Jean-François Tanti

Centre Méditerranéen de Médecine Moléculaire (C3M)/Inserm U1065


Jean-François Tanti
PhD, Research Director

Jean-François Tanti did his PhD in the laboratory of the Professor Emmanuel Van Obberghen in Nice (France) under the supervision of the Doctor Yannick Le Marchand-Brustel where he studied the role of PKC and cAMP dependent kinase in the modulation of the insulin signaling and metabolic effects. In 1990, he obtained a tenured position in CNRS (Centre National de la Recherche Scientifique) to work on the insulin signaling pathways involved in glucose transport. In 2003, he moved to the new laboratory of Dr Y Le Marchand-Brustel focusing mainly on the posttranslational modifications of insulin receptor substrate and the role of different serine kinases in the development of insulin resistance. In 2007, he became a group leader in the Mediterranean Research Center for Molecular Medicine where his team « Cellular and Molecular Pathophysiology of Obesity and Diabetes" focuses on three related and highly integrated areas which are central to obesity-associated insulin resistance and T2D development : 1) mechanisms of insulin signaling and glucose transport in adipocytes and how they are altered in insulin resistant state 2) identification of stress-signaling pathways involved in adipose tissue inflammation and dysfunction 3) identification of new players controlling hepatic gluconeogenesis.He is also the deputy director of the C3M Institute. He is author of 101 original articles or reviews in peer-reviewed journals.


Exploring Adipose Tissue Structure by Methylsalicylate Clearing and 3D Imaging

1Université Côte d'Azur, Inserm UMR1065, C3M, Team "Cellular and Molecular Pathophysiology of Obesity", Nice, France, 2Integrated Cardio Metabolic Center, Department of Medicine, Karolinska Institutet, Stockholm, Sweden, 3Université Côte d'Azur, Inserm UMR1065, C3M, Team "Haematometabolism in Diseases", Nice, France, 4Institut de Pharmacologie et de Biologie Structurale (IPBS), Université de Toulouse, CNRS, UPS, Toulouse, France

JoVE 61640