Haitang Li Department of Moelcular and Cellular Biology Beckman Research Institute of City of Hope Biography Publications Institution JoVE Articles Haitang LiStaff Scientist Haitang Li is a staff scientist in the Department of Molecular & Cellular Biology at City of hope .Graduated from Anhui medical University, Haitang Li relocated to the United States to pursue advanced training in life sciences, majorly focuses on gene therapy developments.She has extensive expertise in nucleic acid based therapeutics with a broad background and knowledge in molecular biology. The focus of her research is to develop highly potent nucleic acid based therapeutic strategies, such as RNA interference (RNAi), anti-microRNAs and aptamers. She has contributed to RNA-based gene therapy for HIV with lentiviral vector-modified CD34(+) cells in patients undergoing transplantation for AIDS-related lymphoma.In addition, Haitang Li has established humanized NSG mice as small animal models for studies related to HIV infection, pathology and HIV-induced immunodeficiency. Studies have demonstrated that humanized mouse models can be effectively used to evaluate HIV persistence and subsequently test latency reactivation strategies during oral combinatorial ART treatment in humanized NSG mouse. Publications Receptor-targeted Aptamer-siRNA Conjugate-directed Transcriptional Regulation of HIV-1 Theranostics. Month, 2018 | Pubmed ID: 29556342 HIV Replication and Latency in a Humanized NSG Mouse Model During Suppressive Oral Combinational Antiretroviral Therapy Journal of Virology. 04, 2018 | Pubmed ID: 29343582 Incorporation of Aptamers in the Terminal Loop of ShRNAs Yields an Effective and Novel Combinatorial Targeting Strategy Nucleic Acids Research. Jan, 2018 | Pubmed ID: 29077949 Interplay Between HIV-1 Infection and Host MicroRNAs Nucleic Acids Research. Nov, 2011 | Pubmed ID: 22080513 Systemic Administration of Combinatorial DsiRNAs Via Nanoparticles Efficiently Suppresses HIV-1 Infection in Humanized Mice Molecular Therapy : the Journal of the American Society of Gene Therapy. Dec, 2011 | Pubmed ID: 21952167 An Aptamer-siRNA Chimera Suppresses HIV-1 Viral Loads and Protects from Helper CD4(+) T Cell Decline in Humanized Mice Science Translational Medicine. Jan, 2011 | Pubmed ID: 21248316 RNA-based Gene Therapy for HIV with Lentiviral Vector-modified CD34(+) Cells in Patients Undergoing Transplantation for AIDS-related Lymphoma Science Translational Medicine. Jun, 2010 | Pubmed ID: 20555022 Rational Design of Micro-RNA-like Bifunctional SiRNAs Targeting HIV and the HIV Coreceptor CCR5 Molecular Therapy : the Journal of the American Society of Gene Therapy. Apr, 2010 | Pubmed ID: 20104214 Sequence Context Outside the Target Region Influences the Effectiveness of MiR-223 Target Sites in the RhoB 3'UTR Nucleic Acids Research. Jan, 2010 | Pubmed ID: 19850724 SNPs in Human MiRNA Genes Affect Biogenesis and Function RNA (New York, N.Y.). Sep, 2009 | Pubmed ID: 19617315 Selection, Characterization and Application of New RNA HIV Gp 120 Aptamers for Facile Delivery of Dicer Substrate SiRNAs into HIV Infected Cells Nucleic Acids Research. May, 2009 | Pubmed ID: 19304999 Functional and Intracellular Localization Properties of U6 Promoter-expressed SiRNAs, ShRNAs, and Chimeric VA1 ShRNAs in Mammalian Cells RNA (New York, N.Y.). Sep, 2008 | Pubmed ID: 18697923 Novel Dual Inhibitory Function Aptamer-siRNA Delivery System for HIV-1 Therapy Molecular Therapy : the Journal of the American Society of Gene Therapy. Aug, 2008 | Pubmed ID: 18461053 Use of a U16 SnoRNA-containing Ribozyme Library to Identify Ribozyme Targets in HIV-1 Molecular Therapy : the Journal of the American Society of Gene Therapy. Jun, 2008 | Pubmed ID: 18388915 Expression of Long Anti-HIV-1 Hairpin RNAs for the Generation of Multiple SiRNAs: Advantages and Limitations Molecular Therapy : the Journal of the American Society of Gene Therapy. Jan, 2008 | Pubmed ID: 17726454 Cloning and Detecting Signature MicroRNAs from Mammalian Cells Methods in Enzymology. Month, 2007 | Pubmed ID: 17720482 Combinatorial Delivery of Small Interfering RNAs Reduces RNAi Efficacy by Selective Incorporation into RISC Nucleic Acids Research. Month, 2007 | Pubmed ID: 17660190 RNAi in Combination with a Ribozyme and TAR Decoy for Treatment of HIV Infection in Hematopoietic Cell Gene Therapy Annals of the New York Academy of Sciences. Oct, 2006 | Pubmed ID: 17145937 Stable Expression of ShRNAs in Human CD34+ Progenitor Cells Can Avoid Induction of Interferon Responses to SiRNAs in Vitro Nature Biotechnology. May, 2006 | Pubmed ID: 16648841 Short Hairpin RNA-directed Cytosine (CpG) Methylation of the RASSF1A Gene Promoter in HeLa Cells Molecular Therapy : the Journal of the American Society of Gene Therapy. Jul, 2005 | Pubmed ID: 15963934 Amplification of RNAi--targeting HLA MRNAs Molecular Therapy : the Journal of the American Society of Gene Therapy. May, 2005 | Pubmed ID: 15851019 Small Interfering RNAs Expressed from a Pol III Promoter Suppress the EWS/Fli-1 Transcript in an Ewing Sarcoma Cell Line Molecular Therapy : the Journal of the American Society of Gene Therapy. Jun, 2003 | Pubmed ID: 12788655 Functional SiRNA Expression from Transfected PCR Products RNA (New York, N.Y.). Nov, 2002 | Pubmed ID: 12458798 Expression of Small Interfering RNAs Targeted Against HIV-1 Rev Transcripts in Human Cells Nature Biotechnology. May, 2002 | Pubmed ID: 11981565 Rev इम्यूनोवेरिसेशन और मास स्पेक्ट्रोमेट्री के माध्यम से एचआईवी-1 प्रतिकृति के दौरान न्यूक्लिओलर कारकों की पहचान Jerlisa Ann C. Arizala1,2, Pritsana Chomchan1, Haitang Li1, Roger Moore3, Helen Ge3, Dominique L. Ouellet1, John J. Rossi1,2 1Molecular and Cellular Biology Department, Beckman Research Institute at the City of Hope, 2Irell & Manella Graduate School of Biological Sciences, 3Department of Molecular Immunology, Beckman Research Institute and the City of Hope JoVE 59329 Immunology and Infection मानवीय मंजूरी/SCID/IL2rγअशक्त (हू-एनएसजी) एचआईवी प्रतिकृति और विलंबता अध्ययन के लिए माउस मॉडल Xin Xia1, Haitang Li1, Sangeetha Satheesan1,2, Jiehua Zhou1, John J. Rossi1 1Department of Molecular and Cellular Biology, Beckman Research Institute of City of Hope, 2Irell and Manela Graduate School of Biological Sciences, Beckman Research Institute of City of Hope JoVE 58255 Immunology and Infection सेल प्रकार विशिष्ट siRNA वितरण के लिए विरोधी एचआईवी gp120 aptamers का विकास Jiehua Zhou1, Haitang Li1, Jane Zhang2, Swiderski Piotr3, John Rossi1 1Department of Molecular and Cellular Biology, Beckman Research Institute of City of Hope, 2Graduate School of Biological Sciences, Beckman Research Institute of City of Hope, 3Shared Resource-DNA/RNA Peptide, Beckman Research Institute of City of Hope JoVE 2954 Immunology and Infection
Rev इम्यूनोवेरिसेशन और मास स्पेक्ट्रोमेट्री के माध्यम से एचआईवी-1 प्रतिकृति के दौरान न्यूक्लिओलर कारकों की पहचान Jerlisa Ann C. Arizala1,2, Pritsana Chomchan1, Haitang Li1, Roger Moore3, Helen Ge3, Dominique L. Ouellet1, John J. Rossi1,2 1Molecular and Cellular Biology Department, Beckman Research Institute at the City of Hope, 2Irell & Manella Graduate School of Biological Sciences, 3Department of Molecular Immunology, Beckman Research Institute and the City of Hope JoVE 59329 Immunology and Infection
मानवीय मंजूरी/SCID/IL2rγअशक्त (हू-एनएसजी) एचआईवी प्रतिकृति और विलंबता अध्ययन के लिए माउस मॉडल Xin Xia1, Haitang Li1, Sangeetha Satheesan1,2, Jiehua Zhou1, John J. Rossi1 1Department of Molecular and Cellular Biology, Beckman Research Institute of City of Hope, 2Irell and Manela Graduate School of Biological Sciences, Beckman Research Institute of City of Hope JoVE 58255 Immunology and Infection
सेल प्रकार विशिष्ट siRNA वितरण के लिए विरोधी एचआईवी gp120 aptamers का विकास Jiehua Zhou1, Haitang Li1, Jane Zhang2, Swiderski Piotr3, John Rossi1 1Department of Molecular and Cellular Biology, Beckman Research Institute of City of Hope, 2Graduate School of Biological Sciences, Beckman Research Institute of City of Hope, 3Shared Resource-DNA/RNA Peptide, Beckman Research Institute of City of Hope JoVE 2954 Immunology and Infection
