Harry Heimberg Diabetes Research Center Vrije Universiteit Brussel Biography Publications Institution JoVE Articles Harry Heimberg has not added a biography. If you are Harry Heimberg and would like to personalize this page please email our Author Liaison for assistance. Publications Islet Transplantation for Type 1 Diabetes: So Close and Yet So Far Away European Journal of Endocrinology / European Federation of Endocrine Societies. Jun, 2015 | Pubmed ID: 26036437 Estrogen Receptor α Regulates Beta Cell Formation During Pancreas Development and Following Injury Diabetes. May, 2015 | Pubmed ID: 26015547 Ex Vivo Expansion and Differentiation of Human and Mouse Fetal Pancreatic Progenitors Are Modulated by Epidermal Growth Factor Stem Cells and Development. Aug, 2015 | Pubmed ID: 25925840 Concise Review: Macrophages: Versatile Gatekeepers During Pancreatic β-Cell Development, Injury, and Regeneration Stem Cells Translational Medicine. Jun, 2015 | Pubmed ID: 25848123 Macrophage Dynamics Are Regulated by Local Macrophage Proliferation and Monocyte Recruitment in Injured Pancreas European Journal of Immunology. May, 2015 | Pubmed ID: 25645754 In Vitro Reprogramming of Pancreatic Alpha Cells Towards a Beta Cell Phenotype Following Ectopic HNF4α Expression Molecular and Cellular Endocrinology. Jan, 2015 | Pubmed ID: 25224487 Combining MK626, a Novel DPP-4 Inhibitor, and Low-dose Monoclonal CD3 Antibody for Stable Remission of New-onset Diabetes in Mice PloS One. 2014 | Pubmed ID: 25268801 Clinical Immunosuppressants Inhibit Inflammatory, Proliferative And Reprogramming Potential, But Not Angiogenesis Of Human Pancreatic Duct Cells Cell Transplantation. Jul, 2014 | Pubmed ID: 25198311 Partial Duct Ligation: β-cell Proliferation and Beyond Diabetes. Aug, 2014 | Pubmed ID: 25060885 IL-6-dependent Proliferation of Alpha Cells in Mice with Partial Pancreatic-duct Ligation Diabetologia. Jul, 2014 | Pubmed ID: 24759958 Downregulation of Sox9 Expression Associates with Hepatogenic Differentiation of Human Liver Mesenchymal Stem/progenitor Cells Stem Cells and Development. Jun, 2014 | Pubmed ID: 24548059 Prospectively Isolated NGN3-expressing Progenitors from Human Embryonic Stem Cells Give Rise to Pancreatic Endocrine Cells Stem Cells Translational Medicine. Apr, 2014 | Pubmed ID: 24493854 Transient Cytokine Treatment Induces Acinar Cell Reprogramming and Regenerates Functional Beta Cell Mass in Diabetic Mice Nature Biotechnology. Jan, 2014 | Pubmed ID: 24240391 Short-term Overexpression of VEGF-A in Mouse Beta Cells Indirectly Stimulates Their Proliferation and Protects Against Diabetes Diabetologia. Jan, 2014 | Pubmed ID: 24121626 Reversal of Hyperglycemia in Diabetic Mice by a Marginal Islet Mass Together with Human Blood Outgrowth Endothelial Cells is Independent of the Delivery Technique and Blood Clot-induced Processes Islets. Sep-Dec, 2013 | Pubmed ID: 24213480 The Inactivation of Arx in Pancreatic α-cells Triggers Their Neogenesis and Conversion into Functional β-like Cells PLoS Genetics. Oct, 2013 | Pubmed ID: 24204325 Unlimited in Vitro Expansion of Adult Bi-potent Pancreas Progenitors Through the Lgr5/R-spondin Axis The EMBO Journal. Oct, 2013 | Pubmed ID: 24045232 Mouse Beta Cell Proliferation is Inhibited by Thymidine Analogue Labelling Diabetologia. Dec, 2013 | Pubmed ID: 24026213 Conditional Hypovascularization and Hypoxia in Islets Do Not Overtly Influence Adult β-cell Mass or Function Diabetes. Dec, 2013 | Pubmed ID: 23974922 Adult Duct-lining Cells Can Reprogram into β-like Cells Able to Counter Repeated Cycles of Toxin-induced Diabetes Developmental Cell. Jul, 2013 | Pubmed ID: 23810513 Reversal of Hyperglycemia by Insulin-secreting Rat Bone Marrow- and Blastocyst-derived Hypoblast Stem Cell-like Cells PloS One. 2013 | Pubmed ID: 23671681 Suppression of Epithelial to Mesenchymal Transitioning (EMT) Enhances Ex Vivo Reprogramming of Human Exocrine Pancreatic Tissue Towards Functional Insulin Producing β-Like Cells Diabetes. Apr, 2013 | Pubmed ID: 23610058 Spatiotemporal Patterns of Multipotentiality in Ptf1a-expressing Cells During Pancreas Organogenesis and Injury-induced Facultative Restoration Development (Cambridge, England). Feb, 2013 | Pubmed ID: 23325761 Gene Delivery to Pancreatic Exocrine Cells in Vivo and in Vitro BMC Biotechnology. 2012 | Pubmed ID: 23088534 Plasticity of Adult Human Pancreatic Duct Cells by Neurogenin3-mediated Reprogramming PloS One. 2012 | Pubmed ID: 22606327 Role of the Ductal Transcription Factors HNF6 and Sox9 in Pancreatic Acinar-to-ductal Metaplasia Gut. Dec, 2012 | Pubmed ID: 22271799 Clusters of Conserved Beta Cell Marker Genes for Assessment of Beta Cell Phenotype PloS One. 2011 | Pubmed ID: 21912665 Lineage Tracing Evidence for Transdifferentiation of Acinar to Duct Cells and Plasticity of Human Pancreas Gastroenterology. Aug, 2011 | Pubmed ID: 21703267 Pdx1- and Ngn3-Cre-mediated PLAG1 Expression in the Pancreas Leads to Endocrine Hormone Imbalances That Affect Glucose Metabolism Cell Transplantation. 2011 | Pubmed ID: 21294959 Pancreatic Beta-cells: from Generation to Regeneration Seminars in Cell & Developmental Biology. Oct, 2010 | Pubmed ID: 20688184 Derepression of Polycomb Targets During Pancreatic Organogenesis Allows Insulin-producing Beta-cells to Adopt a Neural Gene Activity Program Genome Research. Jun, 2010 | Pubmed ID: 20395405 Ectopic Expression of E2F1 Stimulates Beta-cell Proliferation and Function Diabetes. Jun, 2010 | Pubmed ID: 20299467 Pancreatic Exocrine Duct Cells Give Rise to Insulin-producing Beta Cells During Embryogenesis but Not After Birth Developmental Cell. Dec, 2009 | Pubmed ID: 20059954 The Ectopic Expression of Pax4 in the Mouse Pancreas Converts Progenitor Cells into Alpha and Subsequently Beta Cells Cell. Aug, 2009 | Pubmed ID: 19665969 Notch Signaling As Gatekeeper of Rat Acinar-to-beta-cell Conversion in Vitro Gastroenterology. May, 2009 | Pubmed ID: 19208356 Investigation and Characterization of the Duct Cell-enriching Process During Serum-free Suspension and Monolayer Culture Using the Human Exocrine Pancreas Fraction Pancreas. Jan, 2009 | Pubmed ID: 18665014 Boosting Beta-cell Numbers The New England Journal of Medicine. Dec, 2008 | Pubmed ID: 19092158 Beta Cells Within Single Human Islets Originate from Multiple Progenitors PloS One. 2008 | Pubmed ID: 18958289 Prolonged Gene Silencing in Hepatoma Cells and Primary Hepatocytes After Small Interfering RNA Delivery with Biodegradable Poly(beta-amino Esters) The Journal of Gene Medicine. Jul, 2008 | Pubmed ID: 18470950 Akt Activation Protects Pancreatic Beta Cells from AMPK-mediated Death Through Stimulation of MTOR Biochemical Pharmacology. May, 2008 | Pubmed ID: 18377870 Beta Cells Can Be Generated from Endogenous Progenitors in Injured Adult Mouse Pancreas Cell. Jan, 2008 | Pubmed ID: 18243096 The Genetic Programme of Pancreatic Beta-cells: Basic Science for the Development of Beta-cell Therapy. Workshop on Programming Pancreatic Beta-cells EMBO Reports. Apr, 2007 | Pubmed ID: 17363969 Sonic Hedgehog and Other Soluble Factors from Differentiating Embryoid Bodies Inhibit Pancreas Development Stem Cells (Dayton, Ohio). May, 2007 | Pubmed ID: 17272496 Increased Oxygen Radical Formation and Mitochondrial Dysfunction Mediate Beta Cell Apoptosis Under Conditions of AMP-activated Protein Kinase Stimulation Free Radical Biology & Medicine. Jan, 2007 | Pubmed ID: 17157194 Expression of the Notch Signaling Pathway and Effect on Exocrine Cell Proliferation in Adult Rat Pancreas The American Journal of Pathology. Oct, 2006 | Pubmed ID: 17003479 IA1 is NGN3-dependent and Essential for Differentiation of the Endocrine Pancreas The EMBO Journal. Mar, 2006 | Pubmed ID: 16511571 Adiponectin-mediated Stimulation of AMP-activated Protein Kinase (AMPK) in Pancreatic Beta Cells Life Sciences. Jul, 2005 | Pubmed ID: 15893773 EGF-induced Proliferation of Adult Human Pancreatic Duct Cells is Mediated by the MEK/ERK Cascade Laboratory Investigation; a Journal of Technical Methods and Pathology. Jan, 2005 | Pubmed ID: 15543206 Metformin-induced Stimulation of AMP-activated Protein Kinase in Beta-cells Impairs Their Glucose Responsiveness and Can Lead to Apoptosis Biochemical Pharmacology. Aug, 2004 | Pubmed ID: 15242807 Expression of Wnt, Frizzled, SFRP, and DKK Genes in Adult Human Pancreas Gene Expression. 2003 | Pubmed ID: 14686787 Prolonged Culture in Low Glucose Induces Apoptosis of Rat Pancreatic Beta-cells Through Induction of C-myc Biochemical and Biophysical Research Communications. Dec, 2003 | Pubmed ID: 14651961 Variations in IB1/JIP1 Expression Regulate Susceptibility of Beta-cells to Cytokine-induced Apoptosis Irrespective of C-Jun NH2-terminal Kinase Signaling Diabetes. Oct, 2003 | Pubmed ID: 14514632 Nestin is Expressed in Vascular Endothelial Cells in the Adult Human Pancreas The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society. Jun, 2003 | Pubmed ID: 12754281 Purification of Rat Pancreatic B-cells by Fluorescence-activated Cell Sorting Methods in Molecular Medicine. 2003 | Pubmed ID: 12619712 Recapitulation of Embryonic Neuroendocrine Differentiation in Adult Human Pancreatic Duct Cells Expressing Neurogenin 3 The Journal of Cell Biology. Oct, 2002 | Pubmed ID: 12403815 Specific Expression of Bax-omega in Pancreatic Beta-cells is Down-regulated by Cytokines Before the Onset of Apoptosis Endocrinology. Jan, 2002 | Pubmed ID: 11751624 Surgical Injury to the Mouse Pancreas through Ligation of the Pancreatic Duct as a Model for Endocrine and Exocrine Reprogramming and Proliferation Sofie De Groef1, Gunter Leuckx1, Naomi Van Gassen1, Willem Staels1, Ying Cai1, Yixing Yuchi1, Violette Coppens1, Nico De Leu1, Yves Heremans1, Luc Baeyens1, Mark Van de Casteele1, Harry Heimberg1 1Diabetes Research Center, Vrije Universiteit Brussel JoVE 52765 Medicine
Surgical Injury to the Mouse Pancreas through Ligation of the Pancreatic Duct as a Model for Endocrine and Exocrine Reprogramming and Proliferation Sofie De Groef1, Gunter Leuckx1, Naomi Van Gassen1, Willem Staels1, Ying Cai1, Yixing Yuchi1, Violette Coppens1, Nico De Leu1, Yves Heremans1, Luc Baeyens1, Mark Van de Casteele1, Harry Heimberg1 1Diabetes Research Center, Vrije Universiteit Brussel JoVE 52765 Medicine