Henri Xhaard Drug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy University of Helsinki Biography Publications Institution JoVE Articles Henri Xhaard has not added a biography. If you are Henri Xhaard and would like to personalize this page please email our Author Liaison for assistance. Publications Modeling Membrane Proteins: The Importance of Cysteine Amino-acids Journal of Structural Biology. Oct, 2019 | Pubmed ID: 31593760 Asymmetry in Catalysis by Membrane-bound Pyrophosphatase Demonstrated by a Nonphosphorus Allosteric Inhibitor Science Advances. May, 2019 | Pubmed ID: 31131322 Cartography of Rhodopsin-like G Protein-coupled Receptors Across Vertebrate Genomes Scientific Reports. May, 2019 | Pubmed ID: 31064998 Structure-Activity Relationships of 1-Benzoylazulenes at the OX and OX Orexin Receptors ChemMedChem. May, 2019 | Pubmed ID: 30892823 Determinants of Orexin Receptor Binding and Activation-A Molecular Dynamics Study The Journal of Physical Chemistry. B. Mar, 2019 | Pubmed ID: 30786708 Pharmacological Characterization of the Orexin/hypocretin Receptor Agonist Nag 26 European Journal of Pharmacology. Oct, 2018 | Pubmed ID: 30194937 Predictive Classification Models and Targets Identification for Betulin Derivatives As Leishmania Donovani Inhibitors Journal of Cheminformatics. Aug, 2018 | Pubmed ID: 30120601 Azulene-based Compounds for Targeting Orexin Receptors European Journal of Medicinal Chemistry. Sep, 2018 | Pubmed ID: 30077889 Synthesis of 7β-hydroxy-8-ketone Opioid Derivatives with Antagonist Activity at Mu- and Delta-opioid Receptors European Journal of Medicinal Chemistry. May, 2018 | Pubmed ID: 29649744 Stapled Truncated Orexin Peptides As Orexin Receptor Agonists Peptides. 04, 2018 | Pubmed ID: 29475074 Characterization of Ionizable Groups' Environments in Proteins and Protein-Ligand Complexes Through a Statistical Analysis of the Protein Data Bank ACS Omega. Oct, 2017 | Pubmed ID: 31457307 Orexin Receptor Agonist Yan 7874 is a Weak Agonist of Orexin/hypocretin Receptors and Shows Orexin Receptor-independent Cytotoxicity PloS One. 2017 | Pubmed ID: 28575023 A Structure-activity Relationship Study of ABCC2 Inhibitors European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences. May, 2017 | Pubmed ID: 28185990 Predictive Modeling of Ocular Pharmacokinetics and Adverse Effects Current Pharmaceutical Design. 2016 | Pubmed ID: 27669964 Pharmacophore Model To Discover OX1 and OX2 Orexin Receptor Ligands Journal of Medicinal Chemistry. Sep, 2016 | Pubmed ID: 27546834 IDAAPM: Integrated Database of ADMET and Adverse Effects of Predictive Modeling Based on FDA Approved Drug Data Journal of Cheminformatics. 2016 | Pubmed ID: 27303447 Modeling of the OX1R-orexin-A Complex Suggests Two Alternative Binding Modes BMC Structural Biology. May, 2015 | Pubmed ID: 25957175 Exploring the Structure-activity Relationships of ABCC2 Modulators Using a Screening Approach Bioorganic & Medicinal Chemistry. Jul, 2015 | Pubmed ID: 25935289 Integrated in Vitro-in Silico Screening Strategy for the Discovery of Antibacterial Compounds Assay and Drug Development Technologies. Jan-Feb, 2015 | Pubmed ID: 25710544 Nostosins, Trypsin Inhibitors Isolated from the Terrestrial Cyanobacterium Nostoc Sp. Strain FSN Journal of Natural Products. Aug, 2014 | Pubmed ID: 25069058 OX1 and OX2 Orexin/hypocretin Receptor Pharmacogenetics Frontiers in Neuroscience. 2014 | Pubmed ID: 24834023 SVM Classification and CoMSIA Modeling of UGT1A6 Interacting Molecules Journal of Chemical Information and Modeling. Apr, 2014 | Pubmed ID: 24588678 Applying Linear and Non-linear Methods for Parallel Prediction of Volume of Distribution and Fraction of Unbound Drug PloS One. 2013 | Pubmed ID: 24116008 Systematic Structure-activity Study on Potential Chaperone Lead Compounds for Acid α-glucosidase ChemMedChem. Nov, 2012 | Pubmed ID: 22969039 Study of Interaction Between PEG Carrier and Three Relevant Drug Molecules: Piroxicam, Paclitaxel, and Hematoporphyrin The Journal of Physical Chemistry. B. Jun, 2012 | Pubmed ID: 22587534 Impact of Probe Compound in MRP2 Vesicular Transport Assays European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences. May, 2012 | Pubmed ID: 22406294 Detección de inhibidores de la pirofosfatasa ligadas a la membrana Thermotoga maritima Keni Vidilaseris*1, Niklas G. Johansson*2, Ainoleena Turku2, Alexandros Kiriazis2, Gustav Boije af Gennäs2, Jari Yli-Kauhaluoma2, Henri Xhaard2, Adrian Goldman1,3 1Research Program in Molecular and Integrative Biosciences, University of Helsinki, 2Drug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, 3School of Biomedical Sciences and Astbury Centre for Structural Molecular Biology, University of Leeds JoVE 60619 Biochemistry
Detección de inhibidores de la pirofosfatasa ligadas a la membrana Thermotoga maritima Keni Vidilaseris*1, Niklas G. Johansson*2, Ainoleena Turku2, Alexandros Kiriazis2, Gustav Boije af Gennäs2, Jari Yli-Kauhaluoma2, Henri Xhaard2, Adrian Goldman1,3 1Research Program in Molecular and Integrative Biosciences, University of Helsinki, 2Drug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, 3School of Biomedical Sciences and Astbury Centre for Structural Molecular Biology, University of Leeds JoVE 60619 Biochemistry
