models
  Neuroscience Letters. Aug, 2005  |   Pubmed ID: 15963640
• Verification of Somatic CAG Repeat Expansion by Pre-PCR Fractionation
  Journal of Neuroscience Methods. May, 2005  |   Pubmed ID: 15848234
• Role of the Intracellular Domains of LRP5 and LRP6 in Activating the Wnt Canonical Pathway
  Journal of Cellular Biochemistry. May, 2005  |   Pubmed ID: 15778991
• Transglutaminases in Neurodegenerative Disorders
  Progress in Experimental Tumor Research. 2005  |   Pubmed ID: 15746534
• Tau Phosphorylation: Physiological and Pathological Consequences
  Biochimica Et Biophysica Acta. Jan, 2005  |   Pubmed ID: 15615646
• Tissue Transglutaminase Contributes to Disease Progression in the R6/2 Huntington's Disease Mouse Model Via Aggregate-independent Mechanisms
  Journal of Neurochemistry. Jan, 2005  |   Pubmed ID: 15606898
• FRAT-2 Preferentially Increases Glycogen Synthase Kinase 3 Beta-mediated Phosphorylation of Primed Sites, Which Results in Enhanced Tau Phosphorylation
  The Journal of Biological Chemistry. Jan, 2005  |   Pubmed ID: 15522877
• Developmental Regulation of Tissue Transglutaminase in the Mouse Forebrain
  Journal of Neurochemistry. Dec, 2004  |   Pubmed ID: 15584913
• Tau Phosphorylation in Neuronal Cell Function and Dysfunction
  Journal of Cell Science. Nov, 2004  |   Pubmed ID: 15537830
• Glycogen Synthase Kinase 3 Beta Induces Caspase-cleaved Tau Aggregation in Situ
  The Journal of Biological Chemistry. Dec, 2004  |   Pubmed ID: 15494420
• Tissue Transglutaminase is Not Involved in the Aggregate Formation of Stably Expressed Alpha-synuclein in SH-SY5Y Human Neuroblastoma Cells
  Archives of Pharmacal Research. Aug, 2004  |   Pubmed ID: 15460447
• Mutant Huntingtin Directly Increases Susceptibility of Mitochondria to the Calcium-induced Permeability Transition and Cytochrome C Release
  Human Molecular Genetics. Jul, 2004  |   Pubmed ID: 15163634
• The Glamour and Gloom of Glycogen Synthase Kinase-3
  Trends in Biochemical Sciences. Feb, 2004  |   Pubmed ID: 15102436
• Effects of Cyclin-dependent Kinase-5 Activity on Apoptosis and Tau Phosphorylation in Immortalized Mouse Brain Cortical Cells
  Journal of Neuroscience Research. Apr, 2004  |   Pubmed ID: 15048935
• Validity of Mouse Models for the Study of Tissue Transglutaminase in Neurodegenerative Diseases
  Molecular and Cellular Neurosciences. Mar, 2004  |   Pubmed ID: 15033177
• Cyclin-dependent Kinase-5 in Neurodegeneration
  Journal of Neurochemistry. Mar, 2004  |   Pubmed ID: 15009631
• Immunoblot Analysis Reveals That Isopeptide Antibodies Do Not Specifically Recognize the Epsilon-(gamma-glutamyl)lysine Bonds Formed by Transglutaminase Activity
  Journal of Neuroscience Methods. Apr, 2004  |   Pubmed ID: 15003381
• Striatal Cells from Mutant Huntingtin Knock-in Mice Are Selectively Vulnerable to Mitochondrial Complex II Inhibitor-induced Cell Death Through a Non-apoptotic Pathway
  Human Molecular Genetics. Apr, 2004  |   Pubmed ID: 14962977
• Primed Phosphorylation of Tau at Thr231 by Glycogen Synthase Kinase 3beta (GSK3beta) Plays a Critical Role in Regulating Tau's Ability to Bind and Stabilize Microtubules
  Journal of Neurochemistry. Jan, 2004  |   Pubmed ID: 14690523
• Intracellular Localization and Activity State of Tissue Transglutaminase Differentially Impacts Cell Death
  The Journal of Biological Chemistry. Mar, 2004  |   Pubmed ID: 14670969
• Mutant (R406W) Human Tau is Hyperphosphorylated and Does Not Efficiently Bind Microtubules in a Neuronal Cortical Cell Model
  The Journal of Biological Chemistry. Feb, 2004  |   Pubmed ID: 14660557
• The P38 MAP Kinase Signaling Pathway in Alzheimer's Disease
  Experimental Neurology. Oct, 2003  |   Pubmed ID: 14552867
• Tissue Transglutaminase Directly Regulates Adenylyl Cyclase Resulting in Enhanced CAMP-response Element-binding Protein (CREB) Activation
  The Journal of Biological Chemistry. Jul, 2003  |   Pubmed ID: 12743114
• Cystamine Inhibits Caspase Activity. Implications for the Treatment of Polyglutamine Disorders
  The Journal of Biological Chemistry. Feb, 2003  |   Pubmed ID: 12458211
• Glycogen Synthase Kinase 3beta Phosphorylates Tau at Both Primed and Unprimed Sites. Differential Impact on Microtubule Binding
  The Journal of Biological Chemistry. Jan, 2003  |   Pubmed ID: 12409305
• Transient Osmotic Stress Facilitates Mutant Huntingtin Aggregation
  Neuroreport. Dec, 2002  |   Pubmed ID: 12499864
• Tau, Where Are We Now?
  Journal of Alzheimer's Disease : JAD. Oct, 2002  |   Pubmed ID: 12446970
• Axin Negatively Affects Tau Phosphorylation by Glycogen Synthase Kinase 3beta
  Journal of Neurochemistry. Nov, 2002  |   Pubmed ID: 12421363
• Identification of the N-terminal Functional Domains of Cdk5 by Molecular Truncation and Computer Modeling
  Proteins. Aug, 2002  |   Pubmed ID: 12112670
• Tissue Transglutaminase Differentially Modulates Apoptosis in a Stimuli-dependent Manner
  Journal of Neurochemistry. May, 2002  |   Pubmed ID: 12065637
• Cdk5 Phosphorylates P53 and Regulates Its Activity
  Journal of Neurochemistry. Apr, 2002  |   Pubmed ID: 12064478
• Direct, Activating Interaction Between Glycogen Synthase Kinase-3beta and P53 After DNA Damage
  Proceedings of the National Academy of Sciences of the United States of America. Jun, 2002  |   Pubmed ID: 12048243
• Mutant Huntingtin Aggregates Do Not Sensitize Cells to Apoptotic Stressors
  FEBS Letters. Mar, 2002  |   Pubmed ID: 11943195
• Does Tissue Transglutaminase Play a Role in Huntington's Disease?
  Neurochemistry International. Jan, 2002  |   Pubmed ID: 11738471