George Coukos Department of Oncology UNIL CHUV, Ludwig Institute for Cancer Research Lausanne University of Lausanne Biography Publications Institution JoVE Articles George Coukos has not added a biography. If you are George Coukos and would like to personalize this page please email our Author Liaison for assistance. Publications Mass Spectrometry Based Immunopeptidomics Leads to Robust Predictions of Phosphorylated HLA Class I Ligands Molecular & Cellular Proteomics : MCP. Dec, 2019 | Pubmed ID: 31848261 Analysis of Secondary Structure Biases in Naturally Presented HLA-I Ligands Frontiers in Immunology. 2019 | Pubmed ID: 31824508 Neutrophils Suppress Tumor-infiltrating T Cells in Colon Cancer Via Matrix Metalloproteinase-mediated Activation of TGFβ EMBO Molecular Medicine. Dec, 2019 | Pubmed ID: 31793740 A Phase I/II Trial Comparing Autologous Dendritic Cell Vaccine Pulsed Either with Personalized Peptides (PEP-DC) or with Tumor Lysate (OC-DC) in Patients with Advanced High-grade Ovarian Serous Carcinoma Journal of Translational Medicine. Nov, 2019 | Pubmed ID: 31771601 Immunopeptidomics of Colorectal Cancer Organoids Reveals a Sparse HLA Class I Neoantigen Landscape and No Increase in Neoantigens with Interferon or MEK-inhibitor Treatment Journal for Immunotherapy of Cancer. Nov, 2019 | Pubmed ID: 31735170 CD8 Binding of MHC-Peptide Complexes in Cis or Trans Regulates CD8 T-cell Responses Journal of Molecular Biology. Dec, 2019 | Pubmed ID: 31704286 Robust Prediction of HLA Class II Epitopes by Deep Motif Deconvolution of Immunopeptidomes Nature Biotechnology. Nov, 2019 | Pubmed ID: 31611696 Adenosine Mediates Functional and Metabolic Suppression of Peripheral and Tumor-infiltrating CD8 T Cells Journal for Immunotherapy of Cancer. Oct, 2019 | Pubmed ID: 31601268 Integrating SpyCatcher/SpyTag Covalent Fusion Technology into Phage Display Workflows for Rapid Antibody Discovery Scientific Reports. Sep, 2019 | Pubmed ID: 31492910 A Phase Ib Study of the Combination of Personalized Autologous Dendritic Cell Vaccine, Aspirin, and Standard of Care Adjuvant Chemotherapy Followed by Nivolumab for Resected Pancreatic Adenocarcinoma-A Proof of Antigen Discovery Feasibility in Three Patients Frontiers in Immunology. 2019 | Pubmed ID: 31440238 Rational Combinations of Immunotherapy with Radiotherapy in Ovarian Cancer The Lancet. Oncology. Aug, 2019 | Pubmed ID: 31364594 Targeting Adenosine in Cancer Immunotherapy to Enhance T-Cell Function Frontiers in Immunology. 2019 | Pubmed ID: 31244820 Mass Spectrometry Driven Exploration Reveals Nuances of Neoepitope-driven Tumor Rejection JCI Insight. Jun, 2019 | Pubmed ID: 31219806 Cooperation Between Constitutive and Inducible Chemokines Enables T Cell Engraftment and Immune Attack in Solid Tumors Cancer Cell. Jun, 2019 | Pubmed ID: 31185212 High-throughput Screening of Human Tumor Antigen-specific CD4 T Cells, Including Neoantigen-reactive T Cells Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Jul, 2019 | Pubmed ID: 31015344 Going Beyond the Sequences: TCR Binding Patterns at the Service of Cancer Detection Cancer Research. 04, 2019 | Pubmed ID: 30936076 Correction: Tumour-reactive T Cell Subsets in the Microenvironment of Ovarian Cancer British Journal of Cancer. Apr, 2019 | Pubmed ID: 30890776 Computational KIR Copy Number Discovery Reveals Interaction Between Inhibitory Receptor Burden and Survival Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing. 2019 | Pubmed ID: 30864318 The NAD-Booster Nicotinamide Riboside Potently Stimulates Hematopoiesis Through Increased Mitochondrial Clearance Cell Stem Cell. 03, 2019 | Pubmed ID: 30849366 Tumor Landscapes: β-Catenin Drives Immune Desertification Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. May, 2019 | Pubmed ID: 30837277 Tumour-reactive T Cell Subsets in the Microenvironment of Ovarian Cancer British Journal of Cancer. 02, 2019 | Pubmed ID: 30718808 Safety and Tolerability of Adoptive Cell Therapy in Cancer Drug Safety. 02, 2019 | Pubmed ID: 30649750 Addressing Current Challenges and Future Directions in Immuno-oncology: Expert Perspectives from the 2017 NIBIT Foundation Think Tank, Siena, Italy Cancer Immunology, Immunotherapy : CII. Jan, 2019 | Pubmed ID: 30564889 A Severe Case of Refractory Esophageal Stenosis Induced by Nivolumab and Responding to Tocilizumab Therapy Journal for Immunotherapy of Cancer. 12, 2018 | Pubmed ID: 30587227 The Length Distribution and Multiple Specificity of Naturally Presented HLA-I Ligands Journal of Immunology (Baltimore, Md. : 1950). 12, 2018 | Pubmed ID: 30429286 Two-Dimensional Label-Free Affinity Analysis of Tumor-Specific CD8 T Cells with a Biomimetic Plasmonic Sensor ACS Sensors. 11, 2018 | Pubmed ID: 30339020 Correction To: CART Cells Are Prone to Fas- and DR5-mediated Cell Death Journal for Immunotherapy of Cancer. 09, 2018 | Pubmed ID: 30253808 Estimating the Contribution of Proteasomal Spliced Peptides to the HLA-I Ligandome Molecular & Cellular Proteomics : MCP. 12, 2018 | Pubmed ID: 30171158 CART Cells Are Prone to Fas- and DR5-mediated Cell Death Journal for Immunotherapy of Cancer. 07, 2018 | Pubmed ID: 30005714 Label-Free Optofluidic Nanobiosensor Enables Real-Time Analysis of Single-Cell Cytokine Secretion Small (Weinheim an Der Bergstrasse, Germany). 06, 2018 | Pubmed ID: 29806234 Consensus Guidelines for the Use and Interpretation of Angiogenesis Assays Angiogenesis. 08, 2018 | Pubmed ID: 29766399 The C-terminal Extension Landscape of Naturally Presented HLA-I Ligands Proceedings of the National Academy of Sciences of the United States of America. 05, 2018 | Pubmed ID: 29712860 Personalized Cancer Vaccine Effectively Mobilizes Antitumor T Cell Immunity in Ovarian Cancer Science Translational Medicine. 04, 2018 | Pubmed ID: 29643231 T Cell-induced CSF1 Promotes Melanoma Resistance to PD1 Blockade Science Translational Medicine. 04, 2018 | Pubmed ID: 29643229 Sensitive and Frequent Identification of High Avidity Neo-epitope specific CD8 T Cells in Immunotherapy-naive Ovarian Cancer Nature Communications. 03, 2018 | Pubmed ID: 29545564 Correction To: Characterization of the First Fully Human Anti-TEM1 ScFv in Models of Solid Tumor Imaging and Immunotoxin-based Therapy Cancer Immunology, Immunotherapy : CII. 02, 2018 | Pubmed ID: 29313073 Tumour Endothelial Marker 1/endosialin-mediated Targeting of Human Sarcoma European Journal of Cancer (Oxford, England : 1990). 02, 2018 | Pubmed ID: 29304474 High-throughput and Sensitive Immunopeptidomics Platform Reveals Profound Interferonγ-Mediated Remodeling of the Human Leukocyte Antigen (HLA) Ligandome Molecular & Cellular Proteomics : MCP. 03, 2018 | Pubmed ID: 29242379 'Hotspots' of Antigen Presentation Revealed by Human Leukocyte Antigen Ligandomics for Neoantigen Prioritization Frontiers in Immunology. 2017 | Pubmed ID: 29104575 Local Endothelial Complement Activation Reverses Endothelial Quiescence, Enabling T-cell Homing, and Tumor Control During T-cell Immunotherapy Oncoimmunology. 2017 | Pubmed ID: 28932632 Tumour-derived PGD2 and NKp30-B7H6 Engagement Drives an Immunosuppressive ILC2-MDSC Axis Nature Communications. 09, 2017 | Pubmed ID: 28928446 Deciphering HLA-I Motifs Across HLA Peptidomes Improves Neo-antigen Predictions and Identifies Allostery Regulating HLA Specificity PLoS Computational Biology. Aug, 2017 | Pubmed ID: 28832583 The T-Cell Receptor Can Bind to the Peptide-Bound Major Histocompatibility Complex and Uncomplexed β-Microglobulin Through Distinct Binding Sites Biochemistry. 08, 2017 | Pubmed ID: 28671821 and Cell-based Analyses Reveal Strong Divergence Between Prediction and Observation of T-cell-recognized Tumor Antigen T-cell Epitopes The Journal of Biological Chemistry. 07, 2017 | Pubmed ID: 28536262 TIE-2 Expressing Monocytes in Human Cancers Oncoimmunology. 2017 | Pubmed ID: 28507810 Engineering Chimeric Antigen Receptor T-Cells for Racing in Solid Tumors: Don't Forget the Fuel Frontiers in Immunology. 2017 | Pubmed ID: 28421069 Radiotherapy Combination Opportunities Leveraging Immunity for the Next Oncology Practice CA: a Cancer Journal for Clinicians. Jan, 2017 | Pubmed ID: 27570942 Identifying Biological Mechanisms for Favorable Cancer Prognosis Using Non-hypothesis-driven Iterative Survival Analysis NPJ Systems Biology and Applications. 2016 | Pubmed ID: 28725481 Human Melanomas and Ovarian Cancers Overexpressing Mechanical Barrier Molecule Genes Lack Immune Signatures and Have Increased Patient Mortality Risk Oncoimmunology. 2016 | Pubmed ID: 28123876 Combine and Conquer: Double CTLA-4 and PD-1 Blockade Combined with Whole Tumor Antigen Vaccine Cooperate to Eradicate Tumors Cancer Research. 12, 2016 | Pubmed ID: 27909064 Neoantigen-based Cancer Immunotherapy Annals of Translational Medicine. Jul, 2016 | Pubmed ID: 27563649 1,2,3-Triazoles As Inhibitors of Indoleamine 2,3-dioxygenase 2 (IDO2) Bioorganic & Medicinal Chemistry Letters. 09, 2016 | Pubmed ID: 27469130 Ovarian Cancer Chemokines May Not Be a Significant Barrier During Whole Tumor Antigen Dendritic-cell Vaccine and Adoptive T-cell Immunotherapy Oncoimmunology. May, 2016 | Pubmed ID: 27467909 Mass Spectrometry-based Antigen Discovery for Cancer Immunotherapy Current Opinion in Immunology. 08, 2016 | Pubmed ID: 27155075 The Human Vaccines Project: A Roadmap for Cancer Vaccine Development Science Translational Medicine. Apr, 2016 | Pubmed ID: 27075624 TIE-2-expressing Monocytes Are Lymphangiogenic and Associate Specifically with Lymphatics of Human Breast Cancer Oncoimmunology. Feb, 2016 | Pubmed ID: 27057438 TCR-engineered T Cells to Treat Tumors: Seeing but Not Touching? Seminars in Immunology. Feb, 2016 | Pubmed ID: 26997556 Personalized Approaches to Active Immunotherapy in Cancer Biochimica Et Biophysica Acta. Jan, 2016 | Pubmed ID: 26241169 Phage Antibody Display Libraries: a Powerful Antibody Discovery Platform for Immunotherapy Critical Reviews in Biotechnology. 2016 | Pubmed ID: 25394539 Targeting Programmed Cell Death 1 in Ovarian Cancer Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. Dec, 2015 | Pubmed ID: 26503205 Comprehensive Genomic Characterization of Long Non-coding RNAs Across Human Cancers Cancer Cell. Oct, 2015 | Pubmed ID: 26461095 Overexpression of GPC6 and TMEM132D in Early Stage Ovarian Cancer Correlates with CD8+ T-Lymphocyte Infiltration and Increased Patient Survival BioMed Research International. 2015 | Pubmed ID: 26448945 Erratum To: Multifunctional Mitoxantrone-conjugated Magnetic Nanosystem for Targeted Therapy of Folate Receptor-overexpressing Malignant Cells Journal of Nanobiotechnology. Sep, 2015 | Pubmed ID: 26407625 Whole Tumor Antigen Vaccines: Where Are We? Vaccines. Apr, 2015 | Pubmed ID: 26343191 Multifunctional Mitoxantrone-conjugated Magnetic Nanosystem for Targeted Therapy of Folate Receptor-overexpressing Malignant Cells Journal of Nanobiotechnology. Mar, 2015 | Pubmed ID: 25880772 Angiogenic Activity of Breast Cancer Patients' Monocytes Reverted by Combined Use of Systems Modeling and Experimental Approaches PLoS Computational Biology. Mar, 2015 | Pubmed ID: 25768678 Tumor-infiltrating Lymphocytes in Triple-negative Breast Cancer: a Biomarker for Use Beyond Prognosis? Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. Apr, 2015 | Pubmed ID: 25753438 The Ovarian Cancer Chemokine Landscape Is Conducive to Homing of Vaccine-Primed and CD3/CD28-Costimulated T Cells Prepared for Adoptive Therapy Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Jun, 2015 | Pubmed ID: 25712684 Targeting the Tumor Vasculature to Enhance T Cell Activity Current Opinion in Immunology. Apr, 2015 | Pubmed ID: 25665467 T Cells Bearing a Chimeric Antigen Receptor Against Prostate-specific Membrane Antigen Mediate Vascular Disruption and Result in Tumor Regression Cancer Immunology Research. Jan, 2015 | Pubmed ID: 25358763 Development, Optimization, and Validation of Novel Anti-TEM1/CD248 Affinity Agent for Optical Imaging in Cancer Oncotarget. Aug, 2014 | Pubmed ID: 25051365 Overexpression of SMARCE1 is Associated with CD8+ T-cell Infiltration in Early Stage Ovarian Cancer The International Journal of Biochemistry & Cell Biology. Aug, 2014 | Pubmed ID: 24880093 Shikonin-loaded Antibody-armed Nanoparticles for Targeted Therapy of Ovarian Cancer International Journal of Nanomedicine. 2014 | Pubmed ID: 24790428 A Dendritic Cell Vaccine Pulsed with Autologous Hypochlorous Acid-oxidized Ovarian Cancer Lysate Primes Effective Broad Antitumor Immunity: from Bench to Bedside Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Sep, 2013 | Pubmed ID: 23838316 TIE-2 and VEGFR Kinase Activities Drive Immunosuppressive Function of TIE-2-expressing Monocytes in Human Breast Tumors Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Jul, 2013 | Pubmed ID: 23649001 Medição da massa mitocondrial e potencial de membrana em células-tronco hematopoiéticas e células T por citometria flow Mukul Girotra*1,2, Anne-Christine Thierry3, Alexandre Harari1,3, George Coukos1, Olaia Naveiras2,4, Nicola Vannini*1 1Department of Oncology UNIL CHUV, Ludwig Institute for Cancer Research Lausanne, University of Lausanne, 2Swiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences, Swiss Federal Institute of Technology Lausanne (EPFL), 3Center of Experimental Therapeutics, Department of Oncology, Centre Hospitalier Universitaire Vaudois, 4Hematology Service, Department of Oncology, Centre Hospitalier Universitaire Vaudois (CHUV) JoVE 60475 Biology
Medição da massa mitocondrial e potencial de membrana em células-tronco hematopoiéticas e células T por citometria flow Mukul Girotra*1,2, Anne-Christine Thierry3, Alexandre Harari1,3, George Coukos1, Olaia Naveiras2,4, Nicola Vannini*1 1Department of Oncology UNIL CHUV, Ludwig Institute for Cancer Research Lausanne, University of Lausanne, 2Swiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences, Swiss Federal Institute of Technology Lausanne (EPFL), 3Center of Experimental Therapeutics, Department of Oncology, Centre Hospitalier Universitaire Vaudois, 4Hematology Service, Department of Oncology, Centre Hospitalier Universitaire Vaudois (CHUV) JoVE 60475 Biology
