Gerd Geisslinger Institute of Clinical Pharmacology Goethe University Hospital Frankfurt Biography Publications Institution JoVE Articles Gerd Geisslinger has not added a biography. If you are Gerd Geisslinger and would like to personalize this page please email our Author Liaison for assistance. Publications PAFAH1B1 and the LncRNA NONHSAT073641 Maintain an Angiogenic Phenotype in Human Endothelial Cells Acta Physiologica (Oxford, England). Apr, 2016 | Pubmed ID: 27124368 The Impact of Endurance Exercise on Global and AMPK Gene-specific DNA Methylation Biochemical and Biophysical Research Communications. Apr, 2016 | Pubmed ID: 27103439 Loss of HIF-1α in Macrophages Attenuates AhR/ARNT-mediated Tumorigenesis in a PAH-driven Tumor Model Oncotarget. Mar, 2016 | Pubmed ID: 27015123 Tetrahydrobiopterin Attenuates DSS-evoked Colitis in Mice by Rebalancing Redox and Lipid Signalling Journal of Crohn's & Colitis. Feb, 2016 | Pubmed ID: 26928964 The Protein Kinase IKKepsilon Contributes to Tumour Growth and Tumour Pain in a Melanoma Model Biochemical Pharmacology. Mar, 2016 | Pubmed ID: 26793999 Drug Repurposing for the Development of Novel Analgesics Trends in Pharmacological Sciences. Mar, 2016 | Pubmed ID: 26706620 Alpha-methylacyl-CoA Racemase Deletion Has Mutually Counteracting Effects on T-cell Responses, Associated with Unchanged Course of EAE European Journal of Immunology. Mar, 2016 | Pubmed ID: 26648339 Small Molecules with Anti-inflammatory Properties in Clinical Development Pharmacology & Therapeutics. Jan, 2016 | Pubmed ID: 26627986 S1P2/G12/13 Signaling Negatively Regulates Macrophage Activation and Indirectly Shapes the Atheroprotective B1-Cell Population Arteriosclerosis, Thrombosis, and Vascular Biology. Jan, 2016 | Pubmed ID: 26603156 N-Benzylbenzamides: A Novel Merged Scaffold for Orally Available Dual Soluble Epoxide Hydrolase/Peroxisome Proliferator-Activated Receptor γ Modulators Journal of Medicinal Chemistry. Jan, 2016 | Pubmed ID: 26595749 In Vivo Availability of Pro-Resolving Lipid Mediators in Oxazolone Induced Dermal Inflammation in the Mouse PloS One. 2015 | Pubmed ID: 26599340 Age-Dependent Changes in the Inflammatory Nociceptive Behavior of Mice International Journal of Molecular Sciences. 2015 | Pubmed ID: 26593904 Lipoxin and Resolvin Biosynthesis is Dependent on 5-lipoxygenase Activating Protein FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Dec, 2015 | Pubmed ID: 26289316 AMP-activated Protein Kinase Suppresses Arachidonate 15-lipoxygenase Expression in Interleukin 4-polarized Human Macrophages The Journal of Biological Chemistry. Oct, 2015 | Pubmed ID: 26276392 The H2S-producing Enzyme CSE is Dispensable for the Processing of Inflammatory and Neuropathic Pain Brain Research. Oct, 2015 | Pubmed ID: 26271715 Activation of AMPK and Its Impact on Exercise Capacity Sports Medicine (Auckland, N.Z.). Nov, 2015 | Pubmed ID: 26186961 Rhythmic Control of Endocannabinoids in the Rat Pineal Gland Chronobiology International. 2015 | Pubmed ID: 26061461 AMP-activated Protein Kinase is Activated by Non-steroidal Anti-inflammatory Drugs European Journal of Pharmacology. Sep, 2015 | Pubmed ID: 26049010 TANK-binding Kinase 1 (TBK1) Modulates Inflammatory Hyperalgesia by Regulating MAP Kinases and NF-κB Dependent Genes Journal of Neuroinflammation. 2015 | Pubmed ID: 25997745 Activated Platelets Release Sphingosine 1-phosphate and Induce Hypersensitivity to Noxious Heat Stimuli in Vivo Frontiers in Neuroscience. 2015 | Pubmed ID: 25954148 MPGES-1-derived PGE2 Suppresses CD80 Expression on Tumor-associated Phagocytes to Inhibit Anti-tumor Immune Responses in Breast Cancer Oncotarget. Apr, 2015 | Pubmed ID: 25871398 Exacerbation of Experimental Autoimmune Encephalomyelitis in Ceramide Synthase 6 Knockout Mice is Associated with Enhanced Activation/migration of Neutrophils Immunology and Cell Biology. Oct, 2015 | Pubmed ID: 25833068 Quantitation of Endogenous Nucleoside Triphosphates and Nucleosides in Human Cells by Liquid Chromatography Tandem Mass Spectrometry Analytical and Bioanalytical Chemistry. May, 2015 | Pubmed ID: 25749797 Antinociceptive Effects of FTY720 During Trauma-induced Neuropathic Pain Are Mediated by Spinal S1P Receptors Biological Chemistry. Jun, 2015 | Pubmed ID: 25720064 Lack of Ceramide Synthase 2 Suppresses the Development of Experimental Autoimmune Encephalomyelitis by Impairing the Migratory Capacity of Neutrophils Brain, Behavior, and Immunity. May, 2015 | Pubmed ID: 25697397 Pattern of Neuropathic Pain Induced by Topical Capsaicin Application in Healthy Subjects Pain. Mar, 2015 | Pubmed ID: 25687540 Slack Channels Expressed in Sensory Neurons Control Neuropathic Pain in Mice The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Jan, 2015 | Pubmed ID: 25609627 Telaprevir Drug Monitoring During Antiviral Therapy of Hepatitis C Graft Infection After Liver Transplantation Liver International : Official Journal of the International Association for the Study of the Liver. Jan, 2015 | Pubmed ID: 24649882 Regulation of Circulating Endocannabinoids Associated with Cancer and Metastases in Mice and Humans Oncoscience. 2014 | Pubmed ID: 25594019 Ceramide Synthases CerS4 and CerS5 Are Upregulated by 17β-estradiol and GPER1 Via AP-1 in Human Breast Cancer Cells Biochemical Pharmacology. Dec, 2014 | Pubmed ID: 25451689 Role of Telaprevir Plasma Levels for Predicting Response to Antiviral Therapy in Patients with Hepatitis C Virus Genotype 1 Infection Scandinavian Journal of Gastroenterology. Dec, 2014 | Pubmed ID: 25384840 Mechanism-based Treatment for Chemotherapy-induced Peripheral Neuropathic Pain Nature Reviews. Neurology. Dec, 2014 | Pubmed ID: 25366108 R-flurbiprofen Attenuates Experimental Autoimmune Encephalomyelitis in Mice EMBO Molecular Medicine. Nov, 2014 | Pubmed ID: 25269445 Regulation of Ceramide Synthase 6 in a Spontaneous Experimental Autoimmune Encephalomyelitis Model is Sex Dependent Biochemical Pharmacology. Nov, 2014 | Pubmed ID: 25173988 Nox2-dependent Signaling Between Macrophages and Sensory Neurons Contributes to Neuropathic Pain Hypersensitivity Pain. Oct, 2014 | Pubmed ID: 25139590 Chiral Chromatography-tandem Mass Spectrometry Applied to the Determination of Pro-resolving Lipid Mediators Journal of Chromatography. A. Sep, 2014 | Pubmed ID: 25124229 Lack of Effect of a P2Y6 Receptor Antagonist on Neuropathic Pain Behavior in Mice Pharmacology, Biochemistry, and Behavior. Sep, 2014 | Pubmed ID: 25042778 Lipoxin A₄: Problems with Its Determination Using Reversed Phase Chromatography-tandem Mass Spectrometry and Confirmation with Chiral Chromatography Talanta. Sep, 2014 | Pubmed ID: 24913860 Phosphodiesterase 2A Localized in the Spinal Cord Contributes to Inflammatory Pain Processing Anesthesiology. Aug, 2014 | Pubmed ID: 24758774 Consequences of a Human TRPA1 Genetic Variant on the Perception of Nociceptive and Olfactory Stimuli PloS One. 2014 | Pubmed ID: 24752136 Genome-wide Transcriptional Profiling of Skin and Dorsal Root Ganglia After Ultraviolet-B-induced Inflammation PloS One. 2014 | Pubmed ID: 24732968 LPS Inhibits Caspase 3-dependent Apoptosis in RAW264.7 Macrophages Induced by the AMPK Activator AICAR Biochemical and Biophysical Research Communications. May, 2014 | Pubmed ID: 24732361 Neutrophils Mediate Edema Formation but Not Mechanical Allodynia During Zymosan-induced Inflammation Journal of Leukocyte Biology. Jul, 2014 | Pubmed ID: 24555986 Inhibition of Macrophage Fatty Acid β-oxidation Exacerbates Palmitate-induced Inflammatory and Endoplasmic Reticulum Stress Responses Diabetologia. May, 2014 | Pubmed ID: 24488024 Similar Maximum Systemic but Not Local Cyclooxygenase-2 Inhibition by 50 Mg Lumiracoxib and 90 Mg Etoricoxib: a Randomized Controlled Trial in Healthy Subjects Pharmaceutical Research. Jul, 2014 | Pubmed ID: 24469906 Oxidant-induced Activation of CGMP-dependent Protein Kinase Iα Mediates Neuropathic Pain After Peripheral Nerve Injury Antioxidants & Redox Signaling. Oct, 2014 | Pubmed ID: 24450940 PGE2/EP4 Signaling in Peripheral Immune Cells Promotes Development of Experimental Autoimmune Encephalomyelitis Biochemical Pharmacology. Feb, 2014 | Pubmed ID: 24355567 Prostacyclin Mediates Neuropathic Pain Through Interleukin 1β-expressing Resident Macrophages Pain. Mar, 2014 | Pubmed ID: 24333781 BKCa Channels Expressed in Sensory Neurons Modulate Inflammatory Pain in Mice Pain. Mar, 2014 | Pubmed ID: 24333777 TRP-channels As Key Integrators of Lipid Pathways in Nociceptive Neurons Progress in Lipid Research. Jan, 2014 | Pubmed ID: 24287369 Electrophilic Fatty Acid Species Inhibit 5-lipoxygenase and Attenuate Sepsis-induced Pulmonary Inflammation Antioxidants & Redox Signaling. Jun, 2014 | Pubmed ID: 24206143 Prostacyclin Regulates Spinal Nociceptive Processing Through Cyclic Adenosine Monophosphate-induced Translocation of Glutamate Receptors Anesthesiology. Feb, 2014 | Pubmed ID: 23969560 Synthesis of Lipid Mediators During UVB-induced Inflammatory Hyperalgesia in Rats and Mice PloS One. 2013 | Pubmed ID: 24349046 Synthesis and Pharmacological Characterization of Benzenesulfonamides As Dual Species Inhibitors of Human and Murine MPGES-1 Bioorganic & Medicinal Chemistry. Dec, 2013 | Pubmed ID: 24183739 Common Non-epigenetic Drugs As Epigenetic Modulators Trends in Molecular Medicine. Dec, 2013 | Pubmed ID: 24054876 Activation of the AMP-activated Protein Kinase Reduces Inflammatory Nociception The Journal of Pain : Official Journal of the American Pain Society. Nov, 2013 | Pubmed ID: 23916727 Exogenous Delta⁹-tetrahydrocannabinol Influences Circulating Endogenous Cannabinoids in Humans Journal of Clinical Psychopharmacology. Oct, 2013 | Pubmed ID: 23899642 Ceramide Metabolism in Mouse Tissue The International Journal of Biochemistry & Cell Biology. Aug, 2013 | Pubmed ID: 23792024 Non-invasive Combined Surrogates of Remifentanil Blood Concentrations with Relevance to Analgesia Naunyn-Schmiedeberg's Archives of Pharmacology. Oct, 2013 | Pubmed ID: 23775505 Opioids for Chronic Non-cancer Pain BMJ (Clinical Research Ed.). 2013 | Pubmed ID: 23719636 Cysteinyl Leukotriene-receptor-1 Antagonists Interfere with PGE2 Synthesis by Inhibiting MPGES-1 Activity Biochemical Pharmacology. Jul, 2013 | Pubmed ID: 23684692 Heterologously Expressed Formyl Peptide Receptor 2 (FPR2/ALX) Does Not Respond to Lipoxin A₄ Biochemical Pharmacology. Jun, 2013 | Pubmed ID: 23643932 Novel Findings in Pain Processing Pathways: Implications for MiRNAs As Future Therapeutic Targets Expert Review of Neurotherapeutics. May, 2013 | Pubmed ID: 23621309 Proteomics and NF-κB: An update Expert Review of Proteomics. Apr, 2013 | Pubmed ID: 23573785 Functional Genomics of Pain in Analgesic Drug Development and Therapy Pharmacology & Therapeutics. Jul, 2013 | Pubmed ID: 23567662 The Equilibrium Between Long and Very Long Chain Ceramides is Important for the Fate of the Cell and Can Be Influenced by Co-expression of CerS The International Journal of Biochemistry & Cell Biology. Jul, 2013 | Pubmed ID: 23538298 Antioxidant Activity of Sestrin 2 Controls Neuropathic Pain After Peripheral Nerve Injury Antioxidants & Redox Signaling. Dec, 2013 | Pubmed ID: 23495831 Cannabinoid-mediated Diversity of Antinociceptive Efficacy of Parecoxib in Wistar and Sprague Dawley Rats in the Chronic Constriction Injury Model of Neuropathic Pain Naunyn-Schmiedeberg's Archives of Pharmacology. May, 2013 | Pubmed ID: 23371449 Modulation of Central Nervous System-specific MicroRNA-124a Alters the Inflammatory Response in the Formalin Test in Mice Pain. Mar, 2013 | Pubmed ID: 23318130 Phenotyping the Function of TRPV1-expressing Sensory Neurons by Targeted Axonal Silencing The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Jan, 2013 | Pubmed ID: 23283344 NOXious Signaling in Pain Processing Pharmacology & Therapeutics. Mar, 2013 | Pubmed ID: 23146925 Pharmacokinetics of Non-intravenous Formulations of Fentanyl Clinical Pharmacokinetics. Jan, 2013 | Pubmed ID: 23100195 Inhibition of GTP Cyclohydrolase Attenuates Tumor Growth by Reducing Angiogenesis and M2-like Polarization of Tumor Associated Macrophages International Journal of Cancer. Feb, 2013 | Pubmed ID: 22753274 Intrinsic Up-regulation of 2-AG Favors an Area Specific Neuronal Survival in Different in Vitro Models of Neuronal Damage PloS One. 2012 | Pubmed ID: 23284665 Necessity and Risks of Arterial Blood Sampling in Healthy Volunteer Studies Clinical Pharmacokinetics. Oct, 2012 | Pubmed ID: 23018527 NADPH Oxidase-4 Maintains Neuropathic Pain After Peripheral Nerve Injury The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Jul, 2012 | Pubmed ID: 22836249 The P21-activated Kinase PAK 5 is Involved in Formalin-induced Nociception Through Regulation of MAP-kinase Signaling and Formalin-specific Receptors Behavioural Brain Research. Sep, 2012 | Pubmed ID: 22732262 Analysis of Sphingolipid and Prostaglandin Synthesis During Zymosan-induced Inflammation Prostaglandins & Other Lipid Mediators. Oct, 2012 | Pubmed ID: 22732087 Lack of Microsomal Prostaglandin E(2) Synthase-1 in Bone Marrow-derived Myeloid Cells Impairs Left Ventricular Function and Increases Mortality After Acute Myocardial Infarction Circulation. Jun, 2012 | Pubmed ID: 22589381 Inhibitor Kappa B Kinase Beta Dependent Cytokine Upregulation in Nociceptive Neurons Contributes to Nociceptive Hypersensitivity After Sciatic Nerve Injury The Journal of Pain : Official Journal of the American Pain Society. May, 2012 | Pubmed ID: 22564672 5,6-EET is Released Upon Neuronal Activity and Induces Mechanical Pain Hypersensitivity Via TRPA1 on Central Afferent Terminals The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. May, 2012 | Pubmed ID: 22553041 Ceramide Synthase 6 Plays a Critical Role in the Development of Experimental Autoimmune Encephalomyelitis Journal of Immunology (Baltimore, Md. : 1950). Jun, 2012 | Pubmed ID: 22544924 Site-specific and Time-dependent Activation of the Endocannabinoid System After Transection of Long-range Projections PloS One. 2012 | Pubmed ID: 22457773 Structure-activity Relationship of Nonacidic Quinazolinone Inhibitors of Human Microsomal Prostaglandin Synthase 1 (mPGES 1) Journal of Medicinal Chemistry. Apr, 2012 | Pubmed ID: 22449023 The Pharmacogenetic Background of Hepatitis C Treatment Mutation Research. Mar, 2012 | Pubmed ID: 22409946 Sniffing out Pharmacology: Interactions of Drugs with Human Olfaction Trends in Pharmacological Sciences. Apr, 2012 | Pubmed ID: 22361590 Identification of DNA-protein Complexes Using an Improved, Combined Western Blotting-electrophoretic Mobility Shift Assay (WEMSA) with a Fluorescence Imaging System Molecular BioSystems. Apr, 2012 | Pubmed ID: 22358373 Long Chain Ceramides and Very Long Chain Ceramides Have Opposite Effects on Human Breast and Colon Cancer Cell Growth The International Journal of Biochemistry & Cell Biology. Apr, 2012 | Pubmed ID: 22230369 Chain Length-specific Properties of Ceramides Progress in Lipid Research. Jan, 2012 | Pubmed ID: 22133871 Dimethylcelecoxib Induces an Inhibitory Complex Consisting of HDAC1/NF-κB(p65)RelA Leading to Transcriptional Downregulation of MPGES-1 and EGR1 Cellular Signalling. Feb, 2012 | Pubmed ID: 21983014 Inhibitors of Specific Ceramide Synthases Biochimie. Feb, 2012 | Pubmed ID: 21945810 Prolonged Zymosan-induced Inflammatory Pain Hypersensitivity in Mice Lacking Glycine Receptor Alpha2 Behavioural Brain Research. Jan, 2012 | Pubmed ID: 21924294 Additive Antinociceptive Effects of a Combination of Vitamin C and Vitamin E After Peripheral Nerve Injury PloS One. 2011 | Pubmed ID: 22195029 Single and Combined IL28B, ITPA and SLC28A3 Host Genetic Markers Modulating Response to Anti-hepatitis C Therapy Pharmacogenomics. Dec, 2011 | Pubmed ID: 22118055 Low-dose Drug Combinations Along Molecular Pathways Could Maximize Therapeutic Effectiveness While Minimizing Collateral Adverse Effects Drug Discovery Today. Dec, 2011 | Pubmed ID: 22016087 Soluble Epoxide Hydrolase Limits Mechanical Hyperalgesia During Inflammation Molecular Pain. 2011 | Pubmed ID: 21970373 Group V Phospholipase A2 in Bone Marrow-derived Myeloid Cells and Bronchial Epithelial Cells Promotes Bacterial Clearance After Escherichia Coli Pneumonia The Journal of Biological Chemistry. Oct, 2011 | Pubmed ID: 21849511 The Protein Kinase IKKε is a Potential Target for the Treatment of Inflammatory Hyperalgesia Journal of Immunology (Baltimore, Md. : 1950). Sep, 2011 | Pubmed ID: 21813779 CNGA3: a Target of Spinal Nitric Oxide/cGMP Signaling and Modulator of Inflammatory Pain Hypersensitivity The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Aug, 2011 | Pubmed ID: 21813679 Nerve Injury Evoked Loss of Latexin Expression in Spinal Cord Neurons Contributes to the Development of Neuropathic Pain PloS One. 2011 | Pubmed ID: 21572518 Macrophages Programmed by Apoptotic Cells Promote Angiogenesis Via Prostaglandin E2 FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Jul, 2011 | Pubmed ID: 21450910 SNO-ing at the Nociceptive Synapse? Pharmacological Reviews. Jun, 2011 | Pubmed ID: 21436345 MicroRNAs As New Players in the Pain Game Pain. Jul, 2011 | Pubmed ID: 21353390 Role of Nucleoside Transporters SLC28A2/3 and SLC29A1/2 Genetics in Ribavirin Therapy: Protection Against Anemia in Patients with Chronic Hepatitis C Pharmacogenetics and Genomics. May, 2011 | Pubmed ID: 21346688 The Ubiquitin Ligase MYCBP2 Regulates Transient Receptor Potential Vanilloid Receptor 1 (TRPV1) Internalization Through Inhibition of P38 MAPK Signaling The Journal of Biological Chemistry. Feb, 2011 | Pubmed ID: 21098484 Anti-inflammatory Role of Microsomal Prostaglandin E Synthase-1 in a Model of Neuroinflammation The Journal of Biological Chemistry. Jan, 2011 | Pubmed ID: 21075851 Pharmacogenetics of New Analgesics British Journal of Pharmacology. Jun, 2011 | Pubmed ID: 20942817 Epigenetics in Pain and Analgesia: an Imminent Research Field European Journal of Pain (London, England). Jan, 2011 | Pubmed ID: 20584621 Screening for IL28B Gene Variants Identifies Predictors of Hepatitis C Therapy Success Antiviral Therapy. 2010 | Pubmed ID: 21149916 Localization of an Endocannabinoid System in the Hypophysial Pars Tuberalis and Pars Distalis of Man Cell and Tissue Research. Nov, 2010 | Pubmed ID: 20957495 Activation of Ceramide Synthase 6 by Celecoxib Leads to a Selective Induction of C16:0-ceramide Biochemical Pharmacology. Dec, 2010 | Pubmed ID: 20735991 Inhibition of the Soluble Epoxide Hydrolase Promotes Albuminuria in Mice with Progressive Renal Disease PloS One. 2010 | Pubmed ID: 20694143 Dimethylcelecoxib Inhibits MPGES-1 Promoter Activity by Influencing EGR1 and NF-κB Biochemical Pharmacology. Nov, 2010 | Pubmed ID: 20688046 R-flurbiprofen Reduces Neuropathic Pain in Rodents by Restoring Endogenous Cannabinoids PloS One. 2010 | Pubmed ID: 20498712 Higher Pain Scores, Similar Opioid Doses and Side Effects Associated with Antipyretic Analgesics in Specialised Tertiary Pain Care Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]. Nov, 2010 | Pubmed ID: 20490889 A Critical Appraisal of Human Genotyping for Pain Therapy Trends in Pharmacological Sciences. Jul, 2010 | Pubmed ID: 20483491 Alterations in the Hippocampal Endocannabinoid System in Diet-induced Obese Mice The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. May, 2010 | Pubmed ID: 20445053 Ziconotide for Treatment of Severe Chronic Pain Lancet (London, England). May, 2010 | Pubmed ID: 20413151 Analysis of NF-kappaB Signaling Pathways by Proteomic Approaches Expert Review of Proteomics. Apr, 2010 | Pubmed ID: 20377387 Soluble Epoxide Hydrolase Deficiency Attenuates Neointima Formation in the Femoral Cuff Model of Hyperlipidemic Mice Arteriosclerosis, Thrombosis, and Vascular Biology. May, 2010 | Pubmed ID: 20224052 Cleavage of Sphingosine Kinase 2 by Caspase-1 Provokes Its Release from Apoptotic Cells Blood. Apr, 2010 | Pubmed ID: 20197547 An Endocannabinoid System is Localized to the Hypophysial Pars Tuberalis of Syrian Hamsters and Responds to Photoperiodic Changes Cell and Tissue Research. Apr, 2010 | Pubmed ID: 20165884 Sulindac Sulfide Suppresses 5-lipoxygenase at Clinically Relevant Concentrations Cellular and Molecular Life Sciences : CMLS. Mar, 2010 | Pubmed ID: 20091083 Nonacidic Inhibitors of Human Microsomal Prostaglandin Synthase 1 (mPGES 1) Identified by a Multistep Virtual Screening Protocol Journal of Medicinal Chemistry. Jan, 2010 | Pubmed ID: 20025212 Highly Sensitive Determination of HCV Protease Inhibitors Boceprevir (SCH 503034) and Telaprevir (VX 950) in Human Plasma by LC-MS/MS Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences. Dec, 2009 | Pubmed ID: 19864192 Cross-sectional Assessment of the Consequences of a GTP Cyclohydrolase 1 Haplotype for Specialized Tertiary Outpatient Pain Care The Clinical Journal of Pain. Nov-Dec, 2009 | Pubmed ID: 19851158 Inhibitor KappaB Kinase Beta Deficiency in Primary Nociceptive Neurons Increases TRP Channel Sensitivity The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Oct, 2009 | Pubmed ID: 19828806 Analgesic Efficacy of Tramadol, Pregabalin and Ibuprofen in Menthol-evoked Cold Hyperalgesia Pain. Dec, 2009 | Pubmed ID: 19762153 Toponomics Analysis of Drug-induced Changes in Arachidonic Acid-dependent Signaling Pathways During Spinal Nociceptive Processing Journal of Proteome Research. Oct, 2009 | Pubmed ID: 19697962 Identification of Human Cathepsin G As a Functional Target of Boswellic Acids from the Anti-inflammatory Remedy Frankincense Journal of Immunology (Baltimore, Md. : 1950). Sep, 2009 | Pubmed ID: 19648270 Cellular Membranes Function As a Storage Compartment for Celecoxib Journal of Molecular Medicine (Berlin, Germany). Oct, 2009 | Pubmed ID: 19641861 Sphingosine Kinase 2 Deficient Tumor Xenografts Show Impaired Growth and Fail to Polarize Macrophages Towards an Anti-inflammatory Phenotype International Journal of Cancer. Nov, 2009 | Pubmed ID: 19618460 Genetic Modulation of the Pharmacological Treatment of Pain Pharmacology & Therapeutics. Nov, 2009 | Pubmed ID: 19615406 Cross-sectional Analysis of the Influence of Currently Known Pharmacogenetic Modulators on Opioid Therapy in Outpatient Pain Centers Pharmacogenetics and Genomics. Jun, 2009 | Pubmed ID: 19514130 No NO, No Pain? The Role of Nitric Oxide and CGMP in Spinal Pain Processing Trends in Neurosciences. Jun, 2009 | Pubmed ID: 19414201 Can Extremely Low or High Morphine Formation from Codeine Be Predicted Prior to Therapy Initiation? Pain. Jul, 2009 | Pubmed ID: 19395173 Genetic Variants Altering Dopamine D2 Receptor Expression or Function Modulate the Risk of Opiate Addiction and the Dosage Requirements of Methadone Substitution Pharmacogenetics and Genomics. Jun, 2009 | Pubmed ID: 19373123 Capturing Adenylyl Cyclases As Potential Drug Targets Nature Reviews. Drug Discovery. Apr, 2009 | Pubmed ID: 19337273 Ceramide Synthases and Ceramide Levels Are Increased in Breast Cancer Tissue Carcinogenesis. May, 2009 | Pubmed ID: 19279183 Prostaglandin D(2) Sustains the Pyrogenic Effect of Prostaglandin E(2) European Journal of Pharmacology. Apr, 2009 | Pubmed ID: 19249295 Inhibition of the Soluble Epoxide Hydrolase Attenuates Monocrotaline-induced Pulmonary Hypertension in Rats Journal of Hypertension. Feb, 2009 | Pubmed ID: 19226702 Multidrug Resistance-related Protein 2 Genotype of the Donor Affects Kidney Graft Function Pharmacogenetics and Genomics. Apr, 2009 | Pubmed ID: 19214140 The S1P(2) Receptor Expressed in Human Platelets is Linked to the RhoA-Rho Kinase Pathway and is Down Regulated in Type 2 Diabetes Basic Research in Cardiology. May, 2009 | Pubmed ID: 19139947 A Common Human Micro-opioid Receptor Genetic Variant Diminishes the Receptor Signaling Efficacy in Brain Regions Processing the Sensory Information of Pain The Journal of Biological Chemistry. Mar, 2009 | Pubmed ID: 19116204 Comparison of Nociceptive Behavior in Prostaglandin E, F, D, Prostacyclin and Thromboxane Receptor Knockout Mice European Journal of Pain (London, England). Aug, 2009 | Pubmed ID: 18938093 The Selective COX-2 Inhibitor Celecoxib Modulates Sphingolipid Synthesis Journal of Lipid Research. Jan, 2009 | Pubmed ID: 18711209 Update on the Pathobiology of Neuropathic Pain Expert Review of Proteomics. Dec, 2008 | Pubmed ID: 19086860 Sphingosine 1-phosphate Modulates Spinal Nociceptive Processing The Journal of Biological Chemistry. Nov, 2008 | Pubmed ID: 18805787 Toponomics Analysis of Functional Interactions of the Ubiquitin Ligase PAM (Protein Associated with Myc) During Spinal Nociceptive Processing Molecular & Cellular Proteomics : MCP. Dec, 2008 | Pubmed ID: 18753128 CGMP Produced by NO-sensitive Guanylyl Cyclase Essentially Contributes to Inflammatory and Neuropathic Pain by Using Targets Different from CGMP-dependent Protein Kinase I The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Aug, 2008 | Pubmed ID: 18716216 Genetic Deletion of Synapsin II Reduces Neuropathic Pain Due to Reduced Glutamate but Increased GABA in the Spinal Cord Dorsal Horn Pain. Oct, 2008 | Pubmed ID: 18701217 Celecoxib Inhibits 5-lipoxygenase Biochemical Pharmacology. Oct, 2008 | Pubmed ID: 18692027 Keratinocyte-derived Vascular Endothelial Growth Factor Biosynthesis Represents a Pleiotropic Side Effect of Peroxisome Proliferator-activated Receptor-gamma Agonist Troglitazone but Not Rosiglitazone and Involves Activation of P38 Mitogen-activated Protein Kinase: Implications for Diabetes-impaired Skin Repair Molecular Pharmacology. Oct, 2008 | Pubmed ID: 18599600 The IKK-NF-kappaB Pathway: a Source for Novel Molecular Drug Targets in Pain Therapy? FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Oct, 2008 | Pubmed ID: 18559989 The Anti-proliferative Potency of Celecoxib is Not a Class Effect of Coxibs Biochemical Pharmacology. Jul, 2008 | Pubmed ID: 18547544 Dimethylcelecoxib Inhibits Prostaglandin E2 Production Biochemical Pharmacology. Jul, 2008 | Pubmed ID: 18508034 Antinociceptive Activity of the S1P-receptor Agonist FTY720 Journal of Cellular and Molecular Medicine. Jun, 2008 | Pubmed ID: 18494940 Genetic Polymorphism of the Type A Human Natriuretic Peptide Receptor (NPR-A) Gene Contributes to the Interindividual Variability in the BNP System European Journal of Heart Failure. May, 2008 | Pubmed ID: 18436476 Consequences of Altered Eicosanoid Patterns for Nociceptive Processing in MPGES-1-deficient Mice Journal of Cellular and Molecular Medicine. Apr, 2008 | Pubmed ID: 18419601 Biphasic Regulation of HMG-CoA Reductase Expression and Activity During Wound Healing and Its Functional Role in the Control of Keratinocyte Angiogenic and Proliferative Responses The Journal of Biological Chemistry. May, 2008 | Pubmed ID: 18390541 Reduced Hyperalgesia in Homozygous Carriers of a GTP Cyclohydrolase 1 Haplotype European Journal of Pain (London, England). Nov, 2008 | Pubmed ID: 18374612 Microsomal Prostaglandin E2 Synthase-1 Deletion Leads to Adverse Left Ventricular Remodeling After Myocardial Infarction Circulation. Apr, 2008 | Pubmed ID: 18347209 Cysteine-rich Protein 2, a Novel Downstream Effector of CGMP/cGMP-dependent Protein Kinase I-mediated Persistent Inflammatory Pain The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Feb, 2008 | Pubmed ID: 18256252 Proteomics in Neuropathic Pain Research Anesthesiology. Feb, 2008 | Pubmed ID: 18212577 Microarray Analysis of Altered Sphingolipid Metabolism Reveals Prognostic Significance of Sphingosine Kinase 1 in Breast Cancer Breast Cancer Research and Treatment. Nov, 2008 | Pubmed ID: 18058224 P53 is Important for the Anti-proliferative Effect of Ibuprofen in Colon Carcinoma Cells Biochemical and Biophysical Research Communications. Jan, 2008 | Pubmed ID: 18036557 Pyrosequencing of Polymorphisms in the COX-2 Gene (PTGS2) with Reported Clinical Relevance Pharmacogenomics. Dec, 2007 | Pubmed ID: 18085997 Rapid Screening for Potentially Relevant Polymorphisms in the Human Fatty Acid Amide Hydrolase Gene Using Pyrosequencing Prostaglandins & Other Lipid Mediators. Nov, 2007 | Pubmed ID: 17991615 Current Evidence for a Modulation of Nociception by Human Genetic Polymorphisms Pain. Nov, 2007 | Pubmed ID: 17706868 The Impact of CREB and Its Phosphorylation at Ser142 on Inflammatory Nociception Biochemical and Biophysical Research Communications. Oct, 2007 | Pubmed ID: 17692820 Tumor Cell Apoptosis Polarizes Macrophages Role of Sphingosine-1-phosphate Molecular Biology of the Cell. Oct, 2007 | Pubmed ID: 17652460 Effects of Parecoxib and Dipyrone on Platelet Aggregation in Patients Undergoing Meniscectomy: a Double-blind, Randomized, Parallel-group Study Clinical Therapeutics. Mar, 2007 | Pubmed ID: 17577465 Association of Saquinavir Plasma Concentrations with Side Effects but Not with Antiretroviral Outcome in Patients Infected with Protease Inhibitor-susceptible Human Immunodeficiency Virus Type 1 Antimicrobial Agents and Chemotherapy. Sep, 2007 | Pubmed ID: 17576836 FTY720 Ameliorates Oxazolone Colitis in Mice by Directly Affecting T Helper Type 2 Functions Molecular Immunology. Jul, 2007 | Pubmed ID: 17475330 PGD2 Metabolism in Plasma: Kinetics and Relationship with Bioactivity on DP1 and CRTH2 Receptors Biochemical Pharmacology. Jun, 2007 | Pubmed ID: 17452035 Reliable Screening for a Pain-protective Haplotype in the GTP Cyclohydrolase 1 Gene (GCH1) Through the Use of 3 or Fewer Single Nucleotide Polymorphisms Clinical Chemistry. Jun, 2007 | Pubmed ID: 17363416 The Effects of COX-2 Selective and Non-selective NSAIDs on the Initiation and Progression of Atherosclerosis in ApoE-/- Mice Journal of Molecular Medicine (Berlin, Germany). Jun, 2007 | Pubmed ID: 17318614 FTY720 Ameliorates Th1-mediated Colitis in Mice by Directly Affecting the Functional Activity of CD4+CD25+ Regulatory T Cells Journal of Immunology (Baltimore, Md. : 1950). Feb, 2007 | Pubmed ID: 17277153 Impaired Acute and Inflammatory Nociception in Mice Lacking the P50 Subunit of NF-kappaB European Journal of Pharmacology. Mar, 2007 | Pubmed ID: 17217946 Pharmacological and Histopathological Characterization of a Hyperalgesia Model Induced by Freeze Lesion Pain. Feb, 2007 | Pubmed ID: 17189672 The Cyclooxygenase 2 Genetic Variant -765G>C Does Not Modulate the Effects of Celecoxib on Prostaglandin E2 Production Clinical Pharmacology and Therapeutics. Dec, 2006 | Pubmed ID: 17178263 LC-MS/MS-analysis of Sphingosine-1-phosphate and Related Compounds in Plasma Samples Prostaglandins & Other Lipid Mediators. Dec, 2006 | Pubmed ID: 17085324 GTP Cyclohydrolase and Tetrahydrobiopterin Regulate Pain Sensitivity and Persistence Nature Medicine. Nov, 2006 | Pubmed ID: 17057711 Pyrosequencing-based Screening for Genetic Polymorphisms in Cytochrome P450 2B6 of Potential Clinical Relevance Pharmacogenomics. Oct, 2006 | Pubmed ID: 17054410 Fatal Respiratory Depression After Multiple Intravenous Morphine Injections Clinical Pharmacokinetics. 2006 | Pubmed ID: 17048971 The Mu-opioid Receptor Gene Polymorphism 118A>G Depletes Alfentanil-induced Analgesia and Protects Against Respiratory Depression in Homozygous Carriers Pharmacogenetics and Genomics. Sep, 2006 | Pubmed ID: 16906017 Nimodipine Plasma Concentration and Retinal Blood Flow in Healthy Subjects Investigative Ophthalmology & Visual Science. Aug, 2006 | Pubmed ID: 16877419 Inhibition of Prostaglandin E2 Synthesis by SC-560 is Independent of Cyclooxygenase 1 Inhibition FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Jul, 2006 | Pubmed ID: 16816110 Is MPGES-1 a Promising Target for Pain Therapy? Trends in Pharmacological Sciences. Aug, 2006 | Pubmed ID: 16815559 Misestimating the Role of an Active Metabolite when Modeling the Effects After Administration of the Parent Compound Only Clinical Pharmacology and Therapeutics. Jul, 2006 | Pubmed ID: 16815321 The Glutamate Transporter GLAST is Involved in Spinal Nociceptive Processing Biochemical and Biophysical Research Communications. Jul, 2006 | Pubmed ID: 16765320 Cyclooxygenase-2 (COX-2)-independent Anticarcinogenic Effects of Selective COX-2 Inhibitors Journal of the National Cancer Institute. Jun, 2006 | Pubmed ID: 16757698 Evidence of COX-2 Independent Induction of Apoptosis and Cell Cycle Block in Human Colon Carcinoma Cells After S- or R-ibuprofen Treatment European Journal of Pharmacology. Jul, 2006 | Pubmed ID: 16730702 Apoptotic Cells Promote Macrophage Survival by Releasing the Antiapoptotic Mediator Sphingosine-1-phosphate Blood. Sep, 2006 | Pubmed ID: 16690965 High Sensitive Determination of Sufentanil in Human Plasma of Parturients and Neonates Following Patient-controlled Epidural Analgesia (PCEA) Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences. May, 2006 | Pubmed ID: 16621739 Different COX-independent Effects of the COX-2 Inhibitors Etoricoxib and Lumiracoxib Biochemical and Biophysical Research Communications. Apr, 2006 | Pubmed ID: 16598848 Cardiovascular Risk with Cyclooxygenase Inhibitors: General Problem with Substance Specific Differences? Naunyn-Schmiedeberg's Archives of Pharmacology. Apr, 2006 | Pubmed ID: 16586083 Rapid Identification of Three Functionally Relevant Polymorphisms in the OATP1B1 Transporter Gene Using Pyrosequencing Pharmacogenomics. Mar, 2006 | Pubmed ID: 16515396 Current Evidence for a Genetic Modulation of the Response to Analgesics Pain. Mar, 2006 | Pubmed ID: 16472919 Modulation of the Central Nervous Effects of Levomethadone by Genetic Polymorphisms Potentially Affecting Its Metabolism, Distribution, and Drug Action Clinical Pharmacology and Therapeutics. Jan, 2006 | Pubmed ID: 16413243 चूहे और विभिन्न ऊतकों में प्रतिरक्षा कोशिकाओं की रोग-निर्भर वितरण के मूल्यांकन में प्रायोगिक ऑटोइम्यून Encephalomyelitis की प्रेरण Julia Barthelmes*1, Nadja Tafferner*2, Jennifer Kurz2, Natasja de Bruin2, Michael J. Parnham2, Gerd Geisslinger1, Susanne Schiffmann2 1Institute of Clinical Pharmacology, Goethe University Hospital Frankfurt, 2Project Group for Translational Medicine & Pharmacology, Fraunhofer IME Immunology and Infection
चूहे और विभिन्न ऊतकों में प्रतिरक्षा कोशिकाओं की रोग-निर्भर वितरण के मूल्यांकन में प्रायोगिक ऑटोइम्यून Encephalomyelitis की प्रेरण Julia Barthelmes*1, Nadja Tafferner*2, Jennifer Kurz2, Natasja de Bruin2, Michael J. Parnham2, Gerd Geisslinger1, Susanne Schiffmann2 1Institute of Clinical Pharmacology, Goethe University Hospital Frankfurt, 2Project Group for Translational Medicine & Pharmacology, Fraunhofer IME Immunology and Infection
