Ian Parker Biography Publications JoVE Articles Ian Parker has not added a biography. If you are Ian Parker and would like to personalize this page please email our Author Liaison for assistance. Publications Imaging Regulatory T Cell Dynamics and CTLA4-mediated Suppression of T Cell Priming Nature Communications. 2015 | Pubmed ID: 25653051 Molecular Biophysics of Orai Store-Operated Ca(2+) Channels Biophysical Journal. Jan, 2015 | Pubmed ID: 25606672 Modulation of Elementary Calcium Release Mediates a Transition from Puffs to Waves in an IP3R Cluster Model PLoS Computational Biology. Jan, 2015 | Pubmed ID: 25569772 Fluorescence Microscopy Cold Spring Harbor Protocols. Oct, 2014 | Pubmed ID: 25275114 Single-molecule Tracking of Inositol Trisphosphate Receptors Reveals Different Motilities and Distributions Biophysical Journal. Aug, 2014 | Pubmed ID: 25140418 An Algorithm for Automated Detection, Localization and Measurement of Local Calcium Signals from Camera-based Imaging Cell Calcium. Sep, 2014 | Pubmed ID: 25047761 Termination of Calcium Puffs and Coupled Closings of Inositol Trisphosphate Receptor Channels Cell Calcium. Sep, 2014 | Pubmed ID: 25016315 Two-photon Imaging of Remyelination of Spinal Cord Axons by Engrafted Neural Precursor Cells in a Viral Model of Multiple Sclerosis Proceedings of the National Academy of Sciences of the United States of America. Jun, 2014 | Pubmed ID: 24843159 Factors Determining the Recruitment of Inositol Trisphosphate Receptor Channels During Calcium Puffs Biophysical Journal. Dec, 2013 | Pubmed ID: 24314078 Three Phases of CD8 T Cell Response in the Lung Following H1N1 Influenza Infection and Sphingosine 1 Phosphate Agonist Therapy PloS One. 2013 | Pubmed ID: 23533579 Orai1 Function is Essential for T Cell Homing to Lymph Nodes Journal of Immunology (Baltimore, Md. : 1950). Apr, 2013 | Pubmed ID: 23455504 Cytotoxicity of Intracellular Aβ42 Amyloid Oligomers Involves Ca2+ Release from the Endoplasmic Reticulum by Stimulated Production of Inositol Trisphosphate The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Feb, 2013 | Pubmed ID: 23447594 Temperature Dependence of IP3-mediated Local and Global Ca2+ Signals Biophysical Journal. Jan, 2013 | Pubmed ID: 23442860 Structural and Functional Similarities of Calcium Homeostasis Modulator 1 (CALHM1) Ion Channel with Connexins, Pannexins, and Innexins The Journal of Biological Chemistry. Mar, 2013 | Pubmed ID: 23300080 Cytosolic [Ca2+] Regulation of InsP3-evoked Puffs The Biochemical Journal. Jan, 2013 | Pubmed ID: 23035871 The Probability of Triggering Calcium Puffs is Linearly Related to the Number of Inositol Trisphosphate Receptors in a Cluster Biophysical Journal. Apr, 2012 | Pubmed ID: 22768938 Multi-scale Data-driven Modeling and Observation of Calcium Puffs Cell Calcium. Aug, 2012 | Pubmed ID: 22682010 Toll-like Receptor 4-activated B Cells Out-compete Toll-like Receptor 9-activated B Cells to Establish Peripheral Immunological Tolerance Proceedings of the National Academy of Sciences of the United States of America. May, 2012 | Pubmed ID: 22511718 Timescales of IP(3)-Evoked Ca(2+) Spikes Emerge from Ca(2+) Puffs Only at the Cellular Level Biophysical Journal. Dec, 2011 | Pubmed ID: 22261051 Single-channel Ca(2+) Imaging Implicates Aβ1-42 Amyloid Pores in Alzheimer's Disease Pathology The Journal of Cell Biology. Oct, 2011 | Pubmed ID: 22024165 Subunit Stoichiometry of Human Orai1 and Orai3 Channels in Closed and Open States Proceedings of the National Academy of Sciences of the United States of America. Oct, 2011 | Pubmed ID: 21987805 Discursive Social Psychology Now The British Journal of Social Psychology / the British Psychological Society. Jul, 2011 | Pubmed ID: 21790666 Enhanced ER Ca2+ Store Filling by Overexpression of SERCA2b Promotes IP3-evoked Puffs Cell Calcium. Jul, 2011 | Pubmed ID: 21616533 Active Generation and Propagation of Ca2+ Signals Within Tunneling Membrane Nanotubes Biophysical Journal. Apr, 2011 | Pubmed ID: 21504718 Immunoimaging: Studying Immune System Dynamics Using Two-photon Microscopy Cold Spring Harbor Protocols. Jan, 2011 | Pubmed ID: 21285279 In Vivo Lymph Node Imaging Cold Spring Harbor Protocols. Jan, 2011 | Pubmed ID: 21285268 In Situ Lymph Node Imaging Cold Spring Harbor Protocols. Jan, 2011 | Pubmed ID: 21285267 Induction of an Immune Response for Imaging Antigen-presenting Cell/T-cell Interactions Cold Spring Harbor Protocols. Jan, 2011 | Pubmed ID: 21285266 General Approach to Adoptive Transfer and Cell Labeling for Immunoimaging Cold Spring Harbor Protocols. Jan, 2011 | Pubmed ID: 21285265 Recording Single-channel Activity of Inositol Trisphosphate Receptors in Intact Cells with a Microscope, Not a Patch Clamp The Journal of General Physiology. Aug, 2010 | Pubmed ID: 20660654 Essential Regulation of Cell Bioenergetics by Constitutive InsP3 Receptor Ca2+ Transfer to Mitochondria Cell. Jul, 2010 | Pubmed ID: 20655468 Superresolution Localization of Single Functional IP3R Channels Utilizing Ca2+ Flux As a Readout Biophysical Journal. Jul, 2010 | Pubmed ID: 20643061 A Novel Postsynaptic Mechanism for Heterosynaptic Sharing of Short-term Plasticity The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Jun, 2010 | Pubmed ID: 20592201 Modulation of Endoplasmic Reticulum Ca2+ Store Filling by Cyclic ADP-ribose Promotes Inositol Trisphosphate (IP3)-evoked Ca2+ Signals The Journal of Biological Chemistry. Aug, 2010 | Pubmed ID: 20538594 Selective and Site-specific Mobilization of Dermal Dendritic Cells and Langerhans Cells by Th1- and Th2-polarizing Adjuvants Proceedings of the National Academy of Sciences of the United States of America. May, 2010 | Pubmed ID: 20404167 Calcium Signaling and Amyloid Toxicity in Alzheimer Disease The Journal of Biological Chemistry. Apr, 2010 | Pubmed ID: 20212036 NK Cell Patrolling and Elimination of Donor-derived Dendritic Cells Favor Indirect Alloreactivity Journal of Immunology (Baltimore, Md. : 1950). Mar, 2010 | Pubmed ID: 20139277 Acquisition of Chemiluminescent Signals from Immunoblots with a Digital Single-lens Reflex Camera Analytical Biochemistry. Feb, 2010 | Pubmed ID: 19788886 Ca(2+) Puffs Originate from Preestablished Stable Clusters of Inositol Trisphosphate Receptors Science Signaling. 2009 | Pubmed ID: 19934435 Chapter 16. Two-photon Microscopy and Multidimensional Analysis of Cell Dynamics Methods in Enzymology. 2009 | Pubmed ID: 19480927 Imaging the Quantal Substructure of Single IP3R Channel Activity During Ca2+ Puffs in Intact Mammalian Cells Proceedings of the National Academy of Sciences of the United States of America. Apr, 2009 | Pubmed ID: 19332787 CADPR Stimulates SERCA Activity in Xenopus Oocytes Cell Calcium. Mar, 2009 | Pubmed ID: 19131109 Localization of Puff Sites Adjacent to the Plasma Membrane: Functional and Spatial Characterization of Ca2+ Signaling in SH-SY5Y Cells Utilizing Membrane-permeant Caged IP3 Cell Calcium. Jan, 2009 | Pubmed ID: 18639334 Imaging of Effector Memory T Cells During a Delayed-type Hypersensitivity Reaction and Suppression by Kv1.3 Channel Block Immunity. Oct, 2008 | Pubmed ID: 18835197 Quantum Dots for Tracking Dendritic Cells and Priming an Immune Response in Vitro and in Vivo PloS One. 2008 | Pubmed ID: 18820727 The CRAC Channel Consists of a Tetramer Formed by Stim-induced Dimerization of Orai Dimers Nature. Nov, 2008 | Pubmed ID: 18820677 SERCA Pump Activity is Physiologically Regulated by Presenilin and Regulates Amyloid Beta Production The Journal of General Physiology. Aug, 2008 | Pubmed ID: 18663130 Modeling Ca2+ Feedback on a Single Inositol 1,4,5-trisphosphate Receptor and Its Modulation by Ca2+ Buffers Biophysical Journal. Oct, 2008 | Pubmed ID: 18641077 SERCA Pump Activity is Physiologically Regulated by Presenilin and Regulates Amyloid Beta Production The Journal of Cell Biology. Jun, 2008 | Pubmed ID: 18591429 Choreography of Cell Motility and Interaction Dynamics Imaged by Two-photon Microscopy in Lymphoid Organs Annual Review of Immunology. 2008 | Pubmed ID: 18173372 Multi-dimensional Resolution of Elementary Ca2+ Signals by Simultaneous Multi-focal Imaging Cell Calcium. Apr, 2008 | Pubmed ID: 17716727 Mode Switching is the Major Mechanism of Ligand Regulation of InsP3 Receptor Calcium Release Channels The Journal of General Physiology. Dec, 2007 | Pubmed ID: 17998395 Class IA Phosphoinositide 3-kinase Modulates Basal Lymphocyte Motility in the Lymph Node Journal of Immunology (Baltimore, Md. : 1950). Aug, 2007 | Pubmed ID: 17675487 Swingers: Bonobos Are Celebrated As Peace-loving, Matriarchal, and Sexually Liberated. Are They? New Yorker (New York, N.Y. : 1925). Jul, 2007 | Pubmed ID: 17650578 Ca2+ Signals in CD4+ T Cells During Early Contacts with Antigen-bearing Dendritic Cells in Lymph Node Journal of Immunology (Baltimore, Md. : 1950). Aug, 2007 | Pubmed ID: 17641025 Natural Killer Cells Actively Patrol Peripheral Lymph Nodes Forming Stable Conjugates to Eliminate MHC-mismatched Targets Proceedings of the National Academy of Sciences of the United States of America. Jul, 2007 | Pubmed ID: 17609379 A Kinetic Model of Single and Clustered IP3 Receptors in the Absence of Ca2+ Feedback Biophysical Journal. Aug, 2007 | Pubmed ID: 17526578 Enhanced Ryanodine-mediated Calcium Release in Mutant PS1-expressing Alzheimer's Mouse Models Annals of the New York Academy of Sciences. Feb, 2007 | Pubmed ID: 17413028 Loss of MMP-2 Disrupts Skeletal and Craniofacial Development and Results in Decreased Bone Mineralization, Joint Erosion and Defects in Osteoblast and Osteoclast Growth Human Molecular Genetics. May, 2007 | Pubmed ID: 17400654 Psychoanalytic Cyberspace, Beyond Psychology Psychoanalytic Review. Feb, 2007 | Pubmed ID: 17367277 Imaging Single-channel Calcium Microdomains Cell Calcium. Nov-Dec, 2006 | Pubmed ID: 17067668 The Number and Spatial Distribution of IP3 Receptors Underlying Calcium Puffs in Xenopus Oocytes Biophysical Journal. Dec, 2006 | Pubmed ID: 16980372 'Trigger' Events Precede Calcium Puffs in Xenopus Oocytes Biophysical Journal. Dec, 2006 | Pubmed ID: 16980363 Enhancement of Capillary Leakage and Restoration of Lymphocyte Egress by a Chiral S1P1 Antagonist in Vivo Nature Chemical Biology. Aug, 2006 | Pubmed ID: 16829954 Imaging the Choreography of Lymphocyte Trafficking and the Immune Response Current Opinion in Immunology. Aug, 2006 | Pubmed ID: 16765574 Imaging Ca2+ Signals in Xenopus Oocytes Methods in Molecular Biology (Clifton, N.J.). 2006 | Pubmed ID: 16739719 Plasmalemmal Ca2+ Signaling in Arterial Smooth Muscle: It's Elementary! The Journal of General Physiology. Jun, 2006 | Pubmed ID: 16702356 Enhanced Ryanodine Receptor Recruitment Contributes to Ca2+ Disruptions in Young, Adult, and Aged Alzheimer's Disease Mice The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. May, 2006 | Pubmed ID: 16687509 Analysis of Puff Dynamics in Oocytes: Interdependence of Puff Amplitude and Interpuff Interval Biophysical Journal. Jun, 2006 | Pubmed ID: 16533853 Sphingosine 1-phosphate Type 1 Receptor Agonism Inhibits Transendothelial Migration of Medullary T Cells to Lymphatic Sinuses Nature Immunology. Dec, 2005 | Pubmed ID: 16273098 Close Encounters of the First and Second Kind: T-DC and T-B Interactions in the Lymph Node Seminars in Immunology. Dec, 2005 | Pubmed ID: 16263308 "Optical Patch-clamping": Single-channel Recording by Imaging Ca2+ Flux Through Individual Muscle Acetylcholine Receptor Channels The Journal of General Physiology. Sep, 2005 | Pubmed ID: 16103278 In Situ Characterization of CD4+ T Cell Behavior in Mucosal and Systemic Lymphoid Tissues During the Induction of Oral Priming and Tolerance The Journal of Experimental Medicine. Jun, 2005 | Pubmed ID: 15928201 Antigen-engaged B Cells Undergo Chemotaxis Toward the T Zone and Form Motile Conjugates with Helper T Cells PLoS Biology. Jun, 2005 | Pubmed ID: 15857154 Optical Single-channel Recording: Imaging Ca2+ Flux Through Individual Ion Channels with High Temporal and Spatial Resolution Journal of Biomedical Optics. Jan-Feb, 2005 | Pubmed ID: 15847568 Optical Single-channel Recording by Imaging Ca2+ Flux Through Individual Ion Channels: Theoretical Considerations and Limits to Resolution Cell Calcium. Apr, 2005 | Pubmed ID: 15755490 Calcium Dysregulation and Membrane Disruption As a Ubiquitous Neurotoxic Mechanism of Soluble Amyloid Oligomers The Journal of Biological Chemistry. Apr, 2005 | Pubmed ID: 15722360 A Model-independent Algorithm to Derive Ca2+ Fluxes Underlying Local Cytosolic Ca2+ Transients Biophysical Journal. Apr, 2005 | Pubmed ID: 15681645 Dynamic Multiphoton Imaging: a Live View from Cells to Systems Physiology (Bethesda, Md.). Feb, 2005 | Pubmed ID: 15653835 Two Phases of Zymogen Granule Lifetime in Mouse Pancreas: Ghost Granules Linger After Exocytosis of Contents The Journal of Physiology. Mar, 2005 | Pubmed ID: 15637100 Imaging Single-channel Calcium Microdomains by Total Internal Reflection Microscopy Biological Research. 2004 | Pubmed ID: 15709697 Imaging the Single Cell Dynamics of CD4+ T Cell Activation by Dendritic Cells in Lymph Nodes The Journal of Experimental Medicine. Oct, 2004 | Pubmed ID: 15466619 Imaging the Activity and Localization of Single Voltage-gated Ca(2+) Channels by Total Internal Reflection Fluorescence Microscopy Biophysical Journal. May, 2004 | Pubmed ID: 15111438 Zymogen Granule Exocytosis is Characterized by Long Fusion Pore Openings and Preservation of Vesicle Lipid Identity Proceedings of the National Academy of Sciences of the United States of America. Apr, 2004 | Pubmed ID: 15090649 Early Experiences with Computed Axial Tomography Colonography American Journal of Surgery. Apr, 2004 | Pubmed ID: 15041501 Spatiotemporal Patterning of IP3-mediated Ca2+ Signals in Xenopus Oocytes by Ca2+-binding Proteins The Journal of Physiology. Apr, 2004 | Pubmed ID: 14755000 Dysregulated IP3 Signaling in Cortical Neurons of Knock-in Mice Expressing an Alzheimer's-linked Mutation in Presenilin1 Results in Exaggerated Ca2+ Signals and Altered Membrane Excitability The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Jan, 2004 | Pubmed ID: 14724250 T Cell Repertoire Scanning is Promoted by Dynamic Dendritic Cell Behavior and Random T Cell Motility in the Lymph Node Proceedings of the National Academy of Sciences of the United States of America. Jan, 2004 | Pubmed ID: 14722354 Optical Single-channel Recording: Imaging Ca2+ Flux Through Individual N-type Voltage-gated Channels Expressed in Xenopus Oocytes Cell Calcium. Dec, 2003 | Pubmed ID: 14572808 Buffer Kinetics Shape the Spatiotemporal Patterns of IP3-evoked Ca2+ Signals The Journal of Physiology. Dec, 2003 | Pubmed ID: 14555715 A Stochastic View of Lymphocyte Motility and Trafficking Within the Lymph Node Immunological Reviews. Oct, 2003 | Pubmed ID: 12969316 Real-time Imaging of Lymphocytes in Vivo Current Opinion in Immunology. Aug, 2003 | Pubmed ID: 12900266 Video-rate Confocal Microscopy Methods in Enzymology. 2003 | Pubmed ID: 12622163 Photonics for Biologists Methods in Enzymology. 2003 | Pubmed ID: 12622159 Autonomous T Cell Trafficking Examined in Vivo with Intravital Two-photon Microscopy Proceedings of the National Academy of Sciences of the United States of America. Mar, 2003 | Pubmed ID: 12601158 Ca2+ Signaling in Mouse Cortical Neurons Studied by Two-photon Imaging and Photoreleased Inositol Triphosphate The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Feb, 2003 | Pubmed ID: 12574404 Cell Biology of the Human Thiamine Transporter-1 (hTHTR1). Intracellular Trafficking and Membrane Targeting Mechanisms The Journal of Biological Chemistry. Feb, 2003 | Pubmed ID: 12454006 Two-photon Tissue Imaging: Seeing the Immune System in a Fresh Light Nature Reviews. Immunology. Nov, 2002 | Pubmed ID: 12415310 Two-photon Imaging in Intact Lymphoid Tissue Advances in Experimental Medicine and Biology. 2002 | Pubmed ID: 12405205 Intracellular Trafficking and Membrane Targeting Mechanisms of the Human Reduced Folate Carrier in Mammalian Epithelial Cells The Journal of Biological Chemistry. Sep, 2002 | Pubmed ID: 12087110 Two-photon Imaging of Lymphocyte Motility and Antigen Response in Intact Lymph Node Science (New York, N.Y.). Jun, 2002 | Pubmed ID: 12016203 Structural and Functional Relationships Between Ca2+ Puffs and Mitochondria in Xenopus Oocytes American Journal of Physiology. Cell Physiology. Jun, 2002 | Pubmed ID: 11997252 A Preliminary Study of the Spreading of AKD in the Presence of Capillary Structures Journal of Colloid and Interface Science. Aug, 2001 | Pubmed ID: 11446799 Imaging Local Ca2+ Signals in Cultured Mammalian Cells JoVE 52516 Biology Two-photon Imaging of Cellular Dynamics in the Mouse Spinal Cord JoVE 52580 Neuroscience Imaging Effector Memory T cells in the Ear After Induction of Adoptive DTH JoVE 907 Biology Generation of Bone Marrow Derived Murine Dendritic Cells for Use in 2-photon Imaging JoVE 773 Biology Dissection and 2-Photon Imaging of Peripheral Lymph Nodes in Mice JoVE 265 Biology
Generation of Bone Marrow Derived Murine Dendritic Cells for Use in 2-photon Imaging JoVE 773 Biology
