Jean Rommelaere Tumour Virology Division F010 German Cancer Research Center (DKFZ) Biography Publications Institution JoVE Articles Jean Rommelaere has not added a biography. If you are Jean Rommelaere and would like to personalize this page please email our Author Liaison for assistance. Publications Phase I/IIa Study of Intratumoral/intracerebral or Intravenous/intracerebral Administration of Parvovirus H-1 (ParvOryx) in Patients with Progressive Primary or Recurrent Glioblastoma Multiforme: ParvOryx01 Protocol BMC Cancer. Mar, 2012 | Pubmed ID: 22436661 Activation of a Helper and Not Regulatory Human CD4+ T Cell Response by Oncolytic H-1 Parvovirus PloS One. 2012 | Pubmed ID: 22359669 Retargeting of Rat Parvovirus H-1PV to Cancer Cells Through Genetic Engineering of the Viral Capsid Journal of Virology. Apr, 2012 | Pubmed ID: 22258256 Activation of the Human Immune System by Chemotherapeutic or Targeted Agents Combined with the Oncolytic Parvovirus H-1 BMC Cancer. 2011 | Pubmed ID: 22029859 Interferon γ Improves the Vaccination Potential of Oncolytic Parvovirus H-1PV for the Treatment of Peritoneal Carcinomatosis in Pancreatic Cancer Cancer Biology & Therapy. Nov, 2011 | Pubmed ID: 22024742 Regression of Glioma in Rat Models by Intranasal Application of Parvovirus H-1 Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Aug, 2011 | Pubmed ID: 21715567 The Combined Effects of Oncolytic Reovirus Plus Newcastle Disease Virus and Reovirus Plus Parvovirus on U87 and U373 Cells In vitro and In vivo Journal of Neuro-oncology. Sep, 2011 | Pubmed ID: 21607667 Immune Cells Participate in the Oncosuppressive Activity of Parvovirus H-1PV and Are Activated As a Result of Their Abortive Infection with This Agent Cancer Biology & Therapy. Jan, 2011 | Pubmed ID: 21124075 Enhancement of NK Cell Antitumor Responses Using an Oncolytic Parvovirus International Journal of Cancer. Journal International Du Cancer. Feb, 2011 | Pubmed ID: 20473905 Therapeutic Implications of the Enhanced Short and Long-term Cytotoxicity of Radiation Treatment Followed by Oncolytic Parvovirus H-1 Infection in High-grade Glioma Cells Bioengineered Bugs. Nov-Dec, 2010 | Pubmed ID: 21468212 Sodium Butyrate with UCN-01 Has Marked Antitumour Activity Against Cervical Cancer Cells Anticancer Research. Oct, 2010 | Pubmed ID: 21036719 Through Its Nonstructural Protein NS1, Parvovirus H-1 Induces Apoptosis Via Accumulation of Reactive Oxygen Species Journal of Virology. Jun, 2010 | Pubmed ID: 20375165 Regression of Advanced Rat and Human Gliomas by Local or Systemic Treatment with Oncolytic Parvovirus H-1 in Rat Models Neuro-oncology. Aug, 2010 | Pubmed ID: 20299703 Improved Killing of Human High-grade Glioma Cells by Combining Ionizing Radiation with Oncolytic Parvovirus H-1 Infection Journal of Biomedicine & Biotechnology. 2010 | Pubmed ID: 20224643 Oncolytic Parvoviruses As Cancer Therapeutics Cytokine & Growth Factor Reviews. Apr-Jun, 2010 | Pubmed ID: 20211577 Parvovirus H1 Selectively Induces Cytotoxic Effects on Human Neuroblastoma Cells International Journal of Cancer. Journal International Du Cancer. Sep, 2010 | Pubmed ID: 20087864 Activation of an Antiviral Response in Normal but Not Transformed Mouse Cells: a New Determinant of Minute Virus of Mice Oncotropism Journal of Virology. Jan, 2010 | Pubmed ID: 19864388 SMAD4: a Predictive Marker of PDAC Cell Permissiveness for Oncolytic Infection with Parvovirus H-1PV International Journal of Cancer. Journal International Du Cancer. Jun, 2010 | Pubmed ID: 19856310 Oncolytic Rat Parvovirus H-1PV, a Candidate for the Treatment of Human Lymphoma: In Vitro and in Vivo Studies Molecular Therapy : the Journal of the American Society of Gene Therapy. Jul, 2009 | Pubmed ID: 19367260 Ezrin-radixin-moesin Family Proteins Are Involved in Parvovirus Replication and Spreading Journal of Virology. Jun, 2009 | Pubmed ID: 19321616 Improvement of Gemcitabine-based Therapy of Pancreatic Carcinoma by Means of Oncolytic Parvovirus H-1PV Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Jan, 2009 | Pubmed ID: 19147756 Biophysical and Biochemical Characterization of a Liposarcoma-derived Recombinant MnSOD Protein Acting As an Anticancer Agent International Journal of Cancer. Journal International Du Cancer. Dec, 2008 | Pubmed ID: 18798256 Viral Proteins Killing Tumor Cells: New Weapons in the Fight Against Cancer Cancer Biology & Therapy. Sep, 2008 | Pubmed ID: 18769128 Vesicular Egress of Non-enveloped Lytic Parvoviruses Depends on Gelsolin Functioning PLoS Pathogens. 2008 | Pubmed ID: 18704167 Killing of P53-deficient Hepatoma Cells by Parvovirus H-1 and Chemotherapeutics Requires Promyelocytic Leukemia Protein World Journal of Gastroenterology : WJG. Jun, 2008 | Pubmed ID: 18609705 Arming Parvoviruses with CpG Motifs to Improve Their Oncosuppressive Capacity International Journal of Cancer. Journal International Du Cancer. Jun, 2008 | Pubmed ID: 18360875 Parvovirus Interference with Intracellular Signalling: Mechanism of PKCeta Activation in MVM-infected A9 Fibroblasts Cellular Microbiology. Mar, 2008 | Pubmed ID: 18042254 A Viral Adaptor Protein Modulating Casein Kinase II Activity Induces Cytopathic Effects in Permissive Cells Proceedings of the National Academy of Sciences of the United States of America. Jul, 2007 | Pubmed ID: 17636126 Combined Oncolytic and Vaccination Activities of Parvovirus H-1 in a Metastatic Tumor Model Oncology Reports. Jun, 2007 | Pubmed ID: 17487410 Cytosolic Activation of Cathepsins Mediates Parvovirus H-1-induced Killing of Cisplatin and TRAIL-resistant Glioma Cells Journal of Virology. Apr, 2007 | Pubmed ID: 17287256 MCP-3 (CCL7) Delivered by Parvovirus MVMp Reduces Tumorigenicity of Mouse Melanoma Cells Through Activation of T Lymphocytes and NK Cells International Journal of Cancer. Journal International Du Cancer. Mar, 2007 | Pubmed ID: 17154174 Humoral Immune Responses Against Minute Virus of Mice Vectors The Journal of Gene Medicine. Sep, 2006 | Pubmed ID: 16800041 Human SGT Interacts with Bag-6/Bat-3/Scythe and Cells with Reduced Levels of Either Protein Display Persistence of Few Misaligned Chromosomes and Mitotic Arrest Experimental Cell Research. Aug, 2006 | Pubmed ID: 16777091 Oncolytic Murine Autonomous Parvovirus, a Candidate Vector for Glioma Gene Therapy, is Innocuous to Normal and Immunocompetent Mouse Glial Cells Cell and Tissue Research. Sep, 2006 | Pubmed ID: 16699801 NS1 Interaction with CKII Alpha: Novel Protein Complex Mediating Parvovirus-induced Cytotoxicity Journal of Virology. May, 2006 | Pubmed ID: 16641266 Tumor Suppressive Activity of a Variant Isoform of Manganese Superoxide Dismutase Released by a Human Liposarcoma Cell Line International Journal of Cancer. Journal International Du Cancer. Aug, 2006 | Pubmed ID: 16550599 Phosphorylation on Ser106 Modulates the Cellular Functions of the SHOX Homeodomain Protein Journal of Molecular Biology. Jan, 2006 | Pubmed ID: 16325853 Parvovirus H-1-induced Tumor Cell Death Enhances Human Immune Response in Vitro Via Increased Phagocytosis, Maturation, and Cross-presentation by Dendritic Cells Human Gene Therapy. Aug, 2005 | Pubmed ID: 16076257 Changes in Gene Expression Profiles Induced by Parvovirus H-1 in Human Gastric Cancer Cells Chinese Journal of Digestive Diseases. 2005 | Pubmed ID: 15904425 B1 Lymphocytes and Myeloid Dendritic Cells in Lymphoid Organs Are Preferential Extratumoral Sites of Parvovirus Minute Virus of Mice Prototype Strain Expression Journal of Virology. Mar, 2005 | Pubmed ID: 15731246 Expression Profiling of Human Hepatoma Cells Reveals Global Repression of Genes Involved in Cell Proliferation, Growth, and Apoptosis Upon Infection with Parvovirus H-1 Journal of Virology. Feb, 2005 | Pubmed ID: 15681429 The Infectivity and Lytic Activity of Minute Virus of Mice Wild-type and Derived Vector Particles Are Strikingly Different Journal of Virology. Jan, 2005 | Pubmed ID: 15596824 Selective Alterations of the Host Cell Architecture Upon Infection with Parvovirus Minute Virus of Mice Virology. Jan, 2005 | Pubmed ID: 15582663 Cancer Gene Therapy Through Autonomous Parvovirus--mediated Gene Transfer Current Gene Therapy. Sep, 2004 | Pubmed ID: 15384939 Carrier Cell-mediated Delivery of Oncolytic Parvoviruses for Targeting Metastases International Journal of Cancer. Journal International Du Cancer. May, 2004 | Pubmed ID: 14999784 Vectors Based on Autonomous Parvoviruses: Novel Tools to Treat Cancer? The Journal of Gene Medicine. Feb, 2004 | Pubmed ID: 14978762 Parvovirus H-1 Infection of Human Glioma Cells Leads to Complete Viral Replication and Efficient Cell Killing International Journal of Cancer. Journal International Du Cancer. Mar, 2004 | Pubmed ID: 14735471 The Human Small Glutamine-rich TPR-containing Protein is Required for Progress Through Cell Division Experimental Cell Research. Feb, 2004 | Pubmed ID: 14729056 Modulation of Minute Virus of Mice Cytotoxic Activities Through Site-directed Mutagenesis Within the NS Coding Region Journal of Virology. Dec, 2003 | Pubmed ID: 14610171 Oncolytic Parvovirus H1 Induces Release of Heat-shock Protein HSP72 in Susceptible Human Tumor Cells but May Not Affect Primary Immune Cells Cancer Gene Therapy. Jun, 2003 | Pubmed ID: 12768193 Chimeric and Pseudotyped Parvoviruses Minimize the Contamination of Recombinant Stocks with Replication-competent Viruses and Identify a DNA Sequence That Restricts Parvovirus H-1 in Mouse Cells Journal of Virology. Mar, 2003 | Pubmed ID: 12610161 Regulation of Minute Virus of Mice NS1 Replicative Functions by Atypical PKClambda in Vivo Journal of Virology. Jan, 2003 | Pubmed ID: 12477848 Production of Recombinant H1 Parvovirus Stocks Devoid of Replication-competent Viruses Human Gene Therapy. Dec, 2002 | Pubmed ID: 12542845 The NS2 Proteins of Parvovirus Minute Virus of Mice Are Required for Efficient Nuclear Egress of Progeny Virions in Mouse Cells Journal of Virology. Oct, 2002 | Pubmed ID: 12239307 Specific Interaction of the Nonstructural Protein NS1 of Minute Virus of Mice (MVM) with [ACCA](2) Motifs in the Centre of the Right-end MVM DNA Palindrome Induces Hairpin-primed Viral DNA Replication The Journal of General Virology. Jul, 2002 | Pubmed ID: 12075084 Suppression of Metastatic Hemangiosarcoma by a Parvovirus MVMp Vector Transducing the IP-10 Chemokine into Immunocompetent Mice Cancer Gene Therapy. May, 2002 | Pubmed ID: 11961666 Efficient Recombinant Parvovirus Production with the Help of Adenovirus-derived Systems Nazim El-Andaloussi*1,2, Barbara Leuchs*1, Serena Bonifati1,2, Jean Rommelaere1,2, Antonio Marchini1,2 1Tumour Virology Division F010, German Cancer Research Center (DKFZ), 2Inserm Unit 701, German Cancer Research Center (DKFZ) JoVE 3518 Immunology and Infection
Efficient Recombinant Parvovirus Production with the Help of Adenovirus-derived Systems Nazim El-Andaloussi*1,2, Barbara Leuchs*1, Serena Bonifati1,2, Jean Rommelaere1,2, Antonio Marchini1,2 1Tumour Virology Division F010, German Cancer Research Center (DKFZ), 2Inserm Unit 701, German Cancer Research Center (DKFZ) JoVE 3518 Immunology and Infection