Articles by Ivan Gallotta in JoVE

• Biology

  
  Methods to Study Changes in Inherent Protein Aggregation with Age in Caenorhabditis elegans Nicole Groh^1,2, Ivan Gallotta¹, Marie C. Lechler^1,2, Chaolie Huang¹, Raimund Jung¹, Della C. David^{1 1}Protein Aggregation and Aging, German Center for Neurodegenerative Diseases (DZNE), ²Graduate School of Cellular and Molecular Neuroscience, German Center for Neurodegenerative Diseases (DZNE) The goal of the method presented here is to explore protein aggregation during normal aging in the model organism C. elegans. The protocol represents a powerful tool to study the highly insoluble large aggregates that form with age and to determine how changes in proteostasis impact protein aggregation.