Haoxing Xu Department of Internal Medicine-Gastroenterology University of Michigan Biography Publications Institution JoVE Articles Haoxing Xu has not added a biography. If you are Haoxing Xu and would like to personalize this page please email our Author Liaison for assistance. Publications Release and Uptake Mechanisms of Vesicular Ca Stores Protein & Cell. Mar, 2018 | Pubmed ID: 29549599 Structure of Mammalian Endolysosomal TRPML1 Channel in Nanodiscs Nature. 10, 2017 | Pubmed ID: 29019981 Gastrin Induces Nuclear Export and Proteasome Degradation of Menin in Enteric Glial Cells Gastroenterology. 12, 2017 | Pubmed ID: 28859856 Gastric Acid Secretion from Parietal Cells Is Mediated by a Ca Efflux Channel in the Tubulovesicle Developmental Cell. 05, 2017 | Pubmed ID: 28486130 A Voltage-dependent K Channel in the Lysosome is Required for Refilling Lysosomal Ca Stores The Journal of Cell Biology. 06, 2017 | Pubmed ID: 28468834 Visualization of Phosphatidylinositol 3,5-Bisphosphate Dynamics by a Tandem ML1N-Based Fluorescent Protein Probe in Arabidopsis Plant & Cell Physiology. Jul, 2017 | Pubmed ID: 28158631 A Painful TR(i)P to Lysosomes The Journal of Cell Biology. Nov, 2016 | Pubmed ID: 27799365 PIKfyve Regulates Vacuole Maturation and Nutrient Recovery Following Engulfment Developmental Cell. 09, 2016 | Pubmed ID: 27623384 Lysosome Calcium in ROS Regulation of Autophagy Autophagy. Oct, 2016 | Pubmed ID: 27485905 MCOLN1 is a ROS Sensor in Lysosomes That Regulates Autophagy Nature Communications. Jun, 2016 | Pubmed ID: 27357649 The Endoplasmic Reticulum, Not the PH Gradient, Drives Calcium Refilling of Lysosomes ELife. 05, 2016 | Pubmed ID: 27213518 A Molecular Mechanism to Regulate Lysosome Motility for Lysosome Positioning and Tubulation Nature Cell Biology. Apr, 2016 | Pubmed ID: 26950892 Guidelines for the Use and Interpretation of Assays for Monitoring Autophagy (3rd Edition) Autophagy. Jan, 2016 | Pubmed ID: 26799652 Calcium Signaling in Membrane Repair Seminars in Cell & Developmental Biology. Sep, 2015 | Pubmed ID: 26519113 A TRP Channel Senses Lysosome Neutralization by Pathogens to Trigger Their Expulsion Cell. Jun, 2015 | Pubmed ID: 26027738 Organellar Channels and Transporters Cell Calcium. Jul, 2015 | Pubmed ID: 25795199 Up-regulation of Lysosomal TRPML1 Channels is Essential for Lysosomal Adaptation to Nutrient Starvation Proceedings of the National Academy of Sciences of the United States of America. Mar, 2015 | Pubmed ID: 25733853 Lysosomal Calcium Signalling Regulates Autophagy Through Calcineurin and TFEB Nature Cell Biology. Mar, 2015 | Pubmed ID: 25720963 Lysosomal Physiology Annual Review of Physiology. 2015 | Pubmed ID: 25668017 The Intracellular Ca²⁺ Channel MCOLN1 is Required for Sarcolemma Repair to Prevent Muscular Dystrophy Nature Medicine. Oct, 2014 | Pubmed ID: 25216637 Activation of TRPML1 Clears Intraneuronal Aβ in Preclinical Models of HIV Infection The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Aug, 2014 | Pubmed ID: 25143627 TRPML1: an Ion Channel in the Lysosome Handbook of Experimental Pharmacology. 2014 | Pubmed ID: 24756723 Hippo/YAP-mediated Rigidity-dependent Motor Neuron Differentiation of Human Pluripotent Stem Cells Nature Materials. Jun, 2014 | Pubmed ID: 24728461 Lysosomal Exocytosis and Lipid Storage Disorders Journal of Lipid Research. 06, 2014 | Pubmed ID: 24668941 Genetically Encoded Fluorescent Probe to Visualize Intracellular Phosphatidylinositol 3,5-bisphosphate Localization and Dynamics Proceedings of the National Academy of Sciences of the United States of America. Dec, 2013 | Pubmed ID: 24324172 A TRP Channel in the Lysosome Regulates Large Particle Phagocytosis Via Focal Exocytosis Developmental Cell. Sep, 2013 | Pubmed ID: 23993788 Regulation of Membrane Trafficking by Signalling on Endosomal and Lysosomal Membranes The Journal of Physiology. Sep, 2013 | Pubmed ID: 23878375 TPC Proteins Are Phosphoinositide- Activated Sodium-selective Ion Channels in Endosomes and Lysosomes Cell. Oct, 2012 | Pubmed ID: 23063126 Phosphoinositide Isoforms Determine Compartment-specific Ion Channel Activity Proceedings of the National Academy of Sciences of the United States of America. Jul, 2012 | Pubmed ID: 22733759 Ryanodine Receptor Antagonists Adapt NPC1 Proteostasis to Ameliorate Lipid Storage in Niemann-Pick Type C Disease Fibroblasts Human Molecular Genetics. Jul, 2012 | Pubmed ID: 22505584 Lipid Storage Disorders Block Lysosomal Trafficking by Inhibiting a TRP Channel and Lysosomal Calcium Release Nature Communications. Mar, 2012 | Pubmed ID: 22415822 Paarung Phosphoinositides Mit Kalzium-Ionen in Endolysosomal Dynamik: Phosphoinositides Zu Steuern, Die Richtung Und Die Besonderheit Des Handels Durch Die Regulierung Der Aktivität Der Kalzium-Kanäle in Der Endolysosomes Membran BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology. Jun, 2011 | Pubmed ID: 21538413 PI(3,5)P(2) Steuert Die Membran, Die Die Endolysosome Direkte Aktivierung Von Mucolipin Ca(2+)-Freigabe-Kanäle Menschenhandel Nature Communications. 2010 | Pubmed ID: 20802798 TRP Channel Regulates EGFR Signaling in Hair Morphogenesis and Skin Barrier Formation Cell. Apr, 2010 | Pubmed ID: 20403327 Mechanisms of Brain Iron Transport: Insight into Neurodegeneration and CNS Disorders Future Medicinal Chemistry. Jan, 2010 | Pubmed ID: 20161623 TRP-Kanäle Des Intrazellulären Membranen Journal of Neurochemistry. Apr, 2010 | Pubmed ID: 20132470 Mucolipins: Intracellular TRPML1-3 Channels FEBS Letters. May, 2010 | Pubmed ID: 20074572 Aktivierung Von Mutationen Des TRPML1 Kanals Offenbart Durch Scannen Von Prolin Mutagenese The Journal of Biological Chemistry. Nov, 2009 | Pubmed ID: 19638346 The Type IV Mucolipidosis-associated Protein TRPML1 is an Endolysosomal Iron Release Channel Nature. Oct, 2008 | Pubmed ID: 18794901 Isolierung der magensaftresistenten Gliazellen aus der Submukosa und Lamina Propria der Erwachsenen Maus Zhen Wang1,4, Ramon Ocadiz-Ruiz1, Sinju Sundaresan1, Lin Ding1, Michael Hayes1, Nirakar Sahoo3, Haoxing Xu1,2, Juanita L. Merchant1,2,5 1Department of Internal Medicine-Gastroenterology, University of Michigan, 2Department of Molecular and Integrative Physiology, University of Michigan, 3Department of Molecular, Cellular and Developmental Biology, University of Michigan, 4Department of Gastrointestinal Surgery, The First Affiliated Hospital of Guangxi Medical University, 5Division of Gastroenterology, University of Arizona College of Medicine JoVE 57629 Biology
Isolierung der magensaftresistenten Gliazellen aus der Submukosa und Lamina Propria der Erwachsenen Maus Zhen Wang1,4, Ramon Ocadiz-Ruiz1, Sinju Sundaresan1, Lin Ding1, Michael Hayes1, Nirakar Sahoo3, Haoxing Xu1,2, Juanita L. Merchant1,2,5 1Department of Internal Medicine-Gastroenterology, University of Michigan, 2Department of Molecular and Integrative Physiology, University of Michigan, 3Department of Molecular, Cellular and Developmental Biology, University of Michigan, 4Department of Gastrointestinal Surgery, The First Affiliated Hospital of Guangxi Medical University, 5Division of Gastroenterology, University of Arizona College of Medicine JoVE 57629 Biology
