Irena Levitan Department of Medicine, Division of Pulmonary, Critical Care, Sleep and Allergy University of Illinois at Chicago Biography Publications Institution JoVE Articles Irena Levitan has not added a biography. If you are Irena Levitan and would like to personalize this page please email our Author Liaison for assistance. Publications Shear-Stress Sensitive Inwardly-Rectifying K Channels Regulate Developmental Retinal Angiogenesis by Vessel Regression Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology. 2019 | Pubmed ID: 31145841 Comparative Docking Analysis of Cholesterol Analogs to Ion Channels to Discriminate Between Stereospecific Binding Vs. Stereospecific Response Channels (Austin, Tex.). Dec, 2019 | Pubmed ID: 31033379 Endothelial Stiffening in Dyslipidemia Aging. Jan, 2019 | Pubmed ID: 30674709 Chiral Specificity of Cholesterol Orientation Within Cholesterol Binding Sites in Inwardly Rectifying K Channels Advances in Experimental Medicine and Biology. 2019 | Pubmed ID: 30649756 Role of Matrix Metalloproteinases and Histone Deacetylase in Oxidative Stress-induced Degradation of the Endothelial Glycocalyx American Journal of Physiology. Heart and Circulatory Physiology. Mar, 2019 | Pubmed ID: 30632766 Potential Strategies to Reduce Blood Pressure in Treatment-Resistant Hypertension Using Food and Drug Administration-Approved Nanodrug Delivery Platforms Hypertension (Dallas, Tex. : 1979). Feb, 2019 | Pubmed ID: 30624988 Membrane Stiffening in Osmotic Swelling: Analysis of Membrane Tension and Elastic Modulus Current Topics in Membranes. 2018 | Pubmed ID: 30243442 Molecular Dynamics Simulations of Kir2.2 Interactions with an Ensemble of Cholesterol Molecules Biophysical Journal. 10, 2018 | Pubmed ID: 30205899 Comparative Analysis of Endothelial Cell and Sub-endothelial Cell Elastic Moduli in Young and Aged Mice: Role of CD36 Journal of Biomechanics. 07, 2018 | Pubmed ID: 29954596 Hypercholesterolemia-Induced Loss of Flow-Induced Vasodilation and Lesion Formation in Apolipoprotein E-Deficient Mice Critically Depend on Inwardly Rectifying K Channels Journal of the American Heart Association. 03, 2018 | Pubmed ID: 29502106 Hypotonic Challenge of Endothelial Cells Increases Membrane Stiffness with No Effect on Tether Force Biophysical Journal. 02, 2018 | Pubmed ID: 29490252 Proatherogenic Flow Increases Endothelial Stiffness Via Enhanced CD36-Mediated Uptake of Oxidized Low-Density Lipoproteins Arteriosclerosis, Thrombosis, and Vascular Biology. 01, 2018 | Pubmed ID: 29025707 Differential Effects of Sterols on Ion Channels: Stereospecific Binding Vs Stereospecific Response Current Topics in Membranes. 2017 | Pubmed ID: 28863819 OxLDL Induces Endothelial Cell Proliferation Via Rho/ROCK/Akt/p27 Signaling: Opposite Effects of OxLDL and Cholesterol Loading American Journal of Physiology. Cell Physiology. Sep, 2017 | Pubmed ID: 28701359 Molecular-Scale Biophysical Modulation of an Endothelial Membrane by Oxidized Phospholipids Biophysical Journal. Jan, 2017 | Pubmed ID: 28122218 Orthogonal Lipid Sensors Identify Transbilayer Asymmetry of Plasma Membrane Cholesterol Nature Chemical Biology. 03, 2017 | Pubmed ID: 28024150 Inwardly Rectifying K Channels Are Major Contributors to Flow-induced Vasodilatation in Resistance Arteries The Journal of Physiology. 04, 2017 | Pubmed ID: 27859264 Paradoxical Impact of Cholesterol on Lipid Packing and Cell Stiffness Frontiers in Bioscience (Landmark Edition). 06, 2016 | Pubmed ID: 27100504 Oxidized LDL Signals Through Rho-GTPase to Induce Endothelial Cell Stiffening and Promote Capillary Formation Journal of Lipid Research. 05, 2016 | Pubmed ID: 26989083 Cholesterol Increases the Open Probability of Cardiac KACh Currents Biochimica Et Biophysica Acta. Oct, 2015 | Pubmed ID: 26196595 Interplay Between Lipid Modulators of Kir2 Channels: Cholesterol and PIP2 Computational and Structural Biotechnology Journal. Sep, 2014 | Pubmed ID: 25408847 Silencing of Kir2 Channels by Caveolin-1: Cross-talk with Cholesterol The Journal of Physiology. Sep, 2014 | Pubmed ID: 25038242 Cholesterol Binding to Ion Channels Frontiers in Physiology. 2014 | Pubmed ID: 24616704 Upregulated Copper Transporters in Hypoxia-induced Pulmonary Hypertension PloS One. 2014 | Pubmed ID: 24614111 Oxidized Low-density Lipoprotein Alters the Effect of Matrix Stiffness on the Formation of Endothelial Networks and Capillary Lumens Pulmonary Circulation. Sep, 2013 | Pubmed ID: 24618546 Identification of Novel Cholesterol-binding Regions in Kir2 Channels The Journal of Biological Chemistry. Oct, 2013 | Pubmed ID: 24019518 Cholesterol Sensitivity of KIR2.1 Depends on Functional Inter-links Between the N and C Termini Channels (Austin, Tex.). Jul-Aug, 2013 | Pubmed ID: 23807091 Regulation of Ion Channels by Membrane Lipids Comprehensive Physiology. Jan, 2012 | Pubmed ID: 23728970 Residuos Citosólicas Distantes Median Un Conmutador Molecular Que Controla La Modulación De Canales Kir Por Colesterol Y P2 De PI (4,5) The Journal of Biological Chemistry. Sep, 2012 | Pubmed ID: 22995912 Rigidez OxLDL Y Sustrato Promover Transmigración Neutrófila Por Contractilidad De La Célula Endotelial Mejorada Y ICAM-1 Journal of Biomechanics. Jun, 2012 | Pubmed ID: 22560286 El Papel De Oxysterols En Control De Rigidez Endotelial Journal of Lipid Research. Jul, 2012 | Pubmed ID: 22496390 Nuevos Mecanismos De La Hipertensión Arterial Pulmonar: Papel De La Señalización Ca²⁺ American Journal of Physiology. Heart and Circulatory Physiology. Apr, 2012 | Pubmed ID: 22245772 Hipercolesterolemia Induce Para Arriba-regulación De KACh Corrientes Cardiacas Mediante Un Mecanismo Independiente De Fosfatidilinositol 4, 5-bifosfato Y Gβγ The Journal of Biological Chemistry. Feb, 2012 | Pubmed ID: 22174416 Nuevo Papel De P66Shc En La Señalización De VEGF ROS-dependiente Y La Angiogénesis En Las Células Endoteliales American Journal of Physiology. Heart and Circulatory Physiology. Feb, 2012 | Pubmed ID: 22101521 Agotamiento De Colesterol Facilita La Recuperación De Célula Hipotónica Hinchazón En Células CHO Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology. 2011 | Pubmed ID: 22179012 Colesterol Regula Procariota Canal Kir Por Unión Directa a La Proteína De Canal Biochimica Et Biophysica Acta. Oct, 2011 | Pubmed ID: 21798234 Impacto De OxLDL En Balsas De Membrana Ricos En Colesterol Journal of Lipids. 2011 | Pubmed ID: 21490811 Factor Letal ántrax Activa Canales De Capacidad Para Inducir La Secreción De IL-1β En Macrófagos Journal of Immunology (Baltimore, Md. : 1950). May, 2011 | Pubmed ID: 21421849 Sensibilidad De Colesterol De KIR2.1 Es Controlada Por Un Cinturón De Residuos En El Poro Citosólico Biophysical Journal. Jan, 2011 | Pubmed ID: 21244834 Modificación Del Contenido De Colesterol Celular Afecta La Fuerza De La Tracción, Adherencia Y Separarse De La Célula Cellular and Molecular Bioengineering. Jun, 2010 | Pubmed ID: 21461187 Disminución OxLDL Inducida Por Orden De Lípidos De Dominios De Membrana Se Correlaciona Inversamente Con Formación Endotelial De La Rigidez Y La Red American Journal of Physiology. Cell Physiology. Aug, 2010 | Pubmed ID: 20410437 Canales De Colesterol Y Ion Sub-cellular Biochemistry. 2010 | Pubmed ID: 20213557 Análisis Comparativo De La Sensibilidad De Colesterol De Canales Kir: Papel Del Bucle CD Channels (Austin, Tex.). Jan-Feb, 2010 | Pubmed ID: 19923917 LDL Oxidada: Diversidad, Patrones De Reconocimiento Y Fisiopatología Antioxidants & Redox Signaling. Jul, 2010 | Pubmed ID: 19888833 Regulación Directa Del Canal De Kir Procariota Por Colesterol The Journal of Biological Chemistry. Oct, 2009 | Pubmed ID: 19740741 Canales De Colesterol Y Kir IUBMB Life. Aug, 2009 | Pubmed ID: 19548316 Identificación De Un Dominio C-terminal Crítico Para La Sensibilidad De Kir2.1 Para El Colesterol Proceedings of the National Academy of Sciences of the United States of America. May, 2009 | Pubmed ID: 19416905 Rigidez De Actina Y De La Célula Endotelial Es Modulada Por La Rigidez Del Substrato En 2D Y 3D Journal of Biomechanics. May, 2009 | Pubmed ID: 19356760 OxLDL Facilita La Realineación Inducida Por El Flujo De Las Células Endoteliales Aórticas American Journal of Physiology. Cell Physiology. Aug, 2008 | Pubmed ID: 18562483 Balsas De Lípidos En Las Interacciones De La Membrana-citoesqueleto Y Control De Biomecánica Celular: Acciones De OxLDL Antioxidants & Redox Signaling. Sep, 2007 | Pubmed ID: 17576163 El Efecto De Colesterol Celular Sobre La Adherencia De La Membrana-citoesqueleto Journal of Cell Science. Jul, 2007 | Pubmed ID: 17550968 Uso De Ciclodextrinas Para Manipular El Contenido De Colesterol De Membrana Plasmática: Evidencia, Conceptos Erróneos Y Estrategias De Control Biochimica Et Biophysica Acta. Jun, 2007 | Pubmed ID: 17493580 Hipercolesterolemia Suprime Canales Kir En Células Progenitoras De Médula Porcino En Vivo Biochemical and Biophysical Research Communications. Jun, 2007 | Pubmed ID: 17482574 Relación Entre La Actividad De Kir2.1/Kir2.3 Y Su Distribución Entre Los Dominios De Membrana Colesterol-ricos Y Pobres En Colesterol American Journal of Physiology. Cell Physiology. Jul, 2007 | Pubmed ID: 17459945 Hipercolesterolemia Suprime Interiormente Rectificación Canales De K + En El Endotelio Aórtico in Vitro E in Vivo Circulation Research. Apr, 2006 | Pubmed ID: 16556870 OxLDL Aumenta La Rigidez Endotelial, Generación De Fuerza Y Formación De Redes Journal of Lipid Research. Apr, 2006 | Pubmed ID: 16418538 Expresión Funcional De Kir2.x En Células Endoteliales Aórticas Humanas: El Papel Dominante De La Kir2.2 American Journal of Physiology. Cell Physiology. Nov, 2005 | Pubmed ID: 15958527 Sensibilidad De Colesterol Y Lípidos Balsa Selección De Canales De Kir2.1 Biophysical Journal. Dec, 2004 | Pubmed ID: 15465867 Agotamiento De Colesterol Aumenta La Rigidez De La Membrana De Las Células Endoteliales Aórticas Biophysical Journal. Nov, 2004 | Pubmed ID: 15347591 Superficie De La Membrana Plasmática Aumenta Con El Estiramiento De La Tónica De Células Epiteliales Alveolares American Journal of Respiratory Cell and Molecular Biology. Aug, 2004 | Pubmed ID: 15016618 Sensibilidad Del Anión Regulados Por El Volumen Actual De Análogos Estructurales De Colesterol The Journal of General Physiology. Jan, 2004 | Pubmed ID: 14699079 Esfuerzo Cortante Aumenta La Expresión De Un Canal KATP En Rata Y Las Células Endoteliales Vasculares Pulmonares Bovinas American Journal of Physiology. Cell Physiology. Oct, 2003 | Pubmed ID: 12826604 Modulación De Endotelial Interno-rectificador K + Corriente Isómeros ópticos De Colesterol Biophysical Journal. Dec, 2002 | Pubmed ID: 12496090 Doble Efecto De La Tensión De Esquileo Fluida En Anión Regulados Por El Volumen Actual En Células Endoteliales Aórticas Bovinas American Journal of Physiology. Cell Physiology. Apr, 2002 | Pubmed ID: 11880259 Grabaciones electrofisiológicas de corrientes de iones de una sola célula bajo estrés de cizallamiento bien definido Ibra S. Fancher1, Irena Levitan1 1Department of Medicine, Division of Pulmonary, Critical Care, Sleep and Allergy, University of Illinois at Chicago JoVE 59776 Immunology and Infection Aspiración Micropipeta de células adheridas a sustratos para estimar la rigidez Celular Myung-Jin Oh1, Frank Kuhr1, Fitzroy Byfield2, Irena Levitan1 1Section of Respiratory, Critical Care and Sleep Medicine, Department of Medicine, University of Illinois, 2Institute for Medicine and Engineering, University of Pennsylvania JoVE 3886 Bioengineering
Grabaciones electrofisiológicas de corrientes de iones de una sola célula bajo estrés de cizallamiento bien definido Ibra S. Fancher1, Irena Levitan1 1Department of Medicine, Division of Pulmonary, Critical Care, Sleep and Allergy, University of Illinois at Chicago JoVE 59776 Immunology and Infection
Aspiración Micropipeta de células adheridas a sustratos para estimar la rigidez Celular Myung-Jin Oh1, Frank Kuhr1, Fitzroy Byfield2, Irena Levitan1 1Section of Respiratory, Critical Care and Sleep Medicine, Department of Medicine, University of Illinois, 2Institute for Medicine and Engineering, University of Pennsylvania JoVE 3886 Bioengineering