Herman P. Spaink Institute of Biology Leiden University Biography Publications Institution JoVE Articles Herman P. Spaink has not added a biography. If you are Herman P. Spaink and would like to personalize this page please email our Author Liaison for assistance. Publications Intestinal Microbiome Adjusts the Innate Immune Setpoint During Colonization Through Negative Regulation of MyD88 Nature Communications. 10, 2018 | Pubmed ID: 30291253 Pathway Analysis of Systemic Transcriptome Responses to Injected Polystyrene Particles in Zebrafish Larvae Aquatic Toxicology (Amsterdam, Netherlands). Sep, 2017 | Pubmed ID: 28704660 A Full-body Transcriptome and Proteome Resource for the European Common Carp BMC Genomics. 09, 2016 | Pubmed ID: 27590662 Primitive Duplicate Hox Clusters in the European Eel's Genome PloS One. 2012 | Pubmed ID: 22384188 Neutrophil-mediated Experimental Metastasis is Enhanced by VEGFR Inhibition in a Zebrafish Xenograft Model The Journal of Pathology. Feb, 2012 | Pubmed ID: 22374800 Automated Whole Animal Bio-imaging Assay for Human Cancer Dissemination PloS One. 2012 | Pubmed ID: 22347456 An Osteosarcoma Zebrafish Model Implicates Mmp-19 and Ets-1 As Well As Reduced Host Immune Response in Angiogenesis and Migration The Journal of Pathology. Feb, 2012 | Pubmed ID: 22297719 Comparison of Static Immersion and Intravenous Injection Systems for Exposure of Zebrafish Embryos to the Natural Pathogen Edwardsiella Tarda BMC Immunology. 2011 | Pubmed ID: 22003892 Infectious Disease Modeling and Innate Immune Function in Zebrafish Embryos Methods in Cell Biology. 2011 | Pubmed ID: 21951535 Identification of Common Carp Innate Immune Genes with Whole-genome Sequencing and RNA-Seq Data Journal of Integrative Bioinformatics. 2011 | Pubmed ID: 21908900 A ΔRaf1-ER-inducible Oncogenic Zebrafish Liver Cell Model Identifies Hepatocellular Carcinoma Signatures The Journal of Pathology. Sep, 2011 | Pubmed ID: 21744342 Rapid Screening of Innate Immune Gene Expression in Zebrafish Using Reverse Transcription - Multiplex Ligation-dependent Probe Amplification BMC Research Notes. 2011 | Pubmed ID: 21676242 Zebrafish Embryos and Larvae: a New Generation of Disease Models and Drug Screens Birth Defects Research. Part C, Embryo Today : Reviews. Jun, 2011 | Pubmed ID: 21671352 Quantification of GPCR Internalization by Single-molecule Microscopy in Living Cells Integrative Biology : Quantitative Biosciences from Nano to Macro. Jun, 2011 | Pubmed ID: 21541374 First Artificial Hybrid of the Eel Species Anguilla Australis and Anguilla Anguilla BMC Developmental Biology. 2011 | Pubmed ID: 21396126 A High-throughput Screen for Tuberculosis Progression PloS One. 2011 | Pubmed ID: 21390204 Host-pathogen Interactions Made Transparent with the Zebrafish Model Current Drug Targets. Jun, 2011 | Pubmed ID: 21366518 The Epigenetic Regulator Histone Deacetylase 1 Promotes Transcription of a Core Neurogenic Programme in Zebrafish Embryos BMC Genomics. 2011 | Pubmed ID: 21226904 Deep Sequencing of the Innate Immune Transcriptomic Response of Zebrafish Embryos to Salmonella Infection Fish & Shellfish Immunology. Nov, 2011 | Pubmed ID: 20816807 Establishing Zebrafish As a Novel Exercise Model: Swimming Economy, Swimming-enhanced Growth and Muscle Growth Marker Gene Expression PloS One. 2010 | Pubmed ID: 21217817 Transcriptome Analysis of Traf6 Function in the Innate Immune Response of Zebrafish Embryos Molecular Immunology. Nov-Dec, 2010 | Pubmed ID: 20851470 Integrating Heterogeneous Sequence Information for Transcriptome-wide Microarray Design; a Zebrafish Example BMC Research Notes. 2010 | Pubmed ID: 20626891 In Vivo Magnetic Resonance Imaging to Detect Malignant Melanoma in Adult Zebrafish Zebrafish. Jun, 2010 | Pubmed ID: 20515295 Macrophage-specific Gene Functions in Spi1-directed Innate Immunity Blood. Jul, 2010 | Pubmed ID: 20424185 Swimming Suppresses Hepatic Vitellogenesis in European Female Silver Eels As Shown by Expression of the Estrogen Receptor 1, Vitellogenin1 and Vitellogenin2 in the Liver Reproductive Biology and Endocrinology : RB&E. 2010 | Pubmed ID: 20302623 RNA Isolation Method for Single Embryo Transcriptome Analysis in Zebrafish BMC Research Notes. 2010 | Pubmed ID: 20233395 Identification of Hoxb1b Downstream Genes: Hoxb1b As a Regulatory Factor Controlling Transcriptional Networks and Cell Movement During Zebrafish Gastrulation The International Journal of Developmental Biology. 2010 | Pubmed ID: 19876844 Temporal Expression of Hepatic Estrogen Receptor 1, Vitellogenin1 and Vitellogenin2 in European Silver Eels General and Comparative Endocrinology. Mar, 2010 | Pubmed ID: 19766647 Disease Modeling in Zebrafish: Cancer and Immune Responses--a Report on a Workshop Held in Spoleto, Italy, July 20-22, 2009 Zebrafish. Dec, 2009 | Pubmed ID: 20047471 Single-molecule Microscopy Reveals Membrane Microdomain Organization of Cells in a Living Vertebrate Biophysical Journal. Aug, 2009 | Pubmed ID: 19686669 Zebrafish Reward Mutants Reveal Novel Transcripts Mediating the Behavioral Effects of Amphetamine Genome Biology. 2009 | Pubmed ID: 19646228 Deep Sequencing of the Zebrafish Transcriptome Response to Mycobacterium Infection Molecular Immunology. Sep, 2009 | Pubmed ID: 19631987 Zebrafish Development and Regeneration: New Tools for Biomedical Research The International Journal of Developmental Biology. 2009 | Pubmed ID: 19557689 Specificity of the Zebrafish Host Transcriptome Response to Acute and Chronic Mycobacterial Infection and the Role of Innate and Adaptive Immune Components Molecular Immunology. Jul, 2009 | Pubmed ID: 19409617 Transcriptome Profiling and Functional Analyses of the Zebrafish Embryonic Innate Immune Response to Salmonella Infection Journal of Immunology (Baltimore, Md. : 1950). May, 2009 | Pubmed ID: 19380811 Analysis of Interactions of Signaling Proteins with Phage-displayed Ligands by Fluorescence Correlation Spectroscopy Journal of Biomolecular Screening. Sep, 2008 | Pubmed ID: 18753688 Photothermal Detection of Individual Gold Nanoparticles: Perspectives for High-throughput Screening Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry. Aug, 2008 | Pubmed ID: 18666264 Male Silver Eels Mature by Swimming BMC Physiology. 2008 | Pubmed ID: 18616800 Candidates for Membrane Progestin Receptors--past Approaches and Future Challenges Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP. Nov, 2008 | Pubmed ID: 18602498 Distinct Functions for ERK1 and ERK2 in Cell Migration Processes During Zebrafish Gastrulation Developmental Biology. Jul, 2008 | Pubmed ID: 18514184 A Spatially Restricted Increase in Receptor Mobility is Involved in Directional Sensing During Dictyostelium Discoideum Chemotaxis Journal of Cell Science. May, 2008 | Pubmed ID: 18469015 ERK1 and ERK2 MAPK Are Key Regulators of Distinct Gene Sets in Zebrafish Embryogenesis BMC Genomics. 2008 | Pubmed ID: 18442396 Discovery of a Functional Glucocorticoid Receptor Beta-isoform in Zebrafish Endocrinology. Apr, 2008 | Pubmed ID: 18096659 Identification and Real-time Imaging of a Myc-expressing Neutrophil Population Involved in Inflammation and Mycobacterial Granuloma Formation in Zebrafish Developmental and Comparative Immunology. 2008 | Pubmed ID: 17553562 Model Systems for Infectious Disease and Cancer in Zebrafish: a Report on an EMBO Workshop Held at the Lorentz Center, Leiden, The Netherlands, July 16-18, 2007 Zebrafish. 2007 | Pubmed ID: 18284335 Characterization of Genomic Clones and Expression Analysis of the Three Types of Superoxide Dismutases During Nodule Development in Lotus Japonicus Molecular Plant-microbe Interactions : MPMI. Mar, 2007 | Pubmed ID: 17378429 DNA Computing of Solutions to Knapsack Problems Bio Systems. Mar, 2007 | Pubmed ID: 16860927 ZebraFISH: Fluorescent in Situ Hybridization Protocol and Three-dimensional Imaging of Gene Expression Patterns Zebrafish. 2006 | Pubmed ID: 18377226 Genetic and Transcriptome Characterization of Model Zebrafish Cell Lines Zebrafish. 2006 | Pubmed ID: 18377224 Magnetic Resonance Microscopy of the Adult Zebrafish Zebrafish. 2006 | Pubmed ID: 18377223 Functions of the MAPK Family in Vertebrate-development FEBS Letters. Sep, 2006 | Pubmed ID: 16949582 Single-molecule Diffusion Reveals Similar Mobility for the Lck, H-ras, and K-ras Membrane Anchors Biophysical Journal. Aug, 2006 | Pubmed ID: 16920696 Characterization and Expression Patterns of the MAPK Family in Zebrafish Gene Expression Patterns : GEP. Oct, 2006 | Pubmed ID: 16774848 Cloning, Functional Expression and Characterization of Mesorhizobium Loti Arylamine N-acetyltransferases: Rhizobial Symbiosis Supplies Leguminous Plants with the Xenobiotic N-acetylation Pathway Molecular Microbiology. Apr, 2006 | Pubmed ID: 16573698 The Production of Species-specific Highly Unsaturated Fatty Acyl-containing LCOs from Rhizobium Leguminosarum Bv. Trifolii is Stringently Regulated by NodD and Involves the NodRL Genes Molecular Plant-microbe Interactions : MPMI. Mar, 2006 | Pubmed ID: 16570652 MyD88 Innate Immune Function in a Zebrafish Embryo Infection Model Infection and Immunity. Apr, 2006 | Pubmed ID: 16552074 Gene Expression Profiling of the Long-term Adaptive Response to Hypoxia in the Gills of Adult Zebrafish American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. Nov, 2005 | Pubmed ID: 15994372 Genomic Annotation and Expression Analysis of the Zebrafish Rho Small GTPase Family During Development and Bacterial Infection Genomics. Jul, 2005 | Pubmed ID: 15894457 Single-molecule Diffusion Measurements of H-Ras at the Plasma Membrane of Live Cells Reveal Microdomain Localization Upon Activation Journal of Cell Science. May, 2005 | Pubmed ID: 15860728 Transcriptome Profiling of Adult Zebrafish at the Late Stage of Chronic Tuberculosis Due to Mycobacterium Marinum Infection Molecular Immunology. Jun, 2005 | Pubmed ID: 15829308 Programmed Cell Death During the Transition from Multicellular Structures to Globular Embryos in Barley Androgenesis Planta. Jun, 2005 | Pubmed ID: 15645302 Time-lapse Tracking of Barley Androgenesis Reveals Position-determined Cell Death Within Pro-embryos Planta. Feb, 2005 | Pubmed ID: 15449059 Different Subcellular Localization and Trafficking Properties of KNOX Class 1 Homeodomain Proteins from Rice Plant Molecular Biology. Aug, 2004 | Pubmed ID: 15604716 DNA Computing Using Single-molecule Hybridization Detection Nucleic Acids Research. 2004 | Pubmed ID: 15388798 Specific Recognition of Bacteria by Plant LysM Domain Receptor Kinases Trends in Microbiology. May, 2004 | Pubmed ID: 15120137 Isoform-specific Differences in Rapid Nucleocytoplasmic Shuttling Cause Distinct Subcellular Distributions of 14-3-3 Sigma and 14-3-3 Zeta Journal of Cell Science. Mar, 2004 | Pubmed ID: 14996909 Has2 is Required Upstream of Rac1 to Govern Dorsal Migration of Lateral Cells During Zebrafish Gastrulation Development (Cambridge, England). Feb, 2004 | Pubmed ID: 14729574 Single-molecule Imaging of the H-ras Membrane-anchor Reveals Domains in the Cytoplasmic Leaflet of the Cell Membrane Biophysical Journal. Jan, 2004 | Pubmed ID: 14695305 Expression Analysis of the Toll-like Receptor and TIR Domain Adaptor Families of Zebrafish Molecular Immunology. Jan, 2004 | Pubmed ID: 14687934 Auxin Distribution in Lotus Japonicus During Root Nodule Development Plant Molecular Biology. Aug, 2003 | Pubmed ID: 14682616 Structural Motifs in the RNA Encoded by the Early Nodulation Gene Enod40 of Soybean Nucleic Acids Research. Sep, 2003 | Pubmed ID: 12930950 Specific Activation of ERK Pathways by Chitin Oligosaccharides in Embryonic Zebrafish Cell Lines Glycobiology. Oct, 2003 | Pubmed ID: 12881410 14-3-3 Isoforms and Pattern Formation During Barley Microspore Embryogenesis Journal of Experimental Botany. Mar, 2003 | Pubmed ID: 12598573 Genetic Analysis of a PH-regulated Operon from Rhizobium Tropici CIAT899 Involved in Acid Tolerance and Nodulation Competitiveness Molecular Plant-microbe Interactions : MPMI. Feb, 2003 | Pubmed ID: 12575750 Novel Lipochitin Oligosaccharide Structures Produced by Rhizobium Etli KIM5s Carbohydrate Research. Jul, 2002 | Pubmed ID: 12110194 Plant-microbe Interactions: a Receptor in Symbiotic Dialogue Nature. Jun, 2002 | Pubmed ID: 12087390 Lotus Japonicus Gene Ljsbp is Highly Conserved Among Plants and Animals and Encodes a Homologue to the Mammalian Selenium-binding Proteins Molecular Plant-microbe Interactions : MPMI. Apr, 2002 | Pubmed ID: 12026169 מודל העובר דג זברה, ויזואליזציה Vivo, ניתוח Intravital של Biomaterial-הקשורים Staphylococcus aureus זיהום Xiaolin Zhang1,2, Leonie de Boer1, Oliver W. Stockhammer1, Dirk W. Grijpma2,3, Herman P. Spaink4, Sebastian A.J. Zaat1 1Department of Medical Microbiology, Amsterdam UMC, 2Technical Medical Center, Department of Biomaterials Science and Technology, University of Twente, 3Department of Biomedical Engineering, W.J. Kolff Institute, University Medical Center Groningen, University of Groningen, 4Institute of Biology, Leiden University JoVE 58523 Bioengineering הקמה ואופטימיזציה של הגדרת תפוקה גבוהה ללמוד Wouter J. Veneman*1, Rubén Marín-Juez*2, Jan de Sonneville3, Anita Ordas1, Susanne Jong-Raadsen2, Annemarie H. Meijer1, Herman P. Spaink1 1Institute of Biology, Leiden University, 2ZF-screens BV, 3Life Science Methods BV JoVE 51649 Immunology and Infection זיהום של עוברים דג הזברה עם פתוגנים חיידקיים תאיים Erica L. Benard1, Astrid M. van der Sar2, Felix Ellett3, Graham J. Lieschke3, Herman P. Spaink1, Annemarie H. Meijer1 1Department of Molecular Cell Biology, Institute of Biology, Leiden University, 2Department of Medical Microbiology and Infection Control, VU University Medical Center, 3Australian Regenerative Medicine Institute, Monash University JoVE 3781 Immunology and Infection
מודל העובר דג זברה, ויזואליזציה Vivo, ניתוח Intravital של Biomaterial-הקשורים Staphylococcus aureus זיהום Xiaolin Zhang1,2, Leonie de Boer1, Oliver W. Stockhammer1, Dirk W. Grijpma2,3, Herman P. Spaink4, Sebastian A.J. Zaat1 1Department of Medical Microbiology, Amsterdam UMC, 2Technical Medical Center, Department of Biomaterials Science and Technology, University of Twente, 3Department of Biomedical Engineering, W.J. Kolff Institute, University Medical Center Groningen, University of Groningen, 4Institute of Biology, Leiden University JoVE 58523 Bioengineering
הקמה ואופטימיזציה של הגדרת תפוקה גבוהה ללמוד Wouter J. Veneman*1, Rubén Marín-Juez*2, Jan de Sonneville3, Anita Ordas1, Susanne Jong-Raadsen2, Annemarie H. Meijer1, Herman P. Spaink1 1Institute of Biology, Leiden University, 2ZF-screens BV, 3Life Science Methods BV JoVE 51649 Immunology and Infection
זיהום של עוברים דג הזברה עם פתוגנים חיידקיים תאיים Erica L. Benard1, Astrid M. van der Sar2, Felix Ellett3, Graham J. Lieschke3, Herman P. Spaink1, Annemarie H. Meijer1 1Department of Molecular Cell Biology, Institute of Biology, Leiden University, 2Department of Medical Microbiology and Infection Control, VU University Medical Center, 3Australian Regenerative Medicine Institute, Monash University JoVE 3781 Immunology and Infection
