Other Publications (1)
Articles by Irene M. Ogden in JoVE
An Orthotopic Murine Model of Human Prostate Cancer Metastasis Janet Pavese1, Irene M. Ogden1, Raymond C. Bergan1,2,3 1Department of Medicine, Northwestern University, 2Robert H. Lurie Cancer Center, Northwestern University, 3Center for Molecular Innovation and Drug Discovery, Northwestern University This orthotopic model of human prostate cancer allows for quantification of tumor size, circulating tumor cells, and formation of distinct metastasis to the lung. As cells must escape the primary organ, enter the blood stream, and implant into a secondary site, this model effectively recapitulates the scenario in humans.
Other articles by Irene M. Ogden on PubMed
Perfusion Preservation of the Donor Heart: Basic Science to Pre-clinical The Journal of Extra-corporeal Technology. Sep, 2009 | Pubmed ID: 19806796 As a consequence of technology improvements and refinement, perfusion of the donor heart has moved from the research laboratory to clinical studies. Multiple investigators are currently leading pre-clinical trials of devices using perfusion preservation, and one device is now in European clinical trials. One major problem with the donor heart is the high metabolism relative to other organs, and depletion of ATP leads rapidly to acidosis and necrosis of the myocardium. Two techniques in development to address the issue are normothermic and hypothermic perfusion. This review examines the current issues regarding donor heart preservation and techniques of preclinical evaluation necessary for regulatory approval.