Jürgen Götz

Publications

• Altered Brain Endothelial Cell Phenotype from a Familial Alzheimer Mutation and Its Potential Implications for Amyloid Clearance and Drug Delivery
  Stem Cell Reports. 05, 2020  |   Pubmed ID: 32275861
• PTEN Activation Contributes to Neuronal and Synaptic Engulfment by Microglia in Tauopathy
  Acta Neuropathologica. Jul, 2020  |   Pubmed ID: 32236736
• Cell-specific Non-canonical Amino Acid Labelling Identifies Changes in the De Novo Proteome During Memory Formation
  ELife. Jan, 2020  |   Pubmed ID: 31904341
• Mitochondria Modulatory Effects of New TSPO Ligands in a Cellular Model of Tauopathies
  Journal of Neuroendocrinology. 01, 2020  |   Pubmed ID: 31536662
• Experimental Models of Tauopathy - From Mechanisms to Therapies
  Advances in Experimental Medicine and Biology. 2019  |   Pubmed ID: 32096051
• The Blood-brain Barrier: Physiology and Strategies for Drug Delivery
  Advanced Drug Delivery Reviews. Nov, 2019  |   Pubmed ID: 31790711
• The Search for Improved Animal Models of Alzheimer's Disease and Novel Strategies for Therapeutic Intervention
  Future Medicinal Chemistry. 08, 2019  |   Pubmed ID: 31517531
• Scanning Ultrasound in the Absence of Blood-brain Barrier Opening is Not Sufficient to Clear β-amyloid Plaques in the APP23 Mouse Model of Alzheimer's Disease
  Brain Research Bulletin. 11, 2019  |   Pubmed ID: 31400496
• Repeated Ultrasound Treatment of Tau Transgenic Mice Clears Neuronal Tau by Autophagy and Improves Behavioral Functions
  Theranostics. 2019  |   Pubmed ID: 31281511
• Decreased Synthesis of Ribosomal Proteins in Tauopathy Revealed by Non-canonical Amino Acid Labelling
  The EMBO Journal. 07, 2019  |   Pubmed ID: 31268600
• Ultrasound-mediated Blood-brain Barrier Opening Enhances Delivery of Therapeutically Relevant Formats of a Tau-specific Antibody
  Scientific Reports. 06, 2019  |   Pubmed ID: 31239479
• Tauopathy in Veterans with Long-term Posttraumatic Stress Disorder and Traumatic Brain Injury
  European Journal of Nuclear Medicine and Molecular Imaging. May, 2019  |   Pubmed ID: 30617964
• Disease-associated Tau Impairs Mitophagy by Inhibiting Parkin Translocation to Mitochondria
  The EMBO Journal. 02, 2019  |   Pubmed ID: 30538104
• Molecular Pathogenesis of the Tauopathies
  Annual Review of Pathology. 01, 2019  |   Pubmed ID: 30355155
• Multimodal Analysis of Aged Wild-type Mice Exposed to Repeated Scanning Ultrasound Treatments Demonstrates Long-term Safety
  Theranostics. 2018  |   Pubmed ID: 30613294
• Local Oxidative Damage in the Soma and Dendrites Quarantines Neuronal Mitochondria at the Site of Insult
  IScience. Aug, 2018  |   Pubmed ID: 30240605
• Rodent Models for Alzheimer Disease
  Nature Reviews. Neuroscience. 10, 2018  |   Pubmed ID: 30194347
• Modeling Ultrasound Propagation Through Material of Increasing Geometrical Complexity
  Ultrasonics. Nov, 2018  |   Pubmed ID: 29909121
• Pyk2 is a Novel Tau Tyrosine Kinase That is Regulated by the Tyrosine Kinase Fyn
  Journal of Alzheimer's Disease : JAD. 2018  |   Pubmed ID: 29782321
• Establishing Sheep As an Experimental Species to Validate Ultrasound-mediated Blood-brain Barrier Opening for Potential Therapeutic Interventions
  Theranostics. 2018  |   Pubmed ID: 29721100
• Amyloid-β and Tau in Alzheimer's Disease: Novel Pathomechanisms and Non-Pharmacological Treatment Strategies
  Journal of Alzheimer's Disease : JAD. 2018  |   Pubmed ID: 29562514
• Exosomes Taken Up by Neurons Hijack the Endosomal Pathway to Spread to Interconnected Neurons
  Acta Neuropathologica Communications. 02, 2018  |   Pubmed ID: 29448966
• A Novel Antibody Targeting Tau Phosphorylated at Serine 235 Detects Neurofibrillary Tangles
  Journal of Alzheimer's Disease : JAD. 2018  |   Pubmed ID: 29332046
• Retiring the Term FTDP-17 As MAPT Mutations Are Genetic Forms of Sporadic Frontotemporal Tauopathies
  Brain : a Journal of Neurology. 02, 2018  |   Pubmed ID: 29253099
• Amyloid-β and Tau Complexity - Towards Improved Biomarkers and Targeted Therapies
  Nature Reviews. Neurology. Jan, 2018  |   Pubmed ID: 29242522
• Shedding Light on Mitophagy in Neurons: What is the Evidence for PINK1/Parkin Mitophagy in Vivo?
  Cellular and Molecular Life Sciences : CMLS. 04, 2018  |   Pubmed ID: 29085955
• A Corticostriatal Deficit Promotes Temporal Distortion of Automatic Action in Ageing
  ELife. 10, 2017  |   Pubmed ID: 29058672
• Tau-based Therapies in Neurodegeneration: Opportunities and Challenges
  Nature Reviews. Drug Discovery. Dec, 2017  |   Pubmed ID: 28983098
• Ultrasound As a Treatment Modality for Neurological Diseases
  The Medical Journal of Australia. 06, 2017  |   Pubmed ID: 28918723
• Somatodendritic Accumulation of Tau in Alzheimer's Disease is Promoted by Fyn-mediated Local Protein Translation
  The EMBO Journal. 11, 2017  |   Pubmed ID: 28864542
• The Amyloid-β Oligomer Aβ*56 Induces Specific Alterations in Neuronal Signaling That Lead to Tau Phosphorylation and Aggregation
  Science Signaling. May, 2017  |   Pubmed ID: 28487416
• Combined Effects of Scanning Ultrasound and a Tau-specific Single Chain Antibody in a Tau Transgenic Mouse Model
  Brain : a Journal of Neurology. May, 2017  |   Pubmed ID: 28379300
• Accelerated Aging Exacerbates a Pre-existing Pathology in a Tau Transgenic Mouse Model
  Aging Cell. Apr, 2017  |   Pubmed ID: 28160413
• Hyperphosphorylated Tau Causes Reduced Hippocampal CA1 Excitability by Relocating the Axon Initial Segment
  Acta Neuropathologica. 05, 2017  |   Pubmed ID: 28091722
• Mouse Models of Frontotemporal Dementia: A Comparison of Phenotypes with Clinical Symptomatology
  Neuroscience and Biobehavioral Reviews. Mar, 2017  |   Pubmed ID: 28088537
• Scanning Ultrasound (SUS) Causes No Changes to Neuronal Excitability and Prevents Age-Related Reductions in Hippocampal CA1 Dendritic Structure in Wild-Type Mice
  PloS One. 2016  |   Pubmed ID: 27727310
• Munc18-1 is a Molecular Chaperone for α-synuclein, Controlling Its Self-replicating Aggregation
  The Journal of Cell Biology. Sep, 2016  |   Pubmed ID: 27597756
• Special Issue on 'Cytoskeletal Proteins in Health and Neurodegenerative Disease'
  Brain Research Bulletin. 09, 2016  |   Pubmed ID: 27506280
• Motor Cortical Function Determines Prognosis in Sporadic ALS
  Neurology. Aug, 2016  |   Pubmed ID: 27402895
• Mobility and Subcellular Localization of Endogenous, Gene-edited Tau Differs from That of Over-expressed Human Wild-type and P301L Mutant Tau
  Scientific Reports. 07, 2016  |   Pubmed ID: 27378256
• Quantitative Imaging of Cholinergic Interneurons Reveals a Distinctive Spatial Organization and a Functional Gradient Across the Mouse Striatum
  PloS One. 2016  |   Pubmed ID: 27314496
• Tau Physiology and Pathomechanisms in Frontotemporal Lobar Degeneration
  Journal of Neurochemistry. 08, 2016  |   Pubmed ID: 27306859
• Glutamate Receptors in Alzheimer's Disease: Mechanisms and Therapies
  Neural Plasticity. 2016  |   Pubmed ID: 27293907
• A Local Insult of Okadaic Acid in Wild-type Mice Induces Tau Phosphorylation and Protein Aggregation in Anatomically Distinct Brain Regions
  Acta Neuropathologica Communications. Mar, 2016  |   Pubmed ID: 27037086
• Extracellular Vesicles Isolated from the Brains of RTg4510 Mice Seed Tau Protein Aggregation in a Threshold-dependent Manner
  The Journal of Biological Chemistry. Jun, 2016  |   Pubmed ID: 27030011
• Ultrasound Treatment of Neurological Diseases--current and Emerging Applications
  Nature Reviews. Neurology. Mar, 2016  |   Pubmed ID: 26891768
• Co-immunoprecipitation with Tau Isoform-specific Antibodies Reveals Distinct Protein Interactions and Highlights a Putative Role for 2N Tau in Disease
  The Journal of Biological Chemistry. Apr, 2016  |   Pubmed ID: 26861879
• Impulsivity, Decreased Social Exploration, and Executive Dysfunction in a Mouse Model of Frontotemporal Dementia
  Neurobiology of Learning and Memory. Apr, 2016  |   Pubmed ID: 26827932
• Sex Hormone-related Neurosteroids Differentially Rescue Bioenergetic Deficits Induced by Amyloid-β or Hyperphosphorylated Tau Protein
  Cellular and Molecular Life Sciences : CMLS. Jan, 2016  |   Pubmed ID: 26198711
• FTD and ALS--translating Mouse Studies into Clinical Trials
  Nature Reviews. Neurology. Jun, 2015  |   Pubmed ID: 25939274
• What We Can Learn from Animal Models About Cerebral Multi-morbidity
  Alzheimer's Research & Therapy. 2015  |   Pubmed ID: 25810783
• Scanning Ultrasound Removes Amyloid-β and Restores Memory in an Alzheimer's Disease Mouse Model
  Science Translational Medicine. Mar, 2015  |   Pubmed ID: 25761889
• Pseudophosphorylation of Tau at Distinct Epitopes or the Presence of the P301L Mutation Targets the Microtubule-associated Protein Tau to Dendritic Spines
  Biochimica Et Biophysica Acta. May, 2015  |   Pubmed ID: 25558816
• Tau Aggregation and Its Interplay with Amyloid-β
  Acta Neuropathologica. Feb, 2015  |   Pubmed ID: 25492702
• Connecting the Dots Between Tau Dysfunction and Neurodegeneration
  Trends in Cell Biology. Jan, 2015  |   Pubmed ID: 25172552
• Bio-orthogonal Labeling As a Tool to Visualize and Identify Newly Synthesized Proteins in Caenorhabditis Elegans
  Nature Protocols. Sep, 2014  |   Pubmed ID: 25167056
• Granulovacuolar Degeneration and Unfolded Protein Response in Mouse Models of Tauopathy and Aβ Amyloidosis
  Neurobiology of Disease. Nov, 2014  |   Pubmed ID: 25073087
• Premature Lethality, Hyperactivity, and Aberrant Phosphorylation in Transgenic Mice Expressing a Constitutively Active Form of Fyn
  Frontiers in Molecular Neuroscience. 2014  |   Pubmed ID: 24860422
• Visualizing the Microtubule-associated Protein Tau in the Nucleus
  Science China. Life Sciences. Apr, 2014  |   Pubmed ID: 24643416
• Altered Proteostasis in Aging and Heat Shock Response in C. Elegans Revealed by Analysis of the Global and De Novo Synthesized Proteome
  Cellular and Molecular Life Sciences : CMLS. Sep, 2014  |   Pubmed ID: 24458371
• March Separate, Strike Together--role of Phosphorylated TAU in Mitochondrial Dysfunction in Alzheimer's Disease
  Biochimica Et Biophysica Acta. Aug, 2014  |   Pubmed ID: 24051203
• Profiling Murine Tau with 0N, 1N and 2N Isoform-specific Antibodies in Brain and Peripheral Organs Reveals Distinct Subcellular Localization, with the 1N Isoform Being Enriched in the Nucleus
  PloS One. 2013  |   Pubmed ID: 24386422
• Lessons from Two Prevalent Amyloidoses-what Amylin and Aβ Have in Common
  Frontiers in Aging Neuroscience. 2013  |   Pubmed ID: 23964237
• What Renders TAU Toxic
  Frontiers in Neurology. 2013  |   Pubmed ID: 23772223
• Glutamate Metabolism is Impaired in Transgenic Mice with Tau Hyperphosphorylation
  Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. May, 2013  |   Pubmed ID: 23340677
• Alzheimer's Disease Models and Functional Genomics-How Many Needles Are There in the Haystack?
  Frontiers in Physiology. 2012  |   Pubmed ID: 22934069
• Tau Promotes Neurodegeneration Via DRP1 Mislocalization in Vivo
  Neuron. Aug, 2012  |   Pubmed ID: 22920254
• Alzheimer's Disease, Oestrogen and Mitochondria: an Ambiguous Relationship
  Molecular Neurobiology. Aug, 2012  |   Pubmed ID: 22678467