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Other Publications (65)
- Development (Cambridge, England)
- BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology
- Development (Cambridge, England)
- Developmental Dynamics : an Official Publication of the American Association of Anatomists
- Developmental Dynamics : an Official Publication of the American Association of Anatomists
- Developmental Biology
- Mechanisms of Development
- Gene Expression Patterns : GEP
- Genesis (New York, N.Y. : 2000)
- Developmental Dynamics : an Official Publication of the American Association of Anatomists
- Development (Cambridge, England)
- Developmental Biology
- Developmental Biology
- Genome Biology
- The International Journal of Developmental Biology
- Developmental Dynamics : an Official Publication of the American Association of Anatomists
- Zebrafish
- Developmental Dynamics : an Official Publication of the American Association of Anatomists
- CSH Protocols
- CSH Protocols
- CSH Protocols
- CSH Protocols
- CSH Protocols
- CSH Protocols
- CSH Protocols
- CSH Protocols
- CSH Protocols
- CSH Protocols
- CSH Protocols
- CSH Protocols
- CSH Protocols
- CSH Protocols
- CSH Protocols
- CSH Protocols
- CSH Protocols
- CSH Protocols
- CSH Protocols
- CSH Protocols
- CSH Protocols
- CSH Protocols
- Mechanisms of Development
- Anatomical Record (Hoboken, N.J. : 2007)
- Development (Cambridge, England)
- Genes & Development
- BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology
- The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
- Development (Cambridge, England)
- Cold Spring Harbor Protocols
- Cold Spring Harbor Protocols
- Cold Spring Harbor Protocols
- Cold Spring Harbor Protocols
- Cold Spring Harbor Protocols
- Cold Spring Harbor Protocols
- Disease Models & Mechanisms
- Methods in Molecular Biology (Clifton, N.J.)
- FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
- Neuron
- Cell
- Cold Spring Harbor Protocols
- Disease Models & Mechanisms
- Developmental Biology
- Genome Research
- Zebrafish
- Nature
- Nature
Articles by Hazel Sive in JoVE
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在面部移植
Laura A. Jacox*1,3, Amanda J. Dickinson*4, Hazel Sive2,3
1Biological Sciences in Dental Medicine, Harvard University, 2Biology Department, Massachusetts Institute of Technology, 3Whitehead Institute, Massachusetts Institute of Technology, 4Biology Department, Virginia Commonwealth University
的技术移栽“至尊前域” 非洲爪蟾的面巾纸蟾胚胎已经研制成功。组织可以从一个基因表达的背景被转移到另一个,允许对颅面发展和信令面部区域之间的相互作用当地要求的研究。
Other articles by Hazel Sive on PubMed
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Poly(A)-tail Profiling Reveals an Embryonic Switch in Translational Control
Nature.
Jan, 2014 |
Pubmed ID: 24476825 Poly(A) tails enhance the stability and translation of most eukaryotic messenger RNAs, but difficulties in globally measuring poly(A)-tail lengths have impeded greater understanding of poly(A)-tail function. Here we describe poly(A)-tail length profiling by sequencing (PAL-seq) and apply it to measure tail lengths of millions of individual RNAs isolated from yeasts, cell lines, Arabidopsis thaliana leaves, mouse liver, and zebrafish and frog embryos. Poly(A)-tail lengths were conserved between orthologous mRNAs, with mRNAs encoding ribosomal proteins and other 'housekeeping' proteins tending to have shorter tails. As expected, tail lengths were coupled to translational efficiencies in early zebrafish and frog embryos. However, this strong coupling diminished at gastrulation and was absent in non-embryonic samples, indicating a rapid developmental switch in the nature of translational control. This switch complements an earlier switch to zygotic transcriptional control and explains why the predominant effect of microRNA-mediated deadenylation concurrently shifts from translational repression to mRNA destabilization.
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