Howard Chen Department of Biomedical Engineering Washington University in St. Louis Biography Publications Institution JoVE Articles Howard Chen has not added a biography. If you are Howard Chen and would like to personalize this page please email our Author Liaison for assistance. Publications A Comparison of Instrumentation Methods to Estimate Thoracolumbar Motion in Field-based Occupational Studies Applied Ergonomics. May, 2015 | Pubmed ID: 25683549 Cytoprotective Nanoparticles by Conjugation of a Polyhis Tagged Annexin V to a Nanoparticle Drug Nanoscale. Jan, 2015 | Pubmed ID: 25572921 Visnagin Protects Against Doxorubicin-induced Cardiomyopathy Through Modulation of Mitochondrial Malate Dehydrogenase Science Translational Medicine. Dec, 2014 | Pubmed ID: 25504881 Direct Coupling of Annexin A5 to VSOP Yields Small, Protein-covered Nanoprobes for MR Imaging of Apoptosis Contrast Media & Molecular Imaging. Jul-Aug, 2014 | Pubmed ID: 24706613 Microstructural Impact of Ischemia and Bone Marrow-derived Cell Therapy Revealed with Diffusion Tensor Magnetic Resonance Imaging Tractography of the Heart in Vivo Circulation. Apr, 2014 | Pubmed ID: 24619466 Role of Extracellular RNA and TLR3-Trif Signaling in Myocardial Ischemia-reperfusion Injury Journal of the American Heart Association. 2014 | Pubmed ID: 24390148 Fluorescent and Radiolabeled Triphenylphosphonium Probes for Imaging Mitochondria Chemical Communications (Cambridge, England). Nov, 2013 | Pubmed ID: 24072060 Molecular Magnetic Resonance Imaging of Pulmonary Fibrosis in Mice American Journal of Respiratory Cell and Molecular Biology. Dec, 2013 | Pubmed ID: 23927643 Fluorescence Tomography of Rapamycin-induced Autophagy and Cardioprotection in Vivo Circulation. Cardiovascular Imaging. May, 2013 | Pubmed ID: 23537953 Characterization of Printable Cellular Micro-fluidic Channels for Tissue Engineering Biofabrication. Jun, 2013 | Pubmed ID: 23458889 Fluorochrome-functionalized Nanoparticles for Imaging DNA in Biological Systems ACS Nano. Mar, 2013 | Pubmed ID: 23373524 Adult Cardiac Progenitor Cell Aggregates Exhibit Survival Benefit Both in Vitro and in Vivo PloS One. 2012 | Pubmed ID: 23226295 Thrombotic Thrombocytopenic Purpura in Pediatric Patients Zhongguo Dang Dai Er Ke Za Zhi = Chinese Journal of Contemporary Pediatrics. Nov, 2012 | Pubmed ID: 23146723 Architecture De La Fibre Dans Le Myocarde Réagencé a Révélé Avec Un Cadre De Diffusion Quantitative CMR Tractography Et Validation Histologique Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance. Oct, 2012 | Pubmed ID: 23061749 Fluorochrome-functionalized Magnetic Nanoparticles for High-sensitivity Monitoring of the Polymerase Chain Reaction by Magnetic Resonance Angewandte Chemie (International Ed. in English). Jul, 2012 | Pubmed ID: 22684680 In Vivo Fluorescence Lifetime Detection of an Activatable Probe in Infarcted Myocardium Journal of Biomedical Optics. May, 2012 | Pubmed ID: 22612124 Theranostic Imaging of the Kinases and Proteases That Modulate Cell Death and Survival Theranostics. 2012 | Pubmed ID: 22400062 Comparison of Aneuploidies of Chromosomes 21, X, and Y in the Blood Lymphocytes and Sperm of Workers Exposed to Benzene Environmental and Molecular Mutagenesis. Apr, 2012 | Pubmed ID: 22351378 Protective Effect of the Apoptosis-sensing Nanoparticle AnxCLIO-Cy5.5 Nanomedicine : Nanotechnology, Biology, and Medicine. Apr, 2012 | Pubmed ID: 21704591 Molecular MRI of Acute Necrosis with a Novel DNA-binding Gadolinium Chelate: Kinetics of Cell Death and Clearance in Infarcted Myocardium Circulation. Cardiovascular Imaging. Nov, 2011 | Pubmed ID: 21836081 Myocardial Ischemia Activates an Injurious Innate Immune Signaling Via Cardiac Heat Shock Protein 60 and Toll-like Receptor 4 The Journal of Biological Chemistry. Sep, 2011 | Pubmed ID: 21775438 Discovery of a Piperazine Urea Based Compound As a Potent, Selective, Orally Bioavailable Melanocortin Subtype-4 Receptor Partial Agonist Bioorganic & Medicinal Chemistry Letters. Apr, 2011 | Pubmed ID: 21439820 Imaging of Apoptosis in the Heart with Nanoparticle Technology Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology. Jan-Feb, 2011 | Pubmed ID: 20945336 Discovery of Highly Potent and Efficacious MC4R Agonists with Spiroindane N-Me-1,2,4-triazole Privileged Structures for the Treatment of Obesity Bioorganic & Medicinal Chemistry Letters. Nov, 2010 | Pubmed ID: 20933410 Discovery of Potent, Selective, and Orally Bioavailable 3H-spiro[isobenzofuran-1,4'-piperidine] Based Melanocortin Subtype-4 Receptor Agonists Bioorganic & Medicinal Chemistry Letters. Aug, 2010 | Pubmed ID: 20621473 Spiroindane Based Amides As Potent and Selective MC4R Agonists for the Treatment of Obesity Bioorganic & Medicinal Chemistry Letters. Aug, 2010 | Pubmed ID: 20598882 Optimization of Privileged Structures for Selective and Potent Melanocortin Subtype-4 Receptor Ligands Bioorganic & Medicinal Chemistry Letters. Aug, 2010 | Pubmed ID: 20598533 Discovery of a Spiroindane Based Compound As a Potent, Selective, Orally Bioavailable Melanocortin Subtype-4 Receptor Agonist Bioorganic & Medicinal Chemistry Letters. Apr, 2010 | Pubmed ID: 20207541 Discovery of Substituted Biphenyl Imidazoles As Potent, Bioavailable Bombesin Receptor Subtype-3 Agonists Bioorganic & Medicinal Chemistry Letters. Mar, 2010 | Pubmed ID: 20167483 Regulation of Energy Homeostasis by Bombesin Receptor Subtype-3: Selective Receptor Agonists for the Treatment of Obesity Cell Metabolism. Feb, 2010 | Pubmed ID: 20096642 Therapeutic Potential of Histamine H3 Receptor Agonist for the Treatment of Obesity and Diabetes Mellitus Proceedings of the National Academy of Sciences of the United States of America. Sep, 2006 | Pubmed ID: 16954192 Mice Lacking Adiponectin Show Decreased Hepatic Insulin Sensitivity and Reduced Responsiveness to Peroxisome Proliferator-activated Receptor Gamma Agonists The Journal of Biological Chemistry. Feb, 2006 | Pubmed ID: 16326714 Sherrington Innervational Surgery in the Treatment of Chronic Sixth Nerve Paresis Binocular Vision & Strabismus Quarterly. 2005 | Pubmed ID: 16359278 Diet Induction of Monocyte Chemoattractant Protein-1 and Its Impact on Obesity Obesity Research. Aug, 2005 | Pubmed ID: 16129712 11beta-HSD1 Inhibition Ameliorates Metabolic Syndrome and Prevents Progression of Atherosclerosis in Mice The Journal of Experimental Medicine. Aug, 2005 | Pubmed ID: 16103409 Discovery and Activity of (1R,4S,6R)-N-[(1R)-2-[4-cyclohexyl-4-[[(1,1-dimethylethyl)amino]carbonyl]-1-piperidinyl]-1-[(4-fluorophenyl)methyl]-2-oxoethyl]-2-methyl-2-azabicyclo[2.2.2]octane-6-carboxamide (3, RY764), a Potent and Selective Melanocortin Subtype-4 Receptor Agonist Bioorganic & Medicinal Chemistry Letters. Aug, 2005 | Pubmed ID: 15982875 Effects of Melanocortin Receptor Activation and Blockade on Ethanol Intake: a Possible Role for the Melanocortin-4 Receptor Alcoholism, Clinical and Experimental Research. Jun, 2005 | Pubmed ID: 15976520 Somatostatin Receptor Subtype 5 Regulates Insulin Secretion and Glucose Homeostasis Molecular Endocrinology (Baltimore, Md.). Jan, 2003 | Pubmed ID: 12511609 The Role of Melanocortins in Body Weight Regulation: Opportunities for the Treatment of Obesity European Journal of Pharmacology. Aug, 2002 | Pubmed ID: 12176114 Neither Agouti-related Protein nor Neuropeptide Y is Critically Required for the Regulation of Energy Homeostasis in Mice Molecular and Cellular Biology. Jul, 2002 | Pubmed ID: 12077332 The Role of Melanocortins in Body Weight Regulation: Opportunities for the Treatment of Obesity European Journal of Pharmacology. Apr, 2002 | Pubmed ID: 12007532 Melanin-concentrating Hormone 1 Receptor-deficient Mice Are Lean, Hyperactive, and Hyperphagic and Have Altered Metabolism Proceedings of the National Academy of Sciences of the United States of America. Mar, 2002 | Pubmed ID: 11867747 Quantification de Global diastolique fonction de l'analyse basée sur la modélisation cinématique de transmitral débit via le formalisme de remplissage diastolique paramétrée Sina Mossahebi2,5, Simeng Zhu2,5, Howard Chen1,5, Leonid Shmuylovich3,5, Erina Ghosh1,5, Sándor J. Kovács4,5 1Department of Biomedical Engineering, Washington University in St. Louis, 2Department of Physics, Washington University in St. Louis, 3Division of Biology and Biomedical Sciences, Washington University in St. Louis, 4Department of Medicine, Cardiovascular Division, Washington University in St. Louis, 5Cardiovascular Biophysics Lab, Washington University in St. Louis JoVE 51471 Bioengineering
Quantification de Global diastolique fonction de l'analyse basée sur la modélisation cinématique de transmitral débit via le formalisme de remplissage diastolique paramétrée Sina Mossahebi2,5, Simeng Zhu2,5, Howard Chen1,5, Leonid Shmuylovich3,5, Erina Ghosh1,5, Sándor J. Kovács4,5 1Department of Biomedical Engineering, Washington University in St. Louis, 2Department of Physics, Washington University in St. Louis, 3Division of Biology and Biomedical Sciences, Washington University in St. Louis, 4Department of Medicine, Cardiovascular Division, Washington University in St. Louis, 5Cardiovascular Biophysics Lab, Washington University in St. Louis JoVE 51471 Bioengineering
