Horst Thiermann Bundeswehr Institute of Pharmacology and Toxicology Biography Publications Institution JoVE Articles Horst Thiermann has not added a biography. If you are Horst Thiermann and would like to personalize this page please email our Author Liaison for assistance. Publications Impact of Soman and Acetylcholine on the Effects of Propofol in Cultured Cortical Networks Toxicology Letters. Apr, 2020 | Pubmed ID: 31954869 Comparison of the Toxicity of Sulfur Mustard and Its Oxidation Products in Vitro Toxicology Letters. Mar, 2020 | Pubmed ID: 31863871 Validation of Automated Pipetting Systems for Cell Culture Seeding, Exposure and Bio-analytical Assays in Sulfur Mustard Toxicology Toxicology Letters. Mar, 2020 | Pubmed ID: 31809884 Screening of Chiral Shift Reagents Suitable to Generically Separate the Enantiomers of V-agents by P-NMR Spectroscopy Toxicology Letters. Mar, 2020 | Pubmed ID: 31805340 Effect of Sulfur Mustard on Melanogenesis in Vitro Toxicology Letters. Feb, 2020 | Pubmed ID: 31785464 [Chemical Warfare Agent Poisoning] Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz. Nov, 2019 | Pubmed ID: 31602511 Sulfur Mustard Alkylates Steroid Hormones and Impacts Hormone Function in Vitro Archives of Toxicology. Nov, 2019 | Pubmed ID: 31515601 Efficacy of an Organophosphorus Hydrolase Enzyme (OpdA) in Human Serum and Minipig Models of Organophosphorus Insecticide Poisoning Clinical Toxicology (Philadelphia, Pa.). Aug, 2019 | Pubmed ID: 31452424 Skin Sensitizing Effects of Sulfur Mustard and Other Alkylating Agents in Accordance to OECD Guidelines Toxicology Letters. Oct, 2019 | Pubmed ID: 31404593 Forensic Evidence of Sulfur Mustard Exposure in Real Cases of Human Poisoning by Detection of Diverse Albumin-derived Protein Adducts Archives of Toxicology. 07, 2019 | Pubmed ID: 31069408 Evaluation of Selective and Non-selective Cyclooxygenase Inhibitors on Sulfur Mustard-induced Pro-inflammatory Cytokine Formation in Normal Human Epidermal Keratinocytes Toxicology Letters. Sep, 2019 | Pubmed ID: 31048000 Validation of the CULTEX® Radial Flow System for the Assessment of the Acute Inhalation Toxicity of Airborne Particles Toxicology in Vitro : an International Journal Published in Association with BIBRA. Aug, 2019 | Pubmed ID: 30890356 The Arrhythmogenic Potential of Nerve Agents and a Cardiac Safety Profile of Antidotes - A Proof-of-concept Study Using Human Induced Pluripotent Stem Cells Derived Cardiomyocytes (hiPSC-CM) Toxicology Letters. Jun, 2019 | Pubmed ID: 30858091 Human Small Bowel As Model for Poisoning with Organophosphorus Compounds Toxicology in Vitro : an International Journal Published in Association with BIBRA. Jun, 2019 | Pubmed ID: 30763608 COPD and Asthma Therapeutics for Supportive Treatment in Organophosphate Poisoning Clinical Toxicology (Philadelphia, Pa.). Jul, 2019 | Pubmed ID: 30696282 A Novel Exposure System Generating Nebulized Aerosol of Sulfur Mustard in Comparison to the Standard Submerse Exposure Chemico-biological Interactions. Jan, 2019 | Pubmed ID: 30502332 Methionine in Human Serum Albumin: A Novel Target for Alkylation by Sulfur Mustard Drug Testing and Analysis. May, 2019 | Pubmed ID: 30468304 Collision-induced Mass Spectrometric Fragmentation of Protonated Dimethoate and Omethoate Generated by Electrospray Ionization Rapid Communications in Mass Spectrometry : RCM. Feb, 2019 | Pubmed ID: 30402977 Necrosulfonamide - Unexpected Effect in the Course of a Sulfur Mustard Intoxication Chemico-biological Interactions. Jan, 2019 | Pubmed ID: 30391637 Effect of Cholinergic Crisis on the Potency of Different Emergency Anaesthesia Protocols in Soman-poisoned Rats Clinical Toxicology (Philadelphia, Pa.). 05, 2019 | Pubmed ID: 30307341 New Resensitizers for the Nicotinic Acetylcholine Receptor by Ligand-Based Pharmacophore Modeling Current Computer-aided Drug Design. 2019 | Pubmed ID: 29968541 Synthesis of a Series of Non-Symmetric Bispyridinium and Related Compounds and Their Affinity Characterization at the Nicotinic Acetylcholine Receptor ChemMedChem. 12, 2018 | Pubmed ID: 30362667 Interactions Between Acetylcholinesterase, Toxic Organophosphorus Compounds and a Short Series of Structurally Related Non-oxime Reactivators: Analysis of Reactivation and Inhibition Kinetics in Vitro Toxicology Letters. Dec, 2018 | Pubmed ID: 30312685 Transient Receptor Potential Channel A1 (TRPA1) Regulates Sulfur Mustard-Induced Expression of Heat Shock 70 KDa Protein 6 () In Vitro Cells. Aug, 2018 | Pubmed ID: 30200301 Verification of Organophosphorus Pesticide Poisoning: Detection of Phosphorylated Tyrosines and a Cysteine-proline Disulfide-adduct from Human Serum Albumin After Intoxication with Dimethoate/omethoate Toxicology Letters. Dec, 2018 | Pubmed ID: 30165092 Midazolam is Effective to Reduce Cortical Network Activity in Organotypic Cultures During Severe Cholinergic Overstimulation with Soman Toxicology Letters. Nov, 2018 | Pubmed ID: 30165091 Simultaneous Quantification of Atropine and Scopolamine in Infusions of Herbal Tea and Solanaceae Plant Material by Matrix-assisted Laser Desorption/ionization Time-of-flight (tandem) Mass Spectrometry Rapid Communications in Mass Spectrometry : RCM. Nov, 2018 | Pubmed ID: 30117208 Synthesis of a Series of Structurally Diverse MB327 Derivatives and Their Affinity Characterization at the Nicotinic Acetylcholine Receptor ChemMedChem. 09, 2018 | Pubmed ID: 29974635 Novel Cysteine- and Albumin-adduct Biomarkers to Prove Human Poisoning with the Pesticide Oxydemeton-S-methyl Toxicology Letters. Sep, 2018 | Pubmed ID: 29777832 A Toolbox for Microbore Liquid Chromatography Tandem-high-resolution Mass Spectrometry Analysis of Albumin-adducts As Novel Biomarkers of Organophosphorus Pesticide Poisoning Toxicology Letters. Aug, 2018 | Pubmed ID: 29702198 Cytostatic Resistance Profile of the Sulfur Mustard Resistant Keratinocyte Cell Line HaCaT/SM Toxicology Letters. Sep, 2018 | Pubmed ID: 29551593 Mobilization of Human Mesenchymal Stem Cells Through Different Cytokines and Growth Factors After Their Immobilization by Sulfur Mustard Toxicology Letters. Sep, 2018 | Pubmed ID: 29426001 Bioanalytical Verification of V-type Nerve Agent Exposure: Simultaneous Detection of Phosphonylated Tyrosines and Cysteine-containing Disulfide-adducts Derived from Human Albumin Analytical and Bioanalytical Chemistry. Feb, 2018 | Pubmed ID: 29322229 Glutathione As an Antidote for Sulfur Mustard Poisoning: Mass Spectrometric Investigations of Its Potency As a Chemical Scavenger Toxicology Letters. Sep, 2018 | Pubmed ID: 29277572 Counteracting Desensitization of Human α7-nicotinic Acetylcholine Receptors with Bispyridinium Compounds As an Approach Against Organophosphorus Poisoning Toxicology Letters. Sep, 2018 | Pubmed ID: 29248576 Electrophysiological Investigation of the Effect of Structurally Different Bispyridinium Non-oxime Compounds on Human α7-nicotinic Acetylcholine Receptor Activity-An in Vitro Structure-activity Analysis Toxicology Letters. Sep, 2018 | Pubmed ID: 29191791 Accidental Sulfur Mustard Exposure: A Case Report Toxicology Letters. Sep, 2018 | Pubmed ID: 29191789 Sulfur Mustard Resistant Keratinocytes Obtained Elevated Glutathione Levels and Other Changes in the Antioxidative Defense Mechanism Toxicology Letters. Sep, 2018 | Pubmed ID: 29183814 Sulfur Mustard-induced Epigenetic Modifications over Time - a Pilot Study Toxicology Letters. Sep, 2018 | Pubmed ID: 29155286 Human Small Bowel As a Useful Tool to Investigate Smooth Muscle Effects of Potential Therapeutics in Organophosphate Poisoning Toxicology Letters. Sep, 2018 | Pubmed ID: 29154801 Searching for Putative Binding Sites of the Bispyridinium Compound MB327 in the Nicotinic Acetylcholine Receptor Toxicology Letters. Sep, 2018 | Pubmed ID: 29097222 The Oximes HI-6 and MMB-4 Fail to Reactivate Soman-inhibited Human and Guinea Pig AChE: A Kinetic in Vitro Study Toxicology Letters. Sep, 2018 | Pubmed ID: 28993240 Immediate Responses of the Cockroach Blaptica Dubia After the Exposure to Sulfur Mustard Archives of Toxicology. Jan, 2018 | Pubmed ID: 28932886 Zinc Chloride-induced TRPA1 Activation Does Not Contribute to Toxicity in Vitro Toxicology Letters. Sep, 2018 | Pubmed ID: 28919489 Anti-apoptotic and Moderate Anti-inflammatory Effects of Berberine in Sulfur Mustard Exposed Keratinocytes Toxicology Letters. Sep, 2018 | Pubmed ID: 28916288 Effects of Anti-inflammatory Compounds on Sulfur Mustard Injured Cells: Recommendations and Caveats Suggested by in Vitro Cell Culture Models Toxicology Letters. Sep, 2018 | Pubmed ID: 28916287 N-Acetylcysteine As a Chemical Scavenger for Sulfur Mustard: New Insights by Mass Spectrometry Drug Testing and Analysis. Feb, 2018 | Pubmed ID: 28879668 Alteration of MiRNA Expression in a Sulfur Mustard Resistant Cell Line Toxicology Letters. Sep, 2018 | Pubmed ID: 28823541 Effects of Sulfur Mustard on Mesenchymal Stem Cells Toxicology Letters. Sep, 2018 | Pubmed ID: 28818580 Environmental Exposure to Organophosphorus Nerve Agents Environmental Toxicology and Pharmacology. Dec, 2017 | Pubmed ID: 28942081 Development of a Sensitive, Generic and Easy to Use Organophosphate Skin Disclosure Kit Toxicology Letters. Oct, 2017 | Pubmed ID: 28851585 Precision Cut Lung Slices As Test System for Candidate Therapeutics in Organophosphate Poisoning Toxicology. 08, 2017 | Pubmed ID: 28743514 Identification of Novel Disulfide Adducts Between the Thiol Containing Leaving Group of the Nerve Agent VX and Cysteine Containing Tripeptides Derived from Human Serum Albumin Drug Testing and Analysis. Aug, 2017 | Pubmed ID: 27935238 S - and N-alkylating Agents Diminish the Fluorescence of Fluorescent Dye-stained DNA Chemico-biological Interactions. Jan, 2017 | Pubmed ID: 27923644 N-Acetyl-L-cysteine Inhibits Sulfur Mustard-induced and TRPA1-dependent Calcium Influx Archives of Toxicology. May, 2017 | Pubmed ID: 27738742 Pseudocatalytic Scavenging of the Nerve Agent VX with Human Blood Components and the Oximes Obidoxime and HI-6 Archives of Toxicology. Mar, 2017 | Pubmed ID: 27358236 Blaptica Dubia As Sentinels for Exposure to Chemical Warfare Agents - a Pilot Study Toxicology Letters. Nov, 2016 | Pubmed ID: 27639501 Modification of Human Serum Albumin by the Nerve Agent VX: Microbore Liquid Chromatography/electrospray Ionization High-resolution Time-of-flight Tandem Mass Spectrometry Method for Detection of Phosphonylated Tyrosine and Novel Cysteine Containing Disulfide Adducts Rapid Communications in Mass Spectrometry : RCM. Oct, 2016 | Pubmed ID: 27490696 Procedures for Analysis of Dried Plasma Using Microsampling Devices to Detect Sulfur Mustard-Albumin Adducts for Verification of Poisoning Analytical Chemistry. 09, 2016 | Pubmed ID: 27482832 Single Treatment of VX Poisoned Guinea Pigs with the Phosphotriesterase Mutant C23AL: Intraosseous Versus Intravenous Injection Toxicology Letters. Sep, 2016 | Pubmed ID: 27397758 Toxicology of Organophosphorus Compounds in View of an Increasing Terrorist Threat Archives of Toxicology. Sep, 2016 | Pubmed ID: 27349770 Bispyridinium Non-oximes: An Evaluation of Cardiac Effects in Isolated Hearts and Smooth Muscle Relaxing Effects in Jejunum Toxicology in Vitro : an International Journal Published in Association with BIBRA. Sep, 2016 | Pubmed ID: 27184650 Reactivation of Nerve Agent-inhibited Human Acetylcholinesterase by Obidoxime, HI-6 and Obidoxime+HI-6: Kinetic in Vitro Study with Simulated Nerve Agent Toxicokinetics and Oxime Pharmacokinetics Toxicology. 03, 2016 | Pubmed ID: 27153754 Oximes in Organophosphate Poisoning: 60 Years of Hope and Despair Chemico-biological Interactions. Nov, 2016 | Pubmed ID: 27125761 On-site Analysis of Acetylcholinesterase and Butyrylcholinesterase Activity with the ChE Check Mobile Test Kit-Determination of Reference Values and Their Relevance for Diagnosis of Exposure to Organophosphorus Compounds Toxicology Letters. May, 2016 | Pubmed ID: 27033775 Editorial Toxicology Letters. Feb, 2016 | Pubmed ID: 26873068 Catalytic Efficiencies of Directly Evolved Phosphotriesterase Variants with Structurally Different Organophosphorus Compounds in Vitro Archives of Toxicology. Nov, 2016 | Pubmed ID: 26612364 A Novel Fluorogenic Probe for the Investigation of Free Thiols: Application to Kinetic Measurements of Acetylcholinesterase Activity Toxicology Letters. Feb, 2016 | Pubmed ID: 26494253 Development of the Sulfur Mustard Resistant Keratinocyte Cell Line HaCaT/SM Toxicology Letters. Feb, 2016 | Pubmed ID: 26463895 Alteration of MiRNA Expression in Early Endothelial Cells After Exposure with Sub-lethal Sulfur Mustard Concentrations Toxicology Letters. Feb, 2016 | Pubmed ID: 26456178 Characterization of Sulfur Mustard Resistant Keratinocyte Cell Line HaCaT/SM Toxicology Letters. Feb, 2016 | Pubmed ID: 26456177 Optimized Verification Method for Detection of an Albumin-sulfur Mustard Adduct at Cys(34) Using a Hybrid Quadrupole Time-of-flight Tandem Mass Spectrometer After Direct Plasma Proteolysis Toxicology Letters. Feb, 2016 | Pubmed ID: 26449527 Epigenetic Modulations in Early Endothelial Cells and DNA Hypermethylation in Human Skin After Sulfur Mustard Exposure Toxicology Letters. Feb, 2016 | Pubmed ID: 26392148 Immunochemical Analysis of Poly(ADP-ribosyl)ation in HaCaT Keratinocytes Induced by the Mono-alkylating Agent 2-chloroethyl Ethyl Sulfide (CEES): Impact of Experimental Conditions Toxicology Letters. Feb, 2016 | Pubmed ID: 26383632 Sulfur and Nitrogen Mustards Induce Characteristic Poly(ADP-ribosyl)ation Responses in HaCaT Keratinocytes with Distinctive Cellular Consequences Toxicology Letters. Feb, 2016 | Pubmed ID: 26383629 Protective Effects of the Thiol Compounds GSH and NAC Against Sulfur Mustard Toxicity in a Human Keratinocyte Cell Line Toxicology Letters. Feb, 2016 | Pubmed ID: 26361990 Optimization of the CULTEX(®) Radial Flow System for in Vitro Investigation of Lung Damaging Agents Toxicology Letters. Feb, 2016 | Pubmed ID: 26358518 Anesthetic Actions of Thiopental Remain Largely Unaffected During Cholinergic Overstimulation in Cultured Cortical Networks Toxicology Letters. Feb, 2016 | Pubmed ID: 26325215 Medical Documentation, Bioanalytical Evidence of an Accidental Human Exposure to Sulfur Mustard and General Therapy Recommendations Toxicology Letters. Feb, 2016 | Pubmed ID: 26321678 Botulinum Toxin B Increases Intrinsic Muscle Activity in Organotypic Spinal Cord-skeletal Muscle Co-cultures Toxicology Letters. Feb, 2016 | Pubmed ID: 26260118 Self-regeneration of Neuromuscular Function Following Soman and VX Poisoning in Spinal Cord-skeletal Muscle Cocultures Toxicology Letters. Feb, 2016 | Pubmed ID: 26256036 Kinetics of Pesticide Degradation by Human Fresh Frozen Plasma (FFP) in Vitro Toxicology Letters. Feb, 2016 | Pubmed ID: 26220518 Investigation of the Reactivation Kinetics of a Large Series of Bispyridinium Oximes with Organophosphate-inhibited Human Acetylcholinesterase Toxicology Letters. Feb, 2016 | Pubmed ID: 26210933 Catalytic Bioscavengers in Nerve Agent Poisoning: A Promising Approach? Toxicology Letters. Feb, 2016 | Pubmed ID: 26200600 Repetitive Obidoxime Treatment Induced Increase of Red Blood Cell Acetylcholinesterase Activity Even in a Late Phase of a Severe Methamidophos Poisoning: A Case Report Toxicology Letters. Feb, 2016 | Pubmed ID: 26200596 Application of a Dynamic in Vitro Model with Real-time Determination of Acetylcholinesterase Activity for the Investigation of Tabun Analogues and Oximes Toxicology in Vitro : an International Journal Published in Association with BIBRA. Dec, 2015 | Pubmed ID: 26368669 Elimination Kinetics and Molecular Reaction Mechanisms of Cyclosarin (GF) by an Oxime Substituted β-cyclodextrin Derivative in Vitro Toxicology Letters. Nov, 2015 | Pubmed ID: 26272752 Impairment of Hypoxia-induced HIF-1α Signaling in Keratinocytes and Fibroblasts by Sulfur Mustard is Counteracted by a Selective PHD-2 Inhibitor Archives of Toxicology. Jun, 2015 | Pubmed ID: 26082309 Reversed-phase Ion-pair Chromatography-diode Array Detection of the Bispyridinium Compound MB327: Plasma Analysis of a Potential Novel Antidote for the Treatment of Organophosphorus Poisoning Drug Testing and Analysis. Jun, 2015 | Pubmed ID: 26041012 Small-scale Purification of Butyrylcholinesterase from Human Plasma and Implementation of a μLC-UV/ESI MS/MS Method to Detect Its Organophosphorus Adducts Drug Testing and Analysis. Mar, 2015 | Pubmed ID: 25828536 Evidence of Sulfur Mustard Exposure in Human Plasma by LC-ESI-MS-MS Detection of the Albumin-Derived Alkylated HETE-CP Dipeptide and Chromatographic Investigation of Its Cis/Trans Isomerism Journal of Analytical Toxicology. May, 2015 | Pubmed ID: 25712440 Effect of Reversible Ligands on Oxime-induced Reactivation of Sarin- and Cyclosarin-inhibited Human Acetylcholinesterase Toxicology Letters. Feb, 2015 | Pubmed ID: 25522658 Adaptation of a Dynamic in Vitro Model with Real-time Determination of Butyrylcholinesterase Activity in the Presence of Cyclosarin and an Oxime Toxicology in Vitro : an International Journal Published in Association with BIBRA. Feb, 2015 | Pubmed ID: 25450746 In Vitro and in Vivo Toxicological Studies of V Nerve Agents: Molecular and Stereoselective Aspects Toxicology Letters. Jan, 2015 | Pubmed ID: 25448275 Reactivation Kinetics of 31 Structurally Different Bispyridinium Oximes with Organophosphate-inhibited Human Butyrylcholinesterase Archives of Toxicology. Mar, 2015 | Pubmed ID: 24912784 Activation of the Chemosensing Transient Receptor Potential Channel A1 (TRPA1) by Alkylating Agents Archives of Toxicology. Nov, 2014 | Pubmed ID: 25395009 Development of a Co-culture of Keratinocytes and Immune Cells for in Vitro Investigation of Cutaneous Sulfur Mustard Toxicity Chemico-biological Interactions. Sep, 2014 | Pubmed ID: 25256379 Reactions of Methylphosphonic Difluoride with Human Acetylcholinesterase and Oximes--Possible Therapeutic Implications Toxicology Letters. Nov, 2014 | Pubmed ID: 25240274 Post-exposure Treatment of VX Poisoned Guinea Pigs with the Engineered Phosphotriesterase Mutant C23: a Proof-of-concept Study Toxicology Letters. Nov, 2014 | Pubmed ID: 25195526 Spinal Cord--skeletal Muscle Cocultures Detect Muscle-relaxant Action of Botulinum Neurotoxin A ALTEX. 2014 | Pubmed ID: 25127438 Chlorambucil (nitrogen Mustard) Induced Impairment of Early Vascular Endothelial Cell Migration - Effects of α-linolenic Acid and N-acetylcysteine Chemico-biological Interactions. Aug, 2014 | Pubmed ID: 24892517 V-type Nerve Agents Phosphonylate Ubiquitin at Biologically Relevant Lysine Residues and Induce Intramolecular Cyclization by an Isopeptide Bond Analytical and Bioanalytical Chemistry. Aug, 2014 | Pubmed ID: 24652148 In Vitro Toxicokinetic Studies of Cyclosarin: Molecular Mechanisms of Elimination Toxicology Letters. May, 2014 | Pubmed ID: 24641973 Effectiveness of a Substituted β-cyclodextrin to Prevent Cyclosarin Toxicity in Vivo Toxicology Letters. Apr, 2014 | Pubmed ID: 24561299 Efficacy of the RePON1 Mutant IIG1 to Prevent Cyclosarin Toxicity in Vivo and to Detoxify Structurally Different Nerve Agents in Vitro Archives of Toxicology. Jun, 2014 | Pubmed ID: 24477626 Detoxification of Alkyl Methylphosphonofluoridates by an Oxime-substituted β-cyclodextrin--an in Vitro Structure-activity Study Toxicology Letters. Jan, 2014 | Pubmed ID: 24185128 In Vitro Kinetics of Nerve Agent Degradation by Fresh Frozen Plasma (FFP) Archives of Toxicology. Feb, 2014 | Pubmed ID: 24057572 Drug Development for the Management of Organophosphorus Poisoning Expert Opinion on Drug Discovery. Dec, 2013 | Pubmed ID: 24125474 Limitations and Challenges in Treatment of Acute Chemical Warfare Agent Poisoning Chemico-biological Interactions. Dec, 2013 | Pubmed ID: 24091052 Reactivation of Plasma Butyrylcholinesterase by Pralidoxime Chloride in Patients Poisoned by WHO Class II Toxicity Organophosphorus Insecticides Toxicological Sciences : an Official Journal of the Society of Toxicology. Dec, 2013 | Pubmed ID: 24052565 Functional Expression of the Transient Receptor Potential Channel TRPA1, a Sensor for Toxic Lung Inhalants, in Pulmonary Epithelial Cells Chemico-biological Interactions. Aug, 2013 | Pubmed ID: 23994502 Influence of Organophosphate Poisoning on Human Dendritic Cells Chemico-biological Interactions. Dec, 2013 | Pubmed ID: 23994500 Investigation of Kinetic Interactions Between Approved Oximes and Human Acetylcholinesterase Inhibited by Pesticide Carbamates Chemico-biological Interactions. Dec, 2013 | Pubmed ID: 23962483 Mesenchymal Stem Cells Are Highly Resistant to Sulfur Mustard Chemico-biological Interactions. Dec, 2013 | Pubmed ID: 23933411 Modified Immunoslotblot Assay to Detect Hemi and Sulfur Mustard DNA Adducts Chemico-biological Interactions. Dec, 2013 | Pubmed ID: 23933409 Fourteenth International Medical Chemical Defence Conference 2013 "Translation of Experimental Research for Improved Treatment of Chemical Warfare Agents" Chemico-biological Interactions. Dec, 2013 | Pubmed ID: 23920049 Elimination Pathways of Cyclosarin (GF) Mediated by β-cyclodextrin in Vitro: Pharmacokinetic and Toxicokinetic Aspects Toxicology Letters. Oct, 2013 | Pubmed ID: 23906718 Effects of Succinylcholine in an Organotypic Spinal Cord-skeletal Muscle Coculture of Embryonic Mice Chemico-biological Interactions. Dec, 2013 | Pubmed ID: 23838346 Sulfur Mustard Induced Nuclear Translocation of Glyceraldehyde-3-phosphate-dehydrogenase (GAPDH) Chemico-biological Interactions. Dec, 2013 | Pubmed ID: 23827652 Silibinin As a Potential Therapeutic for Sulfur Mustard Injuries Chemico-biological Interactions. Dec, 2013 | Pubmed ID: 23810508 Organophosphate Poisoning in the Developed World - a Single Centre Experience from Here to the Millennium Chemico-biological Interactions. Dec, 2013 | Pubmed ID: 23685200 Use of the Cultex® Radial Flow System As an in Vitro Exposure Method to Assess Acute Pulmonary Toxicity of Fine Dusts and Nanoparticles with Special Focus on the Intra- and Inter-laboratory Reproducibility Chemico-biological Interactions. Dec, 2013 | Pubmed ID: 23669118 The Value of Novel Oximes for Treatment of Poisoning by Organophosphorus Compounds Pharmacology & Therapeutics. Aug, 2013 | Pubmed ID: 23603539 New Modified β-cyclodextrin Derivatives As Detoxifying Agents of Chemical Warfare Agents (I). Synthesis and Preliminary Screening: Evaluation of the Detoxification Using a Half-quantitative Enzymatic Assay Toxicology Letters. Feb, 2013 | Pubmed ID: 23201439 New Modified β-cyclodextrin Derivatives As Detoxifying Agents of Chemical Warfare Agents (II). In Vitro Detoxification of Cyclosarin (GF): General Screening and Toxicokinetic Aspects of OP Scavengers Toxicology Letters. Feb, 2013 | Pubmed ID: 23201438 Structural Requirements for Effective Oximes--evaluation of Kinetic in Vitro Data with Phosphylated Human AChE and Structurally Different Oximes Chemico-biological Interactions. Mar, 2013 | Pubmed ID: 22827894 Detoxification of Tabun at Physiological PH Mediated by Substituted β-cyclodextrin and Glucose Derivatives Containing Oxime Groups Toxicology. Dec, 2012 | Pubmed ID: 22982866 Reactivation Kinetics of a Series of Related Bispyridinium Oximes with Organophosphate-inhibited Human Acetylcholinesterase--Structure-activity Relationships Biochemical Pharmacology. Jun, 2012 | Pubmed ID: 22649796 Kinetic Interactions of a Homologous Series of Bispyridinium Monooximes (HGG Oximes) with Native and Phosphonylated Human Acetylcholinesterase Toxicology Letters. Jul, 2012 | Pubmed ID: 22561105 Reactivation Kinetics of a Homologous Series of Bispyridinium Bis-oximes with Nerve Agent-inhibited Human Acetylcholinesterase Archives of Toxicology. Sep, 2012 | Pubmed ID: 22437842 A Role for Solvents in the Toxicity of Agricultural Organophosphorus Pesticides Toxicology. Apr, 2012 | Pubmed ID: 22365945 Comparative Kinetics of Organophosphates and Oximes with Erythrocyte, Muscle and Brain Acetylcholinesterase Toxicology Letters. Mar, 2012 | Pubmed ID: 22230262 In Vitro and in Vivo Efficacy of PEGylated Diisopropyl Fluorophosphatase (DFPase) Drug Testing and Analysis. Mar-Apr, 2012 | Pubmed ID: 22174192 Quantification of Pralidoxime (2-PAM) in Urine by Ion Pair Chromatography-diode Array Detection: Application to in Vivo Samples from Minipig Drug Testing and Analysis. Mar-Apr, 2012 | Pubmed ID: 22102522 Determination of Acetylcholinesterase Activity by the Ellman Assay: a Versatile Tool for in Vitro Research on Medical Countermeasures Against Organophosphate Poisoning Drug Testing and Analysis. Mar-Apr, 2012 | Pubmed ID: 21998030 Application of an Enantioselective LC-ESI MS/MS Procedure to Determine R- and S-hyoscyamine Following Intravenous Atropine Administration in Swine Drug Testing and Analysis. Mar-Apr, 2012 | Pubmed ID: 21964777 Evaluation of the Test-mate ChE (cholinesterase) Field Kit in Acute Organophosphorus Poisoning Annals of Emergency Medicine. Dec, 2011 | Pubmed ID: 22098995 Reactivation of Organophosphate-inhibited Human Acetylcholinesterase by Isonitrosoacetone (MINA): a Kinetic Analysis Chemico-biological Interactions. Nov, 2011 | Pubmed ID: 21930118 Simultaneous Quantification of VX and Its Toxic Metabolite in Blood and Plasma Samples and Its Application for in Vivo and in Vitro Toxicological Studies Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences. Sep, 2011 | Pubmed ID: 21862421 Atropine Maintenance Dosage in Patients with Severe Organophosphate Pesticide Poisoning Toxicology Letters. Sep, 2011 | Pubmed ID: 21771644 Anaesthetic Potency of Diazepam is Resistant to Cholinergic Overstimulation Toxicology Letters. Sep, 2011 | Pubmed ID: 21699965 Thirteenth International Medical Chemical Defence Conference 2011 "New Developments in the Treatment of Intoxications by Chemical Warfare Agents with Focus on Neurotoxic Agents" Toxicology Letters. Sep, 2011 | Pubmed ID: 21605643 Long-term Evaluation of Organophosphate Toxicity and Antidotal Therapy in Co-cultures of Spinal Cord and Muscle Tissue Toxicology Letters. Sep, 2011 | Pubmed ID: 21530620 Evaluation of Functional and Structural Alterations in Muscle Tissue After Short-term Cold Storage in a New Tissue Preservation Solution Cells, Tissues, Organs. 2011 | Pubmed ID: 21494014 Evaluation of 6,6'-dithionicotinic Acid As Alternative Chromogen in a Modified Ellman Method--comparison in Various Species Toxicology Mechanisms and Methods. Sep, 2011 | Pubmed ID: 21470076 In Vitro Kinetic Interactions of DEET, Pyridostigmine and Organophosphorus Pesticides with Human Cholinesterases Chemico-biological Interactions. Apr, 2011 | Pubmed ID: 21354413 In Vitro Detoxification of Cyclosarin (GF) by Modified Cyclodextrins Toxicology Letters. Jan, 2011 | Pubmed ID: 21035528 Kinetic Analysis of Interactions of Paraoxon and Oximes with Human, Rhesus Monkey, Swine, Rabbit, Rat and Guinea Pig Acetylcholinesterase Toxicology Letters. Jan, 2011 | Pubmed ID: 20971170 Kinetic Prerequisites of Oximes As Effective Reactivators of Organophosphate-inhibited Acetylcholinesterase: a Theoretical Approach Journal of Enzyme Inhibition and Medicinal Chemistry. Jun, 2011 | Pubmed ID: 20807085 High-performance Liquid-chromatographic Tandem-mass Spectrometric Methods for Atropinesterase-mediated Enantioselective and Chiral Determination of R- and S-hyoscyamine in Plasma Analytica Chimica Acta. Nov, 2010 | Pubmed ID: 20969988 Reactivation of Organophosphate-inhibited Human, Cynomolgus Monkey, Swine and Guinea Pig Acetylcholinesterase by MMB-4: a Modified Kinetic Approach Toxicology and Applied Pharmacology. Dec, 2010 | Pubmed ID: 20888357 Effect of N-acetyl Cysteine and Alpha-linolenic Acid on Sulfur Mustard Caused Impairment of in Vitro Endothelial Tube Formation Toxicological Sciences : an Official Journal of the Society of Toxicology. Dec, 2010 | Pubmed ID: 20833707 Matrix-assisted Laser Desorption/ionization Time-of-flight Mass Spectrometry (MALDI-TOF MS) for Detection and Identification of Albumin Phosphylation by Organophosphorus Pesticides and G- and V-type Nerve Agents Analytical and Bioanalytical Chemistry. Nov, 2010 | Pubmed ID: 20730528 Interactions Between Atropine and Etomidate in Cortical and Spinal Networks During Cholinergic Crisis Toxicology Letters. Oct, 2010 | Pubmed ID: 20696220 Pharmacokinetics of Obidoxime in Patients Poisoned with Organophosphorus Compounds Toxicology Letters. Sep, 2010 | Pubmed ID: 20542100 Kinetic Analysis of Interactions Between Alkylene-linked Bis-pyridiniumaldoximes and Human Acetylcholinesterases Inhibited by Various Organophosphorus Compounds Biochemical Pharmacology. Sep, 2010 | Pubmed ID: 20510679 Side-specific Effects by Cadmium Exposure: Apical and Basolateral Treatment in a Coculture Model of the Blood-air Barrier Toxicology and Applied Pharmacology. Jun, 2010 | Pubmed ID: 20399800 Bioanalysis of Organophosphorus Toxicants and Corresponding Antidotes Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences. May, 2010 | Pubmed ID: 20395180 Muscle Force and Acetylcholinesterase Activity in Mouse Hemidiaphragms Exposed to Paraoxon and Treated by Oximes in Vitro Toxicology. Jun, 2010 | Pubmed ID: 20385200 Comparative Study of Oxime-induced Reactivation of Erythrocyte and Muscle AChE from Different Animal Species Following Inhibition by Sarin or Paraoxon Toxicology Letters. May, 2010 | Pubmed ID: 20156534 Simultaneous Quantification of the Organophosphorus Pesticides Dimethoate and Omethoate in Porcine Plasma and Urine by LC-ESI-MS/MS and Flow-injection-ESI-MS/MS Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences. May, 2010 | Pubmed ID: 20106727 Kinetic Analysis of Interactions of Different Sarin and Tabun Analogues with Human Acetylcholinesterase and Oximes: is There a Structure-activity Relationship? Chemico-biological Interactions. Sep, 2010 | Pubmed ID: 20105433 GC-MS and LC-MS Analysis of Nerve Agents in Body Fluids: Intra-laboratory Verification Test Using Spiked Plasma and Urine Samples Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences. May, 2010 | Pubmed ID: 20061191 Assessment of Neuromuscular Dysfunction During Poisoning by Organophosphorus Compounds Chemico-biological Interactions. Sep, 2010 | Pubmed ID: 20036651 Atropine Increases Sevoflurane Potency in Cortical but Not Spinal Networks During Cholinergic Overstimulation Toxicology. Jan, 2010 | Pubmed ID: 20004696 The Toxicokinetics and Toxicodynamics of Organophosphonates Versus the Pharmacokinetics and Pharmacodynamics of Oxime Antidotes: Biological Consequences Basic & Clinical Pharmacology & Toxicology. Feb, 2010 | Pubmed ID: 19961476 Evaluation of Medical Countermeasures Against Organophosphorus Compounds: the Value of Experimental Data and Computer Simulations Chemico-biological Interactions. Sep, 2010 | Pubmed ID: 19917271 Paradox Findings May Challenge Orthodox Reasoning in Acute Organophosphate Poisoning Chemico-biological Interactions. Sep, 2010 | Pubmed ID: 19883634 LC-ESI MS/MS Quantification of Atropine and Six Other Antimuscarinic Tropane Alkaloids in Plasma Analytical and Bioanalytical Chemistry. Jan, 2010 | Pubmed ID: 19855962 Development and Validation of a Sensitive Gas Chromatography-ammonia Chemical Ionization Mass Spectrometry Method for the Determination of Tabun Enantiomers in Hemolysed Blood and Plasma of Different Species Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences. May, 2010 | Pubmed ID: 19766064 Monitoring of Neuromuscular Transmission in Organophosphate Pesticide-poisoned Patients Toxicology Letters. Dec, 2009 | Pubmed ID: 19793545 Obidoxime in Acute Organophosphate Poisoning: 2 - PK/PD Relationships Clinical Toxicology (Philadelphia, Pa.). Sep, 2009 | Pubmed ID: 19778190 Obidoxime in Acute Organophosphate Poisoning: 1 - Clinical Effectiveness Clinical Toxicology (Philadelphia, Pa.). Sep, 2009 | Pubmed ID: 19778163 Plasma Level of Atropine After Accidental Ingestion of Atropa Belladonna Clinical Toxicology (Philadelphia, Pa.). Jul, 2009 | Pubmed ID: 19586361 The Chronic Effects of Sulfur Mustard Exposure Toxicology. Sep, 2009 | Pubmed ID: 19486919 Extreme Variability in the Formation of Chlorpyrifos Oxon (CPO) in Patients Poisoned by Chlorpyrifos (CPF) Biochemical Pharmacology. Sep, 2009 | Pubmed ID: 19433070 Comparison of the Oxime-induced Reactivation of Rhesus Monkey, Swine and Guinea Pig Erythrocyte Acetylcholinesterase Following Inhibition by Sarin or Paraoxon, Using a Perfusion Model for the Real-time Determination of Membrane-bound Acetylcholinesterase Activity Toxicology. Apr, 2009 | Pubmed ID: 19428926 Clinical Picture of Sulfur Mustard Poisoning Toxicology. Sep, 2009 | Pubmed ID: 19386280 Structure-activity Analysis of Aging and Reactivation of Human Butyrylcholinesterase Inhibited by Analogues of Tabun The Biochemical Journal. Jul, 2009 | Pubmed ID: 19368529 Chromatographic Resolution, Characterisation and Quantification of VX Enantiomers in Hemolysed Swine Blood Samples Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences. Sep, 2008 | Pubmed ID: 18718824 Are We Using the Right Dose? - a Tale of Mole and Gram British Journal of Clinical Pharmacology. Oct, 2008 | Pubmed ID: 18662291 Sulfur Mustard Research--strategies for the Development of Improved Medical Therapy Eplasty. 2008 | Pubmed ID: 18615149 Inhibitory Potency Against Human Acetylcholinesterase and Enzymatic Hydrolysis of Fluorogenic Nerve Agent Mimics by Human Paraoxonase 1 and Squid Diisopropyl Fluorophosphatase Biochemistry. May, 2008 | Pubmed ID: 18396898 LC-MS-based Procedures for Monitoring of Toxic Organophosphorus Compounds and Verification of Pesticide and Nerve Agent Poisoning Analytical and Bioanalytical Chemistry. May, 2008 | Pubmed ID: 18330546 Identical Kinetics of Human Erythrocyte and Muscle Acetylcholinesterase with Respect to Carbamate Pre-treatment, Residual Activity Upon Soman Challenge and Spontaneous Reactivation After Withdrawal of the Inhibitors Toxicology. Apr, 2008 | Pubmed ID: 18304715 Comparison of the Oxime-induced Reactivation of Erythrocyte and Muscle Acetylcholinesterase Following Inhibition by Sarin or Paraoxon, Using a Perfusion Model for the Real-time Determination of Membrane-bound Acetylcholinesterase Activity Biochemical Pharmacology. Feb, 2008 | Pubmed ID: 17977518 Red Blood Cell Acetylcholinesterase and Plasma Butyrylcholinesterase Status: Important Indicators for the Treatment of Patients Poisoned by Organophosphorus Compounds Arhiv Za Higijenu Rada I Toksikologiju. Sep, 2007 | Pubmed ID: 17913691 Development and Application of Procedures for the Highly Sensitive Quantification of Cyclosarin Enantiomers in Hemolysed Swine Blood Samples Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences. Nov, 2007 | Pubmed ID: 17888747 Cholinergic Modulation of Sevoflurane Potency in Cortical and Spinal Networks in Vitro Anesthesiology. Jun, 2007 | Pubmed ID: 17525590 Kinetic Analysis of Reactivation and Aging of Human Acetylcholinesterase Inhibited by Different Phosphoramidates Biochemical Pharmacology. Jun, 2007 | Pubmed ID: 17382909 Lessons to Be Learnt from Organophosphorus Pesticide Poisoning for the Treatment of Nerve Agent Poisoning Toxicology. Apr, 2007 | Pubmed ID: 17161895 Anaesthesia in Patients Suffering from Organophosphorus Intoxication--interactions Between General Anaesthetics and Acetylcholine in Cortical Networks in Vitro Toxicology. Apr, 2007 | Pubmed ID: 17030394 Testing of Antidotes for Organophosphorus Compounds: Experimental Procedures and Clinical Reality Toxicology. Apr, 2007 | Pubmed ID: 17010492 Development of Antidotes: Problems and Strategies Toxicology. Apr, 2007 | Pubmed ID: 16949190 Simulation of Cholinesterase Status at Different Scenarios of Nerve Agent Exposure Toxicology. Apr, 2007 | Pubmed ID: 16904807 Estimation of Oxime Efficacy in Nerve Agent Poisoning: a Kinetic Approach Chemico-biological Interactions. Dec, 2005 | Pubmed ID: 16266695 Correlation Between Red Blood Cell Acetylcholinesterase Activity and Neuromuscular Transmission in Organophosphate Poisoning Chemico-biological Interactions. Dec, 2005 | Pubmed ID: 16263103 Diagnostic Aspects of Organophosphate Poisoning Toxicology. Oct, 2005 | Pubmed ID: 16051411 Effects of Oximes on Muscle Force and Acetylcholinesterase Activity in Isolated Mouse Hemidiaphragms Exposed to Paraoxon Toxicology. Oct, 2005 | Pubmed ID: 16040183 Evaluation of Oxime Efficacy in Nerve Agent Poisoning: Development of a Kinetic-based Dynamic Model Toxicology and Applied Pharmacology. Dec, 2005 | Pubmed ID: 15904945 Ketamine Reduces Cholinergic Modulated GABA Release from Rat Striatal Slices Toxicology Letters. Apr, 2005 | Pubmed ID: 15763635 Kinetic Analysis of Interactions Between Human Acetylcholinesterase, Structurally Different Organophosphorus Compounds and Oximes Biochemical Pharmacology. Dec, 2004 | Pubmed ID: 15498514 Human Parathion Poisoning. A Toxicokinetic Analysis Toxicological Reviews. 2003 | Pubmed ID: 15181664 The Effect of Acetylcholinesterase-inhibition on Depolarization-induced GABA Release from Rat Striatal Slices Toxicology. Mar, 2003 | Pubmed ID: 12499118 Bewertung der akuten Inhalationstoxizität von Luftpartikeln durch Aussetzen kultivierter menschlicher Lungenzellen an der Luft-Flüssig-Schnittstelle Amelie Tsoutsoulopoulos1, Katrin Gohlsch2, Niklas Möhle3, Andreas Breit2, Sebastian Hoffmann5, Olaf Krischenowski3,4, Harald Mückter2, Thomas Gudermann2, Horst Thiermann1, Michaela Aufderheide3,4, Dirk Steinritz1,2 1Bundeswehr Institute of Pharmacology and Toxicology, 2Walther Straub Institute of Pharmacology and Toxicology, University of Munich, 3Cultex Laboratories GmbH, 4Cultex Technologies GmbH (formerly Cultex Laboratories GmbH), 5seh consulting + services JoVE 60572 Medicine Bewertung der Endothelzellmigration nach der Exposition gegenüber toxischen Chemikalien Dirk Steinritz1,2, Annette Schmidt1,3, Frank Balszuweit1, Horst Thiermann1, Marwa Ibrahim3, Birgit Bölck3, Wilhelm Bloch3 1Bundeswehr Institute of Pharmacology and Toxicology, 2Walther Straub Institute of Pharmacology and Toxicology, Ludwig-Maximilians-Universität München, 3Department of Molecular and Cellular Sports Medicine, German Sports University Cologne Developmental Biology
Bewertung der akuten Inhalationstoxizität von Luftpartikeln durch Aussetzen kultivierter menschlicher Lungenzellen an der Luft-Flüssig-Schnittstelle Amelie Tsoutsoulopoulos1, Katrin Gohlsch2, Niklas Möhle3, Andreas Breit2, Sebastian Hoffmann5, Olaf Krischenowski3,4, Harald Mückter2, Thomas Gudermann2, Horst Thiermann1, Michaela Aufderheide3,4, Dirk Steinritz1,2 1Bundeswehr Institute of Pharmacology and Toxicology, 2Walther Straub Institute of Pharmacology and Toxicology, University of Munich, 3Cultex Laboratories GmbH, 4Cultex Technologies GmbH (formerly Cultex Laboratories GmbH), 5seh consulting + services JoVE 60572 Medicine
Bewertung der Endothelzellmigration nach der Exposition gegenüber toxischen Chemikalien Dirk Steinritz1,2, Annette Schmidt1,3, Frank Balszuweit1, Horst Thiermann1, Marwa Ibrahim3, Birgit Bölck3, Wilhelm Bloch3 1Bundeswehr Institute of Pharmacology and Toxicology, 2Walther Straub Institute of Pharmacology and Toxicology, Ludwig-Maximilians-Universität München, 3Department of Molecular and Cellular Sports Medicine, German Sports University Cologne Developmental Biology
