Irmgard Tegeder

Publications

• Redox-guided Axonal Regrowth Requires Cyclic GMP Dependent Protein Kinase 1: Implication for Neuropathic Pain
  Redox Biology. Apr, 2017  |   Pubmed ID: 27978504
• Progranulin Protects Against Exaggerated Axonal Injury and Astrogliosis Following Traumatic Brain Injury
  Glia. Feb, 2017  |   Pubmed ID: 27778404
• R-Flurbiprofen Traps Prostaglandins Within Cells by Inhibition of Multidrug Resistance-Associated Protein-4
  International Journal of Molecular Sciences. Dec, 2016  |   Pubmed ID: 28042832
• Data File of a Deep Proteome Analysis of the Prefrontal Cortex in Aged Mice with Progranulin Deficiency or Neuronal Overexpression of Progranulin
  Data in Brief. Dec, 2016  |   Pubmed ID: 27921079
• Yeast-2-Hybrid Data File Showing Progranulin Interactions in Human Fetal Brain and Bone Marrow Libraries
  Data in Brief. Dec, 2016  |   Pubmed ID: 27921076
• Progranulin Promotes Peripheral Nerve Regeneration and Reinnervation: Role of Notch Signaling
  Molecular Neurodegeneration. Oct, 2016  |   Pubmed ID: 27770818
• Progranulin Overexpression in Sensory Neurons Attenuates Neuropathic Pain in Mice: Role of Autophagy
  Neurobiology of Disease. Dec, 2016  |   Pubmed ID: 27629805
• Tetrahydrobiopterin Attenuates DSS-evoked Colitis in Mice by Rebalancing Redox and Lipid Signalling
  Journal of Crohn's & Colitis. Feb, 2016  |   Pubmed ID: 26928964
• Endocannabinoids As Guardians of Metastasis
  International Journal of Molecular Sciences. Feb, 2016  |   Pubmed ID: 26875980
• Expression and Regulation of Redoxins at Nociceptive Signaling Sites After Sciatic Nerve Injury in Mice
  Data in Brief. Dec, 2015  |   Pubmed ID: 26693520
• Molecular Cause and Functional Impact of Altered Synaptic Lipid Signaling Due to a Prg-1 Gene SNP
  EMBO Molecular Medicine. 2015  |   Pubmed ID: 26671989
• Redoxins in Peripheral Neurons After Sciatic Nerve Injury
  Free Radical Biology & Medicine. Dec, 2015  |   Pubmed ID: 26456799
• COX-2-Derived Prostaglandin E2 Produced by Pyramidal Neurons Contributes to Neurovascular Coupling in the Rodent Cerebral Cortex
  The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Aug, 2015  |   Pubmed ID: 26311764
• Reduction of Neuropathic and Inflammatory Pain Through Inhibition of the Tetrahydrobiopterin Pathway
  Neuron. Jun, 2015  |   Pubmed ID: 26087165
• "Disease Modifying Nutricals" for Multiple Sclerosis
  Pharmacology & Therapeutics. Apr, 2015  |   Pubmed ID: 25435020
• Regulation of Circulating Endocannabinoids Associated with Cancer and Metastases in Mice and Humans
  Oncoscience. 2014  |   Pubmed ID: 25594019
• R-flurbiprofen Attenuates Experimental Autoimmune Encephalomyelitis in Mice
  EMBO Molecular Medicine. Nov, 2014  |   Pubmed ID: 25269445
• Hypoxia-inducible Factor 1 Regulates Heat and Cold Pain Sensitivity and Persistence
  Antioxidants & Redox Signaling. Jun, 2014  |   Pubmed ID: 24144405
• Learning and Memory with Neuropathic Pain: Impact of Old Age and Progranulin Deficiency
  Frontiers in Behavioral Neuroscience. 2013  |   Pubmed ID: 24319417
• Exogenous Delta⁹-tetrahydrocannabinol Influences Circulating Endogenous Cannabinoids in Humans
  Journal of Clinical Psychopharmacology. Oct, 2013  |   Pubmed ID: 23899642
• Dichotomy of CCL21 and CXCR3 in Nerve Injury-evoked and Autoimmunity-evoked Hyperalgesia
  Brain, Behavior, and Immunity. Aug, 2013  |   Pubmed ID: 23643685
• Anandamide Deficiency and Heightened Neuropathic Pain in Aged Mice
  Neuropharmacology. Aug, 2013  |   Pubmed ID: 23597506
• Author's Reply to Kapoor S. GTP Cyclohydrolase and Cancer Pain
  International Journal of Cancer. Apr, 2013  |   Pubmed ID: 23011772
• Inhibition of GTP Cyclohydrolase Attenuates Tumor Growth by Reducing Angiogenesis and M2-like Polarization of Tumor Associated Macrophages
  International Journal of Cancer. Feb, 2013  |   Pubmed ID: 22753274
• Peripheral Nerve Injury Produces a Sustained Shift in the Balance Between Glutamate Release and Uptake in the Dorsal Horn of the Spinal Cord
  Pain. Dec, 2012  |   Pubmed ID: 23021150
• Inhibition of GTP Cyclohydrolase Reduces Cancer Pain in Mice and Enhances Analgesic Effects of Morphine
  Journal of Molecular Medicine (Berlin, Germany). Dec, 2012  |   Pubmed ID: 22706600
• Protein S-nitrosylation and Denitrosylation in the Mouse Spinal Cord Upon Injury of the Sciatic Nerve
  Journal of Proteomics. Jul, 2012  |   Pubmed ID: 22588120
• Inhibitor Kappa B Kinase Beta Dependent Cytokine Upregulation in Nociceptive Neurons Contributes to Nociceptive Hypersensitivity After Sciatic Nerve Injury
  The Journal of Pain : Official Journal of the American Pain Society. May, 2012  |   Pubmed ID: 22564672
• Presynaptically Localized Cyclic GMP-dependent Protein Kinase 1 is a Key Determinant of Spinal Synaptic Potentiation and Pain Hypersensitivity
  PLoS Biology. 2012  |   Pubmed ID: 22427743
• Gα(q/11) Signaling Tonically Modulates Nociceptor Function and Contributes to Activity-dependent Sensitization
  Pain. Jan, 2012  |   Pubmed ID: 22071319
• Progranulin Contributes to Endogenous Mechanisms of Pain Defense After Nerve Injury in Mice
  Journal of Cellular and Molecular Medicine. Apr, 2012  |   Pubmed ID: 21645236
• The Protein Kinase IKKε is a Potential Target for the Treatment of Inflammatory Hyperalgesia
  Journal of Immunology (Baltimore, Md. : 1950). Sep, 2011  |   Pubmed ID: 21813779
• CNGA3: a Target of Spinal Nitric Oxide/cGMP Signaling and Modulator of Inflammatory Pain Hypersensitivity
  The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Aug, 2011  |   Pubmed ID: 21813679
• Emerging Country Pharmacology: a 10-year Perspective from Naunyn-Schmiedeberg's Archives of Pharmacology
  Naunyn-Schmiedeberg's Archives of Pharmacology. Sep, 2011  |   Pubmed ID: 21656233
• Nerve Injury Evoked Loss of Latexin Expression in Spinal Cord Neurons Contributes to the Development of Neuropathic Pain
  PloS One. 2011  |   Pubmed ID: 21572518
• SNO-ing at the Nociceptive Synapse?
  Pharmacological Reviews. Jun, 2011  |   Pubmed ID: 21436345
• Peripheral Calcium-permeable AMPA Receptors Regulate Chronic Inflammatory Pain in Mice
  The Journal of Clinical Investigation. Apr, 2011  |   Pubmed ID: 21383497
• Opioid-mediated Drug Actions Cannot Be Concluded from Naloxone Induced Reversal of Anti-nociceptive Effects in Behavioural Tests Only
  European Journal of Pain (London, England). Nov, 2010  |   Pubmed ID: 21070957
• Inter-strain Differences of Serotonergic Inhibitory Pain Control in Inbred Mice
  Molecular Pain. Oct, 2010  |   Pubmed ID: 20977736
• R-flurbiprofen Reduces Neuropathic Pain in Rodents by Restoring Endogenous Cannabinoids
  PloS One. 2010  |   Pubmed ID: 20498712
• Inhibitor KappaB Kinase Beta Deficiency in Primary Nociceptive Neurons Increases TRP Channel Sensitivity
  The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Oct, 2009  |   Pubmed ID: 19828806
• Analgesic Efficacy of Tramadol, Pregabalin and Ibuprofen in Menthol-evoked Cold Hyperalgesia
  Pain. Dec, 2009  |   Pubmed ID: 19762153
• Genetic Modulation of the Pharmacological Treatment of Pain
  Pharmacology & Therapeutics. Nov, 2009  |   Pubmed ID: 19615406
• No NO, No Pain? The Role of Nitric Oxide and CGMP in Spinal Pain Processing
  Trends in Neurosciences. Jun, 2009  |   Pubmed ID: 19414201
• Current Evidence for a Modulation of Low Back Pain by Human Genetic Variants
  Journal of Cellular and Molecular Medicine. Aug, 2009  |   Pubmed ID: 19228264
• Comparison of Nociceptive Behavior in Prostaglandin E, F, D, Prostacyclin and Thromboxane Receptor Knockout Mice
  European Journal of Pain (London, England). Aug, 2009  |   Pubmed ID: 18938093
• CGMP Produced by NO-sensitive Guanylyl Cyclase Essentially Contributes to Inflammatory and Neuropathic Pain by Using Targets Different from CGMP-dependent Protein Kinase I
  The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Aug, 2008  |   Pubmed ID: 18716216
• Genetic Deletion of Synapsin II Reduces Neuropathic Pain Due to Reduced Glutamate but Increased GABA in the Spinal Cord Dorsal Horn
  Pain. Oct, 2008  |   Pubmed ID: 18701217
• GCH1 Haplotype Determines Vascular and Plasma Biopterin Availability in Coronary Artery Disease Effects on Vascular Superoxide Production and Endothelial Function
  Journal of the American College of Cardiology. Jul, 2008  |   Pubmed ID: 18598896
• Clinical Genetics of Functionally Mild Non-coding GTP Cyclohydrolase 1 (GCH1) Polymorphisms Modulating Pain and Cardiovascular Risk
  Mutation Research. Sep-Oct, 2008  |   Pubmed ID: 18515178
• Reduced Hyperalgesia in Homozygous Carriers of a GTP Cyclohydrolase 1 Haplotype
  European Journal of Pain (London, England). Nov, 2008  |   Pubmed ID: 18374612
• Ro5-4864 Promotes Neonatal Motor Neuron Survival and Nerve Regeneration in Adult Rats
  The European Journal of Neuroscience. Feb, 2008  |   Pubmed ID: 18333964
• Cysteine-rich Protein 2, a Novel Downstream Effector of CGMP/cGMP-dependent Protein Kinase I-mediated Persistent Inflammatory Pain
  The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Feb, 2008  |   Pubmed ID: 18256252
• Low-dose Methotrexate Reduces Peripheral Nerve Injury-evoked Spinal Microglial Activation and Neuropathic Pain Behavior in Rats
  Pain. Aug, 2008  |   Pubmed ID: 18215468
• The Impact of CREB and Its Phosphorylation at Ser142 on Inflammatory Nociception
  Biochemical and Biophysical Research Communications. Oct, 2007  |   Pubmed ID: 17692820
• Cannabinoids Mediate Analgesia Largely Via Peripheral Type 1 Cannabinoid Receptors in Nociceptors
  Nature Neuroscience. Jul, 2007  |   Pubmed ID: 17558404
• Reliable Screening for a Pain-protective Haplotype in the GTP Cyclohydrolase 1 Gene (GCH1) Through the Use of 3 or Fewer Single Nucleotide Polymorphisms
  Clinical Chemistry. Jun, 2007  |   Pubmed ID: 17363416
• GTP Cyclohydrolase and Tetrahydrobiopterin Regulate Pain Sensitivity and Persistence
  Nature Medicine. Nov, 2006  |   Pubmed ID: 17057711
• Pathophysiology and Treatment of Pain in Joint Disease
  Advanced Drug Delivery Reviews. May, 2006  |   Pubmed ID: 16626837
• Cardiovascular Risk with Cyclooxygenase Inhibitors: General Problem with Substance Specific Differences?
  Naunyn-Schmiedeberg's Archives of Pharmacology. Apr, 2006  |   Pubmed ID: 16586083
• Comparative Proteomic Analysis of the Rat Spinal Cord in Inflammatory and Neuropathic Pain Models
  Neuroscience Letters. Jun, 2005  |   Pubmed ID: 15896486
• Essential Role of the Synaptic Vesicle Protein Synapsin II in Formalin-induced Hyperalgesia and Glutamate Release in the Spinal Cord
  Pain. May, 2005  |   Pubmed ID: 15836980
• Opioids As Modulators of Cell Death and Survival--unraveling Mechanisms and Revealing New Indications
  Pharmacological Reviews. Sep, 2004  |   Pubmed ID: 15317908
• The Calpain Inhibitor MDL 28170 Prevents Inflammation-induced Neurofilament Light Chain Breakdown in the Spinal Cord and Reduces Thermal Hyperalgesia
  Pain. Jul, 2004  |   Pubmed ID: 15275793
• Specific Inhibition of IkappaB Kinase Reduces Hyperalgesia in Inflammatory and Neuropathic Pain Models in Rats
  The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Feb, 2004  |   Pubmed ID: 14973242
• Reduced Inflammatory Hyperalgesia with Preservation of Acute Thermal Nociception in Mice Lacking CGMP-dependent Protein Kinase I
  Proceedings of the National Academy of Sciences of the United States of America. Mar, 2004  |   Pubmed ID: 14973199
• Protein Associated with Myc (PAM) is Involved in Spinal Nociceptive Processing
  Journal of Neurochemistry. Feb, 2004  |   Pubmed ID: 14756816
• Determination of 8-methoxypsoralen in Human Plasma, and Microdialysates Using Liquid Chromatography-tandem Mass Spectrometry
  Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences. Dec, 2003  |   Pubmed ID: 14643501
• Peripheral and Central Antihyperalgesic Effects of Diclofenac in a Model of Human Inflammatory Pain
  Clinical Pharmacology and Therapeutics. Aug, 2003  |   Pubmed ID: 12891221
• Activation of C-Jun-N-terminal-kinase is Crucial for the Induction of a Cell Cycle Arrest in Human Colon Carcinoma Cells Caused by Flurbiprofen Enantiomers
  FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Jul, 2003  |   Pubmed ID: 12759338
• Cisplatin Tumor Concentrations After Intra-arterial Cisplatin Infusion or Embolization in Patients with Oral Cancer
  Clinical Pharmacology and Therapeutics. May, 2003  |   Pubmed ID: 12732842
• G Protein-independent G1 Cell Cycle Block and Apoptosis with Morphine in Adenocarcinoma Cells: Involvement of P53 Phosphorylation
  Cancer Research. Apr, 2003  |   Pubmed ID: 12702572
• Peripheral Opioid Analgesia in Experimental Human Pain Models
  Brain : a Journal of Neurology. May, 2003  |   Pubmed ID: 12690049
• Inhibition of Cyclic Guanosine 5'-monophosphate-dependent Protein Kinase I (PKG-I) in Lumbar Spinal Cord Reduces Formalin-induced Hyperalgesia and PKG Upregulation
  Nitric Oxide : Biology and Chemistry. Mar, 2003  |   Pubmed ID: 12620371
• Opposite Effects of Rofecoxib on Nuclear Factor-kappaB and Activating Protein-1 Activation
  The Journal of Pharmacology and Experimental Therapeutics. Mar, 2003  |   Pubmed ID: 12604692
• Spatial Distribution of 8-methoxypsoralen Penetration into Human Skin After Systemic or Topical Administration
  British Journal of Clinical Pharmacology. Nov, 2002  |   Pubmed ID: 12445034
• Validation of a New Fluorogenic Real-time PCR Assay for Detection of CYP2C9 Allelic Variants and CYP2C9 Allelic Distribution in a German Population
  British Journal of Clinical Pharmacology. Nov, 2002  |   Pubmed ID: 12445031
• Increased CNS Uptake and Enhanced Antinociception of Morphine-6-glucuronide in Rats After Inhibition of P-glycoprotein
  Journal of Neurochemistry. Oct, 2002  |   Pubmed ID: 12423235
• Dual Effects of Spinally Delivered 8-bromo-cyclic Guanosine Mono-phosphate (8-bromo-cGMP) in Formalin-induced Nociception in Rats
  Neuroscience Letters. Oct, 2002  |   Pubmed ID: 12384231
• The Influence of Inhibition of Probenecid Sensitive Transporters on the Central Nervous System (CNS) Uptake and the Antinociceptive Activity of Morphine-6-glucuronide in Rats
  Neuroscience Letters. Aug, 2002  |   Pubmed ID: 12165398
• Tissue Distribution of Imipenem in Critically Ill Patients
  Clinical Pharmacology and Therapeutics. May, 2002  |   Pubmed ID: 12011818
• Time Course of 8-methoxypsoralen Concentrations in Skin and Plasma After Topical (bath and Cream) and Oral Administration of 8-methoxypsoralen
  Clinical Pharmacology and Therapeutics. Mar, 2002  |   Pubmed ID: 11907489
• Drug Interactions with Patient-controlled Analgesia
  Clinical Pharmacokinetics. 2002  |   Pubmed ID: 11825096