Jeffery D. Molkentin Division of Molecular Cardiovascular Biology Cincinnati Children's Hospital Medical Center Biography Publications Institution JoVE Articles Jeffery D. Molkentin has not added a biography. If you are Jeffery D. Molkentin and would like to personalize this page please email our Author Liaison for assistance. Publications Cysteine 202 of Cyclophilin D is a Site of Multiple Post-translational Modifications and Plays a Role in Cardioprotection Cardiovascular Research. Jan, 2021 | Pubmed ID: 32129829 Resident Macrophages Keep Mitochondria Running in the Heart Cell Research. 12, 2020 | Pubmed ID: 33139923 Interleukin-1α Dependent Survival of Cardiac Fibroblasts is Associated with StAR/STARD1 Expression and Improved Cardiac Remodeling and Function After Myocardial Infarction Journal of Molecular and Cellular Cardiology. Oct, 2020 | Pubmed ID: 33130150 Ontogeny of Arterial Macrophages Defines Their Functions in Homeostasis and Inflammation Nature Communications. 09, 2020 | Pubmed ID: 32917889 A Specialized Population of Periostin-expressing Cardiac Fibroblasts Contributes to Postnatal Cardiomyocyte Maturation and Innervation Proceedings of the National Academy of Sciences of the United States of America. 09, 2020 | Pubmed ID: 32817558 Type 2 Diabetes Risk Gene Dusp8 Regulates Hypothalamic Jnk Signaling and Insulin Sensitivity The Journal of Clinical Investigation. 11, 2020 | Pubmed ID: 32780722 A 20/20 View of ANT Function in Mitochondrial Biology and Necrotic Cell Death Journal of Molecular and Cellular Cardiology. 07, 2020 | Pubmed ID: 32454061 MCUb Induction Protects the Heart From Postischemic Remodeling Circulation Research. 07, 2020 | Pubmed ID: 32299299 Cardiac Cell Therapy Rejuvenates the Infarcted Rodent Heart Via Direct Injection but Not by Vascular Infusion Circulation. 03, 2020 | Pubmed ID: 32202933 Hyperglycemia Acutely Increases Cytosolic Reactive Oxygen Species Via -linked GlcNAcylation and CaMKII Activation in Mouse Ventricular Myocytes Circulation Research. 05, 2020 | Pubmed ID: 32134364 MEF2C Repressor Variant Deregulation Leads to Cell Cycle Re-entry and Development of Heart Failure EBioMedicine. Jan, 2020 | Pubmed ID: 31911274 An Acute Immune Response Underlies the Benefit of Cardiac Stem cell Therapy Nature. 01, 2020 | Pubmed ID: 31775156 A Novel Class of Cardioprotective Small-molecule PTP Inhibitors Pharmacological Research. 01, 2020 | Pubmed ID: 31759087 Hippo Signaling Does It Again: Arbitrating Cardiac Fibroblast Identity and Activation Genes & Development. 11, 2019 | Pubmed ID: 31676733 CARdiac Immunotherapy: T Cells Engineered to Treat the Fibrotic Heart Molecular Therapy : the Journal of the American Society of Gene Therapy. 11, 2019 | Pubmed ID: 31585799 The EYA3 Tyrosine Phosphatase Activity Promotes Pulmonary Vascular Remodeling in Pulmonary Arterial Hypertension Nature Communications. 09, 2019 | Pubmed ID: 31515519 Cell-specific Ablation of Hsp47 Defines the Collagen-producing Cells in the Injured Heart JCI Insight. 08, 2019 | Pubmed ID: 31393098 Disruption of Valosin-containing Protein Activity Causes Cardiomyopathy and Reveals Pleiotropic Functions in Cardiac Homeostasis The Journal of Biological Chemistry. 05, 2019 | Pubmed ID: 31006653 ERK1/2 Signaling Induces Skeletal Muscle Slow Fiber-type Switching and Reduces Muscular Dystrophy Disease Severity JCI Insight. 04, 2019 | Pubmed ID: 30964448 Overlapping and Differential Functions of ATF6α Versus ATF6β in the Mouse Heart Scientific Reports. 02, 2019 | Pubmed ID: 30765833 Thrombospondin-3 Augments Injury-induced Cardiomyopathy by Intracellular Integrin Inhibition and Sarcolemmal Instability Nature Communications. 01, 2019 | Pubmed ID: 30622267 Cardiac-specific Deficiency of the Mitochondrial Calcium Uniporter Augments Fatty Acid Oxidation and Functional Reserve Journal of Molecular and Cellular Cardiology. 02, 2019 | Pubmed ID: 30615880 Evidence for Minimal Cardiogenic Potential of Stem Cell Antigen 1-Positive Cells in the Adult Mouse Heart Circulation. 12, 2018 | Pubmed ID: 30566022 The Mitochondrial Calcium Uniporter Underlies Metabolic Fuel Preference in Skeletal Muscle JCI Insight. 11, 2018 | Pubmed ID: 30429366 Undeniable Evidence That the Adult Mammalian Heart Lacks an Endogenous Regenerative Stem Cell Circulation. 08, 2018 | Pubmed ID: 30359129 Nuclear Calcineurin is a Sensor for Detecting Ca Release from the Nuclear Envelope Via IPR Journal of Molecular Medicine (Berlin, Germany). 11, 2018 | Pubmed ID: 30293136 Genetic Lineage Tracing of Sca-1 Cells Reveals Endothelial but Not Myogenic Contribution to the Murine Heart Circulation. 12, 2018 | Pubmed ID: 29991486 New Myocyte Formation in the Adult Heart: Endogenous Sources and Therapeutic Implications Circulation Research. 07, 2018 | Pubmed ID: 29976685 Developmental Vascular Regression is Regulated by a Wnt/β-catenin, MYC and CDKN1A Pathway That Controls Cell Proliferation and Cell Death Development (Cambridge, England). 06, 2018 | Pubmed ID: 29777010 Defective Flux of Thrombospondin-4 Through the Secretory Pathway Impairs Cardiomyocyte Membrane Stability and Causes Cardiomyopathy Molecular and Cellular Biology. 07, 2018 | Pubmed ID: 29712757 Gata4-Dependent Differentiation of C-Kit Derived Endothelial Cells Underlies Artefactual Cardiomyocyte Regeneration in the Heart Circulation. Apr, 2018 | Pubmed ID: 29666070 Specialized Fibroblast Differentiated States Underlie Scar Formation in the Infarcted Mouse Heart The Journal of Clinical Investigation. 05, 2018 | Pubmed ID: 29664017 Inhibiting Fibronectin Attenuates Fibrosis and Improves Cardiac Function in a Model of Heart Failure Circulation. 09, 2018 | Pubmed ID: 29653926 Van Berlo Et Al. Reply Nature. 03, 2018 | Pubmed ID: 29565361 Genetic Reduction in Left Ventricular Protein Kinase C-α and Adverse Ventricular Remodeling in Human Subjects Circulation. Genomic and Precision Medicine. 03, 2018 | Pubmed ID: 29540468 Molecular Mechanisms of Cell Death: Recommendations of the Nomenclature Committee on Cell Death 2018 Cell Death and Differentiation. Mar, 2018 | Pubmed ID: 29362479 Increasing T-type Calcium Channel Activity by β-adrenergic Stimulation Contributes to β-adrenergic Regulation of Heart Rates The Journal of Physiology. 04, 2018 | Pubmed ID: 29274077 Protein Kinase C Inhibition With Ruboxistaurin Increases Contractility and Reduces Heart Size in a Swine Model of Heart Failure With Reduced Ejection Fraction JACC. Basic to Translational Science. Dec, 2017 | Pubmed ID: 30062182 BEX1 is an RNA-dependent Mediator of Cardiomyopathy Nature Communications. 11, 2017 | Pubmed ID: 29192139 Autophagic Cell Death is Dependent on Lysosomal Membrane Permeability Through Bax and Bak ELife. 11, 2017 | Pubmed ID: 29148970 Identity Crisis for Regenerative Cardiac CKit Cells Circulation Research. 10, 2017 | Pubmed ID: 29074532 Spatial Gene Profiling in the Ischemic Heart: Fibroblasts Put on Their SOX Circulation. 10, 2017 | Pubmed ID: 28993372 Fibroblast-specific TGF-β-Smad2/3 Signaling Underlies Cardiac Fibrosis The Journal of Clinical Investigation. Oct, 2017 | Pubmed ID: 28891814 Pharmacological and Activated Fibroblast Targeting of Gβγ-GRK2 After Myocardial Ischemia Attenuates Heart Failure Progression Journal of the American College of Cardiology. Aug, 2017 | Pubmed ID: 28818206 TGFBI Functions Similar to Periostin but is Uniquely Dispensable During Cardiac Injury PloS One. 2017 | Pubmed ID: 28750100 Mitsugumin 29 Regulates T-tubule Architecture in the Failing Heart Scientific Reports. 07, 2017 | Pubmed ID: 28706255 Cardiomyocyte Regeneration: A Consensus Statement Circulation. 08, 2017 | Pubmed ID: 28684531 An Unbiased High-Throughput Screen to Identify Novel Effectors That Impact on Cardiomyocyte Aggregate Levels Circulation Research. Sep, 2017 | Pubmed ID: 28655832 Preexisting Endothelial Cells Mediate Cardiac Neovascularization After Injury The Journal of Clinical Investigation. Aug, 2017 | Pubmed ID: 28650345 The Mitochondrial Na/Ca Exchanger is Essential for Ca Homeostasis and Viability Nature. 05, 2017 | Pubmed ID: 28445457 Redefining the Identity of Cardiac Fibroblasts Nature Reviews. Cardiology. Aug, 2017 | Pubmed ID: 28436487 Caveolae-localized L-type Ca2+ Channels Do Not Contribute to Function or Hypertrophic Signalling in the Mouse Heart Cardiovascular Research. Jun, 2017 | Pubmed ID: 28402392 Fibroblast-Specific Genetic Manipulation of P38 Mitogen-Activated Protein Kinase In Vivo Reveals Its Central Regulatory Role in Fibrosis Circulation. Aug, 2017 | Pubmed ID: 28356446 The Elusive Progenitor Cell in Cardiac Regeneration: Slip Slidin' Away Circulation Research. Jan, 2017 | Pubmed ID: 28104772 Applying Modern Transcriptomics to Interrogate the Human Cardiac Fibroblast JACC. Basic to Translational Science. Dec, 2016 | Pubmed ID: 30167545 RCANs Regulate the Convergent Roles of NFATc1 in Bone Homeostasis Scientific Reports. 12, 2016 | Pubmed ID: 27917924 Nemo-Like Kinase (NLK) Is a Pathological Signaling Effector in the Mouse Heart PloS One. 2016 | Pubmed ID: 27764156 Thrombospondin Expression in Myofibers Stabilizes Muscle Membranes ELife. 09, 2016 | Pubmed ID: 27669143 Thrombospondin 1 Protects Pancreatic β-cells from Lipotoxicity Via the PERK-NRF2 Pathway Cell Death and Differentiation. 12, 2016 | Pubmed ID: 27588705 Regulation of Cardiac Hypertrophy and Remodeling Through the Dual-specificity MAPK Phosphatases (DUSPs) Journal of Molecular and Cellular Cardiology. Dec, 2016 | Pubmed ID: 27575022 Inositol 1,4,5-trisphosphate-mediated Sarcoplasmic Reticulum-mitochondrial Crosstalk Influences Adenosine Triphosphate Production Via Mitochondrial Ca2+ Uptake Through the Mitochondrial Ryanodine Receptor in Cardiac Myocytes Cardiovascular Research. 10, 2016 | Pubmed ID: 27496868 Genetic Lineage Tracing Defines Myofibroblast Origin and Function in the Injured Heart Nature Communications. 07, 2016 | Pubmed ID: 27447449 DUSP8 Regulates Cardiac Ventricular Remodeling by Altering ERK1/2 Signaling Circulation Research. 07, 2016 | Pubmed ID: 27225478 A Tension-Based Model Distinguishes Hypertrophic Versus Dilated Cardiomyopathy Cell. May, 2016 | Pubmed ID: 27114035 Cathepsin S Contributes to the Pathogenesis of Muscular Dystrophy in Mice The Journal of Biological Chemistry. May, 2016 | Pubmed ID: 26966179 Cyclophilin D Regulates Necrosis, but Not Apoptosis, of Murine Eosinophils American Journal of Physiology. Gastrointestinal and Liver Physiology. 04, 2016 | Pubmed ID: 26893161 Most of the Dust Has Settled: CKit+ Progenitor Cells Are an Irrelevant Source of Cardiac Myocytes In Vivo Circulation Research. Jan, 2016 | Pubmed ID: 26837741 Genetic Overexpression of Serpina3n Attenuates Muscular Dystrophy in Mice Human Molecular Genetics. Mar, 2016 | Pubmed ID: 26744329 Individual Cardiac Mitochondria Undergo Rare Transient Permeability Transition Pore Openings Circulation Research. Mar, 2016 | Pubmed ID: 26712344 Persistent Increases in Ca(2+) Influx Through Cav1.2 Shortens Action Potential and Causes Ca(2+) Overload-induced Afterdepolarizations and Arrhythmias Basic Research in Cardiology. Jan, 2016 | Pubmed ID: 26611208 Deletion of Periostin Protects Against Atherosclerosis in Mice by Altering Inflammation and Extracellular Matrix Remodeling Arteriosclerosis, Thrombosis, and Vascular Biology. Jan, 2016 | Pubmed ID: 26564821 Dissection of Thrombospondin-4 Domains Involved in Intracellular Adaptive Endoplasmic Reticulum Stress-Responsive Signaling Molecular and Cellular Biology. Jan, 2016 | Pubmed ID: 26459760 MBNL1-mediated Regulation of Differentiation RNAs Promotes Myofibroblast Transformation and the Fibrotic Response Nature Communications. Dec, 2015 | Pubmed ID: 26670661 TAK1 Regulates Myocardial Response to Pathological Stress Via NFAT, NFκB, and Bnip3 Pathways Scientific Reports. 2015 | Pubmed ID: 26564789 Calcineurin Links Mitochondrial Elongation with Energy Metabolism Cell Metabolism. Nov, 2015 | Pubmed ID: 26411342 Cardiac-specific Deletion of Protein Phosphatase 1β Promotes Increased Myofilament Protein Phosphorylation and Contractile Alterations Journal of Molecular and Cellular Cardiology. Oct, 2015 | Pubmed ID: 26334248 STIM1 Elevation in the Heart Results in Aberrant Ca²⁺ Handling and Cardiomyopathy Journal of Molecular and Cellular Cardiology. Oct, 2015 | Pubmed ID: 26241845 The Mitochondrial Calcium Uniporter Selectively Matches Metabolic Output to Acute Contractile Stress in the Heart Cell Reports. Jul, 2015 | Pubmed ID: 26119742 Necroptosis Interfaces with MOMP and the MPTP in Mediating Cell Death PloS One. 2015 | Pubmed ID: 26061004 Regulated Necrotic Cell Death: the Passive Aggressive Side of Bax and Bak Circulation Research. May, 2015 | Pubmed ID: 25999420 Exposure to Radiocontrast Agents Induces Pancreatic Inflammation by Activation of Nuclear Factor-κB, Calcium Signaling, and Calcineurin Gastroenterology. Sep, 2015 | Pubmed ID: 25980752 Genetic Analysis of Connective Tissue Growth Factor As an Effector of Transforming Growth Factor β Signaling and Cardiac Remodeling Molecular and Cellular Biology. Jun, 2015 | Pubmed ID: 25870108 Sarcolipin Overexpression Improves Muscle Energetics and Reduces Fatigue Journal of Applied Physiology (Bethesda, Md. : 1985). Apr, 2015 | Pubmed ID: 25701006 SERCA1 Overexpression Minimizes Skeletal Muscle Damage in Dystrophic Mouse Models American Journal of Physiology. Cell Physiology. 05, 2015 | Pubmed ID: 25652448 Physiological and Pathological Roles of the Mitochondrial Permeability Transition Pore in the Heart Cell Metabolism. Feb, 2015 | Pubmed ID: 25651175 An Emerging Consensus on Cardiac Regeneration Nature Medicine. Dec, 2014 | Pubmed ID: 25473919 Targeting Latent TGFβ Release in Muscular Dystrophy Science Translational Medicine. Oct, 2014 | Pubmed ID: 25338755 RhoA Signaling in Cardiomyocytes Protects Against Stress-induced Heart Failure but Facilitates Cardiac Fibrosis Science Signaling. Oct, 2014 | Pubmed ID: 25336613 The β Isoform of the Catalytic Subunit of Protein Phosphatase 2B Restrains Platelet Function by Suppressing Outside-in αII B β3 Integrin Signaling Journal of Thrombosis and Haemostasis : JTH. Dec, 2014 | Pubmed ID: 25330904 Transforming Growth Factor β-activated Kinase 1 Signaling Pathway Critically Regulates Myocardial Survival and Remodeling Circulation. Dec, 2014 | Pubmed ID: 25278099 Letter by Molkentin Regarding Article, "The Absence of Evidence is Not Evidence of Absence: the Pitfalls of Cre Knock-Ins in the C-Kit Locus" Circulation Research. Sep, 2014 | Pubmed ID: 25258403 Myofiber-specific Inhibition of TGFβ Signaling Protects Skeletal Muscle from Injury and Dystrophic Disease in Mice Human Molecular Genetics. Dec, 2014 | Pubmed ID: 25106553 Sumo E2 Enzyme UBC9 is Required for Efficient Protein Quality Control in Cardiomyocytes Circulation Research. Sep, 2014 | Pubmed ID: 25097219 Excess SMAD Signaling Contributes to Heart and Muscle Dysfunction in Muscular Dystrophy Human Molecular Genetics. Dec, 2014 | Pubmed ID: 25070948 Transient Receptor Potential Channels Contribute to Pathological Structural and Functional Remodeling After Myocardial Infarction Circulation Research. Aug, 2014 | Pubmed ID: 25047165 Identifying the Components of the Elusive Mitochondrial Permeability Transition Pore Proceedings of the National Academy of Sciences of the United States of America. Jul, 2014 | Pubmed ID: 25002521 P38α MAPK Underlies Muscular Dystrophy and Myofiber Death Through a Bax-dependent Mechanism Human Molecular Genetics. Oct, 2014 | Pubmed ID: 24876160 Repression of Cyclin D1 Expression is Necessary for the Maintenance of Cell Cycle Exit in Adult Mammalian Cardiomyocytes The Journal of Biological Chemistry. Jun, 2014 | Pubmed ID: 24821722 C-kit+ Cells Minimally Contribute Cardiomyocytes to the Heart Nature. May, 2014 | Pubmed ID: 24805242 Genetic Manipulation of the Cardiac Mitochondrial Phosphate Carrier Does Not Affect Permeability Transition Journal of Molecular and Cellular Cardiology. Jul, 2014 | Pubmed ID: 24768964 Enhanced Ca²⁺ Influx from STIM1-Orai1 Induces Muscle Pathology in Mouse Models of Muscular Dystrophy Human Molecular Genetics. Jul, 2014 | Pubmed ID: 24556214 Response to Torella Et Al Circulation Research. Feb, 2014 | Pubmed ID: 24526680 Overexpression of the Na+/K+ ATPase α2 but Not α1 Isoform Attenuates Pathological Cardiac Hypertrophy and Remodeling Circulation Research. Jan, 2014 | Pubmed ID: 24218169 Myofibroblasts: Trust Your Heart and Let Fate Decide Journal of Molecular and Cellular Cardiology. May, 2014 | Pubmed ID: 24189039 Parsing the Roles of the Transcription Factors GATA-4 and GATA-6 in the Adult Cardiac Hypertrophic Response PloS One. 2013 | Pubmed ID: 24391969 Apoptosis Repressor with a CARD Domain (ARC) Restrains Bax-mediated Pathogenesis in Dystrophic Skeletal Muscle PloS One. 2013 | Pubmed ID: 24312627 Differential Expression of Embryonic Epicardial Progenitor Markers and Localization of Cardiac Fibrosis in Adult Ischemic Injury and Hypertensive Heart Disease Journal of Molecular and Cellular Cardiology. Dec, 2013 | Pubmed ID: 24140724 Bax and Bak Function As the Outer Membrane Component of the Mitochondrial Permeability Pore in Regulating Necrotic Cell Death in Mice ELife. Aug, 2013 | Pubmed ID: 23991283 Parsing Good Versus Bad Signaling Pathways in the Heart: Role of Calcineurin-nuclear Factor of Activated T-cells Circulation Research. Jun, 2013 | Pubmed ID: 23788503 CaMKII Does It Again: Even the Mitochondria Cannot Escape Its Influence Circulation Research. Apr, 2013 | Pubmed ID: 23620234 Physiologic Functions of Cyclophilin D and the Mitochondrial Permeability Transition Pore Circulation Journal : Official Journal of the Japanese Circulation Society. 2013 | Pubmed ID: 23538482 Signaling Effectors Underlying Pathologic Growth and Remodeling of the Heart The Journal of Clinical Investigation. Jan, 2013 | Pubmed ID: 23281408 Molecular Basis of Physiological Heart Growth: Fundamental Concepts and New Players Nature Reviews. Molecular Cell Biology. Jan, 2013 | Pubmed ID: 23258295 Bile Acids Induce Pancreatic Acinar Cell Injury and Pancreatitis by Activating Calcineurin The Journal of Biological Chemistry. Jan, 2013 | Pubmed ID: 23148215 Unrestrained P38 MAPK Activation in Dusp1/4 Double-null Mice Induces Cardiomyopathy Circulation Research. Jan, 2013 | Pubmed ID: 22993413 Mutual Antagonism Between IP(3)RII and MiRNA-133a Regulates Calcium Signals and Cardiac Hypertrophy The Journal of Cell Biology. Nov, 2012 | Pubmed ID: 23166348 Is P53 the Long-sought Molecular Trigger for Cyclophilin D-regulated Mitochondrial Permeability Transition Pore Formation and Necrosis? Circulation Research. Oct, 2012 | Pubmed ID: 23104876 A TRPC6-dependent Pathway for Myofibroblast Transdifferentiation and Wound Healing in Vivo Developmental Cell. Oct, 2012 | Pubmed ID: 23022034 Sarcolipin is a Newly Identified Regulator of Muscle-based Thermogenesis in Mammals Nature Medicine. Oct, 2012 | Pubmed ID: 22961106 Lost in Transgenesis: a User's Guide for Genetically Manipulating the Mouse in Cardiac Research Circulation Research. Aug, 2012 | Pubmed ID: 22935533 Constitutively Active MEK1 Rescues Cardiac Dysfunction Caused by Overexpressed GSK-3α During Aging and Hemodynamic Pressure Overload American Journal of Physiology. Heart and Circulatory Physiology. Oct, 2012 | Pubmed ID: 22904158 A Thrombospondin-dependent Pathway for a Protective ER Stress Response Cell. Jun, 2012 | Pubmed ID: 22682248 Interaction Between NFκB and NFAT Coordinates Cardiac Hypertrophy and Pathological Remodeling Circulation Research. Apr, 2012 | Pubmed ID: 22403241 Pharmacological and Genetic Inhibition of Calcineurin Protects Against Carbachol-induced Pathological Zymogen Activation and Acinar Cell Injury American Journal of Physiology. Gastrointestinal and Liver Physiology. Apr, 2012 | Pubmed ID: 22323127 Decreased Cardiac L-type Ca²⺠Channel Activity Induces Hypertrophy and Heart Failure in Mice The Journal of Clinical Investigation. Jan, 2012 | Pubmed ID: 22133878 Unraveling the Secrets of a Double Life: Contractile Versus Signaling Ca2+ in a Cardiac Myocyte Journal of Molecular and Cellular Cardiology. Feb, 2012 | Pubmed ID: 21600216 Placental Growth Factor As a Protective Paracrine Effector in the Heart Trends in Cardiovascular Medicine. Nov, 2011 | Pubmed ID: 22902069 Inhibition of PKCα/β with Ruboxistaurin Antagonizes Heart Failure in Pigs After Myocardial Infarction Injury Circulation Research. Dec, 2011 | Pubmed ID: 21998327 The Permeability Transition Pore Controls Cardiac Mitochondrial Maturation and Myocyte Differentiation Developmental Cell. Sep, 2011 | Pubmed ID: 21920313 RhoA Protects the Mouse Heart Against Ischemia/reperfusion Injury The Journal of Clinical Investigation. Aug, 2011 | Pubmed ID: 21747165 Serine 105 Phosphorylation of Transcription Factor GATA4 is Necessary for Stress-induced Cardiac Hypertrophy in Vivo Proceedings of the National Academy of Sciences of the United States of America. Jul, 2011 | Pubmed ID: 21746915 Tinman/Nkx2-5 Acts Via MiR-1 and Upstream of Cdc42 to Regulate Heart Function Across Species The Journal of Cell Biology. Jun, 2011 | Pubmed ID: 21690310 Placental Growth Factor Regulates Cardiac Adaptation and Hypertrophy Through a Paracrine Mechanism Circulation Research. Jul, 2011 | Pubmed ID: 21636802 Regulation of Angiogenesis by a Non-canonical Wnt-Flt1 Pathway in Myeloid Cells Nature. May, 2011 | Pubmed ID: 21623369 A Critical Function for Ser-282 in Cardiac Myosin Binding Protein-C Phosphorylation and Cardiac Function Circulation Research. Jul, 2011 | Pubmed ID: 21597010 Modulation of Chromatin Position and Gene Expression by HDAC4 Interaction with Nucleoporins The Journal of Cell Biology. Apr, 2011 | Pubmed ID: 21464227 Myostatin from the Heart: Local and Systemic Actions in Cardiac Failure and Muscle Wasting American Journal of Physiology. Heart and Circulatory Physiology. Jun, 2011 | Pubmed ID: 21421824 Dysfunctional Ryanodine Receptor and Cardiac Hypertrophy: Role of Signaling Molecules American Journal of Physiology. Heart and Circulatory Physiology. Jun, 2011 | Pubmed ID: 21421818 Mechanisms of Necroptosis in T Cells The Journal of Experimental Medicine. Apr, 2011 | Pubmed ID: 21402742 Moderate Calcium Channel Dysfunction in Adult Mice with Inducible Cardiomyocyte-specific Excision of the Cacnb2 Gene The Journal of Biological Chemistry. May, 2011 | Pubmed ID: 21357697 The Transcription Factor C/EBPbeta Serves As a Master Regulator of Physiologic Cardiac Hypertrophy Circulation Research. Feb, 2011 | Pubmed ID: 21293006 Mitigation of Muscular Dystrophy in Mice by SERCA Overexpression in Skeletal Muscle The Journal of Clinical Investigation. Mar, 2011 | Pubmed ID: 21285509 TRPC Channels As Effectors of Cardiac Hypertrophy Circulation Research. Jan, 2011 | Pubmed ID: 21252153 Extracellular Signal-regulated Kinases 1 and 2 Regulate the Balance Between Eccentric and Concentric Cardiac Growth Circulation Research. Jan, 2011 | Pubmed ID: 21127295 GATA6 Promotes Angiogenic Function and Survival in Endothelial Cells by Suppression of Autocrine Transforming Growth Factor Beta/activin Receptor-like Kinase 5 Signaling The Journal of Biological Chemistry. Feb, 2011 | Pubmed ID: 21127043 Calcium Influx Through Cav1.2 is a Proximal Signal for Pathological Cardiomyocyte Hypertrophy Journal of Molecular and Cellular Cardiology. Mar, 2011 | Pubmed ID: 21111744 Monophosphothreonyl Extracellular Signal-regulated Kinases 1 and 2 (ERK1/2) Are Formed Endogenously in Intact Cardiac Myocytes and Are Enzymically Active Cellular Signalling. Feb, 2011 | Pubmed ID: 21044683 Protein Kinase Cα As a Heart Failure Therapeutic Target Journal of Molecular and Cellular Cardiology. Oct, 2011 | Pubmed ID: 20937286 Magnetic Resonance Imaging Assessment of Cardiac Dysfunction in δ-sarcoglycan Null Mice Neuromuscular Disorders : NMD. Jan, 2011 | Pubmed ID: 20934875 Molecular Pathways Underlying Cardiac Remodeling During Pathophysiological Stimulation Circulation. Dec, 2010 | Pubmed ID: 21173361 Cyclophilin D Controls Mitochondrial Pore-dependent Ca(2+) Exchange, Metabolic Flexibility, and Propensity for Heart Failure in Mice The Journal of Clinical Investigation. Oct, 2010 | Pubmed ID: 20890047 Research Priorities in Hypertrophic Cardiomyopathy: Report of a Working Group of the National Heart, Lung, and Blood Institute Circulation. Sep, 2010 | Pubmed ID: 20837938 The Role of Calcium/calmodulin-activated Calcineurin in Rapid and Slow Endocytosis at Central Synapses The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Sep, 2010 | Pubmed ID: 20810903 The Transcription Factor GATA-6 Regulates Pathological Cardiac Hypertrophy Circulation Research. Oct, 2010 | Pubmed ID: 20705924 CIB1 is a Regulator of Pathological Cardiac Hypertrophy Nature Medicine. Aug, 2010 | Pubmed ID: 20639889 Debio-025 is More Effective Than Prednisone in Reducing Muscular Pathology in Mdx Mice Neuromuscular Disorders : NMD. Nov, 2010 | Pubmed ID: 20637615 The IP3 Receptor Regulates Cardiac Hypertrophy in Response to Select Stimuli Circulation Research. Sep, 2010 | Pubmed ID: 20616315 Proteasome Functional Insufficiency Activates the Calcineurin-NFAT Pathway in Cardiomyocytes and Promotes Maladaptive Remodelling of Stressed Mouse Hearts Cardiovascular Research. Dec, 2010 | Pubmed ID: 20601385 Enhanced Basal Contractility but Reduced Excitation-contraction Coupling Efficiency and Beta-adrenergic Reserve of Hearts with Increased Cav1.2 Activity American Journal of Physiology. Heart and Circulatory Physiology. Aug, 2010 | Pubmed ID: 20543081 Functional Divergence of Platelet Protein Kinase C (PKC) Isoforms in Thrombus Formation on Collagen The Journal of Biological Chemistry. Jul, 2010 | Pubmed ID: 20479008 Apoptotic Cell Death "Nixed" by an ER-mitochondrial Necrotic Pathway Proceedings of the National Academy of Sciences of the United States of America. May, 2010 | Pubmed ID: 20448198 TRPC Channels Are Necessary Mediators of Pathologic Cardiac Hypertrophy Proceedings of the National Academy of Sciences of the United States of America. Apr, 2010 | Pubmed ID: 20351294 Extracellular Signal-regulated Kinase 1/2 (ERK1/2) Signaling in Cardiac Hypertrophy Annals of the New York Academy of Sciences. Feb, 2010 | Pubmed ID: 20201891 Genetic Deletion of Myostatin from the Heart Prevents Skeletal Muscle Atrophy in Heart Failure Circulation. Jan, 2010 | Pubmed ID: 20065166 Heart-specific Deletion of CnB1 Reveals Multiple Mechanisms Whereby Calcineurin Regulates Cardiac Growth and Function The Journal of Biological Chemistry. Feb, 2010 | Pubmed ID: 20037164 Calcineurin Protects the Heart in a Murine Model of Dilated Cardiomyopathy Journal of Molecular and Cellular Cardiology. Jun, 2010 | Pubmed ID: 19854199 Alpha1G-dependent T-type Ca2+ Current Antagonizes Cardiac Hypertrophy Through a NOS3-dependent Mechanism in Mice The Journal of Clinical Investigation. Dec, 2009 | Pubmed ID: 19920353 Calcium Influx is Sufficient to Induce Muscular Dystrophy Through a TRPC-dependent Mechanism Proceedings of the National Academy of Sciences of the United States of America. Nov, 2009 | Pubmed ID: 19864620 Blockade of Hsp20 Phosphorylation Exacerbates Cardiac Ischemia/reperfusion Injury by Suppressed Autophagy and Increased Cell Death Circulation Research. Dec, 2009 | Pubmed ID: 19850943 Genetic Manipulation of Dysferlin Expression in Skeletal Muscle: Novel Insights into Muscular Dystrophy The American Journal of Pathology. Nov, 2009 | Pubmed ID: 19834057 ASK1 Regulates Cardiomyocyte Death but Not Hypertrophy in Transgenic Mice Circulation Research. Nov, 2009 | Pubmed ID: 19815822 Cdc42 is an Antihypertrophic Molecular Switch in the Mouse Heart The Journal of Clinical Investigation. Oct, 2009 | Pubmed ID: 19741299 Lack of Periostin Leads to Suppression of Notch1 Signaling and Calcific Aortic Valve Disease Physiological Genomics. Nov, 2009 | Pubmed ID: 19723774 CaMKII Negatively Regulates Calcineurin-NFAT Signaling in Cardiac Myocytes Circulation Research. Aug, 2009 | Pubmed ID: 19608982 Protein Kinase C{alpha}, but Not PKC{beta} or PKC{gamma}, Regulates Contractility and Heart Failure Susceptibility: Implications for Ruboxistaurin As a Novel Therapeutic Approach Circulation Research. Jul, 2009 | Pubmed ID: 19556521 Adenine Nucleotide Translocase-1 Induces Cardiomyocyte Death Through Upregulation of the Pro-apoptotic Protein Bax Journal of Molecular and Cellular Cardiology. Jun, 2009 | Pubmed ID: 19452617 Plasma Membrane Ca2+-ATPase Isoform 4 Antagonizes Cardiac Hypertrophy in Association with Calcineurin Inhibition in Rodents The Journal of Clinical Investigation. Apr, 2009 | Pubmed ID: 19287093 The Mitochondrial Permeability Transition Pore in Motor Neurons: Involvement in the Pathobiology of ALS Mice Experimental Neurology. Aug, 2009 | Pubmed ID: 19272377 Cardiac Myosin Binding Protein-C Phosphorylation in a {beta}-myosin Heavy Chain Background Circulation. Mar, 2009 | Pubmed ID: 19237661 PKCalpha Regulates Platelet Granule Secretion and Thrombus Formation in Mice The Journal of Clinical Investigation. Feb, 2009 | Pubmed ID: 19147982 Interaction Between TAK1-TAB1-TAB2 and RCAN1-calcineurin Defines a Signalling Nodal Control Point Nature Cell Biology. Feb, 2009 | Pubmed ID: 19136967 Rcan1 Negatively Regulates Fc EpsilonRI-mediated Signaling and Mast Cell Function The Journal of Experimental Medicine. Jan, 2009 | Pubmed ID: 19124655 Genetic Manipulation of Periostin Expression in the Heart Does Not Affect Myocyte Content, Cell Cycle Activity, or Cardiac Repair Circulation Research. Jan, 2009 | Pubmed ID: 19038863 With Great Power Comes Great Responsibility: Using Mouse Genetics to Study Cardiac Hypertrophy and Failure Journal of Molecular and Cellular Cardiology. Feb, 2009 | Pubmed ID: 18845155 Periostin As a Heterofunctional Regulator of Cardiac Development and Disease Current Genomics. Dec, 2008 | Pubmed ID: 19516962 Role of ERK1/2 Signaling in Congenital Valve Malformations in Noonan Syndrome Proceedings of the National Academy of Sciences of the United States of America. Dec, 2008 | Pubmed ID: 19017799 Ca2+ Influx Through T- and L-type Ca2+ Channels Have Different Effects on Myocyte Contractility and Induce Unique Cardiac Phenotypes Circulation Research. Nov, 2008 | Pubmed ID: 18832749 DUSP6 (MKP3) Null Mice Show Enhanced ERK1/2 Phosphorylation at Baseline and Increased Myocyte Proliferation in the Heart Affecting Disease Susceptibility The Journal of Biological Chemistry. Nov, 2008 | Pubmed ID: 18753132 Does Contractile Ca2+ Control Calcineurin-NFAT Signaling and Pathological Hypertrophy in Cardiac Myocytes? Science Signaling. Jun, 2008 | Pubmed ID: 18577756 Genetic and Pharmacologic Inhibition of Mitochondrial-dependent Necrosis Attenuates Muscular Dystrophy Nature Medicine. Apr, 2008 | Pubmed ID: 18345011 Cardiomyocyte GATA4 Functions As a Stress-responsive Regulator of Angiogenesis in the Murine Heart The Journal of Clinical Investigation. Nov, 2007 | Pubmed ID: 17975667 Inducible and Myocyte-specific Inhibition of PKCalpha Enhances Cardiac Contractility and Protects Against Infarction-induced Heart Failure American Journal of Physiology. Heart and Circulatory Physiology. Dec, 2007 | Pubmed ID: 17921332 Genetic Inhibition of Cardiac ERK1/2 Promotes Stress-induced Apoptosis and Heart Failure but Has No Effect on Hypertrophy in Vivo Proceedings of the National Academy of Sciences of the United States of America. Aug, 2007 | Pubmed ID: 17709754 Ca2+- and Mitochondrial-dependent Cardiomyocyte Necrosis As a Primary Mediator of Heart Failure The Journal of Clinical Investigation. Sep, 2007 | Pubmed ID: 17694179 Mediating ERK 1/2 Signaling Rescues Congenital Heart Defects in a Mouse Model of Noonan Syndrome The Journal of Clinical Investigation. Aug, 2007 | Pubmed ID: 17641779 Voltage-dependent Anion Channels Are Dispensable for Mitochondrial-dependent Cell Death Nature Cell Biology. May, 2007 | Pubmed ID: 17417626 Genetic Disruption of Calcineurin Improves Skeletal Muscle Pathology and Cardiac Disease in a Mouse Model of Limb-girdle Muscular Dystrophy The Journal of Biological Chemistry. Mar, 2007 | Pubmed ID: 17289669 Pharmacological- and Gene Therapy-based Inhibition of Protein Kinase Calpha/beta Enhances Cardiac Contractility and Attenuates Heart Failure Circulation. Aug, 2006 | Pubmed ID: 16880328 Calcineurin-dependent Cardiomyopathy is Activated by TRPC in the Adult Mouse Heart FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Aug, 2006 | Pubmed ID: 16873889 Age-dependent Effect of Myostatin Blockade on Disease Severity in a Murine Model of Limb-girdle Muscular Dystrophy The American Journal of Pathology. Jun, 2006 | Pubmed ID: 16723712 Direct Interaction and Reciprocal Regulation Between ASK1 and Calcineurin-NFAT Control Cardiomyocyte Death and Growth Molecular and Cellular Biology. May, 2006 | Pubmed ID: 16648474 Modulatory Calcineurin-interacting Proteins 1 and 2 Function As Calcineurin Facilitators in Vivo Proceedings of the National Academy of Sciences of the United States of America. May, 2006 | Pubmed ID: 16648267 Dichotomy of Ca2+ in the Heart: Contraction Versus Intracellular Signaling The Journal of Clinical Investigation. Mar, 2006 | Pubmed ID: 16511595 Myocyte Enhancer Factors 2A and 2C Induce Dilated Cardiomyopathy in Transgenic Mice The Journal of Biological Chemistry. Apr, 2006 | Pubmed ID: 16469744 The DnaJ-related Factor Mrj Interacts with Nuclear Factor of Activated T Cells C3 and Mediates Transcriptional Repression Through Class II Histone Deacetylase Recruitment Molecular and Cellular Biology. Nov, 2005 | Pubmed ID: 16260608 Inhibition of P38 Reduces Myocardial Infarction Injury in the Mouse but Not Pig After Ischemia-reperfusion American Journal of Physiology. Heart and Circulatory Physiology. Dec, 2005 | Pubmed ID: 16143643 Regulation of Calcineurin Through Transcriptional Induction of the Calcineurin A Beta Promoter in Vitro and in Vivo Molecular and Cellular Biology. Aug, 2005 | Pubmed ID: 16024800 Direct and Indirect Interactions Between Calcineurin-NFAT and MEK1-extracellular Signal-regulated Kinase 1/2 Signaling Pathways Regulate Cardiac Gene Expression and Cellular Growth Molecular and Cellular Biology. Feb, 2005 | Pubmed ID: 15657416 Identification of a Cooperative Mechanism Involving Interleukin-13 and Eotaxin-2 in Experimental Allergic Lung Inflammation The Journal of Biological Chemistry. Apr, 2005 | Pubmed ID: 15647285 STRESS Signaling Pathways That Modulate Cardiac Myocyte Apoptosis Journal of Molecular and Cellular Cardiology. Jan, 2005 | Pubmed ID: 15623421 Cardiomyocytes Fuse with Surrounding Noncardiomyocytes and Reenter the Cell Cycle The Journal of Cell Biology. Oct, 2004 | Pubmed ID: 15492039 Calcium-calcineurin Signaling in the Regulation of Cardiac Hypertrophy Biochemical and Biophysical Research Communications. Oct, 2004 | Pubmed ID: 15336966 Calcineurin-NFAT Signaling Regulates the Cardiac Hypertrophic Response in Coordination with the MAPKs Cardiovascular Research. Aug, 2004 | Pubmed ID: 15276472 Genetic Loss of Calcineurin Blocks Mechanical Overload-induced Skeletal Muscle Fiber Type Switching but Not Hypertrophy The Journal of Biological Chemistry. Jun, 2004 | Pubmed ID: 15082723 Redefining the Roles of P38 and JNK Signaling in Cardiac Hypertrophy: Dichotomy Between Cultured Myocytes and Animal Models Journal of Molecular and Cellular Cardiology. Dec, 2003 | Pubmed ID: 14654364 स्वस्थ और घायल माउस दिलों में त्रि-आयामी फाइब्रोब्लास्ट संगठन के लिए परिष्कृत स्पष्टता-आधारित ऊतक समाशोधन Demetria M. Fischesser1,2, Evan C. Meyer3, Michelle Sargent2, Jeffery D. Molkentin2 1Department of Molecular Genetics, Biochemistry, and Microbiology, University of Cincinnati College of Medicine, 2Division of Molecular Cardiovascular Biology, Cincinnati Children's Hospital Medical Center, 3Confocal Imaging Core, Cincinnati Children's Hospital Medical Center JoVE 62023 Medicine
स्वस्थ और घायल माउस दिलों में त्रि-आयामी फाइब्रोब्लास्ट संगठन के लिए परिष्कृत स्पष्टता-आधारित ऊतक समाशोधन Demetria M. Fischesser1,2, Evan C. Meyer3, Michelle Sargent2, Jeffery D. Molkentin2 1Department of Molecular Genetics, Biochemistry, and Microbiology, University of Cincinnati College of Medicine, 2Division of Molecular Cardiovascular Biology, Cincinnati Children's Hospital Medical Center, 3Confocal Imaging Core, Cincinnati Children's Hospital Medical Center JoVE 62023 Medicine
