Hermann Lage Institute of Pathology Charité Campus Mitte Biography Publications Institution JoVE Articles Hermann Lage has not added a biography. If you are Hermann Lage and would like to personalize this page please email our Author Liaison for assistance. Publications Osteogenic Potential of Mesenchymal Cells Embedded in the Provisional Matrix After a 6-week Healing Period in Augmented and Non-augmented Extraction Sockets: an Immunohistochemical Prospective Pilot Study in Humans Clinical Oral Implants Research. Jan, 2012 | Pubmed ID: 21435013 ABCC2 (MRP2, CMOAT) Localized in the Nuclear Envelope of Breast Carcinoma Cells Correlates with Poor Clinical Outcome Pathology Oncology Research : POR. Oct, 2011 | Pubmed ID: 21986666 Elevated YB-1 Expression is a New Unfavorable Prognostic Factor in Non-Hodgkin's Lymphomas Anticancer Research. Sep, 2011 | Pubmed ID: 21868545 YB-1 Dependent Virotherapy in Combination with Temozolomide As a Multimodal Therapy Approach to Eradicate Malignant Glioma International Journal of Cancer. Journal International Du Cancer. Sep, 2011 | Pubmed ID: 21710499 CD46 Expression is an Unfavorable Prognostic Factor in Breast Cancer Cases Applied Immunohistochemistry & Molecular Morphology : AIMM / Official Publication of the Society for Applied Immunohistochemistry. Dec, 2011 | Pubmed ID: 21617523 Healing of Ungrafted and Grafted Extraction Sockets After 12 Weeks: a Prospective Clinical Study The International Journal of Oral & Maxillofacial Implants. Mar-Apr, 2011 | Pubmed ID: 21483892 Loss of Estrogen Receptor Beta Expression Correlates with Shorter Overall Survival and Lack of Clinical Response to Chemotherapy in Ovarian Cancer Patients Anticancer Research. Feb, 2011 | Pubmed ID: 21378361 Estrogen Receptor Alpha Expression in Ovarian Cancer Predicts Longer Overall Survival Pathology Oncology Research : POR. Sep, 2011 | Pubmed ID: 21207255 YB-1 Dependent Virotherapy in Combination with Temozolomide As a Multimodal Therapy Approach to Eradicate Malignant Glioma International Journal of Cancer. Journal International Du Cancer. Nov, 2010 | Pubmed ID: 21086421 Multidrug Resistance Reversal Properties and Cytotoxic Evaluation of Representatives of a Novel Class of HIV-1 Protease Inhibitors The Journal of Pharmacy and Pharmacology. Dec, 2010 | Pubmed ID: 21054396 Novel Structure-activity Relationships and Selectivity Profiling of Cage Dimeric 1,4-dihydropyridines As Multidrug Resistance (MDR) Modulators Bioorganic & Medicinal Chemistry. Jul, 2010 | Pubmed ID: 20598550 Influence of Tamoxifen on Cisplatin-sensitivity and Estrogen Receptors Expression in Ovarian Carcinoma Cell Lines Ginekologia Polska. Mar, 2010 | Pubmed ID: 20486538 Jet-injection of Short Hairpin RNA-encoding Vectors into Tumor Cells Methods in Molecular Biology (Clifton, N.J.). 2010 | Pubmed ID: 20387147 Regulation of MRNA Expression in Drug-sensitive and Drug-resistant Gastric Carcinoma Cells is Independent of YB-1 Expression Anticancer Research. Feb, 2010 | Pubmed ID: 20332492 Effect of YB-1 on the Regulation of Micro RNA Expression in Drug-sensitive and Drug-resistant Gastric Carcinoma Cells Anticancer Research. Feb, 2010 | Pubmed ID: 20332481 Phenolic Compounds As Selective Antineoplasic Agents Against Multidrug-resistant Human Cancer Cells Planta Medica. Jul, 2010 | Pubmed ID: 20157880 Overcoming Multidrug Resistance by RNA Interference Methods in Molecular Biology (Clifton, N.J.). 2010 | Pubmed ID: 19949936 Betulinic Acid Exhibits Stronger Cytotoxic Activity on the Normal Melanocyte NHEM-neo Cell Line Than on Drug-resistant and Drug-sensitive MeWo Melanoma Cell Lines Molecular Medicine Reports. Jul-Aug, 2009 | Pubmed ID: 21475863 Proteomic Approaches for Investigation of Therapy Resistance in Cancer Proteomics. Clinical Applications. Aug, 2009 | Pubmed ID: 21136994 Positive Correlation Between Cyclooxygenase-2 and ABC-transporter Expression in Non-Hodgkin's Lymphomas Oncology Reports. Dec, 2009 | Pubmed ID: 19885582 Delivery of Short Hairpin RNAs by Transkingdom RNA Interference Modulates the Classical ABCB1-mediated Multidrug-resistant Phenotype of Cancer Cells Cell Cycle (Georgetown, Tex.). Oct, 2009 | Pubmed ID: 19770582 Evaluation of Microarray Preprocessing Algorithms Based on Concordance with RT-PCR in Clinical Samples PloS One. 2009 | Pubmed ID: 19461970 Influx and Efflux Transport As Determinants of Melphalan Cytotoxicity: Resistance to Melphalan in MDR1 Overexpressing Tumor Cell Lines Biochemical Pharmacology. Jul, 2009 | Pubmed ID: 19447222 Expression of Multidrug Resistance-associated Protein 1 in Invasive Ovarian Carcinoma: Implication for Prognosis Histopathology. May, 2009 | Pubmed ID: 19438741 Comparision of the Cytotoxic Effects of Birch Bark Extract, Betulin and Betulinic Acid Towards Human Gastric Carcinoma and Pancreatic Carcinoma Drug-sensitive and Drug-resistant Cell Lines Molecules (Basel, Switzerland). 2009 | Pubmed ID: 19396022 Interleukin-1 Beta and Tumor Necrosis Factor-alpha Increase ABCG2 Expression in MCF-7 Breast Carcinoma Cell Line and Its Mitoxantrone-resistant Derivative, MCF-7/MX Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]. Oct, 2009 | Pubmed ID: 19333723 A Prognostic Gene Expression Index in Ovarian Cancer - Validation Across Different Independent Data Sets The Journal of Pathology. Jun, 2009 | Pubmed ID: 19294737 Therapeutic Potential of RNA Interference in Drug-resistant Cancers Future Oncology (London, England). Mar, 2009 | Pubmed ID: 19284376 Topoisomerase IIalpha MRNA and Protein Expression in Ovarian Carcinoma: Correlation with Clinicopathological Factors and Prognosis Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc. Apr, 2009 | Pubmed ID: 19270648 Impact of Novel MDR Modulators on Human Cancer Cells: Reversal Activities and Induction Studies Pharmaceutical Research. Jan, 2009 | Pubmed ID: 18972190 Positive Correlation Between Cyclooxygenase 2 and the Expression of ABC Transporters in Non-small Cell Lung Cancer Anticancer Research. Sep-Oct, 2008 | Pubmed ID: 19031941 Novel Insight in Structure-activity Relationship and Bioanalysis of P-glycoprotein Targeting Highly Potent Tetrakishydroxymethyl Substituted 3,9-diazatetraasteranes Journal of Medicinal Chemistry. Sep, 2008 | Pubmed ID: 18714979 Acquired Cisplatin Resistance in the Head-neck Cancer Cell Line Cal27 is Associated with Decreased DKK1 Expression and Can Partially Be Reversed by Overexpression of DKK1 International Journal of Cancer. Journal International Du Cancer. Nov, 2008 | Pubmed ID: 18688867 Improved Cellular Pharmacokinetics and Pharmacodynamics Underlie the Wide Anticancer Activity of Sagopilone Cancer Research. Jul, 2008 | Pubmed ID: 18593931 Decreased Expression of P16 in Ovarian Cancers Represents an Unfavourable Prognostic Factor Histology and Histopathology. May, 2008 | Pubmed ID: 18283637 Three New Jatrophane Polyesters and Antiproliferative Constituents from Euphorbia Tuckeyana Planta Medica. Jan, 2008 | Pubmed ID: 18176909 Impact of Radiation Therapy on the Oncolytic Adenovirus Dl520: Implications on the Treatment of Glioblastoma Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology. Mar, 2008 | Pubmed ID: 17967494 Complete in Vivo Reversal of the Multidrug Resistance Phenotype by Jet-injection of Anti-MDR1 Short Hairpin RNA-encoding Plasmid DNA Molecular Therapy : the Journal of the American Society of Gene Therapy. Jan, 2008 | Pubmed ID: 17878902 Estradiol, Tamoxifen and ICI 182,780 Alter Alpha3 and Beta1 Integrin Expression and Laminin-1 Adhesion in Oral Squamous Cell Carcinoma Cell Cultures Oral Oncology. Jan, 2008 | Pubmed ID: 17418616 The Gene Polymorphism of the Angiotensin I-converting Enzyme Correlates with Tumor Size and Patient Survival in Colorectal Cancer Patients Neoplasia (New York, N.Y.). Sep, 2007 | Pubmed ID: 17898867 Occurence of Stromal Myofibroblasts in the Invasive Ductal Breast Cancer Tissue is an Unfavourable Prognostic Factor Anticancer Research. Jul-Aug, 2007 | Pubmed ID: 17695471 Antineoplastic Activity of 2-methoxyestradiol in Human Pancreatic and Gastric Cancer Cells with Different Multidrug-resistant Phenotypes Journal of Gastroenterology and Hepatology. Sep, 2007 | Pubmed ID: 17645459 Overcoming the Classical Multidrug Resistance Phenotype by Adenoviral Delivery of Anti-MDR1 Short Hairpin RNAs and Ribozymes International Journal of Oncology. Aug, 2007 | Pubmed ID: 17611700 Resistance to Chemotherapy in Ovarian Carcinoma Recent Results in Cancer Research. Fortschritte Der Krebsforschung. Progrès Dans Les Recherches Sur Le Cancer. 2007 | Pubmed ID: 17607916 Regulation of MDR1 Gene Expression in Multidrug-resistant Cancer Cells is Independent from YB-1 Biochemical and Biophysical Research Communications. May, 2007 | Pubmed ID: 17418094 Expression of Factors Involved in Regulation of DNA Mismatch Repair- and Apoptosis Pathways in Ovarian Cancer Patients Oncology Reports. Mar, 2007 | Pubmed ID: 17273726 Nuclear Metallothionein Expression Correlates with Cisplatin Resistance of Ovarian Cancer Cells and Poor Clinical Outcome Virchows Archiv : an International Journal of Pathology. Mar, 2007 | Pubmed ID: 17235562 Taxol-resistance-associated Gene-3 (TRAG-3/CSAG2) Expression is Predictive for Clinical Outcome in Ovarian Carcinoma Patients Virchows Archiv : an International Journal of Pathology. Feb, 2007 | Pubmed ID: 17216190 A Web-based Data Warehouse on Gene Expression in Human Malignant Melanoma The Journal of Investigative Dermatology. Feb, 2007 | Pubmed ID: 16946712 CD46 Expression is Indicative of Shorter Revival-free Survival for Ovarian Cancer Patients Anticancer Research. Nov-Dec, 2006 | Pubmed ID: 17214367 ABCC2 (MRP2, CMOAT) Can Be Localized in the Nuclear Membrane of Ovarian Carcinomas and Correlates with Resistance to Cisplatin and Clinical Outcome Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Dec, 2006 | Pubmed ID: 17145840 Complete Reversal of ABCG2-depending Atypical Multidrug Resistance by RNA Interference in Human Carcinoma Cells Oligonucleotides. 2006 | Pubmed ID: 16978089 RNA Interference-triggered Reversal of ABCC2-dependent Cisplatin Resistance in Human Cancer Cells Biochemical and Biophysical Research Communications. Sep, 2006 | Pubmed ID: 16876126 Inhibition of the Multidrug-resistant Phenotype by Targeting YB-1 with a Conditionally Oncolytic Adenovirus: Implications for Combinatorial Treatment Regimen with Chemotherapeutic Agents Cancer Research. Jul, 2006 | Pubmed ID: 16849566 MDR1/P-glycoprotein (ABCB1) As Target for RNA Interference-mediated Reversal of Multidrug Resistance Current Drug Targets. Jul, 2006 | Pubmed ID: 16842213 CD24 Expression is Specific for Tamoxifen-resistant Ductal Breast Cancer Cases Anticancer Research. Jan-Feb, 2006 | Pubmed ID: 16739331 Maspin Expression is Characteristic for Cisplatin-sensitive Ovarian Cancer Cells and for Ovarian Cancer Cases of Longer Survival Rates International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists. Apr, 2006 | Pubmed ID: 16633061 Analysis of Gene Expression Profiles in Melanoma Cells with Acquired Resistance Against Antineoplastic Drugs Melanoma Research. Apr, 2006 | Pubmed ID: 16567970 High Antineoplastic Activity of New Heterocyclic Compounds in Cancer Cells with Resistance Against Classical DNA Topoisomerase II-targeting Drugs International Journal of Cancer. Journal International Du Cancer. Jul, 2006 | Pubmed ID: 16450374 Novel Three-pronged Strategy to Enhance Cancer Cell Killing in Glioblastoma Cell Lines: Histone Deacetylase Inhibitor, Chemotherapy, and Oncolytic Adenovirus Dl520 Human Gene Therapy. Jan, 2006 | Pubmed ID: 16409125 Reversal of P-glycoprotein-mediated Multidrug Resistance in Cancer Cells by the C-Jun NH2-terminal Kinase Cancer Research. Jan, 2006 | Pubmed ID: 16397260 Gene Expression Profiling of 30 Cancer Cell Lines Predicts Resistance Towards 11 Anticancer Drugs at Clinically Achieved Concentrations International Journal of Cancer. Journal International Du Cancer. Apr, 2006 | Pubmed ID: 16217747 Significance of Cyclooxygenase 2 and MDR1/P-glycoprotein Coexpression in Ovarian Cancers Cancer Letters. Apr, 2006 | Pubmed ID: 15970376 Potential Applications of RNA Interference Technology in the Treatment of Cancer Future Oncology (London, England). Feb, 2005 | Pubmed ID: 16555980 Relationship Between the Expression of Cyclooxygenase 2 and MDR1/P-glycoprotein in Invasive Breast Cancers and Their Prognostic Significance Breast Cancer Research : BCR. 2005 | Pubmed ID: 16168133 Prognostic Value of Immunohistochemical Estimation of CD24 and Ki67 Expression in Cisplatin and Paclitaxel Treated Ovarian Carcinoma Patients Polish Journal of Pathology : Official Journal of the Polish Society of Pathologists. 2005 | Pubmed ID: 16092668 Prediction of Doxorubicin Sensitivity in Breast Tumors Based on Gene Expression Profiles of Drug-resistant Cell Lines Correlates with Patient Survival Oncogene. Nov, 2005 | Pubmed ID: 16044152 Augmented Expression of Metallothionein and Glutathione S-transferase Pi As Unfavourable Prognostic Factors in Cisplatin-treated Ovarian Cancer Patients Virchows Archiv : an International Journal of Pathology. Sep, 2005 | Pubmed ID: 15968547 Transcriptome Analysis of Different Multidrug-resistant Gastric Carcinoma Cells In Vivo (Athens, Greece). May-Jun, 2005 | Pubmed ID: 15875780 Overexpression of Cathepsin B in Gastric Cancer Identified by Proteome Analysis Proteomics. Apr, 2005 | Pubmed ID: 15789341 Reversal of Different Drug-resistant Phenotypes by an Autocatalytic Multitarget Multiribozyme Directed Against the Transcripts of the ABC Transporters MDR1/P-gp, MRP2, and BCRP Molecular Therapy : the Journal of the American Society of Gene Therapy. Apr, 2005 | Pubmed ID: 15771954 Protection of Platinum-DNA Adduct Formation and Reversal of Cisplatin Resistance by Anti-MRP2 Hammerhead Ribozymes in Human Cancer Cells International Journal of Cancer. Journal International Du Cancer. Jun, 2005 | Pubmed ID: 15688364 Chromosomal Imbalances Associated with Drug Resistance and Thermoresistance in Human Pancreatic Carcinoma Cells European Journal of Cell Biology. Oct, 2004 | Pubmed ID: 15679104 Stable and Complete Overcoming of MDR1/P-glycoprotein-mediated Multidrug Resistance in Human Gastric Carcinoma Cells by RNA Interference Cancer Gene Therapy. Nov, 2004 | Pubmed ID: 15375376 Effective Knock Down of Very High ABCG2 Expression by a Hammerhead Ribozyme Anticancer Research. Jul-Aug, 2004 | Pubmed ID: 15330166 RNA Expression of MDR1/P-glycoprotein, DNA-topoisomerase I, and MRP2 in Ovarian Carcinoma Patients: Correlation with Chemotherapeutic Response Gynecologic Oncology. Jul, 2004 | Pubmed ID: 15262134 Proteomics in Cancer Cell Research: an Analysis of Therapy Resistance Pathology, Research and Practice. 2004 | Pubmed ID: 15237919 Study of the Development of Thermoresistance in Human Pancreatic Carcinoma Cell Lines Using Proteome Analysis Electrophoresis. Jan, 2004 | Pubmed ID: 14730581 Multidrug-resistant Cancer Cells Facilitate E1-independent Adenoviral Replication: Impact for Cancer Gene Therapy Cancer Research. Jan, 2004 | Pubmed ID: 14729641 Glypican-3 is Involved in Cellular Protection Against Mitoxantrone in Gastric Carcinoma Cells Oncogene. Jan, 2004 | Pubmed ID: 14661052 Molecular Analysis of Therapy Resistance in Gastric Cancer Digestive Diseases (Basel, Switzerland). 2003 | Pubmed ID: 14752223 Reversal of Breast Cancer Resistance Protein-mediated Drug Resistance by Tryprostatin A International Journal of Cancer. Journal International Du Cancer. Dec, 2003 | Pubmed ID: 14566821 ABC-transporters: Implications on Drug Resistance from Microorganisms to Human Cancers International Journal of Antimicrobial Agents. Sep, 2003 | Pubmed ID: 13678820 Enhanced Exposure of Phosphatidylserine in Human Gastric Carcinoma Cells Overexpressing the Half-size ABC Transporter BCRP (ABCG2) The Biochemical Journal. Dec, 2003 | Pubmed ID: 12946267 Homozygous Mutation Arg768Trp in the ABC-transporter Encoding Gene MRP2/cMOAT/ABCC2 Causes Dubin-Johnson Syndrome in a Caucasian Patient Journal of Human Genetics. 2003 | Pubmed ID: 12942343 Dynamic Expression Profile of P21WAF1/CIP1 and Ki-67 Predicts Survival in Rectal Carcinoma Treated with Preoperative Radiochemotherapy Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. Sep, 2003 | Pubmed ID: 12885834 Study of the Development of Chemoresistance in Melanoma Cell Lines Using Proteome Analysis Electrophoresis. Jul, 2003 | Pubmed ID: 12874874 Overexpression of CMOAT (MRP2/ABCC2) is Associated with Decreased Formation of Platinum-DNA Adducts and Decreased G2-arrest in Melanoma Cells Resistant to Cisplatin The Journal of Investigative Dermatology. Jul, 2003 | Pubmed ID: 12839578 Modulation of the Classical Multidrug Resistance (MDR) Phenotype by RNA Interference (RNAi) FEBS Letters. Jun, 2003 | Pubmed ID: 12804765 Association of Genomic Imbalances with Drug Resistance and Thermoresistance in Human Gastric Carcinoma Cells International Journal of Cancer. Journal International Du Cancer. Mar, 2003 | Pubmed ID: 12516094 Identification of Differentially Expressed Genes in Classical and Atypical Multidrug-resistant Gastric Carcinoma Cells Anticancer Research. Nov-Dec, 2002 | Pubmed ID: 12530067 Multiple Mechanisms Confer Different Drug-resistant Phenotypes in Pancreatic Carcinoma Cells Journal of Cancer Research and Clinical Oncology. Jul, 2002 | Pubmed ID: 12136248 Modulation of the Atypical Multidrug-resistant Phenotype by a Hammerhead Ribozyme Directed Against the ABC Transporter BCRP/MXR/ABCG2 Cancer Gene Therapy. Jul, 2002 | Pubmed ID: 12082458 Transport of Phosphatidylserine Via MDR1 (multidrug Resistance 1)P-glycoprotein in a Human Gastric Carcinoma Cell Line The Biochemical Journal. Jul, 2002 | Pubmed ID: 12071854 Study of Therapy Resistance in Cancer Cells with Functional Proteome Analysis Clinical Chemistry and Laboratory Medicine : CCLM / FESCC. Mar, 2002 | Pubmed ID: 12005211 Impact of BCRP/MXR, MRP1 and MDR1/P-Glycoprotein on Thermoresistant Variants of Atypical and Classical Multidrug Resistant Cancer Cells International Journal of Cancer. Journal International Du Cancer. Feb, 2002 | Pubmed ID: 11857350 YB-1 Relocates to the Nucleus in Adenovirus-infected Cells and Facilitates Viral Replication by Inducing E2 Gene Expression Through the E2 Late Promoter The Journal of Biological Chemistry. Mar, 2002 | Pubmed ID: 11788582 Bacterial Delivery of RNAi Effectors: Transkingdom RNAi Hermann Lage1, Andrea Krühn1 1Institute of Pathology, Charité Campus Mitte JoVE 2099 Biology
Bacterial Delivery of RNAi Effectors: Transkingdom RNAi Hermann Lage1, Andrea Krühn1 1Institute of Pathology, Charité Campus Mitte JoVE 2099 Biology
