Heather R. Christofk Department of Biological Chemistry David Geffen School of Medicine Biography Publications Institution JoVE Articles Heather R. Christofk has not added a biography. If you are Heather R. Christofk and would like to personalize this page please email our Author Liaison for assistance. Publications The GSK3 Signaling Axis Regulates Adaptive Glutamine Metabolism in Lung Squamous Cell Carcinoma Cancer Cell. May, 2018 | Pubmed ID: 29763624 MTORC2 Regulates Amino Acid Metabolism in Cancer by Phosphorylation of the Cystine-Glutamate Antiporter XCT Molecular Cell. Jul, 2017 | Pubmed ID: 28648777 Recurrent Patterns of DNA Copy Number Alterations in Tumors Reflect Metabolic Selection Pressures Molecular Systems Biology. 02, 2017 | Pubmed ID: 28202506 Targeted Inhibition of EGFR and Glutaminase Induces Metabolic Crisis in EGFR Mutant Lung Cancer Cell Reports. 01, 2017 | Pubmed ID: 28099841 Glycolytic Metabolism Plays a Functional Role in Regulating Human Pluripotent Stem Cell State Cell Stem Cell. 10, 2016 | Pubmed ID: 27618217 Asparagine Promotes Cancer Cell Proliferation Through Use As an Amino Acid Exchange Factor Nature Communications. Apr, 2016 | Pubmed ID: 27126896 MCT1 Modulates Cancer Cell Pyruvate Export and Growth of Tumors That Co-express MCT1 and MCT4 Cell Reports. Feb, 2016 | Pubmed ID: 26876179 MYC-induced Reprogramming of Glutamine Catabolism Supports Optimal Virus Replication Nature Communications. Nov, 2015 | Pubmed ID: 26561297 2-Hydroxyglutarate Inhibits ATP Synthase and MTOR Signaling Cell Metabolism. Sep, 2015 | Pubmed ID: 26190651 The Metabolic Milieu of Metastases Cell. Jan, 2015 | Pubmed ID: 25635452 Adenovirus E4ORF1-induced MYC Activation Promotes Host Cell Anabolic Glucose Metabolism and Virus Replication Cell Metabolism. Apr, 2014 | Pubmed ID: 24703700 Doxycycline Alters Metabolism and Proliferation of Human Cell Lines PloS One. 2013 | Pubmed ID: 23741339 EGFR Mutation-Induced Alternative Splicing of Max Contributes to Growth of Glycolytic Tumors in Brain Cancer Cell Metabolism. May, 2013 | Pubmed ID: 23707073 An Essential Requirement for the SCAP/SREBP Signaling Axis to Protect Cancer Cells from Lipotoxicity Cancer Research. May, 2013 | Pubmed ID: 23440422 Novel Dedifferentiated Liposarcoma Xenograft Models Reveal PTEN Down-regulation As a Malignant Signature and Response to PI3K Pathway Inhibition The American Journal of Pathology. Apr, 2013 | Pubmed ID: 23416162 Histone Acetylation Regulates Intracellular PH Molecular Cell. Jan, 2013 | Pubmed ID: 23201122 Metabolomics Strategy Reveals Subpopulation of Liposarcomas Sensitive to Gemcitabine Treatment Cancer Discovery. Dec, 2012 | Pubmed ID: 23230188 New Aspects of the Warburg Effect in Cancer Cell Biology Seminars in Cell & Developmental Biology. Jun, 2012 | Pubmed ID: 22406683 Metabolismo di mappatura: Monitoraggio dell'attività della deidrogenasi del lattato direttamente nel tessuto David Jelinek1,2, Aimee Flores1,3, Melanie Uebelhoer1, Vincent Pasque2, Kathrin Plath2,3, M. Luisa Iruela-Arispe1,3, Heather R. Christofk2,3, William E. Lowry1,3, Hilary A. Coller1,2,3 1Department of Molecular, Cell and Developmental Biology, UCLA, 2Department of Biological Chemistry, David Geffen School of Medicine, 3Molecular Biology Institute Interdepartmental Program, UCLA JoVE 57760 Biochemistry
Metabolismo di mappatura: Monitoraggio dell'attività della deidrogenasi del lattato direttamente nel tessuto David Jelinek1,2, Aimee Flores1,3, Melanie Uebelhoer1, Vincent Pasque2, Kathrin Plath2,3, M. Luisa Iruela-Arispe1,3, Heather R. Christofk2,3, William E. Lowry1,3, Hilary A. Coller1,2,3 1Department of Molecular, Cell and Developmental Biology, UCLA, 2Department of Biological Chemistry, David Geffen School of Medicine, 3Molecular Biology Institute Interdepartmental Program, UCLA JoVE 57760 Biochemistry
