Articles by Irene M. Ogden in JoVE
人类前列腺癌转移的原位小鼠模型 Janet Pavese1, Irene M. Ogden1, Raymond C. Bergan1,2,3 1Department of Medicine, Northwestern University, 2Robert H. Lurie Cancer Center, Northwestern University, 3Center for Molecular Innovation and Drug Discovery, Northwestern University 人前列腺癌原位此模型允许对肿瘤大小进行量化，循环肿瘤细胞，并形成明显的转移到肺。由于细胞必须逃脱的主要器官，进入血流，并植入到辅助站点，这种模式有效地概括了情景在人。
Other articles by Irene M. Ogden on PubMed
Perfusion Preservation of the Donor Heart: Basic Science to Pre-clinical The Journal of Extra-corporeal Technology. Sep, 2009 | Pubmed ID: 19806796 As a consequence of technology improvements and refinement, perfusion of the donor heart has moved from the research laboratory to clinical studies. Multiple investigators are currently leading pre-clinical trials of devices using perfusion preservation, and one device is now in European clinical trials. One major problem with the donor heart is the high metabolism relative to other organs, and depletion of ATP leads rapidly to acidosis and necrosis of the myocardium. Two techniques in development to address the issue are normothermic and hypothermic perfusion. This review examines the current issues regarding donor heart preservation and techniques of preclinical evaluation necessary for regulatory approval.