Guri Giaever Donnelly Centre for Cellular and Biomolecular Research University of Toronto Biography Publications Institution JoVE Articles Guri Giaever has not added a biography. If you are Guri Giaever and would like to personalize this page please email our Author Liaison for assistance. Publications Open Source Drug Discovery: Highly Potent Antimalarial Compounds Derived from the Tres Cantos Arylpyrroles ACS Central Science. Oct, 2016 | Pubmed ID: 27800551 Genome-wide RNAi Analysis Reveals That Simultaneous Inhibition of Specific Mevalonate Pathway Genes Potentiates Tumor Cell Death Oncotarget. Sep, 2015 | Pubmed ID: 26353928 Caenorhabditis Elegans is a Useful Model for Anthelmintic Discovery Nature Communications. Jun, 2015 | Pubmed ID: 26108372 Genes Required for Survival in Microgravity Revealed by Genome-wide Yeast Deletion Collections Cultured During Spaceflight BioMed Research International. 2015 | Pubmed ID: 25667933 A Genome Scale Overexpression Screen to Reveal Drug Activity in Human Cells Genome Medicine. 2014 | Pubmed ID: 24944581 Mapping the Cellular Response to Small Molecules Using Chemogenomic Fitness Signatures Science (New York, N.Y.). Apr, 2014 | Pubmed ID: 24723613 Large-scale Identification and Analysis of Suppressive Drug Interactions Chemistry & Biology. Apr, 2014 | Pubmed ID: 24704506 PITPs As Targets for Selectively Interfering with Phosphoinositide Signaling in Cells Nature Chemical Biology. Jan, 2014 | Pubmed ID: 24292071 A Novel Small Molecule Methyltransferase is Important for Virulence in Candida Albicans ACS Chemical Biology. Dec, 2013 | Pubmed ID: 24083538 Miniature Short Hairpin RNA Screens to Characterize Antiproliferative Drugs G3 (Bethesda, Md.). Aug, 2013 | Pubmed ID: 23797109 A High-throughput Yeast Assay Identifies Synergistic Drug Combinations Assay and Drug Development Technologies. Jun, 2013 | Pubmed ID: 23772551 DNA-damaging Agents in Cancer Chemotherapy: Serendipity and Chemical Biology Chemistry & Biology. May, 2013 | Pubmed ID: 23706631 相扑链功能的全球分析表明,在染色质调控中的多个角色。 The Journal of Cell Biology. Apr, 2013 | Pubmed ID: 23547032 Lysosomal Disruption Preferentially Targets Acute Myeloid Leukemia Cells and Progenitors The Journal of Clinical Investigation. Jan, 2013 | Pubmed ID: 23202731 Chromatin is an Ancient Innovation Conserved Between Archaea and Eukarya ELife. Dec, 2012 | Pubmed ID: 23240084 A Phenotypic Screening Platform to Identify Small Molecule Modulators of Chlamydomonas Reinhardtii Growth, Motility and Photosynthesis Genome Biology. Nov, 2012 | Pubmed ID: 23158586 Functional Analysis with a Barcoder Yeast Gene Overexpression System G3 (Bethesda, Md.). Oct, 2012 | Pubmed ID: 23050238 Genome-wide Analysis of Intracellular PH Reveals Quantitative Control of Cell Division Rate by PH(c) in Saccharomyces Cerevisiae Genome Biology. Sep, 2012 | Pubmed ID: 23021432 An Algorithm for Chemical Genomic Profiling That Minimizes Batch Effects: Bucket Evaluations BMC Bioinformatics. Sep, 2012 | Pubmed ID: 23009392 Global Gene Deletion Analysis Exploring Yeast Filamentous Growth Science (New York, N.Y.). Sep, 2012 | Pubmed ID: 22984072 Comparative Chemogenomics to Examine the Mechanism of Action of Dna-targeted Platinum-acridine Anticancer Agents ACS Chemical Biology. Nov, 2012 | Pubmed ID: 22928710 为了解药物-基因交互作用的条形码测序。 Methods in Molecular Biology (Clifton, N.J.). 2012 | Pubmed ID: 22821592 环孢素 A 在酿酒酵母中的新型钙调神经磷酸独立活动。 Molecular BioSystems. Aug, 2012 | Pubmed ID: 22751784 Identification of Yeast Genes That Confer Resistance to Chitosan Oligosaccharide (COS) Using Chemogenomics BMC Genomics. Jun, 2012 | Pubmed ID: 22727066 Dafadine 抑制 DAF 9 促进 Dauer 形成和秀丽隐杆线虫的寿命。 Nature Chemical Biology. 2012 | Pubmed ID: 22337098 线粒体呼吸是细胞肿瘤药物 Elesclomol 的目标。 PloS One. 2012 | Pubmed ID: 22253786 Bug、 药物和化学基因组学。 Nature Chemical Biology. Jan, 2012 | Pubmed ID: 22173359 A Global Perspective of the Genetic Basis for Carbonyl Stress Resistance G3 (Bethesda, Md.). Aug, 2011 | Pubmed ID: 22384333 多个手段为了同样的目的: 获得的抗逆性酵母的遗传基础。 PLoS Genetics. Nov, 2011 | Pubmed ID: 22102822 作为人类急性髓细胞白血病的治疗战略的线粒体翻译的抑制作用。 Cancer Cell. Nov, 2011 | Pubmed ID: 22094260 有系统地探讨协同药对。 Molecular Systems Biology. 2011 | Pubmed ID: 22068327 Dafadine 抑制 DAF 9 促进 Dauer 形成和秀丽隐杆线虫的寿命。 Nature Chemical Biology. Dec, 2011 | Pubmed ID: 22057127 复合优先次序方法增加模式生物化学探测器发现的率。 Chemistry & Biology. Oct, 2011 | Pubmed ID: 22035796 系统生物学方法揭示了化学应力和脂质稳态响应新型甲基转移酶的作用。 PLoS Genetics. Oct, 2011 | Pubmed ID: 22028670 姜黄素抑制通过铁螯合酿酒酵母细胞生长。 Eukaryotic Cell. Nov, 2011 | Pubmed ID: 21908599 在使用 Cytoscape 的生物网络上显示化学信息。 Methods in Molecular Biology (Clifton, N.J.). 2011 | Pubmed ID: 21877291 自动化的单元格: 化合物和筛选 Chemogenomic 筛查系统 (访问) 的环境。 Methods in Molecular Biology (Clifton, N.J.). 2011 | Pubmed ID: 21863492 新的唑类抗真菌剂与行动的新型模式: 新种三齿配体基于吡唑和三唑类合成和生物学特性研究。 European Journal of Medicinal Chemistry. Sep, 2011 | Pubmed ID: 21723647 设计、 合成和模拟敏感高效缓蚀阻垢剂 (作为) 激酶的表征。 PloS One. 2011 | Pubmed ID: 21698101 设计、 合成、 表征的一个非常有效的 Hog1 抑制剂: 用于分析 MAP 激酶信号在酵母中的强大工具。 PloS One. 2011 | Pubmed ID: 21655328 剂量抑制基因相互作用网络增强功能接线图的单元格。 Nature Biotechnology. Jun, 2011 | Pubmed ID: 21572441 一个全面的平台高度多路复用功能哺乳动物遗传屏幕。 BMC Genomics. 2011 | Pubmed ID: 21548937 合成基因相互作用网络揭示目标具体途径在酿酒酵母中的小分子。 Molecular BioSystems. Jun, 2011 | Pubmed ID: 21487606 有系统地探讨与温度敏感突变体基本酵母基因功能。 Nature Biotechnology. Apr, 2011 | Pubmed ID: 21441928 挖空性分类和荧光选择循环通过酶裁员。 Nature Methods. Feb, 2011 | Pubmed ID: 21217751 基因注释和药物目标发现白色念珠菌与加标签的转座子突变体集合中。 PLoS Pathogens. 2010 | Pubmed ID: 20949076 探索使用 Chemogenomic 的基因功能和药物行动剂量检测。 Methods in Enzymology. 2010 | Pubmed ID: 20946813 在酿酒酵母中的基因组全屏幕标识排序、 液泡蛋白自噬,生物合成,和 TRNA 甲基化基因参与寿命调控。 PLoS Genetics. Jul, 2010 | Pubmed ID: 20657825 药物和目标发现酵母基因组检测方法的一项调查。 Pharmacology & Therapeutics. Aug, 2010 | Pubmed ID: 20546776 药物生物蓄积作用和生物活性的秀丽隐杆线虫的预测模型。 Nature Chemical Biology. Jul, 2010 | Pubmed ID: 20512140 微生物的并行遗传分析普遍 TagModule 集合。 Nucleic Acids Research. Aug, 2010 | Pubmed ID: 20494978 高度多路复用条形码测序: 汇集样品平行分析的一种有效方法。 Nucleic Acids Research. Jul, 2010 | Pubmed ID: 20460461 基因型到表型: 一个复杂的问题。 Science (New York, N.Y.). Apr, 2010 | Pubmed ID: 20413493 在酵母中健身全基因组数据的系统分析揭示基因功能和药物行动。 Genome Biology. 2010 | Pubmed ID: 20226027 遗传景观的一个单元格。 Science (New York, N.Y.). Jan, 2010 | Pubmed ID: 20093466 DNA 条码芯片特征尺寸的比较分析。 BMC Genomics. 2009 | Pubmed ID: 19825181 通过测序深条码的定量震撼。 Genome Research. Oct, 2009 | Pubmed ID: 19622793 Chemogenomic 的办法澄清的基因功能和基因调控机制。 Methods in Molecular Biology (Clifton, N.J.). 2009 | Pubmed ID: 19521822 分子条形码酵母脓疱库使生物活性化合物的行动模式分析。 Nature Biotechnology. Apr, 2009 | Pubmed ID: 19349972 精确的基因剂量等位基因的化学遗传学。 Genetics. Jun, 2009 | Pubmed ID: 19332878 通过集成的酵母酿酒酵母铁缺模型中的 Deletome 和转录组分析铁代谢的新型洞察。 BMC Genomics. 2009 | Pubmed ID: 19321002 通过计算驱动、 定量实验发现线粒体生物发生学所需的基因。 PLoS Genetics. Mar, 2009 | Pubmed ID: 19300474 到调控的敲击感。 Nature Biotechnology. Feb, 2009 | Pubmed ID: 19204694 结合化学基因组学屏幕在酵母来揭示谱的神经醇磷脂的生物合成化学抑制剂的影响。 BMC Microbiology. 2009 | Pubmed ID: 19144191 Imidazo [1,2-a] 吡啶和嘧啶的化学遗传分析揭示了酵母和细胞之间的保守的目标路径。 PLoS Genetics. Nov, 2008 | Pubmed ID: 19043571 组合化学遗传学。 Nature Chemical Biology. Nov, 2008 | Pubmed ID: 18936752 酵母化学基因组学和药物发现: 更新。 Trends in Pharmacological Sciences. Oct, 2008 | Pubmed ID: 18755517 关闭目标的全基因组检测在酵母中发现的精神科药物的影响。 PLoS Genetics. 2008 | Pubmed ID: 18688276 酵母 Barcoders: Chemogenomic 采集中的应用通用捐助应变携带栏代码标识符。 Nature Methods. Aug, 2008 | Pubmed ID: 18622398 基因检测方法的综合的平台揭示生物活性小分子。 Nature Chemical Biology. Aug, 2008 | Pubmed ID: 18622389 上位性全基因组重复项在酵母中的广泛和依赖条件的性质。 Genome Research. Jul, 2008 | Pubmed ID: 18463300 小分子抑制剂假单胞菌铜绿 Exoenzyme S 使用酵母表型屏幕的标识。 PLoS Genetics. Feb, 2008 | Pubmed ID: 18454192 酵母的化学基因组画像: 揭露所有基因表型。 Science (New York, N.Y.). Apr, 2008 | Pubmed ID: 18420932 化学遗传途径探索自然产品的行动模式。 Progress in Drug Research. Fortschritte Der Arzneimittelforschung. Progrès Des Recherches Pharmaceutiques. 2008 | Pubmed ID: 18416308 定义遗传相互作用。 Proceedings of the National Academy of Sciences of the United States of America. Mar, 2008 | Pubmed ID: 18305163 酿酒酵母细胞对铁和铜的重载的毒性反应基因突变的平行分析的标识。 Toxicological Sciences : an Official Journal of the Society of Toxicology. Jan, 2008 | Pubmed ID: 17785683 全基因组分析的条形码酿酒酵母基因的缺失突变体汇集文化。 Nature Protocols. 2007 | Pubmed ID: 18007632 检查蛋白蛋白质相互作用步之遥使用标记酵母阵列: 跨和捕获系统。 Genome Research. Dec, 2007 | Pubmed ID: 17989249 加速使用高吞吐量酵母晕测定生物活性小分子的发现。 Journal of Natural Products. Mar, 2007 | Pubmed ID: 17291044 使用高分辨率健身分析组合基因缺失的系统途径分析。 Nature Genetics. Feb, 2007 | Pubmed ID: 17206143 化学基因组分析识别有毒物质生产帕金森病的细胞内目标。 Toxicological Sciences : an Official Journal of the Society of Toxicology. Jan, 2007 | Pubmed ID: 17043098 要确定遗传网络的实验方法。 Current Opinion in Biotechnology. Oct, 2006 | Pubmed ID: 16962766 一个独特和普遍的分子条形码数组。 Nature Methods. Aug, 2006 | Pubmed ID: 16862133 全基因组功能明显损害 DNA 的代理商抗性所需经费。 PLoS Genetics. Aug, 2005 | Pubmed ID: 16121259 Chemogenomic 分析的潜在变量模型。 Bioinformatics (Oxford, England). Aug, 2005 | Pubmed ID: 15919724 功能基因组分析的蛋白质进化率。 Proceedings of the National Academy of Sciences of the United States of America. Apr, 2005 | Pubmed ID: 15800036 Haploinsufficiency 的全基因组分析在酵母中发现的机制。 Genetics. Apr, 2005 | Pubmed ID: 15716499 真核基因表达的噪声最小化。 PLoS Biology. Jun, 2004 | Pubmed ID: 15124029 Chemogenomic 分析: 识别功能上的小分子在酵母中的相互作用。 Proceedings of the National Academy of Sciences of the United States of America. Jan, 2004 | Pubmed ID: 14718668 了解药物作用的化学基因组学方法。 Trends in Pharmacological Sciences. Sep, 2003 | Pubmed ID: 12967766 "Chemogenomics: 蛋白家族的工具"和"化学基因组学: 化学和生物武器的一体化"。 Pharmacogenomics. Jan, 2003 | Pubmed ID: 12517281 酵母基因组的功能分析。 Nature. Jul, 2002 | Pubmed ID: 12140549 系统屏幕上的人类疾病基因的酵母。 Nature Genetics. Aug, 2002 | Pubmed ID: 12134146 酿酒酵母转录响应损害 DNA 的代理商不标识的保护免受这些代理的基因。 Proceedings of the National Academy of Sciences of the United States of America. Jun, 2002 | Pubmed ID: 12077312 条形码酵母图书馆竞争力的基因屏幕 Andrew M. Smith*1,2, Tanja Durbic*2,3, Julia Oh*4, Malene Urbanus1,2, Michael Proctor5, Lawrence E. Heisler2,3, Guri Giaever2,6, Corey Nislow1,2,3 1Banting and Best Department of Medical Research and Department of Molecular Genetics, University of Toronto, 2Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, 3Donnelly Sequencing Centre, University of Toronto, 4Genetics and Molecular Biology Branch, National Human Genome Research Institute, NIH, 5Stanford Genome Technology Center, Stanford School of Medicine, Stanford University, 6Department of Pharmaceutical Sciences, University of Toronto JoVE 2864 Biology
条形码酵母图书馆竞争力的基因屏幕 Andrew M. Smith*1,2, Tanja Durbic*2,3, Julia Oh*4, Malene Urbanus1,2, Michael Proctor5, Lawrence E. Heisler2,3, Guri Giaever2,6, Corey Nislow1,2,3 1Banting and Best Department of Medical Research and Department of Molecular Genetics, University of Toronto, 2Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, 3Donnelly Sequencing Centre, University of Toronto, 4Genetics and Molecular Biology Branch, National Human Genome Research Institute, NIH, 5Stanford Genome Technology Center, Stanford School of Medicine, Stanford University, 6Department of Pharmaceutical Sciences, University of Toronto JoVE 2864 Biology