Harry D. Bear Department of Surgery Virginia Commonwealth University- Massey Cancer Center Biography Publications Institution JoVE Articles Harry D. Bear has not added a biography. If you are Harry D. Bear and would like to personalize this page please email our Author Liaison for assistance. Publications Bevacizumab Added to Neoadjuvant Chemotherapy for Breast Cancer The New England Journal of Medicine. Jan, 2012 | Pubmed ID: 22276821 A Signature of Immune Function Genes Associated with Recurrence-free Survival in Breast Cancer Patients Breast Cancer Research and Treatment. Feb, 2012 | Pubmed ID: 21479927 Human Dosimetry and Preliminary Tumor Distribution of 18F-fluoropaclitaxel in Healthy Volunteers and Newly Diagnosed Breast Cancer Patients Using PET/CT Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. Sep, 2011 | Pubmed ID: 21849404 A Gene Transcription Signature of Obesity in Breast Cancer Breast Cancer Research and Treatment. Jul, 2011 | Pubmed ID: 21750966 Methyl-binding Domain Protein 2-dependent Proliferation and Survival of Breast Cancer Cells Molecular Cancer Research : MCR. Aug, 2011 | Pubmed ID: 21693597 Activated NKT Cells and NK Cells Render T Cells Resistant to Myeloid-derived Suppressor Cells and Result in an Effective Adoptive Cellular Therapy Against Breast Cancer in the FVBN202 Transgenic Mouse Journal of Immunology (Baltimore, Md. : 1950). Jul, 2011 | Pubmed ID: 21670315 Tumor Escape and Progression of HER-2/neu Negative Breast Cancer Under Immune Pressure Journal of Translational Medicine. 2011 | Pubmed ID: 21453513 Phenotype, Functions and Fate of Adoptively Transferred Tumor Draining Lymphocytes Activated Ex Vivo in Mice with an Aggressive Weakly Immunogenic Mammary Carcinoma BMC Immunology. 2010 | Pubmed ID: 21050466 Neoadjuvant Chemotherapy for Operable Breast Cancer: Individualizing Locoregional and Systemic Therapy Surgical Oncology Clinics of North America. Jul, 2010 | Pubmed ID: 20620930 Influence of the Phosphodiesterase-5 Inhibitor, Sildenafil, on Sensitivity to Chemotherapy in Breast Tumor Cells Breast Cancer Research and Treatment. Nov, 2010 | Pubmed ID: 20155316 GM-CSF is One of the Main Breast Tumor-derived Soluble Factors Involved in the Differentiation of CD11b-Gr1- Bone Marrow Progenitor Cells into Myeloid-derived Suppressor Cells Breast Cancer Research and Treatment. Aug, 2010 | Pubmed ID: 19898981 IL-7 + IL-15 Are Superior to IL-2 for the Ex Vivo Expansion of 4T1 Mammary Carcinoma-specific T Cells with Greater Efficacy Against Tumors in Vivo Breast Cancer Research and Treatment. Jul, 2010 | Pubmed ID: 19826947 Effects of Surgical Excision on Survival of Patients with Stage IV Breast Cancer The Journal of Surgical Research. Jun, 2010 | Pubmed ID: 19375721 Human T Cells Express CD25 and Foxp3 Upon Activation and Exhibit Effector/memory Phenotypes Without Any Regulatory/suppressor Function Journal of Translational Medicine. 2009 | Pubmed ID: 19849846 Gemcitabine Directly Inhibits Myeloid Derived Suppressor Cells in BALB/c Mice Bearing 4T1 Mammary Carcinoma and Augments Expansion of T Cells from Tumor-bearing Mice International Immunopharmacology. Jul, 2009 | Pubmed ID: 19336265 Adoptive Transfer of HER2/neu-specific T Cells Expanded with Alternating Gamma Chain Cytokines Mediate Tumor Regression when Combined with the Depletion of Myeloid-derived Suppressor Cells Cancer Immunology, Immunotherapy : CII. Jun, 2009 | Pubmed ID: 18979098 Radiofrequency Thermal Ablation of Breast Tumors Combined with Intralesional Administration of IL-7 and IL-15 Augments Anti-tumor Immune Responses and Inhibits Tumor Development and Metastasis Breast Cancer Research and Treatment. Apr, 2009 | Pubmed ID: 18425677 Completion Axillary Lymph Node Dissection for Breast Cancer: Immediate Versus Delayed Versus None Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. Jul, 2008 | Pubmed ID: 18640928 Signatures Associated with Rejection or Recurrence in HER-2/neu-positive Mammary Tumors Cancer Research. Apr, 2008 | Pubmed ID: 18381452 Measuring Circulating Tumor Cells As a Surrogate End Point for Adjuvant Therapy of Breast Cancer: What Do They Mean and What Should We Do About Them? Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. Mar, 2008 | Pubmed ID: 18323543 Statement of the Science Concerning Locoregional Treatments After Preoperative Chemotherapy for Breast Cancer: a National Cancer Institute Conference Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. Feb, 2008 | Pubmed ID: 18258988 Preoperative Chemotherapy: Updates of National Surgical Adjuvant Breast and Bowel Project Protocols B-18 and B-27 Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. Feb, 2008 | Pubmed ID: 18258986 Imaging Multidrug Resistance with 4-[18F]fluoropaclitaxel Nuclear Medicine and Biology. Oct, 2007 | Pubmed ID: 17921033 Reaping the Harvest from Neoadjuvant Therapy for Breast Cancer: Reducing Morbidity with Sentinel Lymph Node Biopsy Journal of Surgical Oncology. Jun, 2007 | Pubmed ID: 17192916 Tumor Bed Boost Omission After Negative Re-excision in Breast-conservation Treatment Annals of Surgical Oncology. Jun, 2006 | Pubmed ID: 16614879 Sequential Preoperative or Postoperative Docetaxel Added to Preoperative Doxorubicin Plus Cyclophosphamide for Operable Breast Cancer:National Surgical Adjuvant Breast and Bowel Project Protocol B-27 Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. May, 2006 | Pubmed ID: 16606972 Sentinel Node Micrometastases and Non-sentinel Nodes in Breast Cancer: How Much Do We Need to Know? Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. Apr, 2006 | Pubmed ID: 16567763 Walter Lawrence, Jr.: a Tribute to a Surgical Oncologist. "Been There, Done That" Journal of Surgical Oncology. Jun, 2005 | Pubmed ID: 15895456 Sentinel Node Biopsy After Neoadjuvant Chemotherapy in Breast Cancer: Results from National Surgical Adjuvant Breast and Bowel Project Protocol B-27 Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. Apr, 2005 | Pubmed ID: 15837984 Bryostatin 1/ionomycin (B/I) Ex Vivo Stimulation Preferentially Activates L-selectinlow Tumor-sensitized Lymphocytes International Immunology. Sep, 2004 | Pubmed ID: 15262898 The Effect on Tumor Response of Adding Sequential Preoperative Docetaxel to Preoperative Doxorubicin and Cyclophosphamide: Preliminary Results from National Surgical Adjuvant Breast and Bowel Project Protocol B-27 Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. Nov, 2003 | Pubmed ID: 14559892 Breast Conservation Therapy Rates Are No Different in Medically Indigent Versus Insured Patients with Early Stage Breast Cancer Journal of Surgical Oncology. Oct, 2003 | Pubmed ID: 14502777 The Impact of Physician and Hospital Volume on the Quality of Surgical Outcomes Journal of Surgical Oncology. Oct, 2003 | Pubmed ID: 14502775 Emerging Role of Taxanes in Adjuvant and Neoadjuvant Therapy for Breast Cancer: the Potential and the Questions The Surgical Clinics of North America. Aug, 2003 | Pubmed ID: 12875604 Successful Adoptive Immunotherapy with Vaccine-sensitized T Cells, Despite No Effect with Vaccination Alone in a Weakly Immunogenic Tumor Model Cancer Immunology, Immunotherapy : CII. Dec, 2003 | Pubmed ID: 12827306 Partial Breast Brachytherapy After Lumpectomy: Low-dose-rate and High-dose-rate Experience International Journal of Radiation Oncology, Biology, Physics. Jul, 2003 | Pubmed ID: 12788173 Taking Action on the Volume-quality Relationship: How Long Can We Hide Our Heads in the Colostomy Bag? Journal of the National Cancer Institute. May, 2003 | Pubmed ID: 12759377 Earlier Chemotherapy for Breast Cancer: Perhaps Too Late but Still Useful Annals of Surgical Oncology. May, 2003 | Pubmed ID: 12734078 Sentinel Node Mapping Identifies Vaccine-draining Lymph Nodes with Tumor-specific Immunological Activity Annals of Surgical Oncology. Jan-Feb, 2002 | Pubmed ID: 11829435 Collaborative Initiatives in the Care of Early Stage Breast Cancer: Reduction in Variation of Breast-Conserving Therapy The Breast Journal. Mar, 2000 | Pubmed ID: 11348345 Ex vivo Expansion of Tumor-reactive T Cells by Means of Bryostatin 1/Ionomycin and the Common Gamma Chain Cytokines Formulation Maciej Kmieciak1, Amir Toor2, Laura Graham3, Harry D. Bear3, Masoud H. Manjili1 1Department of Microbiology & Immunology, Virginia Commonwealth University- Massey Cancer Center, 2Department of Internal Medicine, Virginia Commonwealth University- Massey Cancer Center, 3Department of Surgery, Virginia Commonwealth University- Massey Cancer Center JoVE 2381 Immunology and Infection
Ex vivo Expansion of Tumor-reactive T Cells by Means of Bryostatin 1/Ionomycin and the Common Gamma Chain Cytokines Formulation Maciej Kmieciak1, Amir Toor2, Laura Graham3, Harry D. Bear3, Masoud H. Manjili1 1Department of Microbiology & Immunology, Virginia Commonwealth University- Massey Cancer Center, 2Department of Internal Medicine, Virginia Commonwealth University- Massey Cancer Center, 3Department of Surgery, Virginia Commonwealth University- Massey Cancer Center JoVE 2381 Immunology and Infection
