Other Publications (1)
Articles by Irene M. Ogden in JoVE
En orthotopic Murine Model of Human Prostate Cancer Metastase Janet Pavese1, Irene M. Ogden1, Raymond C. Bergan1,2,3 1Department of Medicine, Northwestern University, 2Robert H. Lurie Cancer Center, Northwestern University, 3Center for Molecular Innovation and Drug Discovery, Northwestern University Denne orthotopic modell av human prostatakreft muliggjør kvantifisering av tumorstørrelse, sirkulerende svulstceller, og dannelse av metastaser distinkt til lungen. Som celler må unnslippe den primære organ, inn i blodstrømmen, og implantat inn i en sekundær side, denne modellen sammenfatter effektivt scenariet hos mennesker.
Other articles by Irene M. Ogden on PubMed
Perfusion Preservation of the Donor Heart: Basic Science to Pre-clinical The Journal of Extra-corporeal Technology. Sep, 2009 | Pubmed ID: 19806796 As a consequence of technology improvements and refinement, perfusion of the donor heart has moved from the research laboratory to clinical studies. Multiple investigators are currently leading pre-clinical trials of devices using perfusion preservation, and one device is now in European clinical trials. One major problem with the donor heart is the high metabolism relative to other organs, and depletion of ATP leads rapidly to acidosis and necrosis of the myocardium. Two techniques in development to address the issue are normothermic and hypothermic perfusion. This review examines the current issues regarding donor heart preservation and techniques of preclinical evaluation necessary for regulatory approval.