Ionita Ghiran Department of Medicine, Division of Allergy and Inflammation Beth Israel Deaconess Medical Center Biography Publications Institution JoVE Articles Ionita Ghiran has not added a biography. If you are Ionita Ghiran and would like to personalize this page please email our Author Liaison for assistance. Publications The NIH Somatic Cell Genome Editing Program Nature. Apr, 2021 | Pubmed ID: 33828315 A Simple, High-throughput Method of Protein and Label Removal from Extracellular Vesicle Samples Nanoscale. Feb, 2021 | Pubmed ID: 33544111 High-Sensitivity Glycan Profiling of Blood-Derived Immunoglobulin G, Plasma, and Extracellular Vesicle Isolates with Capillary Zone Electrophoresis-Mass Spectrometry Analytical Chemistry. 02, 2021 | Pubmed ID: 33433994 Mir-30d Regulates Cardiac Remodeling by Intracellular and Paracrine Signaling Circulation Research. Jan, 2021 | Pubmed ID: 33092465 Measurement and Standardization Challenges for Extracellular Vesicle Therapeutic Delivery Vectors Nanomedicine (London, England). 09, 2020 | Pubmed ID: 32885720 Discovery and Verification of Extracellular MiRNA Biomarkers for Non-invasive Prediction of Pre-eclampsia in Asymptomatic Women Cell Reports. Medicine. May, 2020 | Pubmed ID: 32864636 VWF Maturation and Release Are Controlled by 2 Regulators of Weibel-Palade Body Biogenesis: Exocyst and BLOC-2 Blood. 12, 2020 | Pubmed ID: 32614949 Profiling Extracellular Long RNA Transcriptome in Human Plasma and Extracellular Vesicles for Biomarker Discovery IScience. Jun, 2020 | Pubmed ID: 32512385 MIFlowCyt-EV: a Framework for Standardized Reporting of Extracellular Vesicle Flow Cytometry Experiments Journal of Extracellular Vesicles. 2020 | Pubmed ID: 32128070 Detection of Extracellular Vesicle RNA Using Molecular Beacons IScience. Jan, 2020 | Pubmed ID: 31958756 Rational Design of a Bifunctional AND-Gate Ligand To Modulate Cell-Cell Interactions ACS Synthetic Biology. 02, 2020 | Pubmed ID: 31834794 Characterization of Plasma-derived Protoporphyrin-IX-positive Extracellular Vesicles Following 5-ALA Use in Patients with Malignant Glioma EBioMedicine. Oct, 2019 | Pubmed ID: 31628025 Correction To: Exercise-induced Circulating Extracellular Vesicles Protect Against Cardiac Ischemia-reperfusion Injury Basic Research in Cardiology. Oct, 2019 | Pubmed ID: 31595368 High-fidelity Detection and Sorting of Nanoscale Vesicles in Viral Disease and Cancer Journal of Extracellular Vesicles. 2019 | Pubmed ID: 31258878 A Novel Implementation of Magnetic Levitation to Quantify Leukocyte Size, Morphology, and Magnetic Properties to Identify Patients With Sepsis Shock (Augusta, Ga.). 02, 2019 | Pubmed ID: 29561389 Comprehensive Multi-center Assessment of Small RNA-seq Methods for Quantitative MiRNA Profiling Nature Biotechnology. 09, 2018 | Pubmed ID: 30010675 Myosin IIA Interacts with the Spectrin-actin Membrane Skeleton to Control Red Blood Cell Membrane Curvature and Deformability Proceedings of the National Academy of Sciences of the United States of America. 05, 2018 | Pubmed ID: 29610350 Mast Cells Regulate CD4 T-cell Differentiation in the Absence of Antigen Presentation The Journal of Allergy and Clinical Immunology. 12, 2018 | Pubmed ID: 29470999 Malaria Infected Red Blood Cells Release Small Regulatory RNAs Through Extracellular Vesicles Scientific Reports. Jan, 2018 | Pubmed ID: 29343745 Small RNA-seq During Acute Maximal Exercise Reveal RNAs Involved in Vascular Inflammation and Cardiometabolic Health: Brief Report American Journal of Physiology. Heart and Circulatory Physiology. Dec, 2017 | Pubmed ID: 28916639 Detection of Membrane-bound and Soluble Antigens by Magnetic Levitation Lab on a Chip. 10, 2017 | Pubmed ID: 28905952 Red Blood Cells: A Source of Extracellular Vesicles Methods in Molecular Biology (Clifton, N.J.). 2017 | Pubmed ID: 28828644 Exercise-induced Circulating Extracellular Vesicles Protect Against Cardiac Ischemia-reperfusion Injury Basic Research in Cardiology. 07, 2017 | Pubmed ID: 28534118 DDiT4L Promotes Autophagy and Inhibits Pathological Cardiac Hypertrophy in Response to Stress Science Signaling. Feb, 2017 | Pubmed ID: 28246202 Extracellular Microvesicle Production by Human Eosinophils Activated by "Inflammatory" Stimuli Frontiers in Cell and Developmental Biology. 2016 | Pubmed ID: 27833910 Infected Erythrocyte-derived Extracellular Vesicles Alter Vascular Function Via Regulatory Ago2-miRNA Complexes in Malaria Nature Communications. Oct, 2016 | Pubmed ID: 27721445 Detection and Quantification of Subtle Changes in Red Blood Cell Density Using a Cell Phone Lab on a Chip. Aug, 2016 | Pubmed ID: 27431921 NAD(+) Regulates Treg Cell Fate and Promotes Allograft Survival Via a Systemic IL-10 Production That is CD4(+) CD25(+) Foxp3(+) T Cells Independent Scientific Reports. Mar, 2016 | Pubmed ID: 26928119 Ligation of Glycophorin A Generates Reactive Oxygen Species Leading to Decreased Red Blood Cell Function PloS One. 2016 | Pubmed ID: 26784696 Diurnal Variations of Circulating Extracellular Vesicles Measured by Nano Flow Cytometry PloS One. 2016 | Pubmed ID: 26745887 Potential Functional Applications of Extracellular Vesicles: a Report by the NIH Common Fund Extracellular RNA Communication Consortium Journal of Extracellular Vesicles. 2015 | Pubmed ID: 26320942 Smart-Phone Based Magnetic Levitation for Measuring Densities PloS One. 2015 | Pubmed ID: 26308615 Magnetic Levitation of Single Cells Proceedings of the National Academy of Sciences of the United States of America. Jul, 2015 | Pubmed ID: 26124131 Levitational Image Cytometry with Temporal Resolution Advanced Materials (Deerfield Beach, Fla.). Jul, 2015 | Pubmed ID: 26058598 Dynamic Actin Filaments Control the Mechanical Behavior of the Human Red Blood Cell Membrane Molecular Biology of the Cell. May, 2015 | Pubmed ID: 25717184 NAD+ Protects Against EAE by Regulating CD4+ T-cell Differentiation Nature Communications. Oct, 2014 | Pubmed ID: 25290058 Bio-inspired Cryo-ink Preserves Red Blood Cell Phenotype and Function During Nanoliter Vitrification Advanced Materials (Deerfield Beach, Fla.). Sep, 2014 | Pubmed ID: 25047246 C4d Deposits on the Surface of RBCs in Trauma Patients and Interferes with Their Function Critical Care Medicine. May, 2014 | Pubmed ID: 24448198 CR1-mediated ATP Release by Human Red Blood Cells Promotes CR1 Clustering and Modulates the Immune Transfer Process The Journal of Biological Chemistry. Oct, 2013 | Pubmed ID: 24022490 Malaria-infected Erythrocyte-derived Microvesicles Mediate Cellular Communication Within the Parasite Population and with the Host Immune System Cell Host & Microbe. May, 2013 | Pubmed ID: 23684304 Human Complement Receptor Type 1/CD35 is an Epstein-Barr Virus Receptor Cell Reports. Feb, 2013 | Pubmed ID: 23416052 Eosinophil Extracellular DNA Trap Cell Death Mediates Lytic Release of Free Secretion-competent Eosinophil Granules in Humans Blood. Mar, 2013 | Pubmed ID: 23303825 Systemic Lupus Erythematosus Serum Deposits C4d on Red Blood Cells, Decreases Red Blood Cell Membrane Deformability, and Promotes Nitric Oxide Production Arthritis and Rheumatism. Feb, 2011 | Pubmed ID: 21280005 Introduction to Fluorescence Microscopy Methods in Molecular Biology (Clifton, N.J.). 2011 | Pubmed ID: 21153789 Examining the Role of Microvesicles to Develop Prognostic and Diagnostic Assays Journal of Applied Oral Science : Revista FOB. Sep-Oct, 2010 | Pubmed ID: 21085796 Ligation of Complement Receptor 1 Increases Erythrocyte Membrane Deformability Blood. Dec, 2010 | Pubmed ID: 20861458 Complement Receptor 1 Expression on Mouse Erythrocytes Mediates Clearance of Streptococcus Pneumoniae by Immune Adherence Infection and Immunity. Jul, 2010 | Pubmed ID: 20439480 Helicobacter Pylori Moves Through Mucus by Reducing Mucin Viscoelasticity Proceedings of the National Academy of Sciences of the United States of America. Aug, 2009 | Pubmed ID: 19706518 Light-scattering Spectroscopy Differentiates Fetal from Adult Nucleated Red Blood Cells: May Lead to Noninvasive Prenatal Diagnosis Optics Letters. May, 2009 | Pubmed ID: 19412313 C3b Deposition on Human Erythrocytes Induces the Formation of a Membrane Skeleton-linked Protein Complex The Journal of Clinical Investigation. Apr, 2009 | Pubmed ID: 19258706 Eosinophil Granules Function Extracellularly As Receptor-mediated Secretory Organelles Proceedings of the National Academy of Sciences of the United States of America. Nov, 2008 | Pubmed ID: 19017810 Complex Dynamics of Human Red Blood Cell Flickering: Alterations with in Vivo Aging Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics. Aug, 2008 | Pubmed ID: 18850779 Ligation of Erythrocyte CR1 Induces Its Clustering in Complex with Scaffolding Protein FAP-1 Blood. Oct, 2008 | Pubmed ID: 18684861 Airway Eosinophils: Allergic Inflammation Recruited Professional Antigen-presenting Cells Journal of Immunology (Baltimore, Md. : 1950). Dec, 2007 | Pubmed ID: 18025204 Confocal Light Absorption and Scattering Spectroscopic Microscopy Monitors Organelles in Live Cells with No Exogenous Labels Proceedings of the National Academy of Sciences of the United States of America. Oct, 2007 | Pubmed ID: 17956980 Human Eosinophils Secrete Preformed, Granule-stored Interleukin-4 Through Distinct Vesicular Compartments Traffic (Copenhagen, Denmark). Nov, 2005 | Pubmed ID: 16190985 Phagocytosis of Salmonella Montevideo by Human Neutrophils: Immune Adherence Increases Phagocytosis, Whereas the Bacterial Surface Determines the Route of Intracellular Processing The Journal of Infectious Diseases. Jul, 2005 | Pubmed ID: 15962214 A Role for Lipid Rafts in C1q-triggered O2- Generation by Human Neutrophils Molecular Immunology. Jun, 2004 | Pubmed ID: 15159064 Calreticulin is at the Surface of Circulating Neutrophils and Uses CD59 As an Adaptor Molecule The Journal of Biological Chemistry. Jun, 2003 | Pubmed ID: 12646570 Expression and Function of C1q Receptors and C1q Binding Proteins at the Cell Surface Immunobiology. Sep, 2002 | Pubmed ID: 12396003 Complement Receptor 1/CD35 is a Receptor for Mannan-binding Lectin The Journal of Experimental Medicine. Dec, 2000 | Pubmed ID: 11120776 Quantification of Cellular Densities and Antigenic Properties using Magnetic Levitation Lauren Thompson1, Brandy Pinckney1, Shulin Lu2, Mark Gregory2, John Tigges1, Ionita Ghiran2 1Nano Flow Core Facility, Beth Israel Deaconess Medical Center, Harvard Medical School, 2Department of Medicine, Division of Allergy and Inflammation, Beth Israel Deaconess Medical Center JoVE 62550 Biology
Quantification of Cellular Densities and Antigenic Properties using Magnetic Levitation Lauren Thompson1, Brandy Pinckney1, Shulin Lu2, Mark Gregory2, John Tigges1, Ionita Ghiran2 1Nano Flow Core Facility, Beth Israel Deaconess Medical Center, Harvard Medical School, 2Department of Medicine, Division of Allergy and Inflammation, Beth Israel Deaconess Medical Center JoVE 62550 Biology
