Hilal A. Lashuel Laboratory of Molecular and Chemical Biology of Neurodegeneration Ecole Polytechnique Fédérale de Lausanne (EPFL) Biography Publications Institution JoVE Articles Hilal A. Lashuel has not added a biography. If you are Hilal A. Lashuel and would like to personalize this page please email our Author Liaison for assistance. Publications Discovery and Characterization of Stable and Toxic Tau/phospholipid Oligomeric Complexes Nature Communications. Nov, 2017 | Pubmed ID: 29162800 Phosphorylation of Huntingtin at Residue T3 is Decreased in Huntington's Disease and Modulates Mutant Huntingtin Protein Conformation Proceedings of the National Academy of Sciences of the United States of America. 12, 2017 | Pubmed ID: 29162692 An Intein-based Strategy for the Production of Tag-free Huntingtin Exon 1 Proteins Enables New Insights into the Polyglutamine Dependence of Httex1 Aggregation and Fibril Formation The Journal of Biological Chemistry. Jun, 2016 | Pubmed ID: 27002149 Induction of De Novo α-synuclein Fibrillization in a Neuronal Model for Parkinson's Disease Proceedings of the National Academy of Sciences of the United States of America. Feb, 2016 | Pubmed ID: 26839406 Microtubule-Binding R3 Fragment from Tau Self-Assembles into Giant Multistranded Amyloid Ribbons Angewandte Chemie (International Ed. in English). Jan, 2016 | Pubmed ID: 26636567 Semisynthesis and Enzymatic Preparation of Post-translationally Modified α-Synuclein Methods in Molecular Biology (Clifton, N.J.). 2016 | Pubmed ID: 26453202 Structural Differences of Amyloid-β Fibrils Revealed by Antibodies from Phage Display BMC Biotechnology. Jun, 2015 | Pubmed ID: 26084577 Parkinson Disease Mutant E46K Enhances α-synuclein Phosphorylation in Mammalian Cell Lines, in Yeast, and in Vivo The Journal of Biological Chemistry. Apr, 2015 | Pubmed ID: 25657004 Novel Therapeutic Strategy for Neurodegeneration by Blocking Aβ Seeding Mediated Aggregation in Models of Alzheimer's Disease Neurobiology of Disease. Feb, 2015 | Pubmed ID: 25173807 The H50Q Mutation Enhances α-synuclein Aggregation, Secretion, and Toxicity The Journal of Biological Chemistry. Aug, 2014 | Pubmed ID: 24936070 The Novel Parkinson's Disease Linked Mutation G51D Attenuates in Vitro Aggregation and Membrane Binding of α-synuclein, and Enhances Its Secretion and Nuclear Localization in Cells Human Molecular Genetics. Sep, 2014 | Pubmed ID: 24728187 One-pot Total Chemical Synthesis of Human α-synuclein Chemical Communications (Cambridge, England). Oct, 2013 | Pubmed ID: 23995579 Amyloids Go Genomic: Insights Regarding the Sequence Determinants of Prion Formation from Genome-wide Studies Chembiochem : a European Journal of Chemical Biology. Aug, 2009 | Pubmed ID: 19598186 Rescuing Defective Vesicular Trafficking Protects Against Alpha-synuclein Toxicity in Cellular and Animal Models of Parkinson's Disease ACS Chemical Biology. Aug, 2006 | Pubmed ID: 17168518 Are Amyloid Diseases Caused by Protein Aggregates That Mimic Bacterial Pore-forming Toxins? Quarterly Reviews of Biophysics. May, 2006 | Pubmed ID: 16978447 Amyloid Fibril Formation by Macrophage Migration Inhibitory Factor Biochemical and Biophysical Research Communications. Dec, 2005 | Pubmed ID: 16286092 Membrane Permeabilization: a Common Mechanism in Protein-misfolding Diseases Science of Aging Knowledge Environment : SAGE KE. Sep, 2005 | Pubmed ID: 16186179 Generation of Native, Untagged Huntingtin Exon1 Monomer and Fibrils Using a SUMO Fusion Strategy Andreas Reif1, Anass Chiki1, Jonathan Ricci1, Hilal A. Lashuel1 1Laboratory of Molecular and Chemical Biology of Neurodegeneration, Ecole Polytechnique Fédérale de Lausanne (EPFL) JoVE 57506 Biochemistry
Generation of Native, Untagged Huntingtin Exon1 Monomer and Fibrils Using a SUMO Fusion Strategy Andreas Reif1, Anass Chiki1, Jonathan Ricci1, Hilal A. Lashuel1 1Laboratory of Molecular and Chemical Biology of Neurodegeneration, Ecole Polytechnique Fédérale de Lausanne (EPFL) JoVE 57506 Biochemistry
