Gordon J. Lithgow

Publications

• Dysregulated Iron Metabolism in C. Elegans Catp-6/ATP13A2 Mutant Impairs Mitochondrial Function
  Neurobiology of Disease. 06, 2020  |   Pubmed ID: 32032734
• Intervention Testing Program: the Creatine Analog β-guanidinopropionic Acid Does Not Extend Lifespan in Nematodes
  MicroPublication Biology. 2020  |   Pubmed ID: 31998863
• Intervention Testing Program: the Tyrosine Kinase Inhibitor Imatinib Mesylate Does Not Extend Lifespan in Nematodes
  MicroPublication Biology. 2019  |   Pubmed ID: 32010883
• Automated Lifespan Determination Across Caenorhabditis Strains and Species Reveals Assay-specific Effects of Chemical Interventions
  GeroScience. 12, 2019  |   Pubmed ID: 31820364
• From Discoveries in Ageing Research to Therapeutics for Healthy Ageing
  Nature. 07, 2019  |   Pubmed ID: 31292558
• Drugs That Target Aging: How Do We Discover Them?
  Expert Opinion on Drug Discovery. 06, 2019  |   Pubmed ID: 30973028
• Acarbose Improves Health and Lifespan in Aging HET3 Mice
  Aging Cell. 04, 2019  |   Pubmed ID: 30688027
• Natural Genetic Variation in Yeast Reveals That NEDD4 Is a Conserved Modifier of Mutant Polyglutamine Aggregation
  G3 (Bethesda, Md.). 11, 2018  |   Pubmed ID: 30194090
• A Long Journey to Reproducible Results
  Nature. 08, 2017  |   Pubmed ID: 28836615
• Anti-Inflammatory and Neuroprotective Role of Natural Product Securinine in Activated Glial Cells: Implications for Parkinson's Disease
  Mediators of Inflammation. 2017  |   Pubmed ID: 28473732
• Impact of Genetic Background and Experimental Reproducibility on Identifying Chemical Compounds with Robust Longevity Effects
  Nature Communications. Feb, 2017  |   Pubmed ID: 28220799
• Vitamin D Promotes Protein Homeostasis and Longevity Via the Stress Response Pathway Genes Skn-1, Ire-1, and Xbp-1
  Cell Reports. 10, 2016  |   Pubmed ID: 27783938
• A Caenorhabditis Elegans Model Elucidates a Conserved Role for TRPA1-Nrf Signaling in Reactive α-Dicarbonyl Detoxification
  Current Biology : CB. Nov, 2016  |   Pubmed ID: 27773573
• Chemical Activation of a Food Deprivation Signal Extends Lifespan
  Aging Cell. 10, 2016  |   Pubmed ID: 27220516
• Zinc Levels Modulate Lifespan Through Multiple Longevity Pathways in Caenorhabditis Elegans
  PloS One. 2016  |   Pubmed ID: 27078872
• Long Live FOXO: Unraveling the Role of FOXO Proteins in Aging and Longevity
  Aging Cell. Apr, 2016  |   Pubmed ID: 26643314
• Mitochondrial Quality Control Via the PGC1α-TFEB Signaling Pathway Is Compromised by Parkin Q311X Mutation But Independently Restored by Rapamycin
  The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Sep, 2015  |   Pubmed ID: 26377470
• Iron Promotes Protein Insolubility and Aging in C. Elegans
  Aging. Nov, 2014  |   Pubmed ID: 25554795
• Geroscience: Linking Aging to Chronic Disease
  Cell. Nov, 2014  |   Pubmed ID: 25417146
• Manganese Disturbs Metal and Protein Homeostasis in Caenorhabditis Elegans
  Metallomics : Integrated Biometal Science. Oct, 2014  |   Pubmed ID: 25057947
• Stress Biology and Aging Mechanisms: Toward Understanding the Deep Connection Between Adaptation to Stress and Longevity
  The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences. Jun, 2014  |   Pubmed ID: 24833580
• A DNA Synthesis Inhibitor is Protective Against Proteotoxic Stressors Via Modulation of Fertility Pathways in Caenorhabditis Elegans
  Aging. Oct, 2013  |   Pubmed ID: 24123581
• Age-related Micro-RNA Abundance in Individual C. Elegans
  Aging. Jun, 2013  |   Pubmed ID: 23793570
• Dimethyl Sulfoxide and Dimethyl Formamide Increase Lifespan of C. Elegans in Liquid
  Mechanisms of Ageing and Development. Mar, 2013  |   Pubmed ID: 23313473
• Curcumin and Neurodegenerative Diseases
  BioFactors (Oxford, England). Jan-Feb, 2013  |   Pubmed ID: 23303664
• Pharmacological Lifespan Extension of Invertebrates
  Ageing Research Reviews. Jan, 2013  |   Pubmed ID: 22771382
• Anti-inflammatory Role of the Isoflavone Diadzein in Lipopolysaccharide-stimulated Microglia: Implications for Parkinson's Disease
  Neurotoxicity Research. Feb, 2013  |   Pubmed ID: 22573480
• Translating Longevity Research into Healthspan
  Longevity & Healthspan. 2012  |   Pubmed ID: 24764507
• Tor1 Regulates Protein Solubility in Saccharomyces Cerevisiae
  Molecular Biology of the Cell. Dec, 2012  |   Pubmed ID: 23097491
• Aluminium Exposure Disrupts Elemental Homeostasis in Caenorhabditis Elegans
  Metallomics : Integrated Biometal Science. May, 2012  |   Pubmed ID: 22534883
• Pharmacological Maintenance of Protein Homeostasis Could Postpone Age-related Disease
  Aging Cell. Apr, 2012  |   Pubmed ID: 22226190
• Proteomic Analysis of Age-dependent Changes in Protein Solubility Identifies Genes That Modulate Lifespan
  Aging Cell. Feb, 2012  |   Pubmed ID: 22103665
• Life Span Extension Via EIF4G Inhibition is Mediated by Posttranscriptional Remodeling of Stress Response Gene Expression in C. Elegans
  Cell Metabolism. Jul, 2011  |   Pubmed ID: 21723504
• N-acylethanolamine Signalling Mediates the Effect of Diet on Lifespan in Caenorhabditis Elegans
  Nature. May, 2011  |   Pubmed ID: 21562563
• A New Look at Old Compounds
  Aging. Apr, 2011  |   Pubmed ID: 21512207
• Amyloid-binding Compounds Maintain Protein Homeostasis During Ageing and Extend Lifespan
  Nature. Apr, 2011  |   Pubmed ID: 21451522
• Why Aging Isn't Regulated: a Lamentation on the Use of Language in Aging Literature
  Experimental Gerontology. Oct, 2006  |   Pubmed ID: 16959457
• Does Anti-aging Equal Anti-microbial?
  Science of Aging Knowledge Environment : SAGE KE. Jun, 2003  |   Pubmed ID: 12844540
• Stress Resistance As a Determinate of C. Elegans Lifespan
  Mechanisms of Ageing and Development. Apr, 2002  |   Pubmed ID: 11869734