Gene S. Tan Department of Infectious Disease J. Craig Venter Institute Biography Publications Institution JoVE Articles Gene S. Tan has not added a biography. If you are Gene S. Tan and would like to personalize this page please email our Author Liaison for assistance. Publications Whole-Genome Sequences of Zika Virus FLR Strains After Passage in Vero or C6/36 Cells Genome Announcements. Jan, 2018 | Pubmed ID: 29371358 Alveolar Macrophages Are Critical for Broadly-reactive Antibody-mediated Protection Against Influenza A Virus in Mice Nature Communications. 10, 2017 | Pubmed ID: 29018261 Broadly Protective Murine Monoclonal Antibodies Against Influenza B Virus Target Highly Conserved Neuraminidase Epitopes Nature Microbiology. Aug, 2017 | Pubmed ID: 28827718 Synthetic TLR4 and TLR7 Ligands Work Additively Via MyD88 to Induce Protective Antiviral Immunity in Mice Journal of Virology. Jul, 2017 | Pubmed ID: 28724768 Broadly Neutralizing Hemagglutinin Stalk-Specific Antibodies Induce Potent Phagocytosis of Immune Complexes by Neutrophils in an Fc-Dependent Manner MBio. Oct, 2016 | Pubmed ID: 27703076 Epitope Specificity Plays a Critical Role in Regulating Antibody-dependent Cell-mediated Cytotoxicity Against Influenza A Virus Proceedings of the National Academy of Sciences of the United States of America. Oct, 2016 | Pubmed ID: 27698132 Optimal Activation of Fc-mediated Effector Functions by Influenza Virus Hemagglutinin Antibodies Requires Two Points of Contact Proceedings of the National Academy of Sciences of the United States of America. Oct, 2016 | Pubmed ID: 27647907 Both Neutralizing and Non-Neutralizing Human H7N9 Influenza Vaccine-Induced Monoclonal Antibodies Confer Protection Cell Host & Microbe. Jun, 2016 | Pubmed ID: 27281570 Broadly-Reactive Neutralizing and Non-neutralizing Antibodies Directed Against the H7 Influenza Virus Hemagglutinin Reveal Divergent Mechanisms of Protection PLoS Pathogens. Apr, 2016 | Pubmed ID: 27081859 Cryo-electron Microscopy Structures of Chimeric Hemagglutinin Displayed on a Universal Influenza Vaccine Candidate MBio. Mar, 2016 | Pubmed ID: 27006464 Influenza A Viruses Expressing Intra- or Intergroup Chimeric Hemagglutinins Journal of Virology. Jan, 2016 | Pubmed ID: 26764009 Hemagglutinin Stalk- and Neuraminidase-Specific Monoclonal Antibodies Protect Against Lethal H10N8 Influenza Virus Infection in Mice Journal of Virology. Oct, 2015 | Pubmed ID: 26512088 Anti-HA Glycoforms Drive B Cell Affinity Selection and Determine Influenza Vaccine Efficacy Cell. Jul, 2015 | Pubmed ID: 26140596 Vaccination with Soluble Headless Hemagglutinin Protects Mice from Challenge with Divergent Influenza Viruses Vaccine. Jun, 2015 | Pubmed ID: 26026378 Direct Administration in the Respiratory Tract Improves Efficacy of Broadly Neutralizing Anti-influenza Virus Monoclonal Antibodies Antimicrobial Agents and Chemotherapy. Jul, 2015 | Pubmed ID: 25941218 Vaccination with Adjuvanted Recombinant Neuraminidase Induces Broad Heterologous, but Not Heterosubtypic, Cross-protection Against Influenza Virus Infection in Mice MBio. Mar, 2015 | Pubmed ID: 25759506 Preexisting Human Antibodies Neutralize Recently Emerged H7N9 Influenza Strains The Journal of Clinical Investigation. Mar, 2015 | Pubmed ID: 25689254 Characterization of a Broadly Neutralizing Monoclonal Antibody That Targets the Fusion Domain of Group 2 Influenza A Virus Hemagglutinin Journal of Virology. Dec, 2014 | Pubmed ID: 25210195 Divergent H7 Immunogens Offer Protection from H7N9 Virus Challenge Journal of Virology. Apr, 2014 | Pubmed ID: 24453375 Broadly Neutralizing Hemagglutinin Stalk-specific Antibodies Require FcγR Interactions for Protection Against Influenza Virus in Vivo Nature Medicine. Feb, 2014 | Pubmed ID: 24412922 Assessment of Influenza Virus Hemagglutinin Stalk-based Immunity in Ferrets Journal of Virology. Mar, 2014 | Pubmed ID: 24403585 In Vivo Bioluminescent Imaging of Influenza a Virus Infection and Characterization of Novel Cross-protective Monoclonal Antibodies Journal of Virology. Aug, 2013 | Pubmed ID: 23698304 A Carboxy-terminal Trimerization Domain Stabilizes Conformational Epitopes on the Stalk Domain of Soluble Recombinant Hemagglutinin Substrates PloS One. 2012 | Pubmed ID: 22928001 A Virus-like Particle That Elicits Cross-reactive Antibodies to the Conserved Stem of Influenza Virus Hemagglutinin Journal of Virology. Nov, 2012 | Pubmed ID: 22896619 Hemagglutinin Stalk-Reactive Antibodies Are Boosted Following Sequential Infection with Seasonal and Pandemic H1N1 Influenza Virus in Mice Journal of Virology. Oct, 2012 | Pubmed ID: 22787225 A Pan-H1 Anti-hemagglutinin Monoclonal Antibody with Potent Broad-spectrum Efficacy in Vivo Journal of Virology. Jun, 2012 | Pubmed ID: 22491456 Influenza Viruses Expressing Chimeric Hemagglutinins: Globular Head and Stalk Domains Derived from Different Subtypes Journal of Virology. May, 2012 | Pubmed ID: 22398287 Hemagglutinin Stalk Antibodies Elicited by the 2009 Pandemic Influenza Virus As a Mechanism for the Extinction of Seasonal H1N1 Viruses Proceedings of the National Academy of Sciences of the United States of America. Feb, 2012 | Pubmed ID: 22308500 Vaccination with a Synthetic Peptide from the Influenza Virus Hemagglutinin Provides Protection Against Distinct Viral Subtypes Proceedings of the National Academy of Sciences of the United States of America. Nov, 2010 | Pubmed ID: 20956293 Broadly Protective Monoclonal Antibodies Against H3 Influenza Viruses Following Sequential Immunization with Different Hemagglutinins PLoS Pathogens. Feb, 2010 | Pubmed ID: 20195520 Attenuation of Rabies Virulence: Takeover by the Cytoplasmic Domain of Its Envelope Protein Science Signaling. Jan, 2010 | Pubmed ID: 20086240 Replication-deficient Rabies Virus-based Vaccines Are Safe and Immunogenic in Mice and Nonhuman Primates The Journal of Infectious Diseases. Oct, 2009 | Pubmed ID: 19764884 Intravenous Inoculation of a Bat-associated Rabies Virus Causes Lethal Encephalopathy in Mice Through Invasion of the Brain Via Neurosecretory Hypothalamic Fibers PLoS Pathogens. Jun, 2009 | Pubmed ID: 19543379 Immune Modulating Effect by a Phosphoprotein-deleted Rabies Virus Vaccine Vector Expressing Two Copies of the Rabies Virus Glycoprotein Gene Vaccine. Nov, 2008 | Pubmed ID: 18804506 PPEY Motif Within the Rabies Virus (RV) Matrix Protein is Essential for Efficient Virion Release and RV Pathogenicity Journal of Virology. Oct, 2008 | Pubmed ID: 18667490 The Dynein Light Chain 8 Binding Motif of Rabies Virus Phosphoprotein Promotes Efficient Viral Transcription Proceedings of the National Academy of Sciences of the United States of America. Apr, 2007 | Pubmed ID: 17438267 The Application of Reverse Genetics Technology in the Study of Rabies Virus (RV) Pathogenesis and for the Development of Novel RV Vaccines Journal of Neurovirology. Feb, 2005 | Pubmed ID: 15804964 Strong Cellular and Humoral Anti-HIV Env Immune Responses Induced by a Heterologous Rhabdoviral Prime-boost Approach Virology. Jan, 2005 | Pubmed ID: 15582655 Rabies Virus Nucleoprotein As a Carrier for Foreign Antigens Proceedings of the National Academy of Sciences of the United States of America. Jun, 2004 | Pubmed ID: 15197258 En metod för att bedöma Fc-medierad effektor funktioner induceras av influensa Hemagglutinin specifika antikroppar Mark J. Bailey1,2, Felix Broecker1, Paul E. Leon1,2, Gene S. Tan3 1Department of Microbiology, Icahn School of Medicine at Mount Sinai, 2Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, 3Department of Infectious Disease, J. Craig Venter Institute JoVE 56256 Immunology and Infection Generation av Escape varianter av neutraliserande influensa Virus monoklonala antikroppar Paul E. Leon1,2, Teddy John Wohlbold1,2, Wenqian He1,2, Mark J. Bailey1,2, Carole J. Henry3, Patrick C. Wilson3, Florian Krammer1, Gene S. Tan1 1Department of Microbiology, Icahn School of Medicine at Mount Sinai, 2Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, 3The Department of Medicine, Section of Rheumatology, The Knapp Center for Lupus and Immunology Research, The University of Chicago JoVE 56067 Immunology and Infection
En metod för att bedöma Fc-medierad effektor funktioner induceras av influensa Hemagglutinin specifika antikroppar Mark J. Bailey1,2, Felix Broecker1, Paul E. Leon1,2, Gene S. Tan3 1Department of Microbiology, Icahn School of Medicine at Mount Sinai, 2Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, 3Department of Infectious Disease, J. Craig Venter Institute JoVE 56256 Immunology and Infection
Generation av Escape varianter av neutraliserande influensa Virus monoklonala antikroppar Paul E. Leon1,2, Teddy John Wohlbold1,2, Wenqian He1,2, Mark J. Bailey1,2, Carole J. Henry3, Patrick C. Wilson3, Florian Krammer1, Gene S. Tan1 1Department of Microbiology, Icahn School of Medicine at Mount Sinai, 2Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, 3The Department of Medicine, Section of Rheumatology, The Knapp Center for Lupus and Immunology Research, The University of Chicago JoVE 56067 Immunology and Infection
