Hui Feng Departments of Pharmacology and Medicine Boston University School of Medicine Biography Publications Institution JoVE Articles Hui FengAssociate Professor Trained as a physician and cancer biologist, Dr. Feng has applied the zebrafish as a model to study MYC-driven cancers over seventeen years. Her laboratory at Boston University (www.bu.edu/zgct) utilizes multiple zebrafish models of cancer to gain mechanistic insights into MYC-mediated oncogenic pathways and identify novel therapeutic targets for MYC-driven cancers. Publications Cross Organelle Stress Response Disruption Promotes Gentamicin-induced Proteotoxicity Cell Death & Disease. Apr, 2020 | Pubmed ID: 32245975 Direct Phosphorylation and Stabilization of MYC by Aurora B Kinase Promote T-cell Leukemogenesis Cancer Cell. Feb, 2020 | Pubmed ID: 32049046 Targeting RICTOR Sensitizes SMAD4-Negative Colon Cancer to Irinotecan Molecular Cancer Research : MCR. 03, 2020 | Pubmed ID: 31932471 Glutamine Anabolism Plays a Critical Role in Pancreatic Cancer by Coupling Carbon and Nitrogen Metabolism Cell Reports. Oct, 2019 | Pubmed ID: 31665640 Promoter Demethylation of the Asparagine Synthetase Gene is Required for ATF4-dependent Adaptation to Asparagine Depletion The Journal of Biological Chemistry. Dec, 2019 | Pubmed ID: 31659118 Ultrabright Fluorescent Cellulose Acetate Nanoparticles for Imaging Tumors Through Systemic and Topical Applications Materials Today (Kidlington, England). Mar, 2019 | Pubmed ID: 31057328 Data on Ultrabright Fluorescent Cellulose Acetate Nanoparticles for Imaging Tumors Through Systemic and Topical Applications Data in Brief. Feb, 2019 | Pubmed ID: 30596135 SHQ1 Regulation of RNA Splicing is Required for T-lymphoblastic Leukemia Cell Survival Nature Communications. 10, 2018 | Pubmed ID: 30323192 Functional and Genomic Analyses Reveal Therapeutic Potential of Targeting β-catenin/CBP Activity in Head and Neck Cancer Genome Medicine. 07, 2018 | Pubmed ID: 30029671 UFD1 Contributes to MYC-mediated Leukemia Aggressiveness Through Suppression of the Proapoptotic Unfolded Protein Response Leukemia. 11, 2018 | Pubmed ID: 29743725 Towards Resolving the Pro- and Anti-Tumor Effects of the Aryl Hydrocarbon Receptor International Journal of Molecular Sciences. May, 2018 | Pubmed ID: 29735912 The Emerging Role and Targetability of the TCA Cycle in Cancer Metabolism Protein & Cell. 02, 2018 | Pubmed ID: 28748451 Zebrafish B Cell Development Without a Pre-B Cell Stage, Revealed by CD79 Fluorescence Reporter Transgenes Journal of Immunology (Baltimore, Md. : 1950). 09, 2017 | Pubmed ID: 28739882 Aberrant Activation of the GIMAP Enhancer by Oncogenic Transcription Factors in T-cell Acute Lymphoblastic Leukemia Leukemia. 08, 2017 | Pubmed ID: 28028313 CK2 Inhibitor CX-4945 Destabilizes NOTCH1 and Synergizes with JQ1 Against Human T-acute Lymphoblastic Leukemic Cells Haematologica. 01, 2017 | Pubmed ID: 27758824 Zebrafish Models of Human Leukemia: Technological Advances and Mechanistic Insights Advances in Experimental Medicine and Biology. Month, 2016 | Pubmed ID: 27165361 Efficient Transgenesis Mediated by Pigmentation Rescue in Zebrafish BioTechniques. Jan, 2016 | Pubmed ID: 26757807 Hypoxia-induced Expression of Phosducin-like 3 Regulates Expression of VEGFR-2 and Promotes Angiogenesis Angiogenesis. Oct, 2015 | Pubmed ID: 26059764 The C-Cbl Ubiquitin Ligase Regulates Nuclear β-catenin and Angiogenesis by Its Tyrosine Phosphorylation Mediated Through the Wnt Signaling Pathway The Journal of Biological Chemistry. May, 2015 | Pubmed ID: 25784557 Loss of Function Tp53 Mutations Do Not Accelerate the Onset of Myc-induced T-cell Acute Lymphoblastic Leukaemia in the Zebrafish British Journal of Haematology. Jul, 2014 | Pubmed ID: 24690081 BCL2-specific Inhibitor ABT-199 Synergizes Strongly with Cytarabine Against the Early Immature LOUCY Cell Line but Not More-differentiated T-ALL Cell Lines Leukemia. May, 2014 | Pubmed ID: 24342948 In Vivo Targeting di cellule tumorali umane Xenografted con nanoparticelle di silice fluorescenti funzionalizzate nel pesce zebra Xiaodan Qin*1, Fabrice F. J. Laroche*1, Saquib Ahmed M. A. Peerzade2, Andrew Lam1, Igor Sokolov2,3,4, Hui Feng1 1Departments of Pharmacology and Medicine, Section of Hematology and Medical Oncology, The Cancer Research Center, Boston University School of Medicine, 2Department of Biomedical Engineering, Tufts University, 3Department of Mechanical Engineering, Tufts University, 4Department of Physics, Tufts University JoVE 61187 Cancer Research
In Vivo Targeting di cellule tumorali umane Xenografted con nanoparticelle di silice fluorescenti funzionalizzate nel pesce zebra Xiaodan Qin*1, Fabrice F. J. Laroche*1, Saquib Ahmed M. A. Peerzade2, Andrew Lam1, Igor Sokolov2,3,4, Hui Feng1 1Departments of Pharmacology and Medicine, Section of Hematology and Medical Oncology, The Cancer Research Center, Boston University School of Medicine, 2Department of Biomedical Engineering, Tufts University, 3Department of Mechanical Engineering, Tufts University, 4Department of Physics, Tufts University JoVE 61187 Cancer Research
