Jeffery D. Molkentin

Publications

• Cysteine 202 of Cyclophilin D is a Site of Multiple Post-translational Modifications and Plays a Role in Cardioprotection
  Cardiovascular Research. Jan, 2021  |   Pubmed ID: 32129829
• Resident Macrophages Keep Mitochondria Running in the Heart
  Cell Research. 12, 2020  |   Pubmed ID: 33139923
• Interleukin-1α Dependent Survival of Cardiac Fibroblasts is Associated with StAR/STARD1 Expression and Improved Cardiac Remodeling and Function After Myocardial Infarction
  Journal of Molecular and Cellular Cardiology. Oct, 2020  |   Pubmed ID: 33130150
• Ontogeny of Arterial Macrophages Defines Their Functions in Homeostasis and Inflammation
  Nature Communications. 09, 2020  |   Pubmed ID: 32917889
• A Specialized Population of Periostin-expressing Cardiac Fibroblasts Contributes to Postnatal Cardiomyocyte Maturation and Innervation
  Proceedings of the National Academy of Sciences of the United States of America. 09, 2020  |   Pubmed ID: 32817558
• Type 2 Diabetes Risk Gene Dusp8 Regulates Hypothalamic Jnk Signaling and Insulin Sensitivity
  The Journal of Clinical Investigation. 11, 2020  |   Pubmed ID: 32780722
• A 20/20 View of ANT Function in Mitochondrial Biology and Necrotic Cell Death
  Journal of Molecular and Cellular Cardiology. 07, 2020  |   Pubmed ID: 32454061
• MCUb Induction Protects the Heart From Postischemic Remodeling
  Circulation Research. 07, 2020  |   Pubmed ID: 32299299
• Cardiac Cell Therapy Rejuvenates the Infarcted Rodent Heart Via Direct Injection but Not by Vascular Infusion
  Circulation. 03, 2020  |   Pubmed ID: 32202933
• Hyperglycemia Acutely Increases Cytosolic Reactive Oxygen Species Via -linked GlcNAcylation and CaMKII Activation in Mouse Ventricular Myocytes
  Circulation Research. 05, 2020  |   Pubmed ID: 32134364
• MEF2C Repressor Variant Deregulation Leads to Cell Cycle Re-entry and Development of Heart Failure
  EBioMedicine. Jan, 2020  |   Pubmed ID: 31911274
• An Acute Immune Response Underlies the Benefit of Cardiac Stem cell Therapy
  Nature. 01, 2020  |   Pubmed ID: 31775156
• A Novel Class of Cardioprotective Small-molecule PTP Inhibitors
  Pharmacological Research. 01, 2020  |   Pubmed ID: 31759087
• Hippo Signaling Does It Again: Arbitrating Cardiac Fibroblast Identity and Activation
  Genes & Development. 11, 2019  |   Pubmed ID: 31676733
• CARdiac Immunotherapy: T Cells Engineered to Treat the Fibrotic Heart
  Molecular Therapy : the Journal of the American Society of Gene Therapy. 11, 2019  |   Pubmed ID: 31585799
• The EYA3 Tyrosine Phosphatase Activity Promotes Pulmonary Vascular Remodeling in Pulmonary Arterial Hypertension
  Nature Communications. 09, 2019  |   Pubmed ID: 31515519
• Cell-specific Ablation of Hsp47 Defines the Collagen-producing Cells in the Injured Heart
  JCI Insight. 08, 2019  |   Pubmed ID: 31393098
• Disruption of Valosin-containing Protein Activity Causes Cardiomyopathy and Reveals Pleiotropic Functions in Cardiac Homeostasis
  The Journal of Biological Chemistry. 05, 2019  |   Pubmed ID: 31006653
• ERK1/2 Signaling Induces Skeletal Muscle Slow Fiber-type Switching and Reduces Muscular Dystrophy Disease Severity
  JCI Insight. 04, 2019  |   Pubmed ID: 30964448
• Overlapping and Differential Functions of ATF6α Versus ATF6β in the Mouse Heart
  Scientific Reports. 02, 2019  |   Pubmed ID: 30765833
• Thrombospondin-3 Augments Injury-induced Cardiomyopathy by Intracellular Integrin Inhibition and Sarcolemmal Instability
  Nature Communications. 01, 2019  |   Pubmed ID: 30622267
• Cardiac-specific Deficiency of the Mitochondrial Calcium Uniporter Augments Fatty Acid Oxidation and Functional Reserve
  Journal of Molecular and Cellular Cardiology. 02, 2019  |   Pubmed ID: 30615880
• Evidence for Minimal Cardiogenic Potential of Stem Cell Antigen 1-Positive Cells in the Adult Mouse Heart
  Circulation. 12, 2018  |   Pubmed ID: 30566022
• The Mitochondrial Calcium Uniporter Underlies Metabolic Fuel Preference in Skeletal Muscle
  JCI Insight. 11, 2018  |   Pubmed ID: 30429366
• Undeniable Evidence That the Adult Mammalian Heart Lacks an Endogenous Regenerative Stem Cell
  Circulation. 08, 2018  |   Pubmed ID: 30359129
• Nuclear Calcineurin is a Sensor for Detecting Ca Release from the Nuclear Envelope Via IPR
  Journal of Molecular Medicine (Berlin, Germany). 11, 2018  |   Pubmed ID: 30293136
• Genetic Lineage Tracing of Sca-1 Cells Reveals Endothelial but Not Myogenic Contribution to the Murine Heart
  Circulation. 12, 2018  |   Pubmed ID: 29991486
• New Myocyte Formation in the Adult Heart: Endogenous Sources and Therapeutic Implications
  Circulation Research. 07, 2018  |   Pubmed ID: 29976685
• Developmental Vascular Regression is Regulated by a Wnt/β-catenin, MYC and CDKN1A Pathway That Controls Cell Proliferation and Cell Death
  Development (Cambridge, England). 06, 2018  |   Pubmed ID: 29777010
• Defective Flux of Thrombospondin-4 Through the Secretory Pathway Impairs Cardiomyocyte Membrane Stability and Causes Cardiomyopathy
  Molecular and Cellular Biology. 07, 2018  |   Pubmed ID: 29712757
• Gata4-Dependent Differentiation of C-Kit Derived Endothelial Cells Underlies Artefactual Cardiomyocyte Regeneration in the Heart
  Circulation. Apr, 2018  |   Pubmed ID: 29666070
• Specialized Fibroblast Differentiated States Underlie Scar Formation in the Infarcted Mouse Heart
  The Journal of Clinical Investigation. 05, 2018  |   Pubmed ID: 29664017
• Inhibiting Fibronectin Attenuates Fibrosis and Improves Cardiac Function in a Model of Heart Failure
  Circulation. 09, 2018  |   Pubmed ID: 29653926
• Van Berlo Et Al. Reply
  Nature. 03, 2018  |   Pubmed ID: 29565361
• Genetic Reduction in Left Ventricular Protein Kinase C-α and Adverse Ventricular Remodeling in Human Subjects
  Circulation. Genomic and Precision Medicine. 03, 2018  |   Pubmed ID: 29540468
• Molecular Mechanisms of Cell Death: Recommendations of the Nomenclature Committee on Cell Death 2018
  Cell Death and Differentiation. Mar, 2018  |   Pubmed ID: 29362479
• Increasing T-type Calcium Channel Activity by β-adrenergic Stimulation Contributes to β-adrenergic Regulation of Heart Rates
  The Journal of Physiology. 04, 2018  |   Pubmed ID: 29274077
• Protein Kinase C Inhibition With Ruboxistaurin Increases Contractility and Reduces Heart Size in a Swine Model of Heart Failure With Reduced Ejection Fraction
  JACC. Basic to Translational Science. Dec, 2017  |   Pubmed ID: 30062182
• BEX1 is an RNA-dependent Mediator of Cardiomyopathy
  Nature Communications. 11, 2017  |   Pubmed ID: 29192139
• Autophagic Cell Death is Dependent on Lysosomal Membrane Permeability Through Bax and Bak
  ELife. 11, 2017  |   Pubmed ID: 29148970
• Identity Crisis for Regenerative Cardiac CKit Cells
  Circulation Research. 10, 2017  |   Pubmed ID: 29074532
• Spatial Gene Profiling in the Ischemic Heart: Fibroblasts Put on Their SOX
  Circulation. 10, 2017  |   Pubmed ID: 28993372
• Fibroblast-specific TGF-β-Smad2/3 Signaling Underlies Cardiac Fibrosis
  The Journal of Clinical Investigation. Oct, 2017  |   Pubmed ID: 28891814
• Pharmacological and Activated Fibroblast Targeting of Gβγ-GRK2 After Myocardial Ischemia Attenuates Heart Failure Progression
  Journal of the American College of Cardiology. Aug, 2017  |   Pubmed ID: 28818206
• TGFBI Functions Similar to Periostin but is Uniquely Dispensable During Cardiac Injury
  PloS One. 2017  |   Pubmed ID: 28750100
• Mitsugumin 29 Regulates T-tubule Architecture in the Failing Heart
  Scientific Reports. 07, 2017  |   Pubmed ID: 28706255
• Cardiomyocyte Regeneration: A Consensus Statement
  Circulation. 08, 2017  |   Pubmed ID: 28684531
• An Unbiased High-Throughput Screen to Identify Novel Effectors That Impact on Cardiomyocyte Aggregate Levels
  Circulation Research. Sep, 2017  |   Pubmed ID: 28655832
• Preexisting Endothelial Cells Mediate Cardiac Neovascularization After Injury
  The Journal of Clinical Investigation. Aug, 2017  |   Pubmed ID: 28650345
• The Mitochondrial Na/Ca Exchanger is Essential for Ca Homeostasis and Viability
  Nature. 05, 2017  |   Pubmed ID: 28445457
• Redefining the Identity of Cardiac Fibroblasts
  Nature Reviews. Cardiology. Aug, 2017  |   Pubmed ID: 28436487
• Caveolae-localized L-type Ca2+ Channels Do Not Contribute to Function or Hypertrophic Signalling in the Mouse Heart
  Cardiovascular Research. Jun, 2017  |   Pubmed ID: 28402392
• Fibroblast-Specific Genetic Manipulation of P38 Mitogen-Activated Protein Kinase In Vivo Reveals Its Central Regulatory Role in Fibrosis
  Circulation. Aug, 2017  |   Pubmed ID: 28356446
• The Elusive Progenitor Cell in Cardiac Regeneration: Slip Slidin' Away
  Circulation Research. Jan, 2017  |   Pubmed ID: 28104772
• Applying Modern Transcriptomics to Interrogate the Human Cardiac Fibroblast
  JACC. Basic to Translational Science. Dec, 2016  |   Pubmed ID: 30167545
• RCANs Regulate the Convergent Roles of NFATc1 in Bone Homeostasis
  Scientific Reports. 12, 2016  |   Pubmed ID: 27917924
• Nemo-Like Kinase (NLK) Is a Pathological Signaling Effector in the Mouse Heart
  PloS One. 2016  |   Pubmed ID: 27764156
• Thrombospondin Expression in Myofibers Stabilizes Muscle Membranes
  ELife. 09, 2016  |   Pubmed ID: 27669143
• Thrombospondin 1 Protects Pancreatic β-cells from Lipotoxicity Via the PERK-NRF2 Pathway
  Cell Death and Differentiation. 12, 2016  |   Pubmed ID: 27588705
• Regulation of Cardiac Hypertrophy and Remodeling Through the Dual-specificity MAPK Phosphatases (DUSPs)
  Journal of Molecular and Cellular Cardiology. Dec, 2016  |   Pubmed ID: 27575022
• Inositol 1,4,5-trisphosphate-mediated Sarcoplasmic Reticulum-mitochondrial Crosstalk Influences Adenosine Triphosphate Production Via Mitochondrial Ca2+ Uptake Through the Mitochondrial Ryanodine Receptor in Cardiac Myocytes
  Cardiovascular Research. 10, 2016  |   Pubmed ID: 27496868
• Genetic Lineage Tracing Defines Myofibroblast Origin and Function in the Injured Heart
  Nature Communications. 07, 2016  |   Pubmed ID: 27447449
• DUSP8 Regulates Cardiac Ventricular Remodeling by Altering ERK1/2 Signaling
  Circulation Research. 07, 2016  |   Pubmed ID: 27225478
• A Tension-Based Model Distinguishes Hypertrophic Versus Dilated Cardiomyopathy
  Cell. May, 2016  |   Pubmed ID: 27114035
• Cathepsin S Contributes to the Pathogenesis of Muscular Dystrophy in Mice
  The Journal of Biological Chemistry. May, 2016  |   Pubmed ID: 26966179
• Cyclophilin D Regulates Necrosis, but Not Apoptosis, of Murine Eosinophils
  American Journal of Physiology. Gastrointestinal and Liver Physiology. 04, 2016  |   Pubmed ID: 26893161
• Most of the Dust Has Settled: CKit+ Progenitor Cells Are an Irrelevant Source of Cardiac Myocytes In Vivo
  Circulation Research. Jan, 2016  |   Pubmed ID: 26837741
• Genetic Overexpression of Serpina3n Attenuates Muscular Dystrophy in Mice
  Human Molecular Genetics. Mar, 2016  |   Pubmed ID: 26744329
• Individual Cardiac Mitochondria Undergo Rare Transient Permeability Transition Pore Openings
  Circulation Research. Mar, 2016  |   Pubmed ID: 26712344
• Persistent Increases in Ca(2+) Influx Through Cav1.2 Shortens Action Potential and Causes Ca(2+) Overload-induced Afterdepolarizations and Arrhythmias
  Basic Research in Cardiology. Jan, 2016  |   Pubmed ID: 26611208
• Deletion of Periostin Protects Against Atherosclerosis in Mice by Altering Inflammation and Extracellular Matrix Remodeling
  Arteriosclerosis, Thrombosis, and Vascular Biology. Jan, 2016  |   Pubmed ID: 26564821
• Dissection of Thrombospondin-4 Domains Involved in Intracellular Adaptive Endoplasmic Reticulum Stress-Responsive Signaling
  Molecular and Cellular Biology. Jan, 2016  |   Pubmed ID: 26459760
• MBNL1-mediated Regulation of Differentiation RNAs Promotes Myofibroblast Transformation and the Fibrotic Response
  Nature Communications. Dec, 2015  |   Pubmed ID: 26670661
• TAK1 Regulates Myocardial Response to Pathological Stress Via NFAT, NFκB, and Bnip3 Pathways
  Scientific Reports. 2015  |   Pubmed ID: 26564789
• Calcineurin Links Mitochondrial Elongation with Energy Metabolism
  Cell Metabolism. Nov, 2015  |   Pubmed ID: 26411342
• Cardiac-specific Deletion of Protein Phosphatase 1β Promotes Increased Myofilament Protein Phosphorylation and Contractile Alterations
  Journal of Molecular and Cellular Cardiology. Oct, 2015  |   Pubmed ID: 26334248
• STIM1 Elevation in the Heart Results in Aberrant Ca²⁺ Handling and Cardiomyopathy
  Journal of Molecular and Cellular Cardiology. Oct, 2015  |   Pubmed ID: 26241845
• The Mitochondrial Calcium Uniporter Selectively Matches Metabolic Output to Acute Contractile Stress in the Heart
  Cell Reports. Jul, 2015  |   Pubmed ID: 26119742
• Necroptosis Interfaces with MOMP and the MPTP in Mediating Cell Death
  PloS One. 2015  |   Pubmed ID: 26061004
• Regulated Necrotic Cell Death: the Passive Aggressive Side of Bax and Bak
  Circulation Research. May, 2015  |   Pubmed ID: 25999420
• Exposure to Radiocontrast Agents Induces Pancreatic Inflammation by Activation of Nuclear Factor-κB, Calcium Signaling, and Calcineurin
  Gastroenterology. Sep, 2015  |   Pubmed ID: 25980752
• Genetic Analysis of Connective Tissue Growth Factor As an Effector of Transforming Growth Factor β Signaling and Cardiac Remodeling
  Molecular and Cellular Biology. Jun, 2015  |   Pubmed ID: 25870108
• Sarcolipin Overexpression Improves Muscle Energetics and Reduces Fatigue
  Journal of Applied Physiology (Bethesda, Md. : 1985). Apr, 2015  |   Pubmed ID: 25701006
• SERCA1 Overexpression Minimizes Skeletal Muscle Damage in Dystrophic Mouse Models
  American Journal of Physiology. Cell Physiology. 05, 2015  |   Pubmed ID: 25652448
• Physiological and Pathological Roles of the Mitochondrial Permeability Transition Pore in the Heart
  Cell Metabolism. Feb, 2015  |   Pubmed ID: 25651175
• An Emerging Consensus on Cardiac Regeneration
  Nature Medicine. Dec, 2014  |   Pubmed ID: 25473919
• Targeting Latent TGFβ Release in Muscular Dystrophy
  Science Translational Medicine. Oct, 2014  |   Pubmed ID: 25338755
• RhoA Signaling in Cardiomyocytes Protects Against Stress-induced Heart Failure but Facilitates Cardiac Fibrosis
  Science Signaling. Oct, 2014  |   Pubmed ID: 25336613
• The β Isoform of the Catalytic Subunit of Protein Phosphatase 2B Restrains Platelet Function by Suppressing Outside-in αII B β3 Integrin Signaling
  Journal of Thrombosis and Haemostasis : JTH. Dec, 2014  |   Pubmed ID: 25330904
• Transforming Growth Factor β-activated Kinase 1 Signaling Pathway Critically Regulates Myocardial Survival and Remodeling
  Circulation. Dec, 2014  |   Pubmed ID: 25278099
• Letter by Molkentin Regarding Article, "The Absence of Evidence is Not Evidence of Absence: the Pitfalls of Cre Knock-Ins in the C-Kit Locus"
  Circulation Research. Sep, 2014  |   Pubmed ID: 25258403
• Myofiber-specific Inhibition of TGFβ Signaling Protects Skeletal Muscle from Injury and Dystrophic Disease in Mice
  Human Molecular Genetics. Dec, 2014  |   Pubmed ID: 25106553
• Sumo E2 Enzyme UBC9 is Required for Efficient Protein Quality Control in Cardiomyocytes
  Circulation Research. Sep, 2014  |   Pubmed ID: 25097219
• Excess SMAD Signaling Contributes to Heart and Muscle Dysfunction in Muscular Dystrophy
  Human Molecular Genetics. Dec, 2014  |   Pubmed ID: 25070948
• Transient Receptor Potential Channels Contribute to Pathological Structural and Functional Remodeling After Myocardial Infarction
  Circulation Research. Aug, 2014  |   Pubmed ID: 25047165
• Identifying the Components of the Elusive Mitochondrial Permeability Transition Pore
  Proceedings of the National Academy of Sciences of the United States of America. Jul, 2014  |   Pubmed ID: 25002521
• P38α MAPK Underlies Muscular Dystrophy and Myofiber Death Through a Bax-dependent Mechanism
  Human Molecular Genetics. Oct, 2014  |   Pubmed ID: 24876160
• Repression of Cyclin D1 Expression is Necessary for the Maintenance of Cell Cycle Exit in Adult Mammalian Cardiomyocytes
  The Journal of Biological Chemistry. Jun, 2014  |   Pubmed ID: 24821722
• C-kit+ Cells Minimally Contribute Cardiomyocytes to the Heart
  Nature. May, 2014  |   Pubmed ID: 24805242
• Genetic Manipulation of the Cardiac Mitochondrial Phosphate Carrier Does Not Affect Permeability Transition
  Journal of Molecular and Cellular Cardiology. Jul, 2014  |   Pubmed ID: 24768964
• Enhanced Ca²⁺ Influx from STIM1-Orai1 Induces Muscle Pathology in Mouse Models of Muscular Dystrophy
  Human Molecular Genetics. Jul, 2014  |   Pubmed ID: 24556214
• Response to Torella Et Al
  Circulation Research. Feb, 2014  |   Pubmed ID: 24526680
• Overexpression of the Na+/K+ ATPase α2 but Not α1 Isoform Attenuates Pathological Cardiac Hypertrophy and Remodeling
  Circulation Research. Jan, 2014  |   Pubmed ID: 24218169
• Myofibroblasts: Trust Your Heart and Let Fate Decide
  Journal of Molecular and Cellular Cardiology. May, 2014  |   Pubmed ID: 24189039
• Parsing the Roles of the Transcription Factors GATA-4 and GATA-6 in the Adult Cardiac Hypertrophic Response
  PloS One. 2013  |   Pubmed ID: 24391969
• Apoptosis Repressor with a CARD Domain (ARC) Restrains Bax-mediated Pathogenesis in Dystrophic Skeletal Muscle
  PloS One. 2013  |   Pubmed ID: 24312627
• Differential Expression of Embryonic Epicardial Progenitor Markers and Localization of Cardiac Fibrosis in Adult Ischemic Injury and Hypertensive Heart Disease
  Journal of Molecular and Cellular Cardiology. Dec, 2013  |   Pubmed ID: 24140724
• Bax and Bak Function As the Outer Membrane Component of the Mitochondrial Permeability Pore in Regulating Necrotic Cell Death in Mice
  ELife. Aug, 2013  |   Pubmed ID: 23991283
• Parsing Good Versus Bad Signaling Pathways in the Heart: Role of Calcineurin-nuclear Factor of Activated T-cells
  Circulation Research. Jun, 2013  |   Pubmed ID: 23788503
• CaMKII Does It Again: Even the Mitochondria Cannot Escape Its Influence
  Circulation Research. Apr, 2013  |   Pubmed ID: 23620234
• Physiologic Functions of Cyclophilin D and the Mitochondrial Permeability Transition Pore
  Circulation Journal : Official Journal of the Japanese Circulation Society. 2013  |   Pubmed ID: 23538482
• Signaling Effectors Underlying Pathologic Growth and Remodeling of the Heart
  The Journal of Clinical Investigation. Jan, 2013  |   Pubmed ID: 23281408
• Molecular Basis of Physiological Heart Growth: Fundamental Concepts and New Players
  Nature Reviews. Molecular Cell Biology. Jan, 2013  |   Pubmed ID: 23258295
• Bile Acids Induce Pancreatic Acinar Cell Injury and Pancreatitis by Activating Calcineurin
  The Journal of Biological Chemistry. Jan, 2013  |   Pubmed ID: 23148215
• Unrestrained P38 MAPK Activation in Dusp1/4 Double-null Mice Induces Cardiomyopathy
  Circulation Research. Jan, 2013  |   Pubmed ID: 22993413
• Mutual Antagonism Between IP(3)RII and MiRNA-133a Regulates Calcium Signals and Cardiac Hypertrophy
  The Journal of Cell Biology. Nov, 2012  |   Pubmed ID: 23166348
• Is P53 the Long-sought Molecular Trigger for Cyclophilin D-regulated Mitochondrial Permeability Transition Pore Formation and Necrosis?
  Circulation Research. Oct, 2012  |   Pubmed ID: 23104876
• A TRPC6-dependent Pathway for Myofibroblast Transdifferentiation and Wound Healing in Vivo
  Developmental Cell. Oct, 2012  |   Pubmed ID: 23022034
• Sarcolipin is a Newly Identified Regulator of Muscle-based Thermogenesis in Mammals
  Nature Medicine. Oct, 2012  |   Pubmed ID: 22961106
• Lost in Transgenesis: a User's Guide for Genetically Manipulating the Mouse in Cardiac Research
  Circulation Research. Aug, 2012  |   Pubmed ID: 22935533
• Constitutively Active MEK1 Rescues Cardiac Dysfunction Caused by Overexpressed GSK-3α During Aging and Hemodynamic Pressure Overload
  American Journal of Physiology. Heart and Circulatory Physiology. Oct, 2012  |   Pubmed ID: 22904158
• A Thrombospondin-dependent Pathway for a Protective ER Stress Response
  Cell. Jun, 2012  |   Pubmed ID: 22682248
• Interaction Between NFκB and NFAT Coordinates Cardiac Hypertrophy and Pathological Remodeling
  Circulation Research. Apr, 2012  |   Pubmed ID: 22403241
• Pharmacological and Genetic Inhibition of Calcineurin Protects Against Carbachol-induced Pathological Zymogen Activation and Acinar Cell Injury
  American Journal of Physiology. Gastrointestinal and Liver Physiology. Apr, 2012  |   Pubmed ID: 22323127
• Decreased Cardiac L-type Ca²⁺ Channel Activity Induces Hypertrophy and Heart Failure in Mice
  The Journal of Clinical Investigation. Jan, 2012  |   Pubmed ID: 22133878
• Unraveling the Secrets of a Double Life: Contractile Versus Signaling Ca2+ in a Cardiac Myocyte
  Journal of Molecular and Cellular Cardiology. Feb, 2012  |   Pubmed ID: 21600216
• Placental Growth Factor As a Protective Paracrine Effector in the Heart
  Trends in Cardiovascular Medicine. Nov, 2011  |   Pubmed ID: 22902069
• Inhibition of PKCα/β with Ruboxistaurin Antagonizes Heart Failure in Pigs After Myocardial Infarction Injury
  Circulation Research. Dec, 2011  |   Pubmed ID: 21998327
• The Permeability Transition Pore Controls Cardiac Mitochondrial Maturation and Myocyte Differentiation
  Developmental Cell. Sep, 2011  |   Pubmed ID: 21920313
• RhoA Protects the Mouse Heart Against Ischemia/reperfusion Injury
  The Journal of Clinical Investigation. Aug, 2011  |   Pubmed ID: 21747165
• Serine 105 Phosphorylation of Transcription Factor GATA4 is Necessary for Stress-induced Cardiac Hypertrophy in Vivo
  Proceedings of the National Academy of Sciences of the United States of America. Jul, 2011  |   Pubmed ID: 21746915
• Tinman/Nkx2-5 Acts Via MiR-1 and Upstream of Cdc42 to Regulate Heart Function Across Species
  The Journal of Cell Biology. Jun, 2011  |   Pubmed ID: 21690310
• Placental Growth Factor Regulates Cardiac Adaptation and Hypertrophy Through a Paracrine Mechanism
  Circulation Research. Jul, 2011  |   Pubmed ID: 21636802
• Regulation of Angiogenesis by a Non-canonical Wnt-Flt1 Pathway in Myeloid Cells
  Nature. May, 2011  |   Pubmed ID: 21623369
• A Critical Function for Ser-282 in Cardiac Myosin Binding Protein-C Phosphorylation and Cardiac Function
  Circulation Research. Jul, 2011  |   Pubmed ID: 21597010
• Modulation of Chromatin Position and Gene Expression by HDAC4 Interaction with Nucleoporins
  The Journal of Cell Biology. Apr, 2011  |   Pubmed ID: 21464227
• Myostatin from the Heart: Local and Systemic Actions in Cardiac Failure and Muscle Wasting
  American Journal of Physiology. Heart and Circulatory Physiology. Jun, 2011  |   Pubmed ID: 21421824
• Dysfunctional Ryanodine Receptor and Cardiac Hypertrophy: Role of Signaling Molecules
  American Journal of Physiology. Heart and Circulatory Physiology. Jun, 2011  |   Pubmed ID: 21421818
• Mechanisms of Necroptosis in T Cells
  The Journal of Experimental Medicine. Apr, 2011  |   Pubmed ID: 21402742
• Moderate Calcium Channel Dysfunction in Adult Mice with Inducible Cardiomyocyte-specific Excision of the Cacnb2 Gene
  The Journal of Biological Chemistry. May, 2011  |   Pubmed ID: 21357697
• The Transcription Factor C/EBPbeta Serves As a Master Regulator of Physiologic Cardiac Hypertrophy
  Circulation Research. Feb, 2011  |   Pubmed ID: 21293006
• Mitigation of Muscular Dystrophy in Mice by SERCA Overexpression in Skeletal Muscle
  The Journal of Clinical Investigation. Mar, 2011  |   Pubmed ID: 21285509
• TRPC Channels As Effectors of Cardiac Hypertrophy
  Circulation Research. Jan, 2011  |   Pubmed ID: 21252153
• Extracellular Signal-regulated Kinases 1 and 2 Regulate the Balance Between Eccentric and Concentric Cardiac Growth
  Circulation Research. Jan, 2011  |   Pubmed ID: 21127295
• GATA6 Promotes Angiogenic Function and Survival in Endothelial Cells by Suppression of Autocrine Transforming Growth Factor Beta/activin Receptor-like Kinase 5 Signaling
  The Journal of Biological Chemistry. Feb, 2011  |   Pubmed ID: 21127043
• Calcium Influx Through Cav1.2 is a Proximal Signal for Pathological Cardiomyocyte Hypertrophy
  Journal of Molecular and Cellular Cardiology. Mar, 2011  |   Pubmed ID: 21111744
• Monophosphothreonyl Extracellular Signal-regulated Kinases 1 and 2 (ERK1/2) Are Formed Endogenously in Intact Cardiac Myocytes and Are Enzymically Active
  Cellular Signalling. Feb, 2011  |   Pubmed ID: 21044683
• Protein Kinase Cα As a Heart Failure Therapeutic Target
  Journal of Molecular and Cellular Cardiology. Oct, 2011  |   Pubmed ID: 20937286
• Magnetic Resonance Imaging Assessment of Cardiac Dysfunction in δ-sarcoglycan Null Mice
  Neuromuscular Disorders : NMD. Jan, 2011  |   Pubmed ID: 20934875
• Molecular Pathways Underlying Cardiac Remodeling During Pathophysiological Stimulation
  Circulation. Dec, 2010  |   Pubmed ID: 21173361
• Cyclophilin D Controls Mitochondrial Pore-dependent Ca(2+) Exchange, Metabolic Flexibility, and Propensity for Heart Failure in Mice
  The Journal of Clinical Investigation. Oct, 2010  |   Pubmed ID: 20890047
• Research Priorities in Hypertrophic Cardiomyopathy: Report of a Working Group of the National Heart, Lung, and Blood Institute
  Circulation. Sep, 2010  |   Pubmed ID: 20837938
• The Role of Calcium/calmodulin-activated Calcineurin in Rapid and Slow Endocytosis at Central Synapses
  The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Sep, 2010  |   Pubmed ID: 20810903
• The Transcription Factor GATA-6 Regulates Pathological Cardiac Hypertrophy
  Circulation Research. Oct, 2010  |   Pubmed ID: 20705924
• CIB1 is a Regulator of Pathological Cardiac Hypertrophy
  Nature Medicine. Aug, 2010  |   Pubmed ID: 20639889
• Debio-025 is More Effective Than Prednisone in Reducing Muscular Pathology in Mdx Mice
  Neuromuscular Disorders : NMD. Nov, 2010  |   Pubmed ID: 20637615
• The IP3 Receptor Regulates Cardiac Hypertrophy in Response to Select Stimuli
  Circulation Research. Sep, 2010  |   Pubmed ID: 20616315
• Proteasome Functional Insufficiency Activates the Calcineurin-NFAT Pathway in Cardiomyocytes and Promotes Maladaptive Remodelling of Stressed Mouse Hearts
  Cardiovascular Research. Dec, 2010  |   Pubmed ID: 20601385
• Enhanced Basal Contractility but Reduced Excitation-contraction Coupling Efficiency and Beta-adrenergic Reserve of Hearts with Increased Cav1.2 Activity
  American Journal of Physiology. Heart and Circulatory Physiology. Aug, 2010  |   Pubmed ID: 20543081
• Functional Divergence of Platelet Protein Kinase C (PKC) Isoforms in Thrombus Formation on Collagen
  The Journal of Biological Chemistry. Jul, 2010  |   Pubmed ID: 20479008
• Apoptotic Cell Death "Nixed" by an ER-mitochondrial Necrotic Pathway
  Proceedings of the National Academy of Sciences of the United States of America. May, 2010  |   Pubmed ID: 20448198
• TRPC Channels Are Necessary Mediators of Pathologic Cardiac Hypertrophy
  Proceedings of the National Academy of Sciences of the United States of America. Apr, 2010  |   Pubmed ID: 20351294
• Extracellular Signal-regulated Kinase 1/2 (ERK1/2) Signaling in Cardiac Hypertrophy
  Annals of the New York Academy of Sciences. Feb, 2010  |   Pubmed ID: 20201891
• Genetic Deletion of Myostatin from the Heart Prevents Skeletal Muscle Atrophy in Heart Failure
  Circulation. Jan, 2010  |   Pubmed ID: 20065166
• Heart-specific Deletion of CnB1 Reveals Multiple Mechanisms Whereby Calcineurin Regulates Cardiac Growth and Function
  The Journal of Biological Chemistry. Feb, 2010  |   Pubmed ID: 20037164
• Calcineurin Protects the Heart in a Murine Model of Dilated Cardiomyopathy
  Journal of Molecular and Cellular Cardiology. Jun, 2010  |   Pubmed ID: 19854199
• Alpha1G-dependent T-type Ca2+ Current Antagonizes Cardiac Hypertrophy Through a NOS3-dependent Mechanism in Mice
  The Journal of Clinical Investigation. Dec, 2009  |   Pubmed ID: 19920353
• Calcium Influx is Sufficient to Induce Muscular Dystrophy Through a TRPC-dependent Mechanism
  Proceedings of the National Academy of Sciences of the United States of America. Nov, 2009  |   Pubmed ID: 19864620
• Blockade of Hsp20 Phosphorylation Exacerbates Cardiac Ischemia/reperfusion Injury by Suppressed Autophagy and Increased Cell Death
  Circulation Research. Dec, 2009  |   Pubmed ID: 19850943
• Genetic Manipulation of Dysferlin Expression in Skeletal Muscle: Novel Insights into Muscular Dystrophy
  The American Journal of Pathology. Nov, 2009  |   Pubmed ID: 19834057
• ASK1 Regulates Cardiomyocyte Death but Not Hypertrophy in Transgenic Mice
  Circulation Research. Nov, 2009  |   Pubmed ID: 19815822
• Cdc42 is an Antihypertrophic Molecular Switch in the Mouse Heart
  The Journal of Clinical Investigation. Oct, 2009  |   Pubmed ID: 19741299
• Lack of Periostin Leads to Suppression of Notch1 Signaling and Calcific Aortic Valve Disease
  Physiological Genomics. Nov, 2009  |   Pubmed ID: 19723774
• CaMKII Negatively Regulates Calcineurin-NFAT Signaling in Cardiac Myocytes
  Circulation Research. Aug, 2009  |   Pubmed ID: 19608982
• Protein Kinase C{alpha}, but Not PKC{beta} or PKC{gamma}, Regulates Contractility and Heart Failure Susceptibility: Implications for Ruboxistaurin As a Novel Therapeutic Approach
  Circulation Research. Jul, 2009  |   Pubmed ID: 19556521
• Adenine Nucleotide Translocase-1 Induces Cardiomyocyte Death Through Upregulation of the Pro-apoptotic Protein Bax
  Journal of Molecular and Cellular Cardiology. Jun, 2009  |   Pubmed ID: 19452617
• Plasma Membrane Ca2+-ATPase Isoform 4 Antagonizes Cardiac Hypertrophy in Association with Calcineurin Inhibition in Rodents
  The Journal of Clinical Investigation. Apr, 2009  |   Pubmed ID: 19287093
• The Mitochondrial Permeability Transition Pore in Motor Neurons: Involvement in the Pathobiology of ALS Mice
  Experimental Neurology. Aug, 2009  |   Pubmed ID: 19272377
• Cardiac Myosin Binding Protein-C Phosphorylation in a {beta}-myosin Heavy Chain Background
  Circulation. Mar, 2009  |   Pubmed ID: 19237661
• PKCalpha Regulates Platelet Granule Secretion and Thrombus Formation in Mice
  The Journal of Clinical Investigation. Feb, 2009  |   Pubmed ID: 19147982
• Interaction Between TAK1-TAB1-TAB2 and RCAN1-calcineurin Defines a Signalling Nodal Control Point
  Nature Cell Biology. Feb, 2009  |   Pubmed ID: 19136967
• Rcan1 Negatively Regulates Fc EpsilonRI-mediated Signaling and Mast Cell Function
  The Journal of Experimental Medicine. Jan, 2009  |   Pubmed ID: 19124655
• Genetic Manipulation of Periostin Expression in the Heart Does Not Affect Myocyte Content, Cell Cycle Activity, or Cardiac Repair
  Circulation Research. Jan, 2009  |   Pubmed ID: 19038863
• With Great Power Comes Great Responsibility: Using Mouse Genetics to Study Cardiac Hypertrophy and Failure
  Journal of Molecular and Cellular Cardiology. Feb, 2009  |   Pubmed ID: 18845155
• Periostin As a Heterofunctional Regulator of Cardiac Development and Disease
  Current Genomics. Dec, 2008  |   Pubmed ID: 19516962
• Role of ERK1/2 Signaling in Congenital Valve Malformations in Noonan Syndrome
  Proceedings of the National Academy of Sciences of the United States of America. Dec, 2008  |   Pubmed ID: 19017799
• Ca2+ Influx Through T- and L-type Ca2+ Channels Have Different Effects on Myocyte Contractility and Induce Unique Cardiac Phenotypes
  Circulation Research. Nov, 2008  |   Pubmed ID: 18832749
• DUSP6 (MKP3) Null Mice Show Enhanced ERK1/2 Phosphorylation at Baseline and Increased Myocyte Proliferation in the Heart Affecting Disease Susceptibility
  The Journal of Biological Chemistry. Nov, 2008  |   Pubmed ID: 18753132
• Does Contractile Ca2+ Control Calcineurin-NFAT Signaling and Pathological Hypertrophy in Cardiac Myocytes?
  Science Signaling. Jun, 2008  |   Pubmed ID: 18577756
• Genetic and Pharmacologic Inhibition of Mitochondrial-dependent Necrosis Attenuates Muscular Dystrophy
  Nature Medicine. Apr, 2008  |   Pubmed ID: 18345011
• Cardiomyocyte GATA4 Functions As a Stress-responsive Regulator of Angiogenesis in the Murine Heart
  The Journal of Clinical Investigation. Nov, 2007  |   Pubmed ID: 17975667
• Inducible and Myocyte-specific Inhibition of PKCalpha Enhances Cardiac Contractility and Protects Against Infarction-induced Heart Failure
  American Journal of Physiology. Heart and Circulatory Physiology. Dec, 2007  |   Pubmed ID: 17921332
• Genetic Inhibition of Cardiac ERK1/2 Promotes Stress-induced Apoptosis and Heart Failure but Has No Effect on Hypertrophy in Vivo
  Proceedings of the National Academy of Sciences of the United States of America. Aug, 2007  |   Pubmed ID: 17709754
• Ca2+- and Mitochondrial-dependent Cardiomyocyte Necrosis As a Primary Mediator of Heart Failure
  The Journal of Clinical Investigation. Sep, 2007  |   Pubmed ID: 17694179
• Mediating ERK 1/2 Signaling Rescues Congenital Heart Defects in a Mouse Model of Noonan Syndrome
  The Journal of Clinical Investigation. Aug, 2007  |   Pubmed ID: 17641779
• Voltage-dependent Anion Channels Are Dispensable for Mitochondrial-dependent Cell Death
  Nature Cell Biology. May, 2007  |   Pubmed ID: 17417626
• Genetic Disruption of Calcineurin Improves Skeletal Muscle Pathology and Cardiac Disease in a Mouse Model of Limb-girdle Muscular Dystrophy
  The Journal of Biological Chemistry. Mar, 2007  |   Pubmed ID: 17289669
• Pharmacological- and Gene Therapy-based Inhibition of Protein Kinase Calpha/beta Enhances Cardiac Contractility and Attenuates Heart Failure
  Circulation. Aug, 2006  |   Pubmed ID: 16880328
• Calcineurin-dependent Cardiomyopathy is Activated by TRPC in the Adult Mouse Heart
  FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Aug, 2006  |   Pubmed ID: 16873889
• Age-dependent Effect of Myostatin Blockade on Disease Severity in a Murine Model of Limb-girdle Muscular Dystrophy
  The American Journal of Pathology. Jun, 2006  |   Pubmed ID: 16723712
• Direct Interaction and Reciprocal Regulation Between ASK1 and Calcineurin-NFAT Control Cardiomyocyte Death and Growth
  Molecular and Cellular Biology. May, 2006  |   Pubmed ID: 16648474
• Modulatory Calcineurin-interacting Proteins 1 and 2 Function As Calcineurin Facilitators in Vivo
  Proceedings of the National Academy of Sciences of the United States of America. May, 2006  |   Pubmed ID: 16648267
• Dichotomy of Ca2+ in the Heart: Contraction Versus Intracellular Signaling
  The Journal of Clinical Investigation. Mar, 2006  |   Pubmed ID: 16511595
• Myocyte Enhancer Factors 2A and 2C Induce Dilated Cardiomyopathy in Transgenic Mice
  The Journal of Biological Chemistry. Apr, 2006  |   Pubmed ID: 16469744
• The DnaJ-related Factor Mrj Interacts with Nuclear Factor of Activated T Cells C3 and Mediates Transcriptional Repression Through Class II Histone Deacetylase Recruitment
  Molecular and Cellular Biology. Nov, 2005  |   Pubmed ID: 16260608
• Inhibition of P38 Reduces Myocardial Infarction Injury in the Mouse but Not Pig After Ischemia-reperfusion
  American Journal of Physiology. Heart and Circulatory Physiology. Dec, 2005  |   Pubmed ID: 16143643
• Regulation of Calcineurin Through Transcriptional Induction of the Calcineurin A Beta Promoter in Vitro and in Vivo
  Molecular and Cellular Biology. Aug, 2005  |   Pubmed ID: 16024800
• Direct and Indirect Interactions Between Calcineurin-NFAT and MEK1-extracellular Signal-regulated Kinase 1/2 Signaling Pathways Regulate Cardiac Gene Expression and Cellular Growth
  Molecular and Cellular Biology. Feb, 2005  |   Pubmed ID: 15657416
• Identification of a Cooperative Mechanism Involving Interleukin-13 and Eotaxin-2 in Experimental Allergic Lung Inflammation
  The Journal of Biological Chemistry. Apr, 2005  |   Pubmed ID: 15647285
• STRESS Signaling Pathways That Modulate Cardiac Myocyte Apoptosis
  Journal of Molecular and Cellular Cardiology. Jan, 2005  |   Pubmed ID: 15623421
• Cardiomyocytes Fuse with Surrounding Noncardiomyocytes and Reenter the Cell Cycle
  The Journal of Cell Biology. Oct, 2004  |   Pubmed ID: 15492039
• Calcium-calcineurin Signaling in the Regulation of Cardiac Hypertrophy
  Biochemical and Biophysical Research Communications. Oct, 2004  |   Pubmed ID: 15336966
• Calcineurin-NFAT Signaling Regulates the Cardiac Hypertrophic Response in Coordination with the MAPKs
  Cardiovascular Research. Aug, 2004  |   Pubmed ID: 15276472
• Genetic Loss of Calcineurin Blocks Mechanical Overload-induced Skeletal Muscle Fiber Type Switching but Not Hypertrophy
  The Journal of Biological Chemistry. Jun, 2004  |   Pubmed ID: 15082723
• Redefining the Roles of P38 and JNK Signaling in Cardiac Hypertrophy: Dichotomy Between Cultured Myocytes and Animal Models
  Journal of Molecular and Cellular Cardiology. Dec, 2003  |   Pubmed ID: 14654364