Gregory J. Morton

Publications

• The Role of Vasodilator-stimulated Phosphoprotein (VASP) in the Control of Hepatic Gluconeogenic Gene Expression
  PloS One. 2019  |   Pubmed ID: 31017943
• The Central Fibroblast Growth Factor Receptor/beta Klotho System: Comprehensive Mapping in Mus Musculus and Comparisons to Nonhuman Primate and Human Samples Using an Automated in Situ Hybridization Platform
  The Journal of Comparative Neurology. Aug, 2019  |   Pubmed ID: 30809795
• The Hypothalamic Arcuate Nucleus-Median Eminence Is a Target for Sustained Diabetes Remission Induced by Fibroblast Growth Factor 1
  Diabetes. 05, 2019  |   Pubmed ID: 30796029
• Glucoregulatory Responses to Hypothalamic Preoptic Area Cooling
  Brain Research. 05, 2019  |   Pubmed ID: 30610874
• Peripheral Mechanisms Mediating the Sustained Antidiabetic Action of FGF1 in the Brain
  Diabetes. 03, 2019  |   Pubmed ID: 30523024
• Distinct Neuronal Projections From the Hypothalamic Ventromedial Nucleus Mediate Glycemic and Behavioral Effects
  Diabetes. 12, 2018  |   Pubmed ID: 30257978
• Leptin Regulation of Core Body Temperature Involves Mechanisms Independent of the Thyroid Axis
  American Journal of Physiology. Endocrinology and Metabolism. 10, 2018  |   Pubmed ID: 29944392
• In Uncontrolled Diabetes, Hyperglucagonemia and Ketosis Result From Deficient Leptin Action in the Parabrachial Nucleus
  Endocrinology. 04, 2018  |   Pubmed ID: 29438473
• Androgen Receptor Deficiency in Monocytes/macrophages Does Not Alter Adiposity or Glucose Homeostasis in Male Mice
  Asian Journal of Andrology. May-Jun, 2018  |   Pubmed ID: 29205180
• Chronic Hindbrain Administration of Oxytocin is Sufficient to Elicit Weight Loss in Diet-induced Obese Rats
  American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. Oct, 2017  |   Pubmed ID: 28747407
• How Should We Think About the Role of the Brain in Glucose Homeostasis and Diabetes?
  Diabetes. 07, 2017  |   Pubmed ID: 28603139
• Response to
  Molecular Metabolism. 04, 2017  |   Pubmed ID: 28377869
• Metabolically Distinct Weight Loss by 10,12 CLA and Caloric Restriction Highlight the Importance of Subcutaneous White Adipose Tissue for Glucose Homeostasis in Mice
  PloS One. 2017  |   Pubmed ID: 28245284
• Sex Differences in Microglial CX3CR1 Signalling Determine Obesity Susceptibility in Mice
  Nature Communications. 02, 2017  |   Pubmed ID: 28223698
• Evidence That the Sympathetic Nervous System Elicits Rapid, Coordinated, and Reciprocal Adjustments of Insulin Secretion and Insulin Sensitivity During Cold Exposure
  Diabetes. 04, 2017  |   Pubmed ID: 28115396
• Deletion of Protein Kinase C λ in POMC Neurons Predisposes to Diet-Induced Obesity
  Diabetes. 04, 2017  |   Pubmed ID: 28073831
• Physiological Role for Leptin in the Control of Thermal Conductance
  Molecular Metabolism. Oct, 2016  |   Pubmed ID: 27689002
• Central Injection of Fibroblast Growth Factor 1 Induces Sustained Remission of Diabetic Hyperglycemia in Rodents
  Nature Medicine. 07, 2016  |   Pubmed ID: 27213816
• Functional Identification of a Neurocircuit Regulating Blood Glucose
  Proceedings of the National Academy of Sciences of the United States of America. Apr, 2016  |   Pubmed ID: 27001850
• The Role of Leptin in Diabetes: Metabolic Effects
  Diabetologia. May, 2016  |   Pubmed ID: 26969486
• Chronic CNS Oxytocin Signaling Preferentially Induces Fat Loss in High-fat Diet-fed Rats by Enhancing Satiety Responses and Increasing Lipid Utilization
  American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. Apr, 2016  |   Pubmed ID: 26791828
• Evidence Against Hypothalamic-pituitary-adrenal Axis Suppression in the Antidiabetic Action of Leptin
  The Journal of Clinical Investigation. Nov, 2015  |   Pubmed ID: 26529250
• Glucose Intolerance Induced by Blockade of Central FGF Receptors is Linked to an Acute Stress Response
  Molecular Metabolism. Aug, 2015  |   Pubmed ID: 26266088
• In Vivo Structure-function Studies of Human Hepatic Lipase: the Catalytic Function Rescues the Lean Phenotype of HL-deficient (hl-/-) Mice
  Physiological Reports. Apr, 2015  |   Pubmed ID: 25862097
• Leptin Signaling is Required for Adaptive Changes in Food Intake, but Not Energy Expenditure, in Response to Different Thermal Conditions
  PloS One. 2015  |   Pubmed ID: 25756181
• Evidence That in Uncontrolled Diabetes, Hyperglucagonemia Is Required for Ketosis but Not for Increased Hepatic Glucose Production or Hyperglycemia
  Diabetes. Jul, 2015  |   Pubmed ID: 25633417
• Chronic Oxytocin Administration Inhibits Food Intake, Increases Energy Expenditure, and Produces Weight Loss in Fructose-fed Obese Rhesus Monkeys
  American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. Mar, 2015  |   Pubmed ID: 25540103
• Role of Melanocortin Signaling in Neuroendocrine and Metabolic Actions of Leptin in Male Rats with Uncontrolled Diabetes
  Endocrinology. Nov, 2014  |   Pubmed ID: 25137027
• Genetic Determinants of Atherosclerosis, Obesity, and Energy Balance in Consomic Mice
  Mammalian Genome : Official Journal of the International Mammalian Genome Society. Dec, 2014  |   Pubmed ID: 25001233
• Hindbrain Oxytocin Receptors Contribute to the Effects of Circulating Oxytocin on Food Intake in Male Rats
  Endocrinology. Aug, 2014  |   Pubmed ID: 24877632
• Neurobiology of Food Intake in Health and Disease
  Nature Reviews. Neuroscience. Jun, 2014  |   Pubmed ID: 24840801
• Carbohydrate Feeding Dissociates the Postprandial FGF19 Response from Circulating Bile Acid Levels in Humans
  The Journal of Clinical Endocrinology and Metabolism. Feb, 2014  |   Pubmed ID: 24297792
• Is There Evidence That Estrogen Therapy Promotes Weight Maintenance Via Effects on Leptin?
  Menopause (New York, N.Y.). Apr, 2014  |   Pubmed ID: 24149922
• Cooperation Between Brain and Islet in Glucose Homeostasis and Diabetes
  Nature. Nov, 2013  |   Pubmed ID: 24201279
• Rapid Glutamate Release in the Mediobasal Hypothalamus Accompanies Feeding and is Exaggerated by an Obesogenic Food
  Molecular Metabolism. 2013  |   Pubmed ID: 24199157
• FGF19 Action in the Brain Induces Insulin-independent Glucose Lowering
  The Journal of Clinical Investigation. Nov, 2013  |   Pubmed ID: 24084738
• Molecular and Functional Analysis of Human β-defensin 3 Action at Melanocortin Receptors
  Chemistry & Biology. Jun, 2013  |   Pubmed ID: 23790489
• Leptin Action in the Ventromedial Hypothalamic Nucleus is Sufficient, but Not Necessary, to Normalize Diabetic Hyperglycemia
  Endocrinology. Sep, 2013  |   Pubmed ID: 23782941
• In Uncontrolled Diabetes, Thyroid Hormone and Sympathetic Activators Induce Thermogenesis Without Increasing Glucose Uptake in Brown Adipose Tissue
  American Journal of Physiology. Endocrinology and Metabolism. Apr, 2013  |   Pubmed ID: 23384771
• BDNF Action in the Brain Attenuates Diabetic Hyperglycemia Via Insulin-independent Inhibition of Hepatic Glucose Production
  Diabetes. May, 2013  |   Pubmed ID: 23274899
• Leptin, Diabetes, and the Brain
  Indian Journal of Endocrinology and Metabolism. Dec, 2012  |   Pubmed ID: 23565487
• Acutely Decreased Thermoregulatory Energy Expenditure or Decreased Activity Energy Expenditure Both Acutely Reduce Food Intake in Mice
  PloS One. 2012  |   Pubmed ID: 22936977
• Obesity is Associated with Hypothalamic Injury in Rodents and Humans
  The Journal of Clinical Investigation. Jan, 2012  |   Pubmed ID: 22201683
• Peripheral Oxytocin Suppresses Food Intake and Causes Weight Loss in Diet-induced Obese Rats
  American Journal of Physiology. Endocrinology and Metabolism. Jan, 2012  |   Pubmed ID: 22008455
• Endothelial NO/cGMP/VASP Signaling Attenuates Kupffer Cell Activation and Hepatic Insulin Resistance Induced by High-fat Feeding
  Diabetes. Nov, 2011  |   Pubmed ID: 21911751
• Subcutaneous Administration of Leptin Normalizes Fasting Plasma Glucose in Obese Type 2 Diabetic UCD-T2DM Rats
  Proceedings of the National Academy of Sciences of the United States of America. Aug, 2011  |   Pubmed ID: 21873226
• Leptin and the Central Nervous System Control of Glucose Metabolism
  Physiological Reviews. Apr, 2011  |   Pubmed ID: 21527729
• A Novel Rodent Model That Mimics the Metabolic Sequelae of Obese Craniopharyngioma Patients
  Pediatric Research. Mar, 2011  |   Pubmed ID: 21372758
• Leptin Activates a Novel CNS Mechanism for Insulin-independent Normalization of Severe Diabetic Hyperglycemia
  Endocrinology. Feb, 2011  |   Pubmed ID: 21159853
• Identification of a Physiological Role for Leptin in the Regulation of Ambulatory Activity and Wheel Running in Mice
  American Journal of Physiology. Endocrinology and Metabolism. Feb, 2011  |   Pubmed ID: 21062956
• Standard Operating Procedures for Describing and Performing Metabolic Tests of Glucose Homeostasis in Mice
  Disease Models & Mechanisms. Sep-Oct, 2010  |   Pubmed ID: 20713647
• Assessment of Feeding Behavior in Laboratory Mice
  Cell Metabolism. Jul, 2010  |   Pubmed ID: 20620991
• A New Oxytocin-saporin Cytotoxin for Lesioning Oxytocin-receptive Neurons in the Rat Hindbrain
  Endocrinology. Sep, 2010  |   Pubmed ID: 20610562
• Leptin Deficiency Causes Insulin Resistance Induced by Uncontrolled Diabetes
  Diabetes. Jul, 2010  |   Pubmed ID: 20424233
• Identification of Body Fat Mass As a Major Determinant of Metabolic Rate in Mice
  Diabetes. Jul, 2010  |   Pubmed ID: 20413511
• Central Administration of Interleukin-4 Exacerbates Hypothalamic Inflammation and Weight Gain During High-fat Feeding
  American Journal of Physiology. Endocrinology and Metabolism. Jul, 2010  |   Pubmed ID: 20371733
• Fibroblast Growth Factor 21 Action in the Brain Increases Energy Expenditure and Insulin Sensitivity in Obese Rats
  Diabetes. Jul, 2010  |   Pubmed ID: 20357365
• Mice Lacking Hepatic Lipase Are Lean and Protected Against Diet-induced Obesity and Hepatic Steatosis
  Endocrinology. Mar, 2010  |   Pubmed ID: 20056822
• Hypothalamic Leptin Signaling Regulates Hepatic Insulin Sensitivity Via a Neurocircuit Involving the Vagus Nerve
  Endocrinology. Oct, 2009  |   Pubmed ID: 19574396
• The Action of Leptin in the Ventral Tegmental Area to Decrease Food Intake is Dependent on Jak-2 Signaling
  American Journal of Physiology. Endocrinology and Metabolism. Jul, 2009  |   Pubmed ID: 19435852
• Hypothalamic Proinflammatory Lipid Accumulation, Inflammation, and Insulin Resistance in Rats Fed a High-fat Diet
  American Journal of Physiology. Endocrinology and Metabolism. May, 2009  |   Pubmed ID: 19116375
• Forebrain Melanocortin Signaling Enhances the Hindbrain Satiety Response to CCK-8
  American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. Mar, 2009  |   Pubmed ID: 19109369
• Vascular Inflammation, Insulin Resistance, and Reduced Nitric Oxide Production Precede the Onset of Peripheral Insulin Resistance
  Arteriosclerosis, Thrombosis, and Vascular Biology. Nov, 2008  |   Pubmed ID: 18772497
• Deficiency of TNFalpha Converting Enzyme (TACE/ADAM17) Causes a Lean, Hypermetabolic Phenotype in Mice
  Endocrinology. Dec, 2008  |   Pubmed ID: 18687778
• Signal Transducer and Activator of Transcription-3 is Required in Hypothalamic Agouti-related Protein/neuropeptide Y Neurons for Normal Energy Homeostasis
  Endocrinology. Jul, 2008  |   Pubmed ID: 18403487
• Hypothalamic Leptin Regulation of Energy Homeostasis and Glucose Metabolism
  The Journal of Physiology. Sep, 2007  |   Pubmed ID: 17584844
• Central Interleukin-1 (IL1) Signaling is Required for Pharmacological, but Not Physiological, Effects of Leptin on Energy Balance
  Brain Research. May, 2007  |   Pubmed ID: 17320056
• Thermoregulatory and Metabolic Defects in Huntington's Disease Transgenic Mice Implicate PGC-1alpha in Huntington's Disease Neurodegeneration
  Cell Metabolism. Nov, 2006  |   Pubmed ID: 17055784
• Insulin Action in the Brain Contributes to Glucose Lowering During Insulin Treatment of Diabetes
  Cell Metabolism. Jan, 2006  |   Pubmed ID: 16399506
• Leptin Regulates Insulin Sensitivity Via Phosphatidylinositol-3-OH Kinase Signaling in Mediobasal Hypothalamic Neurons
  Cell Metabolism. Dec, 2005  |   Pubmed ID: 16330326
• Effects of Hypothalamic Neurodegeneration on Energy Balance
  PLoS Biology. Dec, 2005  |   Pubmed ID: 16296893
• Leptin Inhibits Hypothalamic Npy and Agrp Gene Expression Via a Mechanism That Requires Phosphatidylinositol 3-OH-kinase Signaling
  American Journal of Physiology. Endocrinology and Metabolism. Dec, 2005  |   Pubmed ID: 16046456
• Leptin Action in the Forebrain Regulates the Hindbrain Response to Satiety Signals
  The Journal of Clinical Investigation. Mar, 2005  |   Pubmed ID: 15711637
• Increased Hypothalamic Melanin Concentrating Hormone Gene Expression During Energy Restriction Involves a Melanocortin-independent, Estrogen-sensitive Mechanism
  Peptides. Apr, 2004  |   Pubmed ID: 15165723
• Neuropeptide Y is Required for Hyperphagic Feeding in Response to Neuroglucopenia
  Endocrinology. Jul, 2004  |   Pubmed ID: 15064281
• Arcuate Nucleus-specific Leptin Receptor Gene Therapy Attenuates the Obesity Phenotype of Koletsky (fa(k)/fa(k)) Rats
  Endocrinology. May, 2003  |   Pubmed ID: 12697710