Jack Gorski Laboratory of Molecular Genetics Blood Research Institute Biography Publications Institution JoVE Articles Jack Gorski has not added a biography. If you are Jack Gorski and would like to personalize this page please email our Author Liaison for assistance. Publications A Requisite Role for Induced Regulatory T Cells in Tolerance Based on Expanding Antigen Receptor Diversity Immunity. Jul, 2011 | Pubmed ID: 21723159 The Polyclonal CD8 T Cell Response to Influenza M158-66 Generates a Fully Connected Network of Cross-reactive Clonotypes to Structurally Related Peptides: a Paradigm for Memory Repertoire Coverage of Novel Epitopes or Escape Mutants Journal of Immunology (Baltimore, Md. : 1950). Jun, 2011 | Pubmed ID: 21518969 Selective T Cell Expansion During Aging of CD8 Memory Repertoires to Influenza Revealed by Modeling Journal of Immunology (Baltimore, Md. : 1950). Jun, 2011 | Pubmed ID: 21515795 Naive T Cell Repertoire Skewing in HLA-A2 Individuals by a Specialized Rearrangement Mechanism Results in Public Memory Clonotypes Journal of Immunology (Baltimore, Md. : 1950). Mar, 2011 | Pubmed ID: 21282510 Functional Dichotomy Between NKG2D and CD28-mediated Co-stimulation in Human CD8+ T Cells PloS One. 2010 | Pubmed ID: 20844584 Disproportional Effects in Populations of Concern for Pandemic Influenza: Insights from Seasonal Epidemics in Wisconsin, 1967-2004 Influenza and Other Respiratory Viruses. Jul, 2010 | Pubmed ID: 20836795 Phospholipase C{gamma}1 is Essential for T Cell Development, Activation, and Tolerance The Journal of Experimental Medicine. Feb, 2010 | Pubmed ID: 20123962 Cutting Edge: HLA-DM-mediated Peptide Exchange Functions Normally on MHC Class II-peptide Complexes That Have Been Weakened by Elimination of a Conserved Hydrogen Bond Journal of Immunology (Baltimore, Md. : 1950). Feb, 2010 | Pubmed ID: 20038641 Peptide-MHC Class II Complex Stability Governs CD4 T Cell Clonal Selection Journal of Immunology (Baltimore, Md. : 1950). Jan, 2010 | Pubmed ID: 20007533 Two Compensatory Pathways Maintain Long-term Stability and Diversity in CD8 T Cell Memory Repertoires Journal of Immunology (Baltimore, Md. : 1950). Aug, 2009 | Pubmed ID: 19635925 The Transcription Factor RFX Protects MHC Class II Genes Against Epigenetic Silencing by DNA Methylation Journal of Immunology (Baltimore, Md. : 1950). Aug, 2009 | Pubmed ID: 19620312 A Clonotype Nomenclature for T Cell Receptors Immunogenetics. Jul, 2009 | Pubmed ID: 19568742 An Accessible Micro-capillary Electrophoresis Device Using Surface-tension-driven Flow Electrophoresis. May, 2009 | Pubmed ID: 19425002 Simulation Studies for a Multistage Dynamic Process of Immune Memory Response to Influenza: Experiment in Silico Annales Zoologici Fennici. Jan, 2008 | Pubmed ID: 20717502 HLA-DM Mediates Epitope Selection by a "compare-exchange" Mechanism when a Potential Peptide Pool is Available PloS One. 2008 | Pubmed ID: 19005572 Impaired Survival of Peripheral T Cells, Disrupted NK/NKT Cell Development, and Liver Failure in Mice Lacking Gimap5 Blood. Dec, 2008 | Pubmed ID: 18796632 Long-term Results of Bone Marrow Transplantation in Complete DiGeorge Syndrome The Journal of Allergy and Clinical Immunology. Oct, 2007 | Pubmed ID: 17931564 Quantitative Measurement of Pathogen-specific Human Memory T Cell Repertoire Diversity Using a CDR3 Beta-specific Microarray BMC Genomics. 2007 | Pubmed ID: 17880719 Crystallographic Structure of the Human Leukocyte Antigen DRA, DRB3*0101: Models of a Directional Alloimmune Response and Autoimmunity Journal of Molecular Biology. Aug, 2007 | Pubmed ID: 17583734 Cooperativity of Hydrophobic Anchor Interactions: Evidence for Epitope Selection by MHC Class II As a Folding Process Journal of Immunology (Baltimore, Md. : 1950). Jun, 2007 | Pubmed ID: 17513767 Homeostatic Expansion and Repertoire Regeneration of Donor T Cells During Graft Versus Host Disease is Constrained by the Host Environment Blood. Jun, 2007 | Pubmed ID: 17347406 Complex T Cell Memory Repertoires Participate in Recall Responses at Extremes of Antigenic Load Journal of Immunology (Baltimore, Md. : 1950). Aug, 2006 | Pubmed ID: 16849515 Factor VIII Ectopically Targeted to Platelets is Therapeutic in Hemophilia A with High-titer Inhibitory Antibodies The Journal of Clinical Investigation. Jul, 2006 | Pubmed ID: 16823491 Cooperativity During the Formation of Peptide/MHC Class II Complexes Biochemistry. Apr, 2005 | Pubmed ID: 15823020 A Polymorphic Pocket at the P10 Position Contributes to Peptide Binding Specificity in Class II MHC Proteins Chemistry & Biology. Oct, 2004 | Pubmed ID: 15489166 Gamma Delta T Cell Regulation of IFN-gamma Production by Central Nervous System-infiltrating Encephalitogenic T Cells: Correlation with Recovery from Experimental Autoimmune Encephalomyelitis Journal of Immunology (Baltimore, Md. : 1950). Aug, 2004 | Pubmed ID: 15265886 Selective Elimination of Alloreactive Donor T Cells Attenuates Graft-versus-host Disease and Enhances T-cell Reconstitution Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation. Dec, 2003 | Pubmed ID: 14677113 Cutting Edge: TCR Contacts As Anchors: Effects on Affinity and HLA-DM Stability Journal of Immunology (Baltimore, Md. : 1950). Dec, 2003 | Pubmed ID: 14634075 T Cell Receptor CDR3 Loop Length Repertoire is Determined Primarily by Features of the V(D)J Recombination Reaction European Journal of Immunology. Jun, 2003 | Pubmed ID: 12778474 A Fractal Clonotype Distribution in the CD8+ Memory T Cell Repertoire Could Optimize Potential for Immune Responses Journal of Immunology (Baltimore, Md. : 1950). Apr, 2003 | Pubmed ID: 12682227 Elimination of Leukemia in the Absence of Lethal Graft-versus-host Disease After Allogenic Bone Marrow Transplantation Journal of Immunology (Baltimore, Md. : 1950). Mar, 2003 | Pubmed ID: 12626559 Evidence for Preferred MHC Class II-TCR Recognition Independent of the Source of Bound Peptide European Journal of Immunology. Aug, 2002 | Pubmed ID: 12209630 Re-establishing Peripheral Tolerance in the Absence of CTLA-4: Complementation by Wild-type T Cells Points to an Indirect Role for CTLA-4 Journal of Immunology (Baltimore, Md. : 1950). Aug, 2002 | Pubmed ID: 12165509 A Molecular Marker for Thymocyte-positive Selection: Selection of CD4 Single-positive Thymocytes with Shorter TCRB CDR3 During T Cell Development Journal of Immunology (Baltimore, Md. : 1950). Apr, 2002 | Pubmed ID: 11937532 Overlap of Direct and Indirect Alloreactive T-cell Repertoires when MHC Polymorphism is Limited to the Peptide Binding Groove Human Immunology. Feb, 2002 | Pubmed ID: 11821156 C-terminal Anchoring of a Peptide to Class II MHC Via the P10 Residue is Compatible with a Peptide Bulge Journal of Immunology (Baltimore, Md. : 1950). Feb, 2002 | Pubmed ID: 11801666 High-throughput Detection Method for Influenza Virus Pawan Kumar1, Allison E. Bartoszek1, Thomas M. Moran2, Jack Gorski3, Sanjib Bhattacharyya4, Jose F. Navidad4, Monica S. Thakar1,5, Subramaniam Malarkannan1,6 1Laboratory of Molecular Immunology and Immunotherapy, Blood Research Institute, 2Department of Microbiology, Mount Sinai School of Medicine, 3Laboratory of Molecular Genetics, Blood Research Institute, 4City of Milwaukee Health Department Laboratory, 5Division of Hematology-Oncology/BMT, Children's Hospital of Wisconsin, Medical College of Wisconsin, 6Division of Hematology and Oncology, Dept Medicine, Medical College of Wisconsin JoVE 3623 Immunology and Infection
High-throughput Detection Method for Influenza Virus Pawan Kumar1, Allison E. Bartoszek1, Thomas M. Moran2, Jack Gorski3, Sanjib Bhattacharyya4, Jose F. Navidad4, Monica S. Thakar1,5, Subramaniam Malarkannan1,6 1Laboratory of Molecular Immunology and Immunotherapy, Blood Research Institute, 2Department of Microbiology, Mount Sinai School of Medicine, 3Laboratory of Molecular Genetics, Blood Research Institute, 4City of Milwaukee Health Department Laboratory, 5Division of Hematology-Oncology/BMT, Children's Hospital of Wisconsin, Medical College of Wisconsin, 6Division of Hematology and Oncology, Dept Medicine, Medical College of Wisconsin JoVE 3623 Immunology and Infection
