James R. Woodgett

Publications

• Towards the Preparation of Radiolabeled 1-aryl-3-benzyl Ureas: Radiosynthesis of [(11)C-carbonyl] AR-A014418 by [(11)C]CO(2) Fixation
  Bioorganic & Medicinal Chemistry Letters. Jan, 2012  |   Pubmed ID: 22321216
• Genetic Inactivation of GSK3α Rescues Spine Deficits in Disc1-L100P Mutant Mice
  Schizophrenia Research. Jun, 2011  |   Pubmed ID: 21498050
• Selective Loss of Glycogen Synthase Kinase-3α in Birds Reveals Distinct Roles for GSK-3 Isozymes in Tau Phosphorylation
  FEBS Letters. Apr, 2011  |   Pubmed ID: 21419127
• Tissue-specific Analysis of Glycogen Synthase Kinase-3α (GSK-3α) in Glucose Metabolism: Effect of Strain Variation
  PloS One. 2011  |   Pubmed ID: 21253590
• Genetic and Pharmacological Evidence for Schizophrenia-related Disc1 Interaction with GSK-3
  Synapse (New York, N.Y.). Mar, 2011  |   Pubmed ID: 20687111
• Does GSK-3 Provide a Shortcut for PI3K Activation of Wnt Signalling?
  F1000 Biology Reports. 2010  |   Pubmed ID: 21283602
• Inhibitory Phosphorylation of GSK-3 by CaMKII Couples Depolarization to Neuronal Survival
  The Journal of Biological Chemistry. Dec, 2010  |   Pubmed ID: 20841359
• Role of Phosphoinositide 3-kinase {alpha}, Protein Kinase C, and L-type Ca2+ Channels in Mediating the Complex Actions of Angiotensin II on Mouse Cardiac Contractility
  Hypertension. Sep, 2010  |   Pubmed ID: 20696985
• When Pathways Collide: Collaboration and Connivance Among Signalling Proteins in Development
  Nature Reviews. Molecular Cell Biology. Jun, 2010  |   Pubmed ID: 20461097
• Glycogen Synthase Kinase-3beta Regulates Post-myocardial Infarction Remodeling and Stress-induced Cardiomyocyte Proliferation in Vivo
  Circulation Research. May, 2010  |   Pubmed ID: 20360256
• Abnormalities in Brain Structure and Behavior in GSK-3alpha Mutant Mice
  Molecular Brain. 2009  |   Pubmed ID: 19925672
• GSK-3 is a Master Regulator of Neural Progenitor Homeostasis
  Nature Neuroscience. Nov, 2009  |   Pubmed ID: 19801986
• Akt1 and Akt2 Play Distinct Roles in the Initiation and Metastatic Phases of Mammary Tumor Progression
  Cancer Research. Jun, 2009  |   Pubmed ID: 19491266
• IL-17 Receptor Signaling Inhibits C/EBPbeta by Sequential Phosphorylation of the Regulatory 2 Domain
  Science Signaling. Feb, 2009  |   Pubmed ID: 19244213
• Exploring Pluripotency with Chemical Genetics
  Cell Stem Cell. Feb, 2009  |   Pubmed ID: 19200796
• Unique and Overlapping Functions of GSK-3 Isoforms in Cell Differentiation and Proliferation and Cardiovascular Development
  The Journal of Biological Chemistry. Apr, 2009  |   Pubmed ID: 19064989
• Utility of Metformin in Breast Cancer Treatment, is Neoangiogenesis a Risk Factor?
  Breast Cancer Research and Treatment. Mar, 2009  |   Pubmed ID: 18438706
• Deletion of GSK-3beta in Mice Leads to Hypertrophic Cardiomyopathy Secondary to Cardiomyoblast Hyperproliferation
  The Journal of Clinical Investigation. Nov, 2008  |   Pubmed ID: 18830417
• GSK-3beta in Mouse Fibroblasts Controls Wound Healing and Fibrosis Through an Endothelin-1-dependent Mechanism
  The Journal of Clinical Investigation. Oct, 2008  |   Pubmed ID: 18802478
• Targeting Glycogen Synthase Kinase-3 (GSK-3) in the Treatment of Type 2 Diabetes
  Expert Opinion on Therapeutic Targets. Oct, 2008  |   Pubmed ID: 18781825
• Tissue-specific Role of Glycogen Synthase Kinase 3beta in Glucose Homeostasis and Insulin Action
  Molecular and Cellular Biology. Oct, 2008  |   Pubmed ID: 18694957
• Phosphorylation of GSK-3beta by CGMP-dependent Protein Kinase II Promotes Hypertrophic Differentiation of Murine Chondrocytes
  The Journal of Clinical Investigation. Jul, 2008  |   Pubmed ID: 18551195
• Glycogen Synthase Kinase-3beta Heterozygote Knockout Mice As a Model of Findings in Postmortem Schizophrenia Brain or As a Model of Behaviors Mimicking Lithium Action: Negative Results
  Behavioural Pharmacology. May, 2008  |   Pubmed ID: 18469539
• Homozygous Deletion of Glycogen Synthase Kinase 3beta Bypasses Senescence Allowing Ras Transformation of Primary Murine Fibroblasts
  Proceedings of the National Academy of Sciences of the United States of America. Apr, 2008  |   Pubmed ID: 18367674
• Rationally Designed PKA Inhibitors for Positron Emission Tomography: Synthesis and Cerebral Biodistribution of N-(2-(4-bromocinnamylamino)ethyl)-N-[11C]methyl-isoquinoline-5-sulfonamide
  Bioorganic & Medicinal Chemistry. May, 2008  |   Pubmed ID: 18346896
• Genetic Deficiency of Glycogen Synthase Kinase-3beta Corrects Diabetes in Mouse Models of Insulin Resistance
  PLoS Biology. Feb, 2008  |   Pubmed ID: 18288891
• Frequent Accumulation of Nuclear E-cadherin and Alterations in the Wnt Signaling Pathway in Esophageal Squamous Cell Carcinomas
  Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc. Mar, 2008  |   Pubmed ID: 18084253
• Glycogen Synthase Kinase 3alpha-specific Regulation of Murine Hepatic Glycogen Metabolism
  Cell Metabolism. Oct, 2007  |   Pubmed ID: 17908561
• GSK-3beta Controls Osteogenesis Through Regulating Runx2 Activity
  PloS One. 2007  |   Pubmed ID: 17786208
• Glycogen Synthase Kinase-3beta Induces Neuronal Cell Death Via Direct Phosphorylation of Mixed Lineage Kinase 3
  The Journal of Biological Chemistry. Oct, 2007  |   Pubmed ID: 17711861
• Role of Glycogen Synthase Kinase-3 in Cell Fate and Epithelial-mesenchymal Transitions
  Cells, Tissues, Organs. 2007  |   Pubmed ID: 17587811
• Systematic Discovery of in Vivo Phosphorylation Networks
  Cell. Jun, 2007  |   Pubmed ID: 17570479
• Functional Redundancy of GSK-3alpha and GSK-3beta in Wnt/beta-catenin Signaling Shown by Using an Allelic Series of Embryonic Stem Cell Lines
  Developmental Cell. Jun, 2007  |   Pubmed ID: 17543867
• CD4+ and CD8+ T Cell Survival is Regulated Differentially by Protein Kinase Ctheta, C-Rel, and Protein Kinase B
  Journal of Immunology (Baltimore, Md. : 1950). Mar, 2007  |   Pubmed ID: 17312138
• Glycogen Synthase Kinase 3, Circadian Rhythms, and Bipolar Disorder: a Molecular Link in the Therapeutic Action of Lithium
  Journal of Circadian Rhythms. 2007  |   Pubmed ID: 17295926
• Essential Roles for GSK-3s and GSK-3-primed Substrates in Neurotrophin-induced and Hippocampal Axon Growth
  Neuron. Dec, 2006  |   Pubmed ID: 17178402
• Glycogen Synthase Kinase-3--an Overview of an Over-achieving Protein Kinase
  Current Drug Targets. Nov, 2006  |   Pubmed ID: 17100578
• Functional Distinctions of Protein Kinase B/Akt Isoforms Defined by Their Influence on Cell Migration
  Trends in Cell Biology. Sep, 2006  |   Pubmed ID: 16870447
• Role of the Phox Homology Domain and Phosphorylation in Activation of Serum and Glucocorticoid-regulated Kinase-3
  The Journal of Biological Chemistry. Aug, 2006  |   Pubmed ID: 16790420
• IFN-gamma Suppresses IL-10 Production and Synergizes with TLR2 by Regulating GSK3 and CREB/AP-1 Proteins
  Immunity. May, 2006  |   Pubmed ID: 16713974
• Serum and Glucocorticoid-regulated Protein Kinases: Variations on a Theme
  Journal of Cellular Biochemistry. Aug, 2006  |   Pubmed ID: 16619268
• Expression of Wnt-signaling Pathway Proteins in Intraductal Papillary Mucinous Neoplasms of the Pancreas: a Tissue Microarray Analysis
  Human Pathology. Feb, 2006  |   Pubmed ID: 16426922
• NF-kappaB Couples Protein Kinase B/Akt Signaling to Distinct Survival Pathways and the Regulation of Lymphocyte Homeostasis in Vivo
  Journal of Immunology (Baltimore, Md. : 1950). Sep, 2005  |   Pubmed ID: 16148125
• Modulating Autoimmunity: Pick Your PI3 Kinase
  Nature Medicine. Sep, 2005  |   Pubmed ID: 16145571
• GSK3: an In-Toll-erant Protein Kinase?
  Nature Immunology. Aug, 2005  |   Pubmed ID: 16034428
• Chronic Activation of Protein Kinase Bbeta/Akt2 Leads to Multinucleation and Cell Fusion in Human Epithelial Kidney Cells: Events Associated with Tumorigenesis
  Oncogene. Aug, 2005  |   Pubmed ID: 16007218
• Differential Gene Expression Profile Reveals Deregulation of Pregnancy Specific Beta1 Glycoprotein 9 Early During Colorectal Carcinogenesis
  BMC Cancer. 2005  |   Pubmed ID: 15982419
• Problems with Co-funding in Canada
  Science (New York, N.Y.). Jun, 2005  |   Pubmed ID: 15976286
• CpG Island Microarray Probe Sequences Derived from a Physical Library Are Representative of CpG Islands Annotated on the Human Genome
  Nucleic Acids Research. 2005  |   Pubmed ID: 15911630
• Recent Advances in the Protein Kinase B Signaling Pathway
  Current Opinion in Cell Biology. Apr, 2005  |   Pubmed ID: 15780591
• Phosphoinositide-dependent Phosphorylation of PDK1 Regulates Nuclear Translocation
  Molecular and Cellular Biology. Mar, 2005  |   Pubmed ID: 15743829
• Glycogen Synthase Kinase 3beta is a Negative Regulator of Growth Factor-induced Activation of the C-Jun N-terminal Kinase
  The Journal of Biological Chemistry. Dec, 2004  |   Pubmed ID: 15466414
• Proteomic, Functional, and Domain-based Analysis of in Vivo 14-3-3 Binding Proteins Involved in Cytoskeletal Regulation and Cellular Organization
  Current Biology : CB. Aug, 2004  |   Pubmed ID: 15324660
• Glycogen Synthase Kinase-3beta Haploinsufficiency Mimics the Behavioral and Molecular Effects of Lithium
  The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Jul, 2004  |   Pubmed ID: 15282284
• Lithium Antagonizes Dopamine-dependent Behaviors Mediated by an AKT/glycogen Synthase Kinase 3 Signaling Cascade
  Proceedings of the National Academy of Sciences of the United States of America. Apr, 2004  |   Pubmed ID: 15044694
• Unravelling the Activation Mechanisms of Protein Kinase B/Akt
  FEBS Letters. Jul, 2003  |   Pubmed ID: 12829245
• JNK1 Activity Lowers the Cellular Production of H2O2 and Modulates the Growth Arrest Response to Scavenging of H2O2 by Catalase
  Experimental Cell Research. Apr, 2003  |   Pubmed ID: 12681294
• GSK-3: Tricks of the Trade for a Multi-tasking Kinase
  Journal of Cell Science. Apr, 2003  |   Pubmed ID: 12615961
• Negative Regulation of Mixed Lineage Kinase 3 by Protein Kinase B/AKT Leads to Cell Survival
  The Journal of Biological Chemistry. Feb, 2003  |   Pubmed ID: 12458207
• Negative Regulation of Phosphatidylinositol 3-kinase and Akt Signalling Pathway by PKC
  Cellular Signalling. Jan, 2003  |   Pubmed ID: 12401518
• Open Heart Surgery of PI-3 Kinase Signaling
  Cell Cycle (Georgetown, Tex.). Nov-Dec, 2002  |   Pubmed ID: 12548014
• A Molecular Compendium of Genes Expressed in Multiple Myeloma
  Blood. Sep, 2002  |   Pubmed ID: 12200383
• Multiple Phosphoinositide 3-kinase-dependent Steps in Activation of Protein Kinase B
  Molecular and Cellular Biology. Sep, 2002  |   Pubmed ID: 12167717
• CD28-dependent Activation of Protein Kinase B/Akt Blocks Fas-mediated Apoptosis by Preventing Death-inducing Signaling Complex Assembly
  The Journal of Experimental Medicine. Aug, 2002  |   Pubmed ID: 12163562
• Convergence of Multiple Signaling Cascades at Glycogen Synthase Kinase 3: Edg Receptor-mediated Phosphorylation and Inactivation by Lysophosphatidic Acid Through a Protein Kinase C-dependent Intracellular Pathway
  Molecular and Cellular Biology. Apr, 2002  |   Pubmed ID: 11884598
• Role of Glycogen Synthase Kinase-3 in Cancer: Regulation by Wnts and Other Signaling Pathways
  Advances in Cancer Research. 2002  |   Pubmed ID: 11883528
• The Active Form of Glycogen Synthase Kinase-3beta is Associated with Granulovacuolar Degeneration in Neurons in Alzheimer's Disease
  Acta Neuropathologica. Feb, 2002  |   Pubmed ID: 11810173
• DREAM is a Critical Transcriptional Repressor for Pain Modulation
  Cell. Jan, 2002  |   Pubmed ID: 11792319