George Daley Childrens Hospital, Harvard Stem Cell Institute Harvard Medical School Biography Publications Institution JoVE Articles George Daley has not added a biography. If you are George Daley and would like to personalize this page please email our Author Liaison for assistance. Publications Biotechnology. A Prudent Path Forward for Genomic Engineering and Germline Gene Modification Science (New York, N.Y.). Apr, 2015 | Pubmed ID: 25791083 De Novo Generation of HSCs from Somatic and Pluripotent Stem Cell Sources Blood. Mar, 2015 | Pubmed ID: 25762177 Metabolic Switches Linked to Pluripotency and Embryonic Stem Cell Differentiation Cell Metabolism. Mar, 2015 | Pubmed ID: 25738450 Notch1 Acts Via Foxc2 to Promote Definitive Hematopoiesis Via Effects on Hemogenic Endothelium Blood. Feb, 2015 | Pubmed ID: 25587036 A Comparison of Non-integrating Reprogramming Methods Nature Biotechnology. Jan, 2015 | Pubmed ID: 25437882 Defining Cellular Identity Through Network Biology Cell Cycle (Georgetown, Tex.). 2014 | Pubmed ID: 25485572 Deconstructing Transcriptional Heterogeneity in Pluripotent Stem Cells Nature. Dec, 2014 | Pubmed ID: 25471879 Deriving Blood Stem Cells from Pluripotent Stem Cells for Research and Therapy Best Practice & Research. Clinical Haematology. Sep-Dec, 2014 | Pubmed ID: 25455281 A Nontranscriptional Role for Oct4 in the Regulation of Mitotic Entry Proceedings of the National Academy of Sciences of the United States of America. Nov, 2014 | Pubmed ID: 25324523 The Epithelial-mesenchymal Transition Factor SNAIL Paradoxically Enhances Reprogramming Stem Cell Reports. Nov, 2014 | Pubmed ID: 25316190 Stem Cell Therapy. Use of Differentiated Pluripotent Stem Cells As Replacement Therapy for Treating Disease Science (New York, N.Y.). Aug, 2014 | Pubmed ID: 25146295 CellNet: Network Biology Applied to Stem Cell Engineering Cell. Aug, 2014 | Pubmed ID: 25126793 Dissecting Engineered Cell Types and Enhancing Cell Fate Conversion Via CellNet Cell. Aug, 2014 | Pubmed ID: 25126792 Lin28b is Sufficient to Drive Liver Cancer and Necessary for Its Maintenance in Murine Models Cancer Cell. Aug, 2014 | Pubmed ID: 25117712 Effect of Developmental Stage of HSC and Recipient on Transplant Outcomes Developmental Cell. Jun, 2014 | Pubmed ID: 24914562 Alternative Splicing of MBD2 Supports Self-renewal in Human Pluripotent Stem Cells Cell Stem Cell. Jul, 2014 | Pubmed ID: 24813856 Functional Evaluation of ES-somatic Cell Hybrids in Vitro and in Vivo Cellular Reprogramming. Jun, 2014 | Pubmed ID: 24787484 Lin28 Sustains Early Renal Progenitors and Induces Wilms Tumor Genes & Development. May, 2014 | Pubmed ID: 24732380 Musashi-2 Controls Cell Fate, Lineage Bias, and TGF-β Signaling in HSCs The Journal of Experimental Medicine. Jan, 2014 | Pubmed ID: 24395885 Distinct and Combinatorial Functions of Jmjd2b/Kdm4b and Jmjd2c/Kdm4c in Mouse Embryonic Stem Cell Identity Molecular Cell. Jan, 2014 | Pubmed ID: 24361252 Lin28 Enhances Tissue Repair by Reprogramming Cellular Metabolism Cell. Nov, 2013 | Pubmed ID: 24209617 Development. A Stem Cell Perspective on Cellular Engineering Science (New York, N.Y.). Nov, 2013 | Pubmed ID: 24202165 Human Endogenous Retrovirus K (HML-2) RNA and Protein Expression is a Marker for Human Embryonic and Induced Pluripotent Stem Cells Retrovirology. 2013 | Pubmed ID: 24156636 Proteolytic Autodigestion: Common Tissue Pathology in Shwachman-Diamond Syndrome? Cell Cycle (Georgetown, Tex.). 2013 | Pubmed ID: 24107623 Induction of Multipotential Hematopoietic Progenitors from Human Pluripotent Stem Cells Via Respecification of Lineage-restricted Precursors Cell Stem Cell. Oct, 2013 | Pubmed ID: 24094326 Hematopoietic Defects and IPSC Disease Modeling: Lessons Learned Immunology Letters. Sep-Oct, 2013 | Pubmed ID: 24076116 Stem Cells: Reprogramming in Situ Nature. Oct, 2013 | Pubmed ID: 24025771 A Chemical Logic for Reprogramming to Pluripotency Cell Research. Dec, 2013 | Pubmed ID: 23979017 Optimization of Scarless Human Stem Cell Genome Editing Nucleic Acids Research. Jul, 2013 | Pubmed ID: 23907390 A New Route to Human Embryonic Stem Cells Nature Medicine. Jul, 2013 | Pubmed ID: 23836223 Comment on "Drug Screening for ALS Using Patient-specific Induced Pluripotent Stem Cells" Science Translational Medicine. Jun, 2013 | Pubmed ID: 23740897 Notch-HES1 Signaling Axis Controls Hemato-endothelial Fate Decisions of Human Embryonic and Induced Pluripotent Stem Cells Blood. Aug, 2013 | Pubmed ID: 23733337 Stem Cell Metabolism in Tissue Development and Aging Development (Cambridge, England). Jun, 2013 | Pubmed ID: 23715547 Origins and Implications of Pluripotent Stem Cell Variability and Heterogeneity Nature Reviews. Molecular Cell Biology. Jun, 2013 | Pubmed ID: 23673969 Fetal Deficiency of Lin28 Programs Life-long Aberrations in Growth and Glucose Metabolism Stem Cells (Dayton, Ohio). Aug, 2013 | Pubmed ID: 23666760 Regulation of Stem Cell Therapies Under Attack in Europe: for Whom the Bell Tolls The EMBO Journal. May, 2013 | Pubmed ID: 23644381 Deciphering the Rules of CeRNA Networks Proceedings of the National Academy of Sciences of the United States of America. Apr, 2013 | Pubmed ID: 23620514 Pluripotent Stem Cell Models of Shwachman-Diamond Syndrome Reveal a Common Mechanism for Pancreatic and Hematopoietic Dysfunction Cell Stem Cell. Jun, 2013 | Pubmed ID: 23602541 Lin28: Primal Regulator of Growth and Metabolism in Stem Cells Cell Stem Cell. Apr, 2013 | Pubmed ID: 23561442 The Src Homology 2 Protein Shb Promotes Cell Cycle Progression in Murine Hematopoietic Stem Cells by Regulation of Focal Adhesion Kinase Activity Experimental Cell Research. Jul, 2013 | Pubmed ID: 23528453 Induced Pluripotent Stem Cells with a Mitochondrial DNA Deletion Stem Cells (Dayton, Ohio). Jul, 2013 | Pubmed ID: 23400930 Lin28a Regulates Germ Cell Pool Size and Fertility Stem Cells (Dayton, Ohio). Feb, 2013 | Pubmed ID: 23378032 Reprogrammed Cells for Disease Modeling and Regenerative Medicine Annual Review of Medicine. 2013 | Pubmed ID: 23327523 A Blueprint for Engineering Cell Fate: Current Technologies to Reprogram Cell Identity Cell Research. Jan, 2013 | Pubmed ID: 23277278 Signaling Axis Involving Hedgehog, Notch, and Scl Promotes the Embryonic Endothelial-to-hematopoietic Transition Proceedings of the National Academy of Sciences of the United States of America. Jan, 2013 | Pubmed ID: 23236128 Influence of Threonine Metabolism on S-adenosylmethionine and Histone Methylation Science (New York, N.Y.). Jan, 2013 | Pubmed ID: 23118012 Therapeutic Potential of Human Induced Pluripotent Stem Cells in Experimental Stroke Cell Transplantation. 2013 | Pubmed ID: 23044029 Cellular Alchemy and the Golden Age of Reprogramming Cell. Dec, 2012 | Pubmed ID: 23217698 Zcchc11 Uridylates Mature MiRNAs to Enhance Neonatal IGF-1 Expression, Growth, and Survival PLoS Genetics. 2012 | Pubmed ID: 23209448 The Transcriptional Landscape of Hematopoietic Stem Cell Ontogeny Cell Stem Cell. Nov, 2012 | Pubmed ID: 23122293 Metabolic Regulation in Pluripotent Stem Cells During Reprogramming and Self-renewal Cell Stem Cell. Nov, 2012 | Pubmed ID: 23122286 Impaired Intrinsic Immunity to HSV-1 in Human IPSC-derived TLR3-deficient CNS Cells Nature. Oct, 2012 | Pubmed ID: 23103873 Euchromatin Islands in Large Heterochromatin Domains Are Enriched for CTCF Binding and Differentially DNA-methylated Regions BMC Genomics. 2012 | Pubmed ID: 23102236 Altered Hematopoiesis in Trisomy 21 As Revealed Through in Vitro Differentiation of Isogenic Human Pluripotent Cells Proceedings of the National Academy of Sciences of the United States of America. Oct, 2012 | Pubmed ID: 23045682 Functional Vascular Smooth Muscle Cells Derived from Human Induced Pluripotent Stem Cells Via Mesenchymal Stem Cell Intermediates Cardiovascular Research. Dec, 2012 | Pubmed ID: 22941255 Caudal Genes in Blood Development and Leukemia Annals of the New York Academy of Sciences. Aug, 2012 | Pubmed ID: 22901255 New Lessons Learned from Disease Modeling with Induced Pluripotent Stem Cells Current Opinion in Genetics & Development. Oct, 2012 | Pubmed ID: 22749051 The Promise and Perils of Stem Cell Therapeutics Cell Stem Cell. Jun, 2012 | Pubmed ID: 22704514 Quantitative Proteomic Analysis of Induced Pluripotent Stem Cells Derived from a Human Huntington's Disease Patient The Biochemical Journal. Sep, 2012 | Pubmed ID: 22694310 Stem Cells Assessed Nature Reviews. Molecular Cell Biology. Jul, 2012 | Pubmed ID: 22678486 Neuronal Properties, in Vivo Effects, and Pathology of a Huntington's Disease Patient-derived Induced Pluripotent Stem Cells Stem Cells (Dayton, Ohio). Sep, 2012 | Pubmed ID: 22628015 Excision of a Viral Reprogramming Cassette by Delivery of Synthetic Cre MRNA Current Protocols in Stem Cell Biology. 2012 | Pubmed ID: 22605648 Pluripotent Stem Cells in Research and Treatment of Hemoglobinopathies Cold Spring Harbor Perspectives in Medicine. Apr, 2012 | Pubmed ID: 22474618 Accessing Naïve Human Pluripotency Current Opinion in Genetics & Development. Jun, 2012 | Pubmed ID: 22463982 Mutant Induced Pluripotent Stem Cell Lines Recapitulate Aspects of TDP-43 Proteinopathies and Reveal Cell-specific Vulnerability Proceedings of the National Academy of Sciences of the United States of America. Mar, 2012 | Pubmed ID: 22451909 Reprogramming Cellular Identity for Regenerative Medicine Cell. Mar, 2012 | Pubmed ID: 22424223 Nanog-like Regulates Endoderm Formation Through the Mxtx2-Nodal Pathway Developmental Cell. Mar, 2012 | Pubmed ID: 22421047 Chromatin-modifying Enzymes As Modulators of Reprogramming Nature. Mar, 2012 | Pubmed ID: 22388813 Overcoming Reprogramming Resistance of Fanconi Anemia Cells Blood. Feb, 2012 | Pubmed ID: 22371882 Derivation of Human Embryonic Stem Cells with NEMO Deficiency Stem Cell Research. Jan, 2012 | Pubmed ID: 22284529 The Promise of Induced Pluripotent Stem Cells in Research and Therapy Nature. Jan, 2012 | Pubmed ID: 22258608 Polycomb Repressive Complex 2 Regulates Normal Development of the Mouse Heart Circulation Research. Feb, 2012 | Pubmed ID: 22158708 Live-cell Immunofluorescence Staining of Human Pluripotent Stem Cells Current Protocols in Stem Cell Biology. Dec, 2011 | Pubmed ID: 22135082 Screening Ethnically Diverse Human Embryonic Stem Cells Identifies a Chromosome 20 Minimal Amplicon Conferring Growth Advantage Nature Biotechnology. Dec, 2011 | Pubmed ID: 22119741 Donor Cell Type Can Influence the Epigenome and Differentiation Potential of Human Induced Pluripotent Stem Cells Nature Biotechnology. Dec, 2011 | Pubmed ID: 22119740 Cell Cycle Adaptations of Embryonic Stem Cells Proceedings of the National Academy of Sciences of the United States of America. Nov, 2011 | Pubmed ID: 22084091 Induced Pluripotent Stem Cells--opportunities for Disease Modelling and Drug Discovery Nature Reviews. Drug Discovery. Dec, 2011 | Pubmed ID: 22076509 Lineage Regulators Direct BMP and Wnt Pathways to Cell-specific Programs During Differentiation and Regeneration Cell. Oct, 2011 | Pubmed ID: 22036566 Stem Cells: Triple Genomes Go Far Nature. Oct, 2011 | Pubmed ID: 21979039 The Lin28/let-7 Axis Regulates Glucose Metabolism Cell. Sep, 2011 | Pubmed ID: 21962509 Midbody Accumulation Through Evasion of Autophagy Contributes to Cellular Reprogramming and Tumorigenicity Nature Cell Biology. Oct, 2011 | Pubmed ID: 21909099 Metabolic Regulation of Protein N-alpha-acetylation by Bcl-xL Promotes Cell Survival Cell. Aug, 2011 | Pubmed ID: 21854985 Genomic Approaches to Deconstruct Pluripotency Annual Review of Genomics and Human Genetics. Sep, 2011 | Pubmed ID: 21801025 Telomere Dynamics in Dyskeratosis Congenita: the Long and the Short of IPS Cell Research. Aug, 2011 | Pubmed ID: 21788988 Induced Pluripotent Stem Cells for Modelling Human Diseases Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. Aug, 2011 | Pubmed ID: 21727133 Induced Pluripotent Stem Cell Models from X-linked Adrenoleukodystrophy Patients Annals of Neurology. Sep, 2011 | Pubmed ID: 21721033 MicroRNAs Become Macro Players in Somatic Cell Reprogramming Genome Medicine. 2011 | Pubmed ID: 21699744 The Nomenclature System Should Be Sustainable, but Also Practical Cell Stem Cell. Jun, 2011 | Pubmed ID: 21624802 Transplantation of Adult Mouse IPS Cell-derived Photoreceptor Precursors Restores Retinal Structure and Function in Degenerative Mice PloS One. 2011 | Pubmed ID: 21559507 Genome-wide Mapping of 5-hydroxymethylcytosine in Embryonic Stem Cells Nature. May, 2011 | Pubmed ID: 21552279 Induced Pluripotent Stem Cells for Neural Tissue Engineering Biomaterials. Aug, 2011 | Pubmed ID: 21514663 Interactions Between Cdx Genes and Retinoic Acid Modulate Early Cardiogenesis Developmental Biology. Jun, 2011 | Pubmed ID: 21466798 Investigating Monogenic and Complex Diseases with Pluripotent Stem Cells Nature Reviews. Genetics. Apr, 2011 | Pubmed ID: 21386866 Somatic Coding Mutations in Human Induced Pluripotent Stem Cells Nature. Mar, 2011 | Pubmed ID: 21368825 Tet1 and Tet2 Regulate 5-hydroxymethylcytosine Production and Cell Lineage Specification in Mouse Embryonic Stem Cells Cell Stem Cell. Feb, 2011 | Pubmed ID: 21295276 Stage-specific Signaling Through TGFβ Family Members and WNT Regulates Patterning and Pancreatic Specification of Human Pluripotent Stem Cells Development (Cambridge, England). Mar, 2011 | Pubmed ID: 21270052 Cellular Therapy for Fanconi Anemia: the Past, Present, and Future Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation. Jan, 2011 | Pubmed ID: 21195298 Induced Pluripotent Stem Cells: a Novel Frontier in the Study of Human Primary Immunodeficiencies The Journal of Allergy and Clinical Immunology. Jun, 2011 | Pubmed ID: 21185069 Hematopoietic Differentiation of Induced Pluripotent Stem Cells from Patients with Mucopolysaccharidosis Type I (Hurler Syndrome) Blood. Jan, 2011 | Pubmed ID: 21037085 From Hen House to Bedside: Tracing Hanafusa's Legacy from Avian Leukemia Viruses to SRC to ABL and Beyond Genes & Cancer. Dec, 2010 | Pubmed ID: 21779439 MicroRNA Profiling Reveals Two Distinct P53-related Human Pluripotent Stem Cell States Cell Stem Cell. Dec, 2010 | Pubmed ID: 21112562 Another Horse in the Meta-stable State of Pluripotency Cell Stem Cell. Dec, 2010 | Pubmed ID: 21112555 Large Intergenic Non-coding RNA-RoR Modulates Reprogramming of Human Induced Pluripotent Stem Cells Nature Genetics. Dec, 2010 | Pubmed ID: 21057500 Highly Efficient Reprogramming to Pluripotency and Directed Differentiation of Human Cells with Synthetic Modified MRNA Cell Stem Cell. Nov, 2010 | Pubmed ID: 20888316 Dynamic Instability of Genomic Methylation Patterns in Pluripotent Stem Cells Epigenetics & Chromatin. 2010 | Pubmed ID: 20868487 Clump Passaging and Expansion of Human Embryonic and Induced Pluripotent Stem Cells on Mouse Embryonic Fibroblast Feeder Cells Current Protocols in Stem Cell Biology. Aug, 2010 | Pubmed ID: 20814935 Comprehensive Methylome Map of Lineage Commitment from Haematopoietic Progenitors Nature. Sep, 2010 | Pubmed ID: 20720541 All-trans Retinoic Acid Directs Urothelial Specification of Murine Embryonic Stem Cells Via GATA4/6 Signaling Mechanisms PloS One. 2010 | Pubmed ID: 20644631 Molecular Basis of the First Cell Fate Determination in Mouse Embryogenesis Cell Research. Sep, 2010 | Pubmed ID: 20628366 Reprogramming of T Cells from Human Peripheral Blood Cell Stem Cell. Jul, 2010 | Pubmed ID: 20621044 Musashi-2 Regulates Normal Hematopoiesis and Promotes Aggressive Myeloid Leukemia Nature Medicine. Aug, 2010 | Pubmed ID: 20616797 Straight Talk With...George Daley. Interview by Elie Dolgin Nature Medicine. Jun, 2010 | Pubmed ID: 20526308 Lin28a Transgenic Mice Manifest Size and Puberty Phenotypes Identified in Human Genetic Association Studies Nature Genetics. Jul, 2010 | Pubmed ID: 20512147 Cdx4 is Dispensable for Murine Adult Hematopoietic Stem Cells but Promotes MLL-AF9-mediated Leukemogenesis Haematologica. Oct, 2010 | Pubmed ID: 20494928 Differential Modeling of Fragile X Syndrome by Human Embryonic Stem Cells and Induced Pluripotent Stem Cells Cell Stem Cell. May, 2010 | Pubmed ID: 20452313 Interaction of Retinoic Acid and Scl Controls Primitive Blood Development Blood. Jul, 2010 | Pubmed ID: 20410509 Robust Enhancement of Neural Differentiation from Human ES and IPS Cells Regardless of Their Innate Difference in Differentiation Propensity Stem Cell Reviews. Jun, 2010 | Pubmed ID: 20376579 AID for Reprogramming Cell Research. Mar, 2010 | Pubmed ID: 20190775 Lin28: A MicroRNA Regulator with a Macro Role Cell. Feb, 2010 | Pubmed ID: 20178735 Telomere Elongation in Induced Pluripotent Stem Cells from Dyskeratosis Congenita Patients Nature. Mar, 2010 | Pubmed ID: 20164838 Knockdown of Fanconi Anemia Genes in Human Embryonic Stem Cells Reveals Early Developmental Defects in the Hematopoietic Lineage Blood. Apr, 2010 | Pubmed ID: 20089964 Targeting Bcr-Abl by Combining Allosteric with ATP-binding-site Inhibitors Nature. Jan, 2010 | Pubmed ID: 20072125 Stem Cells: Roadmap to the Clinic The Journal of Clinical Investigation. Jan, 2010 | Pubmed ID: 20051631 AP24163 Inhibits the Gatekeeper Mutant of BCR-ABL and Suppresses in Vitro Resistance Chemical Biology & Drug Design. Feb, 2010 | Pubmed ID: 20028401 Autologous Blood Cell Therapies from Pluripotent Stem Cells Blood Reviews. Jan, 2010 | Pubmed ID: 19910091 Generation of Functional Human Hepatic Endoderm from Human Induced Pluripotent Stem Cells Hepatology (Baltimore, Md.). Jan, 2010 | Pubmed ID: 19877180 Application of Induced Pluripotent Stem Cells to Hematologic Disease Cytotherapy. 2009 | Pubmed ID: 19929461 A Robust Approach to Identifying Tissue-specific Gene Expression Regulatory Variants Using Personalized Human Induced Pluripotent Stem Cells PLoS Genetics. Nov, 2009 | Pubmed ID: 19911041 Differential Methylation of Tissue- and Cancer-specific CpG Island Shores Distinguishes Human Induced Pluripotent Stem Cells, Embryonic Stem Cells and Fibroblasts Nature Genetics. Dec, 2009 | Pubmed ID: 19881528 Live Cell Imaging Distinguishes Bona Fide Human IPS Cells from Partially Reprogrammed Cells Nature Biotechnology. Nov, 2009 | Pubmed ID: 19826408 Hematopoietic Development from Human Induced Pluripotent Stem Cells Annals of the New York Academy of Sciences. Sep, 2009 | Pubmed ID: 19796250 Disease Models from Pluripotent Stem Cells Annals of the New York Academy of Sciences. Sep, 2009 | Pubmed ID: 19796247 MicroRNA Expression During Trophectoderm Specification PloS One. 2009 | Pubmed ID: 19582159 A Role for Lin28 in Primordial Germ-cell Development and Germ-cell Malignancy Nature. Aug, 2009 | Pubmed ID: 19578360 9-(Arenethenyl)purines As Dual Src/Abl Kinase Inhibitors Targeting the Inactive Conformation: Design, Synthesis, and Biological Evaluation Journal of Medicinal Chemistry. Aug, 2009 | Pubmed ID: 19572547 Cross-regulation of the Nanog and Cdx2 Promoters Cell Research. Sep, 2009 | Pubmed ID: 19564890 Balancing Work and Life: a Conversation with George Daley. Interviewed by Majlinda Lako and Susan Daher Stem Cells (Dayton, Ohio). Jul, 2009 | Pubmed ID: 19544404 Gene Targeting of a Disease-related Gene in Human Induced Pluripotent Stem and Embryonic Stem Cells Cell Stem Cell. Jul, 2009 | Pubmed ID: 19540188 Bone-marrow Adipocytes As Negative Regulators of the Haematopoietic Microenvironment Nature. Jul, 2009 | Pubmed ID: 19516257 Lin28 Promotes Transformation and is Associated with Advanced Human Malignancies Nature Genetics. Jul, 2009 | Pubmed ID: 19483683 Down's Syndrome Suppression of Tumour Growth and the Role of the Calcineurin Inhibitor DSCR1 Nature. Jun, 2009 | Pubmed ID: 19458618 Biomechanical Forces Promote Embryonic Haematopoiesis Nature. Jun, 2009 | Pubmed ID: 19440194 Surface Antigen Phenotypes of Hematopoietic Stem Cells from Embryos and Murine Embryonic Stem Cells Blood. Jul, 2009 | Pubmed ID: 19420357 Functional Evidence That the Self-renewal Gene NANOG Regulates Human Tumor Development Stem Cells (Dayton, Ohio). May, 2009 | Pubmed ID: 19415763 Upping the Ante: Recent Advances in Direct Reprogramming Molecular Therapy : the Journal of the American Society of Gene Therapy. Jun, 2009 | Pubmed ID: 19337233 Targeted Bisulfite Sequencing Reveals Changes in DNA Methylation Associated with Nuclear Reprogramming Nature Biotechnology. Apr, 2009 | Pubmed ID: 19330000 Targeted and Genome-scale Strategies Reveal Gene-body Methylation Signatures in Human Cells Nature Biotechnology. Apr, 2009 | Pubmed ID: 19329998 Genetic Interaction of PGE2 and Wnt Signaling Regulates Developmental Specification of Stem Cells and Regeneration Cell. Mar, 2009 | Pubmed ID: 19303855 Generation of Induced Pluripotent Stem Cells from Human Blood Blood. May, 2009 | Pubmed ID: 19299331 Broader Implications of Defining Standards for the Pluripotency of IPSCs Cell Stem Cell. Mar, 2009 | Pubmed ID: 19265657 ICSBP-mediated Immune Protection Against BCR-ABL-induced Leukemia Requires the CCL6 and CCL9 Chemokines Blood. Apr, 2009 | Pubmed ID: 19171873 Human IPS Cell Derivation/reprogramming Current Protocols in Stem Cell Biology. Jan, 2009 | Pubmed ID: 19170021 Efficient Gene Knockdowns in Human Embryonic Stem Cells Using Lentiviral-based RNAi Methods in Molecular Biology (Clifton, N.J.). 2009 | Pubmed ID: 19089348 New ISSCR Guidelines Underscore Major Principles for Responsible Translational Stem Cell Research Cell Stem Cell. Dec, 2008 | Pubmed ID: 19041777 Mesodermal Patterning Activity of SCL Experimental Hematology. Dec, 2008 | Pubmed ID: 18809240 Activation of Tyrosine Kinases by Mutation of the Gatekeeper Threonine Nature Structural & Molecular Biology. Oct, 2008 | Pubmed ID: 18794843 Isolation of Hematopoietic Stem Cells from Mouse Embryonic Stem Cells Current Protocols in Stem Cell Biology. Feb, 2008 | Pubmed ID: 18770632 Disease-specific Induced Pluripotent Stem Cells Cell. Sep, 2008 | Pubmed ID: 18691744 From Fibroblasts to IPS Cells: Induced Pluripotency by Defined Factors Journal of Cellular Biochemistry. Nov, 2008 | Pubmed ID: 18668528 Molecular Basis of Pluripotency Human Molecular Genetics. Apr, 2008 | Pubmed ID: 18632692 Generation of Human-induced Pluripotent Stem Cells Nature Protocols. 2008 | Pubmed ID: 18600223 Determinants of MicroRNA Processing Inhibition by the Developmentally Regulated RNA-binding Protein Lin28 The Journal of Biological Chemistry. Aug, 2008 | Pubmed ID: 18550544 Ras-MAPK Signaling Promotes Trophectoderm Formation from Embryonic Stem Cells and Mouse Embryos Nature Genetics. Jul, 2008 | Pubmed ID: 18536715 Cdx Gene Deficiency Compromises Embryonic Hematopoiesis in the Mouse Proceedings of the National Academy of Sciences of the United States of America. Jun, 2008 | Pubmed ID: 18511567 Derivation and Maintenance of Human Embryonic Stem Cells from Poor-quality in Vitro Fertilization Embryos Nature Protocols. 2008 | Pubmed ID: 18451800 BMP and Wnt Specify Hematopoietic Fate by Activation of the Cdx-Hox Pathway Cell Stem Cell. Jan, 2008 | Pubmed ID: 18371423 Mitotic Spindle Destabilization and Genomic Instability in Shwachman-Diamond Syndrome The Journal of Clinical Investigation. Apr, 2008 | Pubmed ID: 18324336 Prospects for Stem Cell-based Therapy Cell. Feb, 2008 | Pubmed ID: 18295571 Selective Blockade of MicroRNA Processing by Lin28 Science (New York, N.Y.). Apr, 2008 | Pubmed ID: 18292307 Modulation of Murine Embryonic Stem Cell-derived CD41+c-kit+ Hematopoietic Progenitors by Ectopic Expression of Cdx Genes Blood. May, 2008 | Pubmed ID: 18252864 Enhanced Plating Efficiency of Trypsin-adapted Human Embryonic Stem Cells is Reversible and Independent of Trisomy 12/17 Cloning and Stem Cells. Mar, 2008 | Pubmed ID: 18241122 Human Embryonic Stem Cell Derivation from Poor-quality Embryos Nature Biotechnology. Feb, 2008 | Pubmed ID: 18223642 Reprogramming of Human Somatic Cells to Pluripotency with Defined Factors Nature. Jan, 2008 | Pubmed ID: 18157115 Recombination Signatures Distinguish Embryonic Stem Cells Derived by Parthenogenesis and Somatic Cell Nuclear Transfer Cell Stem Cell. Sep, 2007 | Pubmed ID: 18371368 Teratoma Formation Assays with Human Embryonic Stem Cells: a Rationale for One Type of Human-animal Chimera Cell Stem Cell. Sep, 2007 | Pubmed ID: 18371359 Towards the Generation of Patient-specific Pluripotent Stem Cells for Combined Gene and Cell Therapy of Hematologic Disorders Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program. 2007 | Pubmed ID: 18024604 Current Prospects for the Generation of Patient-specific Pluripotent Cells from Adult Tissues Regenerative Medicine. Sep, 2007 | Pubmed ID: 17907926 Debugging Cellular Reprogramming Nature Cell Biology. Aug, 2007 | Pubmed ID: 17671453 Hemogenic Endothelial Progenitor Cells Isolated from Human Umbilical Cord Blood Stem Cells (Dayton, Ohio). Nov, 2007 | Pubmed ID: 17641248 Phase 1 Study of Lonafarnib (SCH 66336) and Imatinib Mesylate in Patients with Chronic Myeloid Leukemia Who Have Failed Prior Single-agent Therapy with Imatinib Cancer. Sep, 2007 | Pubmed ID: 17623836 Human Embryonic Stem Cells Flock Together Nature Biotechnology. Jul, 2007 | Pubmed ID: 17621300 Prostaglandin E2 Regulates Vertebrate Haematopoietic Stem Cell Homeostasis Nature. Jun, 2007 | Pubmed ID: 17581586 Farnesyl Transferase Inhibitor Resistance Probed by Target Mutagenesis Blood. Sep, 2007 | Pubmed ID: 17536018 Towards Hematopoietic Reconstitution from Embryonic Stem Cells: a Sanguine Future Current Opinion in Hematology. Jul, 2007 | Pubmed ID: 17534159 Gametes from Embryonic Stem Cells: a Cup Half Empty or Half Full? Science (New York, N.Y.). Apr, 2007 | Pubmed ID: 17446394 The May-Hegglin Anomaly Gene MYH9 is a Negative Regulator of Platelet Biogenesis Modulated by the Rho-ROCK Pathway Blood. Jul, 2007 | Pubmed ID: 17392504 Differentiation Potential of Histocompatible Parthenogenetic Embryonic Stem Cells Annals of the New York Academy of Sciences. Jun, 2007 | Pubmed ID: 17360798 The Cdx-hox Pathway in Hematopoietic Stem Cell Formation from Embryonic Stem Cells Annals of the New York Academy of Sciences. Jun, 2007 | Pubmed ID: 17303828 Ethics. The ISSCR Guidelines for Human Embryonic Stem Cell Research Science (New York, N.Y.). Feb, 2007 | Pubmed ID: 17272706 Histocompatible Embryonic Stem Cells by Parthenogenesis Science (New York, N.Y.). Jan, 2007 | Pubmed ID: 17170255 In Vitro Generation of Germ Cells from Murine Embryonic Stem Cells Nature Protocols. 2006 | Pubmed ID: 17487192 Transgene Expression and RNA Interference in Embryonic Stem Cells Methods in Enzymology. 2006 | Pubmed ID: 17161693 Male Germ Cells Methods in Enzymology. 2006 | Pubmed ID: 17141043 Cdx4 Dysregulates Hox Gene Expression and Generates Acute Myeloid Leukemia Alone and in Cooperation with Meis1a in a Murine Model Proceedings of the National Academy of Sciences of the United States of America. Nov, 2006 | Pubmed ID: 17068127 Activity of Dual SRC-ABL Inhibitors Highlights the Role of BCR/ABL Kinase Dynamics in Drug Resistance Proceedings of the National Academy of Sciences of the United States of America. Jun, 2006 | Pubmed ID: 16754879 Anticipating Clinical Resistance to Target-directed Agents : the BCR-ABL Paradigm Molecular Diagnosis & Therapy. 2006 | Pubmed ID: 16669605 Acceleration of Mesoderm Development and Expansion of Hematopoietic Progenitors in Differentiating ES Cells by the Mouse Mix-like Homeodomain Transcription Factor Blood. Apr, 2006 | Pubmed ID: 16403910 Pilot Study of Lonafarnib, a Farnesyl Transferase Inhibitor, in Patients with Chronic Myeloid Leukemia in the Chronic or Accelerated Phase That is Resistant or Refractory to Imatinib Therapy Cancer. Jan, 2006 | Pubmed ID: 16342165 Scientific and Clinical Opportunities for Modeling Blood Disorders with Embryonic Stem Cells Blood. Apr, 2006 | Pubmed ID: 16332966 Embryonic Stem Cell-derived Hematopoietic Stem Cells Proceedings of the National Academy of Sciences of the United States of America. Dec, 2005 | Pubmed ID: 16357205 Novel Role for PDEF in Epithelial Cell Migration and Invasion Cancer Research. Dec, 2005 | Pubmed ID: 16357167 Therapeutic Potential of Embryonic Stem Cells Blood Reviews. Nov, 2005 | Pubmed ID: 16275420 Patterning Definitive Hematopoietic Stem Cells from Embryonic Stem Cells Experimental Hematology. Sep, 2005 | Pubmed ID: 16140144 Customized Human Embryonic Stem Cells Nature Biotechnology. Jul, 2005 | Pubmed ID: 16003368 Stem Cell Research: Science, Ethics and Policy Medical Ethics (Burlington, Mass.). 2005 | Pubmed ID: 15856604 High-efficiency RNA Interference in Human Embryonic Stem Cells Stem Cells (Dayton, Ohio). Mar, 2005 | Pubmed ID: 15749924 Chronic Myeloid Leukaemia: an Investigation into the Role of Bcr-Abl-induced Abnormalities in Glucose Transport Regulation Oncogene. May, 2005 | Pubmed ID: 15735728 The Homeobox Gene HEX Regulates Proliferation and Differentiation of Hemangioblasts and Endothelial Cells During ES Cell Differentiation Blood. Jun, 2005 | Pubmed ID: 15728128 Characterization of AMN107, a Selective Inhibitor of Native and Mutant Bcr-Abl Cancer Cell. Feb, 2005 | Pubmed ID: 15710326 Inducible Transgene Expression in Mouse Stem Cells Methods in Molecular Medicine. 2005 | Pubmed ID: 15492386 Bayesian Analysis of Signaling Networks Governing Embryonic Stem Cell Fate Decisions Bioinformatics (Oxford, England). Mar, 2005 | Pubmed ID: 15479714 Altered Nuclear Transfer in Stem-cell Research - a Flawed Proposal The New England Journal of Medicine. Dec, 2004 | Pubmed ID: 15625329 In Vitro Gametogenesis from Embryonic Stem Cells Current Opinion in Cell Biology. Dec, 2004 | Pubmed ID: 15530782 Chronic Myeloid Leukemia: Proving Ground for Cancer Stem Cells Cell. Oct, 2004 | Pubmed ID: 15507204 LIF/STAT3 Signaling Fails to Maintain Self-renewal of Human Embryonic Stem Cells Stem Cells (Dayton, Ohio). 2004 | Pubmed ID: 15342941 Missed Opportunities in Embryonic Stem-cell Research The New England Journal of Medicine. Aug, 2004 | Pubmed ID: 15302910 Alchemy in the Liver: Fact or Fusion? Nature Medicine. Jul, 2004 | Pubmed ID: 15229507 Nuclear Transplantation, Embryonic Stem Cells and the Potential for Cell Therapy The Hematology Journal : the Official Journal of the European Haematology Association / EHA. 2004 | Pubmed ID: 15190291 Origins of Mammalian Hematopoiesis: in Vivo Paradigms and in Vitro Models Current Topics in Developmental Biology. 2004 | Pubmed ID: 15094298 A Cytoskeleton-based Functional Genetic Screen Identifies Bcl-xL As an Enhancer of Metastasis, but Not Primary Tumor Growth Oncogene. Jun, 2004 | Pubmed ID: 15064711 Taking Stock and Planning for the Next Decade: Realistic Prospects for Stem Cell Therapies for the Nervous System Journal of Neuroscience Research. Apr, 2004 | Pubmed ID: 15048913 Proceedings of the National Academy of Sciences of the United States of America. Mar, 2004 | Pubmed ID: 14978270 Mechanisms and Implications of Imatinib Resistance Mutations in BCR-ABL Current Opinion in Hematology. Jan, 2004 | Pubmed ID: 14676625 Derivation of Embryonic Germ Cells and Male Gametes from Embryonic Stem Cells Nature. Jan, 2004 | Pubmed ID: 14668819 Genetic Complementation of Cytokine Signaling Identifies Central Role of Kinases in Hematopoietic Cell Proliferation Oncogene. Feb, 2004 | Pubmed ID: 14647454 Development of Hematopoietic Repopulating Cells from Embryonic Stem Cells Methods in Enzymology. 2003 | Pubmed ID: 14696341 Realistic Prospects for Stem Cell Therapeutics Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program. 2003 | Pubmed ID: 14633792 A Screen to Identify Drug Resistant Variants to Target-directed Anti-cancer Agents Biological Procedures Online. 2003 | Pubmed ID: 14615817 Hematopoiesis from Embryonic Stem Cells: Lessons from and for Ontogeny Experimental Hematology. Nov, 2003 | Pubmed ID: 14585361 Cdx4 Mutants Fail to Specify Blood Progenitors and Can Be Rescued by Multiple Hox Genes Nature. Sep, 2003 | Pubmed ID: 13679919 Enhanced Hematopoietic Differentiation of Embryonic Stem Cells Conditionally Expressing Stat5 Proceedings of the National Academy of Sciences of the United States of America. Sep, 2003 | Pubmed ID: 12930895 Cloning and Stem Cells--handicapping the Political and Scientific Debates The New England Journal of Medicine. Jul, 2003 | Pubmed ID: 12867604 ES Cells Prove Egg-straordinary Nature Biotechnology. Jul, 2003 | Pubmed ID: 12833097 From Embryos to Embryoid Bodies: Generating Blood from Embryonic Stem Cells Annals of the New York Academy of Sciences. May, 2003 | Pubmed ID: 12799290 Towards Combination Target-directed Chemotherapy for Chronic Myeloid Leukemia: Role of Farnesyl Transferase Inhibitors Seminars in Hematology. Apr, 2003 | Pubmed ID: 12783369 A Role for Thrombopoietin in Hemangioblast Development Stem Cells (Dayton, Ohio). 2003 | Pubmed ID: 12743322 Gleevec Resistance: Lessons for Target-directed Drug Development Cell Cycle (Georgetown, Tex.). May-Jun, 2003 | Pubmed ID: 12734421 Dodging the Magic Bullet: Understanding Imatinib Resistance Cancer Biology & Therapy. Jan-Feb, 2003 | Pubmed ID: 12673130 Mechanisms of Autoinhibition and STI-571/imatinib Resistance Revealed by Mutagenesis of BCR-ABL Cell. Mar, 2003 | Pubmed ID: 12654249 Novel Retroviral Vectors to Facilitate Expression Screens in Mammalian Cells Nucleic Acids Research. Dec, 2002 | Pubmed ID: 12490733 Prospects for Stem Cell Therapeutics: Myths and Medicines Current Opinion in Genetics & Development. Oct, 2002 | Pubmed ID: 12200167 Overcoming STI571 Resistance with the Farnesyl Transferase Inhibitor SCH66336 Blood. Aug, 2002 | Pubmed ID: 12130526 HoxB4 Confers Definitive Lymphoid-myeloid Engraftment Potential on Embryonic Stem Cell and Yolk Sac Hematopoietic Progenitors Cell. Apr, 2002 | Pubmed ID: 11955444 Correction of a Genetic Defect by Nuclear Transplantation and Combined Cell and Gene Therapy Cell. Apr, 2002 | Pubmed ID: 11955443 Efficiency of Embryoid Body Formation and Hematopoietic Development from Embryonic Stem Cells in Different Culture Systems Biotechnology and Bioengineering. May, 2002 | Pubmed ID: 11948451 A Senescence Rescue Screen Identifies BCL6 As an Inhibitor of Anti-proliferative P19(ARF)-p53 Signaling Genes & Development. Mar, 2002 | Pubmed ID: 11914273 A Functional Screen Identifies HDRIL1 As an Oncogene That Rescues RAS-induced Senescence Nature Cell Biology. Feb, 2002 | Pubmed ID: 11812999 Critical Role for Cyclin D2 in BCR/ABL-induced Proliferation of Hematopoietic Cells Cancer Research. Jan, 2002 | Pubmed ID: 11809706 גזירת בתאי גזע hematopoietic מ Murine בתאי גזע עובריים Shannon McKinney-Freeman1, George Daley1 1Childrens Hospital, Harvard Stem Cell Institute, Harvard Medical School JoVE 162 Biology
גזירת בתאי גזע hematopoietic מ Murine בתאי גזע עובריים Shannon McKinney-Freeman1, George Daley1 1Childrens Hospital, Harvard Stem Cell Institute, Harvard Medical School JoVE 162 Biology