Hsing-Jien Kung UC Davis Cancer Center University of California, Davis Biography Publications Institution JoVE Articles Hsing-Jien Kung has not added a biography. If you are Hsing-Jien Kung and would like to personalize this page please email our Author Liaison for assistance. Publications KDM4A Coactivates E2F1 to Regulate the PDK-Dependent Metabolic Switch Between Mitochondrial Oxidation and Glycolysis Cell Reports. 09, 2016 | Pubmed ID: 27626669 Non-Coding RNAs in Castration-Resistant Prostate Cancer: Regulation of Androgen Receptor Signaling and Cancer Metabolism International Journal of Molecular Sciences. Dec, 2015 | Pubmed ID: 26690121 SUMO and KSHV Replication Cancers. Sep, 2014 | Pubmed ID: 25268162 Arginine Starvation-associated Atypical Cellular Death Involves Mitochondrial Dysfunction, Nuclear DNA Leakage, and Chromatin Autophagy Proceedings of the National Academy of Sciences of the United States of America. Sep, 2014 | Pubmed ID: 25122679 Oncomir MiR-125b Suppresses P14(ARF) to Modulate P53-Dependent and P53-Independent Apoptosis in Prostate Cancer PloS One. 2013 | Pubmed ID: 23585871 Kaposi's Sarcoma-Associated Herpesvirus (KSHV) Latency Associated Nuclear Antigen Regulates KSHV Epigenome by Association with Histone Demethylase, KDM3A Journal of Virology. Apr, 2013 | Pubmed ID: 23576503 Genotyping and Genomic Profiling of Non-small-cell Lung Cancer: Implications for Current and Future Therapies Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. Mar, 2013 | Pubmed ID: 23401433 Modeling Truncated AR Expression in a Natural Androgen Responsive Environment and Identification of RHOB As a Direct Transcriptional Target PloS One. 2012 | Pubmed ID: 23209612 Enhancing the Effectiveness of Androgen Deprivation in Prostate Cancer by Inducing Filamin A Nuclear Localization Endocrine-related Cancer. Dec, 2012 | Pubmed ID: 22993077 Directrices Para El Uso E Interpretación De Ensayos Para El Control De La Autofagia Autophagy. Apr, 2012 | Pubmed ID: 22966490 Molecular Characteristics of CTA056, a Novel Interleukin-2-inducible T-cell Kinase Inhibitor That Selectively Targets Malignant T Cells and Modulates Oncomirs Molecular Pharmacology. Nov, 2012 | Pubmed ID: 22899868 Histone Methyltransferase NSD2/MMSET Mediates Constitutive NF-κB Signaling for Cancer Cell Proliferation, Survival, and Tumor Growth Via a Feed-forward Loop Molecular and Cellular Biology. Aug, 2012 | Pubmed ID: 22645312 MicroRNA Let-7c is Downregulated in Prostate Cancer and Suppresses Prostate Cancer Growth PloS One. 2012 | Pubmed ID: 22479342 ASC-J9 Suppresses Castration-resistant Prostate Cancer Growth Through Degradation of Full-length and Splice Variant Androgen Receptors Neoplasia (New York, N.Y.). Jan, 2012 | Pubmed ID: 22355276 Protein Arginine Methyltransferase 1-directed Methylation of Kaposi Sarcoma-associated Herpesvirus Latency-associated Nuclear Antigen The Journal of Biological Chemistry. Feb, 2012 | Pubmed ID: 22179613 MicroRNA Dejó - 7C Suprime La Expresión Del Receptor Del Andrógeno Y Actividad a Través De La Regulación De La Expresión De Myc En Las Células De Cáncer De Próstata The Journal of Biological Chemistry. Jan, 2012 | Pubmed ID: 22128178 Simultaneous Targeting of Src Kinase and Receptor Tyrosine Kinase Results in Synergistic Inhibition of Renal Cell Carcinoma Proliferation and Migration International Journal of Cancer. Journal International Du Cancer. Jun, 2012 | Pubmed ID: 21792888 Statins and Prostate Cancer: Role of Cholesterol Inhibition Vs. Prevention of Small GTP-binding Proteins American Journal of Cancer Research. 2011 | Pubmed ID: 21984972 Ligand-independent Activation of the Arylhydrocarbon Receptor by ETK (Bmx) Tyrosine Kinase Helps MCF10AT1 Breast Cancer Cells to Survive in an Apoptosis-inducing Environment Biological Chemistry. Oct, 2011 | Pubmed ID: 21861773 Recombinante Origen Del Retrovirus XMRV Science (New York, N.Y.). Jul, 2011 | Pubmed ID: 21628392 Novel Flavonoids with Antiproliferative Activities Against Breast Cancer Cells Journal of Medicinal Chemistry. Jul, 2011 | Pubmed ID: 21599001 Targeting Tyrosine Kinases and Autophagy in Prostate Cancer Hormones & Cancer. Feb, 2011 | Pubmed ID: 21350583 Histone Demethylase JMJD2A Regulates Kaposi's Sarcoma-associated Herpesvirus Replication and is Targeted by a Viral Transcriptional Factor Journal of Virology. Apr, 2011 | Pubmed ID: 21228229 MiR-125b Promotes Growth of Prostate Cancer Xenograft Tumor Through Targeting Pro-apoptotic Genes The Prostate. Apr, 2011 | Pubmed ID: 20886540 Autophagy Blockade Sensitizes Prostate Cancer Cells Towards Src Family Kinase Inhibitors Genes & Cancer. Jan, 2010 | Pubmed ID: 20811583 Genome-wide Analysis of Androgen Receptor Binding and Gene Regulation in Two CWR22-derived Prostate Cancer Cell Lines Endocrine-related Cancer. Dec, 2010 | Pubmed ID: 20634343 Effect of the Specific Src Family Kinase Inhibitor Saracatinib on Osteolytic Lesions Using the PC-3 Bone Model Molecular Cancer Therapeutics. Jun, 2010 | Pubmed ID: 20484016 Multiplex Analysis of Src Family Kinase Signaling by Microbead Suspension Arrays Assay and Drug Development Technologies. Aug, 2010 | Pubmed ID: 20482378 KDM8, a H3K36me2 Histone Demethylase That Acts in the Cyclin A1 Coding Region to Regulate Cancer Cell Proliferation Proceedings of the National Academy of Sciences of the United States of America. May, 2010 | Pubmed ID: 20457893 Aberrant Activation of the Androgen Receptor by NF-kappaB2/p52 in Prostate Cancer Cells Cancer Research. Apr, 2010 | Pubmed ID: 20388792 Both Homo and Heterodimers of Marek's Disease Virus Encoded Meq Protein Contribute to Transformation of Lymphocytes in Chickens Virology. Apr, 2010 | Pubmed ID: 20137800 Microbead Arrays for the Analysis of ErbB Receptor Tyrosine Kinase Activation and Dimerization in Breast Cancer Cells Assay and Drug Development Technologies. Feb, 2010 | Pubmed ID: 20035613 Kaposi's Sarcoma-associated Herpesvirus (KSHV) Encodes a SUMO E3 Ligase That is SIM-dependent and SUMO-2/3-specific The Journal of Biological Chemistry. Feb, 2010 | Pubmed ID: 20034935 ERK Regulates Calpain 2-induced Androgen Receptor Proteolysis in CWR22 Relapsed Prostate Tumor Cell Lines The Journal of Biological Chemistry. Jan, 2010 | Pubmed ID: 19946123 Interleukin-6 Regulates Androgen Synthesis in Prostate Cancer Cells Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Aug, 2009 | Pubmed ID: 19638459 Kruppel-associated Box Domain-associated Protein-1 As a Latency Regulator for Kaposi's Sarcoma-associated Herpesvirus and Its Modulation by the Viral Protein Kinase Cancer Research. Jul, 2009 | Pubmed ID: 19584288 Androgen-induced Coactivator ANCCA Mediates Specific Androgen Receptor Signaling in Prostate Cancer Cancer Research. Apr, 2009 | Pubmed ID: 19318566 ADI, Autophagy and Apoptosis: Metabolic Stress As a Therapeutic Option for Prostate Cancer Autophagy. May, 2009 | Pubmed ID: 19276647 A Comprehensive Analysis of Recruitment and Transactivation Potential of K-Rta and K-bZIP During Reactivation of Kaposi's Sarcoma-associated Herpesvirus Virology. Apr, 2009 | Pubmed ID: 19269659 NF-kappaB Serves As a Cellular Sensor of Kaposi's Sarcoma-associated Herpesvirus Latency and Negatively Regulates K-Rta by Antagonizing the RBP-Jkappa Coactivator Journal of Virology. May, 2009 | Pubmed ID: 19244329 A Novel Androgen Receptor Splice Variant is Up-regulated During Prostate Cancer Progression and Promotes Androgen Depletion-resistant Growth Cancer Research. Mar, 2009 | Pubmed ID: 19244107 The Src Inhibitor AZD0530 Blocks Invasion and May Act As a Radiosensitizer in Lung Cancer Cells Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer. Apr, 2009 | Pubmed ID: 19240653 In Vitro Characterization of the Meq Proteins of Marek's Disease Virus Vaccine Strain CVI988 Virus Research. Jun, 2009 | Pubmed ID: 19189855 Arginine Deiminase Como Una Nueva Terapia Para El Cáncer De Próstata Induce La Autofagia Y Apoptosis Caspasa-independiente Cancer Research. Jan, 2009 | Pubmed ID: 19147587 Aberrant Activation of Androgen Receptor in a New Neuropeptide-autocrine Model of Androgen-insensitive Prostate Cancer Cancer Research. Jan, 2009 | Pubmed ID: 19117998 Oncogenic Activation of Androgen Receptor Urologic Oncology. Jan-Feb, 2009 | Pubmed ID: 19111798 Homodimerization of Marek's Disease Virus-encoded Meq Protein is Not Sufficient for Transformation of Lymphocytes in Chickens Journal of Virology. Jan, 2009 | Pubmed ID: 18971275 RNA Editing of Androgen Receptor Gene Transcripts in Prostate Cancer Cells The Journal of Biological Chemistry. Oct, 2008 | Pubmed ID: 18708348 Pancreatic Cancer Cell Lines Deficient in Argininosuccinate Synthetase Are Sensitive to Arginine Deprivation by Arginine Deiminase International Journal of Cancer. Journal International Du Cancer. Oct, 2008 | Pubmed ID: 18661517 Impairment of the DNA Repair and Growth Arrest Pathways by P53R2 Silencing Enhances DNA Damage-induced Apoptosis in a P53-dependent Manner in Prostate Cancer Cells Molecular Cancer Research : MCR. May, 2008 | Pubmed ID: 18505925 Regulation of Id1 Expression by SRC: Implications for Targeting of the Bone Morphogenetic Protein Pathway in Cancer Cancer Research. Apr, 2008 | Pubmed ID: 18381431 Recombinant Marek's Disease Virus (MDV) Lacking the Meq Oncogene Confers Protection Against Challenge with a Very Virulent Plus Strain of MDV Vaccine. Mar, 2008 | Pubmed ID: 18313812 An Androgen-regulated MiRNA Suppresses Bak1 Expression and Induces Androgen-independent Growth of Prostate Cancer Cells Proceedings of the National Academy of Sciences of the United States of America. Dec, 2007 | Pubmed ID: 18056640 BCL-2 Functions As an Activator of the AKT Signaling Pathway in Pancreatic Cancer Journal of Cellular Biochemistry. Dec, 2007 | Pubmed ID: 17960583 Evidence for Calpain-mediated Androgen Receptor Cleavage As a Mechanism for Androgen Independence Cancer Research. Oct, 2007 | Pubmed ID: 17909000 Nonreceptor Tyrosine Kinases in Prostate Cancer Neoplasia (New York, N.Y.). Feb, 2007 | Pubmed ID: 17357254 Heptad Repeats Regulate Protein Phosphatase 2a Recruitment to I-kappaB Kinase Gamma/NF-kappaB Essential Modulator and Are Targeted by Human T-lymphotropic Virus Type 1 Tax The Journal of Biological Chemistry. Apr, 2007 | Pubmed ID: 17314097 The Oncogenic Potential of a Prostate Cancer-derived Androgen Receptor Mutant The Prostate. May, 2007 | Pubmed ID: 17262801 Proline-, Glutamic Acid-, and Leucine-rich Protein-1/modulator of Nongenomic Activity of Estrogen Receptor Enhances Androgen Receptor Functions Through LIM-only Coactivator, Four-and-a-half LIM-only Protein 2 Molecular Endocrinology (Baltimore, Md.). Mar, 2007 | Pubmed ID: 17192406 Kaposi's Sarcoma-associated Herpesvirus-encoded Protein Kinase and Its Interaction with K-bZIP Journal of Virology. Feb, 2007 | Pubmed ID: 17108053 Inappropriate Activation of the Androgen Receptor by Nonsteroids: Involvement of the Src Kinase Pathway and Its Therapeutic Implications Cancer Research. Nov, 2006 | Pubmed ID: 17079466 Male Germ Cell-associated Kinase, a Male-specific Kinase Regulated by Androgen, is a Coactivator of Androgen Receptor in Prostate Cancer Cells Cancer Research. Sep, 2006 | Pubmed ID: 16951154 ACTR/AIB1/SRC-3 and Androgen Receptor Control Prostate Cancer Cell Proliferation and Tumor Growth Through Direct Control of Cell Cycle Genes The Prostate. Oct, 2006 | Pubmed ID: 16921507 Tyrosine Kinase Etk/BMX is Up-regulated in Human Prostate Cancer and Its Overexpression Induces Prostate Intraepithelial Neoplasia in Mouse Cancer Research. Aug, 2006 | Pubmed ID: 16912182 Multiplex Analysis of Intracellular Signaling Pathways in Lymphoid Cells by Microbead Suspension Arrays Molecular & Cellular Proteomics : MCP. Apr, 2006 | Pubmed ID: 16369048 Virus De La Enfermedad De Marek Meq Transforma Células De Pollo Mediante La Cascada Transcripcional V-Jun: Una Convergentes Transformar Vía Oncovirus Aviar Proceedings of the National Academy of Sciences of the United States of America. Oct, 2005 | Pubmed ID: 16203997 Profiling of Gene Expression Changes Caused by P53 Gain-of-function Mutant Alleles in Prostate Cancer Cells The Prostate. Dec, 2005 | Pubmed ID: 16037992 Kaposi's Sarcoma-associated Herpesvirus K-bZIP Represses Gene Transcription Via SUMO Modification Journal of Virology. Aug, 2005 | Pubmed ID: 16014952 C-Jun Controls the Efficiency of MAP Kinase Signaling by Transcriptional Repression of MAP Kinase Phosphatases Experimental Cell Research. Aug, 2005 | Pubmed ID: 15950217 VLIP, a Viral Lipase Homologue, is a Virulence Factor of Marek's Disease Virus Journal of Virology. Jun, 2005 | Pubmed ID: 15890938 Ku is a Novel Transcriptional Recycling Coactivator of the Androgen Receptor in Prostate Cancer Cells The Journal of Biological Chemistry. Mar, 2005 | Pubmed ID: 15640154 Negative Modulation of Androgen Receptor Transcriptional Activity by Daxx Molecular and Cellular Biology. Dec, 2004 | Pubmed ID: 15572661 Signal Pathways in Up-regulation of Chemokines by Tyrosine Kinase MER/NYK in Prostate Cancer Cells Cancer Research. Oct, 2004 | Pubmed ID: 15492251 Bi-directional Regulation Between Tyrosine Kinase Etk/BMX and Tumor Suppressor P53 in Response to DNA Damage The Journal of Biological Chemistry. Nov, 2004 | Pubmed ID: 15355990 Cocoa Procyanidins Inhibit Proliferation and Angiogenic Signals in Human Dermal Microvascular Endothelial Cells Following Stimulation by Low-level H2O2 Experimental Biology and Medicine (Maywood, N.J.). Sep, 2004 | Pubmed ID: 15337830 Marek's Disease Virus-encoded Meq Gene is Involved in Transformation of Lymphocytes but is Dispensable for Replication Proceedings of the National Academy of Sciences of the United States of America. Aug, 2004 | Pubmed ID: 15289599 ORF36 Protein Kinase of Kaposi's Sarcoma Herpesvirus Activates the C-Jun N-terminal Kinase Signaling Pathway The Journal of Biological Chemistry. Sep, 2004 | Pubmed ID: 15247271 Molecular Alterations Associated with LNCaP Cell Progression to Androgen Independence The Prostate. Aug, 2004 | Pubmed ID: 15176055 Marek's Disease Virus-encoded VIL-8 Gene is Involved in Early Cytolytic Infection but Dispensable for Establishment of Latency Journal of Virology. May, 2004 | Pubmed ID: 15078957 Pentameric Procyanidins Isolated from Theobroma Cacao Seeds Selectively Downregulate ErbB2 in Human Aortic Endothelial Cells Experimental Biology and Medicine (Maywood, N.J.). Mar, 2004 | Pubmed ID: 14988518 Interleukin-8 Confers Androgen-independent Growth and Migration of LNCaP: Differential Effects of Tyrosine Kinases Src and FAK Oncogene. Mar, 2004 | Pubmed ID: 14767470 El Inhibidor De La Cinasa Tyr AG879, Que Bloquea La Interacción ETK-PAK1, Suprime La Activación Inducida Por RAS PAK1 Y Transformación Maligna Cancer Biology & Therapy. Jan, 2004 | Pubmed ID: 14726663 The Role of Tyrosine Kinase Etk/Bmx in EGF-induced Apoptosis of MDA-MB-468 Breast Cancer Cells Oncogene. Mar, 2004 | Pubmed ID: 14676838 Characterization of the Chromosomal Binding Sites and Dimerization Partners of the Viral Oncoprotein Meq in Marek's Disease Virus-transformed T Cells Journal of Virology. Dec, 2003 | Pubmed ID: 14610205 Poly(ADP-ribose) Polymerase 1 and Ste20-like Kinase HKFC Act As Transcriptional Repressors for Gamma-2 Herpesvirus Lytic Replication Molecular and Cellular Biology. Nov, 2003 | Pubmed ID: 14585985 Comparative Studies of a New Subfamily of Human Ste20-like Kinases: Homodimerization, Subcellular Localization, and Selective Activation of MKK3 and P38 Oncogene. Sep, 2003 | Pubmed ID: 13679851 Cell Cycle Regulation by Kaposi's Sarcoma-associated Herpesvirus K-bZIP: Direct Interaction with Cyclin-CDK2 and Induction of G1 Growth Arrest Journal of Virology. Sep, 2003 | Pubmed ID: 12915577 K-bZIP of Kaposi's Sarcoma-associated Herpesvirus/human Herpesvirus 8 (KSHV/HHV-8) Binds KSHV/HHV-8 Rta and Represses Rta-mediated Transactivation Journal of Virology. Mar, 2003 | Pubmed ID: 12610155 Androgen-induced Recruitment of RNA Polymerase II to a Nuclear Receptor-p160 Coactivator Complex Proceedings of the National Academy of Sciences of the United States of America. Mar, 2003 | Pubmed ID: 12589022 Kaposi's Sarcoma-associated Herpesvirus K-bZIP is a Coregulator of K-Rta: Physical Association and Promoter-dependent Transcriptional Repression Journal of Virology. Jan, 2003 | Pubmed ID: 12502859 Elevated Expression of Tyrosine Kinase DDR2 in Primary Biliary Cirrhosis Autoimmunity. Dec, 2002 | Pubmed ID: 12765478 Lung Tumorigenesis Associated with Erb-B-2 and Erb-B-3 Overexpression in Human Erb-B-3 Transgenic Mice is Enhanced by Methylnitrosourea Oncogene. Dec, 2002 | Pubmed ID: 12483526 Characterization of a Novel Androgen Receptor Mutation in a Relapsed CWR22 Prostate Cancer Xenograft and Cell Line Cancer Research. Nov, 2002 | Pubmed ID: 12438256 Elevated C-met in Thymic Dendritic Cells of New Zealand Black Mice Developmental Immunology. Mar, 2002 | Pubmed ID: 12353660 Identification of the BZIP and Rta Homologues in the Genome of Rhesus Monkey Rhadinovirus Virology. Jul, 2002 | Pubmed ID: 12127781 Caspase Activation of Mammalian Sterile 20-like Kinase 3 (Mst3). Nuclear Translocation and Induction of Apoptosis The Journal of Biological Chemistry. Sep, 2002 | Pubmed ID: 12107159 Identification of Human Male Germ Cell-associated Kinase, a Kinase Transcriptionally Activated by Androgen in Prostate Cancer Cells The Journal of Biological Chemistry. Sep, 2002 | Pubmed ID: 12084720 Functional Analysis of 44 Mutant Androgen Receptors from Human Prostate Cancer Cancer Research. Mar, 2002 | Pubmed ID: 11888926 Expression Profile of Tyrosine Kinases in Breast Cancer Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Feb, 2002 | Pubmed ID: 11839650 In Vitro Ensayo de la sumoilación estudiar SUMO E3 ligasa actividad Wan-Shan Yang1, Mel Campbell2, Hsing-Jien Kung2,3,4,5, Pei-Ching Chang1,6 1Institute of Microbiology and Immunology, National Yang-Ming University, 2UC Davis Cancer Center, University of California, Davis, 3Department of Biochemistry and Molecular Medicine, University of California, Davis, 4Institute for Translational Medicine, College of Medical Science and Technology, Taipei Medical University, 5Division of Molecular and Genomic Medicine, National Health Research Institutes, 6Center for Infectious Disease and Cancer Research, Kaohsiung Medical University JoVE 56629 Biology Análisis cuantitativo de la autofagia mediante microscopía de fluorescencia avanzada 3D Chun A. Changou1,2, Deanna L. Wolfson2, Balpreet Singh Ahluwalia2,3, Richard J. Bold4,5, Hsing-Jien Kung5,6, Frank Y.S. Chuang1,2,5 1Department of Biochemistry and Molecular Medicine, University of California, Davis, 2NSF Center for Biophotonics Science & Technology, University of California, Davis, 3University of Tromsø, 4Department of Surgery (Division of Surgical Oncology), University of California, Davis, 5UC Davis Comprehensive Cancer Center, University of California, Davis, 6Department of Biological Chemistry, University of California, Davis JoVE 50047 Biology
In Vitro Ensayo de la sumoilación estudiar SUMO E3 ligasa actividad Wan-Shan Yang1, Mel Campbell2, Hsing-Jien Kung2,3,4,5, Pei-Ching Chang1,6 1Institute of Microbiology and Immunology, National Yang-Ming University, 2UC Davis Cancer Center, University of California, Davis, 3Department of Biochemistry and Molecular Medicine, University of California, Davis, 4Institute for Translational Medicine, College of Medical Science and Technology, Taipei Medical University, 5Division of Molecular and Genomic Medicine, National Health Research Institutes, 6Center for Infectious Disease and Cancer Research, Kaohsiung Medical University JoVE 56629 Biology
Análisis cuantitativo de la autofagia mediante microscopía de fluorescencia avanzada 3D Chun A. Changou1,2, Deanna L. Wolfson2, Balpreet Singh Ahluwalia2,3, Richard J. Bold4,5, Hsing-Jien Kung5,6, Frank Y.S. Chuang1,2,5 1Department of Biochemistry and Molecular Medicine, University of California, Davis, 2NSF Center for Biophotonics Science & Technology, University of California, Davis, 3University of Tromsø, 4Department of Surgery (Division of Surgical Oncology), University of California, Davis, 5UC Davis Comprehensive Cancer Center, University of California, Davis, 6Department of Biological Chemistry, University of California, Davis JoVE 50047 Biology
