Jae Yong Chung Department of Clinical Pharmacology Seoul National University Bundang Hospital Biography Publications Institution JoVE Articles Jae Yong Chung has not added a biography. If you are Jae Yong Chung and would like to personalize this page please email our Author Liaison for assistance. Publications An Analysis of QTc Prolongation with Atypical Antipsychotic Medications and Selective Serotonin Reuptake Inhibitors Using a Large ECG Record Database Expert Opinion on Drug Safety. Jun, 2016 | Pubmed ID: 27276059 Intraocular Pharmacokinetics of Intravitreal Aflibercept (Eylea) in a Rabbit Model Investigative Ophthalmology & Visual Science. May, 2016 | Pubmed ID: 27258433 A Thorough QT Study to Evaluate the QTc Prolongation Potential of Two Neuropsychiatric Drugs, Quetiapine and Escitalopram, in Healthy Volunteers International Clinical Psychopharmacology. Jul, 2016 | Pubmed ID: 26950553 The MATE1 Rs2289669 Polymorphism Affects the Renal Clearance of Metformin Following Ranitidine Treatment International Journal of Clinical Pharmacology and Therapeutics. Apr, 2016 | Pubmed ID: 26784938 Pharmacokinetics, Safety, and Tolerability of Metformin in Healthy Elderly Subjects Journal of Clinical Pharmacology. Dec, 2015 | Pubmed ID: 26710683 Discovery of URAT1 SNPs and Association Between Serum Uric Acid Levels and URAT1 BMJ Open. 2015 | Pubmed ID: 26603249 Impact of Area Under the Concentration-time Curve to Minimum Inhibitory Concentration Ratio on Vancomycin Treatment Outcomes in Methicillin-resistant Staphylococcus Aureus Bacteraemia International Journal of Antimicrobial Agents. Dec, 2015 | Pubmed ID: 26555059 Pharmacokinetics of Second-Line Antituberculosis Drugs After Multiple Administrations in Healthy Volunteers Antimicrobial Agents and Chemotherapy. Aug, 2015 | Pubmed ID: 25987620 Pharmacokinetic-pharmacodynamic Analysis to Evaluate the Effect of Moxifloxacin on QT Interval Prolongation in Healthy Korean Male Subjects Drug Design, Development and Therapy. 2015 | Pubmed ID: 25750520 Erratum. Intraocular Pharmacokinetics of Ranibizumab in Vitrectomized Versus Nonvitrectomized Eyes Investigative Ophthalmology & Visual Science. Mar, 2015 | Pubmed ID: 25737148 Antihyperglycemic Mechanism of Metformin Occurs Via the AMPK/LXRα/POMC Pathway Scientific Reports. 2015 | Pubmed ID: 25634597 Pharmacokinetics and Tolerability of the New Second-generation Nonnucleoside Reverse- Transcriptase Inhibitor KM-023 in Healthy Subjects Drug Design, Development and Therapy. 2014 | Pubmed ID: 25302016 Verapamil Decreases the Glucose-lowering Effect of Metformin in Healthy Volunteers British Journal of Clinical Pharmacology. Dec, 2014 | Pubmed ID: 25060604 Korean, Japanese, and Chinese Populations Featured Similar Genes Encoding Drug-metabolizing Enzymes and Transporters: a DMET Plus Microarray Assessment Pharmacogenetics and Genomics. Oct, 2014 | Pubmed ID: 25029633 Effects of Proton Pump Inhibitors on Metformin Pharmacokinetics and Pharmacodynamics Drug Metabolism and Disposition: the Biological Fate of Chemicals. Jul, 2014 | Pubmed ID: 24764147 The Effects of Moxifloxacin on QTc Interval in Healthy Korean Male Subjects Drugs in R&D. Jun, 2014 | Pubmed ID: 24691742 Intraocular Pharmacokinetics of Ranibizumab in Vitrectomized Versus Nonvitrectomized Eyes Investigative Ophthalmology & Visual Science. Jan, 2014 | Pubmed ID: 24398088 Area Under the Concentration-time Curve to Minimum Inhibitory Concentration Ratio As a Predictor of Vancomycin Treatment Outcome in Methicillin-resistant Staphylococcus Aureus Bacteraemia International Journal of Antimicrobial Agents. Feb, 2014 | Pubmed ID: 24315788 SIU/ICUD Consultation On Urethral Strictures: Epidemiology, Etiology, Anatomy, and Nomenclature of Urethral Stenoses, Strictures, and Pelvic Fracture Urethral Disruption Injuries Urology. Mar, 2014 | Pubmed ID: 24210733 Pharmacokinetics, Safety and Tolerability of DA-6034, an Anti-inflammatory Agent, After Single and Multiple Oral Administrations in Healthy Volunteers Clinical Drug Investigation. Jan, 2014 | Pubmed ID: 24158940 Percutaneous Nephrolithotomy: Comparison of the Efficacies and Feasibilities of Regional and General Anesthesia Korean Journal of Urology. Dec, 2013 | Pubmed ID: 24363866 Sustained Increase in the Oral Bioavailability of Loperamide After a Single Oral Dose of HM30181, a P-glycoprotein Inhibitor, in Healthy Male Participants Basic & Clinical Pharmacology & Toxicology. Dec, 2013 | Pubmed ID: 23829508 Functional Characterization of MATE2-K Genetic Variants and Their Effects on Metformin Pharmacokinetics Pharmacogenetics and Genomics. Jul, 2013 | Pubmed ID: 23652408 Serum Cystatin C is a Major Predictor of Vancomycin Clearance in a Population Pharmacokinetic Analysis of Patients with Normal Serum Creatinine Concentrations Journal of Korean Medical Science. Jan, 2013 | Pubmed ID: 23341711 Impact of ABCC2, ABCG2 and SLCO1B1 Polymorphisms on the Pharmacokinetics of Pitavastatin in Humans Drug Metabolism and Pharmacokinetics. 2013 | Pubmed ID: 23007012 Efficacy and Safety of Emergency Ureteroscopic Management of Ureteral Calculi Korean Journal of Urology. Sep, 2012 | Pubmed ID: 23061001 Modeling of the LDL Cholesterol-lowering Effect of Atorvastatin in Korean Dyslipidemic Patients and Non-patient Volunteers International Journal of Clinical Pharmacology and Therapeutics. Sep, 2012 | Pubmed ID: 22981146 The UGT1A3*2 Polymorphism Affects Atorvastatin Lactonization and Lipid-lowering Effect in Healthy Volunteers Pharmacogenetics and Genomics. Aug, 2012 | Pubmed ID: 22555810 Influence of ABCC2, SLCO1B1, and ABCG2 Polymorphisms on the Pharmacokinetics of Olmesartan Journal of Cardiovascular Pharmacology. Jul, 2012 | Pubmed ID: 22494992 One-year Outcomes of Mid-urethral Sling Procedures for Stress Urinary Incontinence According to Body Mass Index Korean Journal of Urology. Mar, 2012 | Pubmed ID: 22468212 Effect of Prostatitis on Lower Urinary Tract Symptoms: Retrospective Analysis of Prostate Biopsy Tissue Korean Journal of Urology. Feb, 2012 | Pubmed ID: 22379590 Effects of Cytochrome P450 (CYP)2C19 Polymorphisms on Pharmacokinetics of Phenobarbital in Neonates and Infants with Seizures Archives of Disease in Childhood. Jun, 2012 | Pubmed ID: 22331680 Effect of HMGCR Variant Alleles on Low-density Lipoprotein Cholesterol-lowering Response to Atorvastatin in Healthy Korean Subjects Journal of Clinical Pharmacology. Mar, 2012 | Pubmed ID: 21427285 Pharmacokinetic Comparison of Sustained- and Immediate-release Oral Formulations of Cilostazol in Healthy Korean Subjects: a Randomized, Open-label, 3-part, Sequential, 2-period, Crossover, Single-dose, Food-effect, and Multiple-dose Study Clinical Therapeutics. Dec, 2011 | Pubmed ID: 22129569 Safety and Pharmacokinetics of Intrathecal Administration of Pemetrexed in Rats Cancer Chemotherapy and Pharmacology. Aug, 2011 | Pubmed ID: 21107572 Effects of Pregnane X Receptor (NR1I2) and CYP2B6 Genetic Polymorphisms on the Induction of Bupropion Hydroxylation by Rifampin Drug Metabolism and Disposition: the Biological Fate of Chemicals. Jan, 2011 | Pubmed ID: 20876786 Activation of MAP Kinases During Progression of Radiation-induced Pneumonitis in Rats Human & Experimental Toxicology. Aug, 2011 | Pubmed ID: 20819845 Effect of CYP2B6 Genotype on the Pharmacokinetics of Sibutramine and Active Metabolites in Healthy Subjects Journal of Clinical Pharmacology. Jan, 2011 | Pubmed ID: 20350955 Comparison of Percutaneous Nephrolithotomy Using Pneumatic Lithotripsy (lithoclast®) Alone or in Combination with Ultrasonic Lithotripsy Korean Journal of Urology. Nov, 2010 | Pubmed ID: 21165200 Evaluation of Possible Predictive Variables for the Outcome of Shock Wave Lithotripsy of Renal Stones Korean Journal of Urology. Oct, 2010 | Pubmed ID: 21031093 Comparison of the Bioavailability and Tolerability of Fixed-dose Combination Glimepiride/metformin 2/500-mg Tablets Versus Separate Tablets: A Single-dose, Randomized-sequence, Open-label, Two-period Crossover Study in Healthy Korean Volunteers Clinical Therapeutics. Jul, 2010 | Pubmed ID: 20678687 CYP3A5*3 Genotype Associated with Intrasubject Pharmacokinetic Variation Toward Tacrolimus in Bioequivalence Study Therapeutic Drug Monitoring. Feb, 2010 | Pubmed ID: 20010459 Development of Korean Academy of Medical Sciences Guideline Rating the Physical Impairment; Kidney, Bladder, Urethra, Male and Female Reproductive Systems (preliminary Report) Journal of Korean Medical Science. May, 2009 | Pubmed ID: 19503685 Eosinophilic Myositis in a Slaughtered Korean Native Cattle Journal of Veterinary Science. Dec, 2008 | Pubmed ID: 19043319 Bone-protecting Effect of Rubus Coreanus by Dual Regulation of Osteoblasts and Osteoclasts Menopause (New York, N.Y.). Jul-Aug, 2008 | Pubmed ID: 18709701 Safety, Tolerability and Pharmacokinetics of Udenafil, a Novel PDE-5 Inhibitor, in Healthy Young Korean Subjects British Journal of Clinical Pharmacology. Jun, 2008 | Pubmed ID: 18318773 Angiotensin II Type 1 Receptor 1166A/C Polymorphism in Association with Blood Pressure Response to Exogenous Angiotensin II European Journal of Clinical Pharmacology. Jan, 2007 | Pubmed ID: 17146658 Effects of Bio-active Ceramic Resources in Cutaneous Wound Healing and the Role of TGF-beta Signaling Molecular and Cellular Biochemistry. Jan, 2007 | Pubmed ID: 16871359 Up-regulation of Metabotropic Glutamate Receptor 3 (mGluR3) in Rat Fibrosis and Cirrhosis Model of Persistent Hypoxic Condition Molecular and Cellular Biochemistry. Jan, 2007 | Pubmed ID: 16845489 Canine Renal Failure Syndrome in Three Dogs Journal of Veterinary Science. Sep, 2006 | Pubmed ID: 16871028 Effect of OATP1B1 (SLCO1B1) Variant Alleles on the Pharmacokinetics of Pitavastatin in Healthy Volunteers Clinical Pharmacology and Therapeutics. Oct, 2005 | Pubmed ID: 16198653 Effect of the UGT2B15 Genotype on the Pharmacokinetics, Pharmacodynamics, and Drug Interactions of Intravenous Lorazepam in Healthy Volunteers Clinical Pharmacology and Therapeutics. Jun, 2005 | Pubmed ID: 15961980 A Variant 2677A Allele of the MDR1 Gene Affects Fexofenadine Disposition Clinical Pharmacology and Therapeutics. Nov, 2004 | Pubmed ID: 15536457 Haplotype Structure and Allele Frequencies of CYP2B6 in a Korean Population Drug Metabolism and Disposition: the Biological Fate of Chemicals. Dec, 2004 | Pubmed ID: 15383491 Effect of the CYP3A5 Genotype on the Pharmacokinetics of Intravenous Midazolam During Inhibited and Induced Metabolic States Clinical Pharmacology and Therapeutics. Aug, 2004 | Pubmed ID: 15289787 Phase I and Pharmacokinetic Study of Genexol-PM, a Cremophor-free, Polymeric Micelle-formulated Paclitaxel, in Patients with Advanced Malignancies Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Jun, 2004 | Pubmed ID: 15173077 Pharmacokinetic and Pharmacodynamic Evaluation of a Novel Proton Pump Inhibitor, YH1885, in Healthy Volunteers Journal of Clinical Pharmacology. Jan, 2004 | Pubmed ID: 14681344 Hepatic Cirrhosis Occurring in a Young Woodchuck (Marmota Monax) Due to Vertical Transmission of Woodchuck Hepatitis Virus (WHV) Journal of Veterinary Science. Aug, 2003 | Pubmed ID: 14610377 Effect of the CYP2D6 Genotype on the Pharmacokinetics of Tropisetron in Healthy Korean Subjects European Journal of Clinical Pharmacology. Jun, 2003 | Pubmed ID: 12728290 Fetal Bladder Outlet Obstruction in a Stillborn Bovine Fetus The Journal of Veterinary Medical Science / the Japanese Society of Veterinary Science. Mar, 2003 | Pubmed ID: 12679573 Kinetics of Macrophages, Myofibroblasts and Mast Cells in Carbon Tetrachloride-induced Rat Liver Cirrhosis Anticancer Research. Mar-Apr, 2002 | Pubmed ID: 12014664 Use of Rabbit Eyes in Pharmacokinetic Studies of Intraocular Drugs Seong Joon Ahn1,2,3, Hye Kyoung Hong1, Young Mi Na1, Sang Jun Park1,2, Jeeyun Ahn1,2,4, Jaeseong Oh5, Jae Yong Chung6, Kyu Hyung Park1,2, Se Joon Woo1,2 1Department of Ophthalmology, Seoul National University Bundang Hospital, 2Department of Ophthalmology, College of Medicine, Seoul National University, 3Department of Ophthalmology, Hanyang University Hospital, 4Department of Ophthalmology, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, 5Department of Clinical Pharmacology, Seoul National University Hospital, 6Department of Clinical Pharmacology, Seoul National University Bundang Hospital JoVE 53878 Medicine
Use of Rabbit Eyes in Pharmacokinetic Studies of Intraocular Drugs Seong Joon Ahn1,2,3, Hye Kyoung Hong1, Young Mi Na1, Sang Jun Park1,2, Jeeyun Ahn1,2,4, Jaeseong Oh5, Jae Yong Chung6, Kyu Hyung Park1,2, Se Joon Woo1,2 1Department of Ophthalmology, Seoul National University Bundang Hospital, 2Department of Ophthalmology, College of Medicine, Seoul National University, 3Department of Ophthalmology, Hanyang University Hospital, 4Department of Ophthalmology, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, 5Department of Clinical Pharmacology, Seoul National University Hospital, 6Department of Clinical Pharmacology, Seoul National University Bundang Hospital JoVE 53878 Medicine
