Articles by Iris M. Wolff in JoVE
Establishment of a Clinically Relevant Ex Vivo Mock Cataract Surgery Model for Investigating Epithelial Wound Repair in a Native Microenvironment Janice L. Walker1, Brigid M. Bleaken1, Iris M. Wolff1, A. Sue Menko1 1Pathology, Anatomy and Cell Biology, Thomas Jefferson University Described here is the establishment of a clinically relevant ex vivo mock cataract surgery model that can be used to investigate mechanisms of the injury response of epithelial tissues within their native microenvironment.
Other articles by Iris M. Wolff on PubMed
Activation of SRC Kinases Signals Induction of Posterior Capsule Opacification Investigative Ophthalmology & Visual Science. May, 2007 | Pubmed ID: 17460282 Posterior capsule opacification (PCO) is a complication of cataract surgery resulting from the proliferation, migration, and epithelial-to-mesenchymal transition (EMT) of lens epithelial cells that remain associated with the lens capsule. These changes cause a loss of vision. The authors developed a chick embryo lens capsular bag model to study mechanisms involved in the onset of PCO. Because Src family kinases (SFKs) signal cell proliferation, migration, and EMT, the authors examined whether the inhibition of SFKs can prevent PCO.