Jeffery D. Molkentin

Publications

• Cysteine 202 of Cyclophilin D is a Site of Multiple Post-translational Modifications and Plays a Role in Cardioprotection
  Cardiovascular Research. Jan, 2021  |   Pubmed ID: 32129829
• Resident Macrophages Keep Mitochondria Running in the Heart
  Cell Research. 12, 2020  |   Pubmed ID: 33139923
• Interleukin-1α Dependent Survival of Cardiac Fibroblasts is Associated with StAR/STARD1 Expression and Improved Cardiac Remodeling and Function After Myocardial Infarction
  Journal of Molecular and Cellular Cardiology. Oct, 2020  |   Pubmed ID: 33130150
• Ontogeny of Arterial Macrophages Defines Their Functions in Homeostasis and Inflammation
  Nature Communications. 09, 2020  |   Pubmed ID: 32917889
• A Specialized Population of Periostin-expressing Cardiac Fibroblasts Contributes to Postnatal Cardiomyocyte Maturation and Innervation
  Proceedings of the National Academy of Sciences of the United States of America. 09, 2020  |   Pubmed ID: 32817558
• Type 2 Diabetes Risk Gene Dusp8 Regulates Hypothalamic Jnk Signaling and Insulin Sensitivity
  The Journal of Clinical Investigation. 11, 2020  |   Pubmed ID: 32780722
• A 20/20 View of ANT Function in Mitochondrial Biology and Necrotic Cell Death
  Journal of Molecular and Cellular Cardiology. 07, 2020  |   Pubmed ID: 32454061
• MCUb Induction Protects the Heart From Postischemic Remodeling
  Circulation Research. 07, 2020  |   Pubmed ID: 32299299
• Cardiac Cell Therapy Rejuvenates the Infarcted Rodent Heart Via Direct Injection but Not by Vascular Infusion
  Circulation. 03, 2020  |   Pubmed ID: 32202933
• Hyperglycemia Acutely Increases Cytosolic Reactive Oxygen Species Via -linked GlcNAcylation and CaMKII Activation in Mouse Ventricular Myocytes
  Circulation Research. 05, 2020  |   Pubmed ID: 32134364
• MEF2C Repressor Variant Deregulation Leads to Cell Cycle Re-entry and Development of Heart Failure
  EBioMedicine. Jan, 2020  |   Pubmed ID: 31911274
• An Acute Immune Response Underlies the Benefit of Cardiac Stem cell Therapy
  Nature. 01, 2020  |   Pubmed ID: 31775156
• A Novel Class of Cardioprotective Small-molecule PTP Inhibitors
  Pharmacological Research. 01, 2020  |   Pubmed ID: 31759087
• Hippo Signaling Does It Again: Arbitrating Cardiac Fibroblast Identity and Activation
  Genes & Development. 11, 2019  |   Pubmed ID: 31676733
• CARdiac Immunotherapy: T Cells Engineered to Treat the Fibrotic Heart
  Molecular Therapy : the Journal of the American Society of Gene Therapy. 11, 2019  |   Pubmed ID: 31585799
• The EYA3 Tyrosine Phosphatase Activity Promotes Pulmonary Vascular Remodeling in Pulmonary Arterial Hypertension
  Nature Communications. 09, 2019  |   Pubmed ID: 31515519
• Cell-specific Ablation of Hsp47 Defines the Collagen-producing Cells in the Injured Heart
  JCI Insight. 08, 2019  |   Pubmed ID: 31393098
• Disruption of Valosin-containing Protein Activity Causes Cardiomyopathy and Reveals Pleiotropic Functions in Cardiac Homeostasis
  The Journal of Biological Chemistry. 05, 2019  |   Pubmed ID: 31006653
• ERK1/2 Signaling Induces Skeletal Muscle Slow Fiber-type Switching and Reduces Muscular Dystrophy Disease Severity
  JCI Insight. 04, 2019  |   Pubmed ID: 30964448
• Overlapping and Differential Functions of ATF6α Versus ATF6β in the Mouse Heart
  Scientific Reports. 02, 2019  |   Pubmed ID: 30765833
• Thrombospondin-3 Augments Injury-induced Cardiomyopathy by Intracellular Integrin Inhibition and Sarcolemmal Instability
  Nature Communications. 01, 2019  |   Pubmed ID: 30622267
• Cardiac-specific Deficiency of the Mitochondrial Calcium Uniporter Augments Fatty Acid Oxidation and Functional Reserve
  Journal of Molecular and Cellular Cardiology. 02, 2019  |   Pubmed ID: 30615880
• Evidence for Minimal Cardiogenic Potential of Stem Cell Antigen 1-Positive Cells in the Adult Mouse Heart
  Circulation. 12, 2018  |   Pubmed ID: 30566022
• The Mitochondrial Calcium Uniporter Underlies Metabolic Fuel Preference in Skeletal Muscle
  JCI Insight. 11, 2018  |   Pubmed ID: 30429366
• Undeniable Evidence That the Adult Mammalian Heart Lacks an Endogenous Regenerative Stem Cell
  Circulation. 08, 2018  |   Pubmed ID: 30359129
• Nuclear Calcineurin is a Sensor for Detecting Ca Release from the Nuclear Envelope Via IPR
  Journal of Molecular Medicine (Berlin, Germany). 11, 2018  |   Pubmed ID: 30293136
• Genetic Lineage Tracing of Sca-1 Cells Reveals Endothelial but Not Myogenic Contribution to the Murine Heart
  Circulation. 12, 2018  |   Pubmed ID: 29991486
• New Myocyte Formation in the Adult Heart: Endogenous Sources and Therapeutic Implications
  Circulation Research. 07, 2018  |   Pubmed ID: 29976685
• Developmental Vascular Regression is Regulated by a Wnt/β-catenin, MYC and CDKN1A Pathway That Controls Cell Proliferation and Cell Death
  Development (Cambridge, England). 06, 2018  |   Pubmed ID: 29777010
• Defective Flux of Thrombospondin-4 Through the Secretory Pathway Impairs Cardiomyocyte Membrane Stability and Causes Cardiomyopathy
  Molecular and Cellular Biology. 07, 2018  |   Pubmed ID: 29712757
• Gata4-Dependent Differentiation of C-Kit Derived Endothelial Cells Underlies Artefactual Cardiomyocyte Regeneration in the Heart
  Circulation. Apr, 2018  |   Pubmed ID: 29666070
• Specialized Fibroblast Differentiated States Underlie Scar Formation in the Infarcted Mouse Heart
  The Journal of Clinical Investigation. 05, 2018  |   Pubmed ID: 29664017
• Inhibiting Fibronectin Attenuates Fibrosis and Improves Cardiac Function in a Model of Heart Failure
  Circulation. 09, 2018  |   Pubmed ID: 29653926
• Van Berlo Et Al. Reply
  Nature. 03, 2018  |   Pubmed ID: 29565361
• Genetic Reduction in Left Ventricular Protein Kinase C-α and Adverse Ventricular Remodeling in Human Subjects
  Circulation. Genomic and Precision Medicine. 03, 2018  |   Pubmed ID: 29540468
• Molecular Mechanisms of Cell Death: Recommendations of the Nomenclature Committee on Cell Death 2018
  Cell Death and Differentiation. Mar, 2018  |   Pubmed ID: 29362479
• Increasing T-type Calcium Channel Activity by β-adrenergic Stimulation Contributes to β-adrenergic Regulation of Heart Rates
  The Journal of Physiology. 04, 2018  |   Pubmed ID: 29274077
• Protein Kinase C Inhibition With Ruboxistaurin Increases Contractility and Reduces Heart Size in a Swine Model of Heart Failure With Reduced Ejection Fraction
  JACC. Basic to Translational Science. Dec, 2017  |   Pubmed ID: 30062182
• BEX1 is an RNA-dependent Mediator of Cardiomyopathy
  Nature Communications. 11, 2017  |   Pubmed ID: 29192139
• Autophagic Cell Death is Dependent on Lysosomal Membrane Permeability Through Bax and Bak
  ELife. 11, 2017  |   Pubmed ID: 29148970
• Identity Crisis for Regenerative Cardiac CKit Cells
  Circulation Research. 10, 2017  |   Pubmed ID: 29074532
• Spatial Gene Profiling in the Ischemic Heart: Fibroblasts Put on Their SOX
  Circulation. 10, 2017  |   Pubmed ID: 28993372
• Fibroblast-specific TGF-β-Smad2/3 Signaling Underlies Cardiac Fibrosis
  The Journal of Clinical Investigation. Oct, 2017  |   Pubmed ID: 28891814
• Pharmacological and Activated Fibroblast Targeting of Gβγ-GRK2 After Myocardial Ischemia Attenuates Heart Failure Progression
  Journal of the American College of Cardiology. Aug, 2017  |   Pubmed ID: 28818206
• TGFBI Functions Similar to Periostin but is Uniquely Dispensable During Cardiac Injury
  PloS One. 2017  |   Pubmed ID: 28750100
• Mitsugumin 29 Regulates T-tubule Architecture in the Failing Heart
  Scientific Reports. 07, 2017  |   Pubmed ID: 28706255
• Cardiomyocyte Regeneration: A Consensus Statement
  Circulation. 08, 2017  |   Pubmed ID: 28684531
• An Unbiased High-Throughput Screen to Identify Novel Effectors That Impact on Cardiomyocyte Aggregate Levels
  Circulation Research. Sep, 2017  |   Pubmed ID: 28655832
• Preexisting Endothelial Cells Mediate Cardiac Neovascularization After Injury
  The Journal of Clinical Investigation. Aug, 2017  |   Pubmed ID: 28650345
• The Mitochondrial Na/Ca Exchanger is Essential for Ca Homeostasis and Viability
  Nature. 05, 2017  |   Pubmed ID: 28445457
• Redefining the Identity of Cardiac Fibroblasts
  Nature Reviews. Cardiology. Aug, 2017  |   Pubmed ID: 28436487
• Caveolae-localized L-type Ca2+ Channels Do Not Contribute to Function or Hypertrophic Signalling in the Mouse Heart
  Cardiovascular Research. Jun, 2017  |   Pubmed ID: 28402392
• Fibroblast-Specific Genetic Manipulation of P38 Mitogen-Activated Protein Kinase In Vivo Reveals Its Central Regulatory Role in Fibrosis
  Circulation. Aug, 2017  |   Pubmed ID: 28356446
• The Elusive Progenitor Cell in Cardiac Regeneration: Slip Slidin' Away
  Circulation Research. Jan, 2017  |   Pubmed ID: 28104772
• Applying Modern Transcriptomics to Interrogate the Human Cardiac Fibroblast
  JACC. Basic to Translational Science. Dec, 2016  |   Pubmed ID: 30167545
• RCANs Regulate the Convergent Roles of NFATc1 in Bone Homeostasis
  Scientific Reports. 12, 2016  |   Pubmed ID: 27917924
• Nemo-Like Kinase (NLK) Is a Pathological Signaling Effector in the Mouse Heart
  PloS One. 2016  |   Pubmed ID: 27764156
• Thrombospondin Expression in Myofibers Stabilizes Muscle Membranes
  ELife. 09, 2016  |   Pubmed ID: 27669143
• Thrombospondin 1 Protects Pancreatic β-cells from Lipotoxicity Via the PERK-NRF2 Pathway
  Cell Death and Differentiation. 12, 2016  |   Pubmed ID: 27588705
• Regulation of Cardiac Hypertrophy and Remodeling Through the Dual-specificity MAPK Phosphatases (DUSPs)
  Journal of Molecular and Cellular Cardiology. Dec, 2016  |   Pubmed ID: 27575022
• Inositol 1,4,5-trisphosphate-mediated Sarcoplasmic Reticulum-mitochondrial Crosstalk Influences Adenosine Triphosphate Production Via Mitochondrial Ca2+ Uptake Through the Mitochondrial Ryanodine Receptor in Cardiac Myocytes
  Cardiovascular Research. 10, 2016  |   Pubmed ID: 27496868
• Genetic Lineage Tracing Defines Myofibroblast Origin and Function in the Injured Heart
  Nature Communications. 07, 2016  |   Pubmed ID: 27447449
• DUSP8 Regulates Cardiac Ventricular Remodeling by Altering ERK1/2 Signaling
  Circulation Research. 07, 2016  |   Pubmed ID: 27225478
• A Tension-Based Model Distinguishes Hypertrophic Versus Dilated Cardiomyopathy
  Cell. May, 2016  |   Pubmed ID: 27114035
• Cathepsin S Contributes to the Pathogenesis of Muscular Dystrophy in Mice
  The Journal of Biological Chemistry. May, 2016  |   Pubmed ID: 26966179
• Cyclophilin D Regulates Necrosis, but Not Apoptosis, of Murine Eosinophils
  American Journal of Physiology. Gastrointestinal and Liver Physiology. 04, 2016  |   Pubmed ID: 26893161
• Most of the Dust Has Settled: CKit+ Progenitor Cells Are an Irrelevant Source of Cardiac Myocytes In Vivo
  Circulation Research. Jan, 2016  |   Pubmed ID: 26837741
• Genetic Overexpression of Serpina3n Attenuates Muscular Dystrophy in Mice
  Human Molecular Genetics. Mar, 2016  |   Pubmed ID: 26744329
• Individual Cardiac Mitochondria Undergo Rare Transient Permeability Transition Pore Openings
  Circulation Research. Mar, 2016  |   Pubmed ID: 26712344
• Persistent Increases in Ca(2+) Influx Through Cav1.2 Shortens Action Potential and Causes Ca(2+) Overload-induced Afterdepolarizations and Arrhythmias
  Basic Research in Cardiology. Jan, 2016  |   Pubmed ID: 26611208
• Deletion of Periostin Protects Against Atherosclerosis in Mice by Altering Inflammation and Extracellular Matrix Remodeling
  Arteriosclerosis, Thrombosis, and Vascular Biology. Jan, 2016  |   Pubmed ID: 26564821
• Dissection of Thrombospondin-4 Domains Involved in Intracellular Adaptive Endoplasmic Reticulum Stress-Responsive Signaling
  Molecular and Cellular Biology. Jan, 2016  |   Pubmed ID: 26459760
• MBNL1-mediated Regulation of Differentiation RNAs Promotes Myofibroblast Transformation and the Fibrotic Response
  Nature Communications. Dec, 2015  |   Pubmed ID: 26670661
• TAK1 Regulates Myocardial Response to Pathological Stress Via NFAT, NFκB, and Bnip3 Pathways
  Scientific Reports. 2015  |   Pubmed ID: 26564789
• Calcineurin Links Mitochondrial Elongation with Energy Metabolism
  Cell Metabolism. Nov, 2015  |   Pubmed ID: 26411342
• Cardiac-specific Deletion of Protein Phosphatase 1β Promotes Increased Myofilament Protein Phosphorylation and Contractile Alterations
  Journal of Molecular and Cellular Cardiology. Oct, 2015  |   Pubmed ID: 26334248
• STIM1 Elevation in the Heart Results in Aberrant Ca²⁺ Handling and Cardiomyopathy
  Journal of Molecular and Cellular Cardiology. Oct, 2015  |   Pubmed ID: 26241845
• The Mitochondrial Calcium Uniporter Selectively Matches Metabolic Output to Acute Contractile Stress in the Heart
  Cell Reports. Jul, 2015  |   Pubmed ID: 26119742
• Necroptosis Interfaces with MOMP and the MPTP in Mediating Cell Death
  PloS One. 2015  |   Pubmed ID: 26061004
• Regulated Necrotic Cell Death: the Passive Aggressive Side of Bax and Bak
  Circulation Research. May, 2015  |   Pubmed ID: 25999420
• Exposure to Radiocontrast Agents Induces Pancreatic Inflammation by Activation of Nuclear Factor-κB, Calcium Signaling, and Calcineurin
  Gastroenterology. Sep, 2015  |   Pubmed ID: 25980752
• Genetic Analysis of Connective Tissue Growth Factor As an Effector of Transforming Growth Factor β Signaling and Cardiac Remodeling
  Molecular and Cellular Biology. Jun, 2015  |   Pubmed ID: 25870108
• Sarcolipin Overexpression Improves Muscle Energetics and Reduces Fatigue
  Journal of Applied Physiology (Bethesda, Md. : 1985). Apr, 2015  |   Pubmed ID: 25701006
• SERCA1 Overexpression Minimizes Skeletal Muscle Damage in Dystrophic Mouse Models
  American Journal of Physiology. Cell Physiology. 05, 2015  |   Pubmed ID: 25652448
• Physiological and Pathological Roles of the Mitochondrial Permeability Transition Pore in the Heart
  Cell Metabolism. Feb, 2015  |   Pubmed ID: 25651175
• An Emerging Consensus on Cardiac Regeneration
  Nature Medicine. Dec, 2014  |   Pubmed ID: 25473919
• Targeting Latent TGFβ Release in Muscular Dystrophy
  Science Translational Medicine. Oct, 2014  |   Pubmed ID: 25338755
• RhoA Signaling in Cardiomyocytes Protects Against Stress-induced Heart Failure but Facilitates Cardiac Fibrosis
  Science Signaling. Oct, 2014  |   Pubmed ID: 25336613
• The β Isoform of the Catalytic Subunit of Protein Phosphatase 2B Restrains Platelet Function by Suppressing Outside-in αII B β3 Integrin Signaling
  Journal of Thrombosis and Haemostasis : JTH. Dec, 2014  |   Pubmed ID: 25330904
• Transforming Growth Factor β-activated Kinase 1 Signaling Pathway Critically Regulates Myocardial Survival and Remodeling
  Circulation. Dec, 2014  |   Pubmed ID: 25278099
• Letter by Molkentin Regarding Article, "The Absence of Evidence is Not Evidence of Absence: the Pitfalls of Cre Knock-Ins in the C-Kit Locus"
  Circulation Research. Sep, 2014  |   Pubmed ID: 25258403
• Myofiber-specific Inhibition of TGFβ Signaling Protects Skeletal Muscle from Injury and Dystrophic Disease in Mice
  Human Molecular Genetics. Dec, 2014  |   Pubmed ID: 25106553
• Sumo E2 Enzyme UBC9 is Required for Efficient Protein Quality Control in Cardiomyocytes
  Circulation Research. Sep, 2014  |   Pubmed ID: 25097219
• Excess SMAD Signaling Contributes to Heart and Muscle Dysfunction in Muscular Dystrophy
  Human Molecular Genetics. Dec, 2014  |   Pubmed ID: 25070948
• Transient Receptor Potential Channels Contribute to Pathological Structural and Functional Remodeling After Myocardial Infarction
  Circulation Research. Aug, 2014  |   Pubmed ID: 25047165
• Identifying the Components of the Elusive Mitochondrial Permeability Transition Pore
  Proceedings of the National Academy of Sciences of the United States of America. Jul, 2014  |   Pubmed ID: 25002521
• P38α MAPK Underlies Muscular Dystrophy and Myofiber Death Through a Bax-dependent Mechanism
  Human Molecular Genetics. Oct, 2014  |   Pubmed ID: 24876160
• Repression of Cyclin D1 Expression is Necessary for the Maintenance of Cell Cycle Exit in Adult Mammalian Cardiomyocytes
  The Journal of Biological Chemistry. Jun, 2014  |   Pubmed ID: 24821722
• C-kit+ Cells Minimally Contribute Cardiomyocytes to the Heart
  Nature. May, 2014  |   Pubmed ID: 24805242
• Genetic Manipulation of the Cardiac Mitochondrial Phosphate Carrier Does Not Affect Permeability Transition
  Journal of Molecular and Cellular Cardiology. Jul, 2014  |   Pubmed ID: 24768964
• Enhanced Ca²⁺ Influx from STIM1-Orai1 Induces Muscle Pathology in Mouse Models of Muscular Dystrophy
  Human Molecular Genetics. Jul, 2014  |   Pubmed ID: 24556214
• Response to Torella Et Al
  Circulation Research. Feb, 2014  |   Pubmed ID: 24526680
• Overexpression of the Na+/K+ ATPase α2 but Not α1 Isoform Attenuates Pathological Cardiac Hypertrophy and Remodeling
  Circulation Research. Jan, 2014  |   Pubmed ID: 24218169
• Myofibroblasts: Trust Your Heart and Let Fate Decide
  Journal of Molecular and Cellular Cardiology. May, 2014  |   Pubmed ID: 24189039
• Parsing the Roles of the Transcription Factors GATA-4 and GATA-6 in the Adult Cardiac Hypertrophic Response
  PloS One. 2013  |   Pubmed ID: 24391969
• Apoptosis Repressor with a CARD Domain (ARC) Restrains Bax-mediated Pathogenesis in Dystrophic Skeletal Muscle
  PloS One. 2013  |   Pubmed ID: 24312627
• Differential Expression of Embryonic Epicardial Progenitor Markers and Localization of Cardiac Fibrosis in Adult Ischemic Injury and Hypertensive Heart Disease
  Journal of Molecular and Cellular Cardiology. Dec, 2013  |   Pubmed ID: 24140724
• Bax and Bak Function As the Outer Membrane Component of the Mitochondrial Permeability Pore in Regulating Necrotic Cell Death in Mice
  ELife. Aug, 2013  |   Pubmed ID: 23991283
• Parsing Good Versus Bad Signaling Pathways in the Heart: Role of Calcineurin-nuclear Factor of Activated T-cells
  Circulation Research. Jun, 2013  |   Pubmed ID: 23788503
• CaMKII Does It Again: Even the Mitochondria Cannot Escape Its Influence
  Circulation Research. Apr, 2013  |   Pubmed ID: 23620234
• Physiologic Functions of Cyclophilin D and the Mitochondrial Permeability Transition Pore
  Circulation Journal : Official Journal of the Japanese Circulation Society. 2013  |   Pubmed ID: 23538482
• Signaling Effectors Underlying Pathologic Growth and Remodeling of the Heart
  The Journal of Clinical Investigation. Jan, 2013  |   Pubmed ID: 23281408
• Molecular Basis of Physiological Heart Growth: Fundamental Concepts and New Players
  Nature Reviews. Molecular Cell Biology. Jan, 2013  |   Pubmed ID: 23258295
• Bile Acids Induce Pancreatic Acinar Cell Injury and Pancreatitis by Activating Calcineurin
  The Journal of Biological Chemistry. Jan, 2013  |   Pubmed ID: 23148215
• Unrestrained P38 MAPK Activation in Dusp1/4 Double-null Mice Induces Cardiomyopathy
  Circulation Research. Jan, 2013  |   Pubmed ID: 22993413
• Mutual Antagonism Between IP(3)RII and MiRNA-133a Regulates Calcium Signals and Cardiac Hypertrophy
  The Journal of Cell Biology. Nov, 2012  |   Pubmed ID: 23166348
• Is P53 the Long-sought Molecular Trigger for Cyclophilin D-regulated Mitochondrial Permeability Transition Pore Formation and Necrosis?
  Circulation Research. Oct, 2012  |   Pubmed ID: 23104876
• A TRPC6-dependent Pathway for Myofibroblast Transdifferentiation and Wound Healing in Vivo
  Developmental Cell. Oct, 2012  |   Pubmed ID: 23022034
• Sarcolipin is a Newly Identified Regulator of Muscle-based Thermogenesis in Mammals
  Nature Medicine. Oct, 2012  |   Pubmed ID: 22961106
• Lost in Transgenesis: a User's Guide for Genetically Manipulating the Mouse in Cardiac Research
  Circulation Research. Aug, 2012  |   Pubmed ID: 22935533
• Constitutively Active MEK1 Rescues Cardiac Dysfunction Caused by Overexpressed GSK-3α During Aging and Hemodynamic Pressure Overload
  American Journal of Physiology. Heart and Circulatory Physiology. Oct, 2012  |   Pubmed ID: 22904158
• A Thrombospondin-dependent Pathway for a Protective ER Stress Response
  Cell. Jun, 2012  |   Pubmed ID: 22682248
• Interaction Between NFκB and NFAT Coordinates Cardiac Hypertrophy and Pathological Remodeling
  Circulation Research. Apr, 2012  |   Pubmed ID: 22403241
• Pharmacological and Genetic Inhibition of Calcineurin Protects Against Carbachol-induced Pathological Zymogen Activation and Acinar Cell Injury
  American Journal of Physiology. Gastrointestinal and Liver Physiology. Apr, 2012  |   Pubmed ID: 22323127
• 心筋 L 型 Ca²⁺ チャネル活性の低下は肥大と心不全マウスを誘導します。
  The Journal of Clinical Investigation. Jan, 2012  |   Pubmed ID: 22133878
• Unraveling the Secrets of a Double Life: Contractile Versus Signaling Ca2+ in a Cardiac Myocyte
  Journal of Molecular and Cellular Cardiology. Feb, 2012  |   Pubmed ID: 21600216
• Placental Growth Factor As a Protective Paracrine Effector in the Heart
  Trends in Cardiovascular Medicine. Nov, 2011  |   Pubmed ID: 22902069
• RuboxistaurinとPKCα/βの阻害は、心筋梗塞損傷後のブタの心不全に拮抗
  Circulation Research. Dec, 2011  |   Pubmed ID: 21998327
• The Permeability Transition Pore Controls Cardiac Mitochondrial Maturation and Myocyte Differentiation
  Developmental Cell. Sep, 2011  |   Pubmed ID: 21920313
• RhoA Protects the Mouse Heart Against Ischemia/reperfusion Injury
  The Journal of Clinical Investigation. Aug, 2011  |   Pubmed ID: 21747165
• Serine 105 Phosphorylation of Transcription Factor GATA4 is Necessary for Stress-induced Cardiac Hypertrophy in Vivo
  Proceedings of the National Academy of Sciences of the United States of America. Jul, 2011  |   Pubmed ID: 21746915
• Cdc42のmiR - 1およびアップストリーム経由Tinman/Nkx2-5行為は種を越えて心機能を調節する
  The Journal of Cell Biology. Jun, 2011  |   Pubmed ID: 21690310
• Placental Growth Factor Regulates Cardiac Adaptation and Hypertrophy Through a Paracrine Mechanism
  Circulation Research. Jul, 2011  |   Pubmed ID: 21636802
• Regulation of Angiogenesis by a Non-canonical Wnt-Flt1 Pathway in Myeloid Cells
  Nature. May, 2011  |   Pubmed ID: 21623369
• A Critical Function for Ser-282 in Cardiac Myosin Binding Protein-C Phosphorylation and Cardiac Function
  Circulation Research. Jul, 2011  |   Pubmed ID: 21597010
• Modulation of Chromatin Position and Gene Expression by HDAC4 Interaction with Nucleoporins
  The Journal of Cell Biology. Apr, 2011  |   Pubmed ID: 21464227
• Myostatin from the Heart: Local and Systemic Actions in Cardiac Failure and Muscle Wasting
  American Journal of Physiology. Heart and Circulatory Physiology. Jun, 2011  |   Pubmed ID: 21421824
• Dysfunctional Ryanodine Receptor and Cardiac Hypertrophy: Role of Signaling Molecules
  American Journal of Physiology. Heart and Circulatory Physiology. Jun, 2011  |   Pubmed ID: 21421818
• Mechanisms of Necroptosis in T Cells
  The Journal of Experimental Medicine. Apr, 2011  |   Pubmed ID: 21402742
• Cacnb2遺伝子の誘導心筋細胞特異的切除と大人のマウスの中等度のカルシウムチャネルの機能不全
  The Journal of Biological Chemistry. May, 2011  |   Pubmed ID: 21357697
• The Transcription Factor C/EBPbeta Serves As a Master Regulator of Physiologic Cardiac Hypertrophy
  Circulation Research. Feb, 2011  |   Pubmed ID: 21293006
• 骨格筋におけるSERCAの過剰発現によるマウスの筋ジストロフィーの緩和
  The Journal of Clinical Investigation. Mar, 2011  |   Pubmed ID: 21285509
• TRPC Channels As Effectors of Cardiac Hypertrophy
  Circulation Research. Jan, 2011  |   Pubmed ID: 21252153
• Extracellular Signal-regulated Kinases 1 and 2 Regulate the Balance Between Eccentric and Concentric Cardiac Growth
  Circulation Research. Jan, 2011  |   Pubmed ID: 21127295
• GATA6 Promotes Angiogenic Function and Survival in Endothelial Cells by Suppression of Autocrine Transforming Growth Factor Beta/activin Receptor-like Kinase 5 Signaling
  The Journal of Biological Chemistry. Feb, 2011  |   Pubmed ID: 21127043
• Calcium Influx Through Cav1.2 is a Proximal Signal for Pathological Cardiomyocyte Hypertrophy
  Journal of Molecular and Cellular Cardiology. Mar, 2011  |   Pubmed ID: 21111744
• Monophosphothreonyl Extracellular Signal-regulated Kinases 1 and 2 (ERK1/2) Are Formed Endogenously in Intact Cardiac Myocytes and Are Enzymically Active
  Cellular Signalling. Feb, 2011  |   Pubmed ID: 21044683
• Protein Kinase Cα As a Heart Failure Therapeutic Target
  Journal of Molecular and Cellular Cardiology. Oct, 2011  |   Pubmed ID: 20937286
• 磁気共鳴イメージング δ Sarcoglycan 欠損マウスの心機能障害の評価。
  Neuromuscular Disorders : NMD. Jan, 2011  |   Pubmed ID: 20934875
• Molecular Pathways Underlying Cardiac Remodeling During Pathophysiological Stimulation
  Circulation. Dec, 2010  |   Pubmed ID: 21173361
• Cyclophilin D Controls Mitochondrial Pore-dependent Ca(2+) Exchange, Metabolic Flexibility, and Propensity for Heart Failure in Mice
  The Journal of Clinical Investigation. Oct, 2010  |   Pubmed ID: 20890047
• 肥大型心筋症における研究の優先順位：国立心臓のワーキンググループの報告書、肺、血液研究所
  Circulation. Sep, 2010  |   Pubmed ID: 20837938
• 中央シナプスにおける迅速かつスローエンドサイトーシスにおけるカルシウム/カルモジュリン活性化カルシニューリンの役割
  The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Sep, 2010  |   Pubmed ID: 20810903
• The Transcription Factor GATA-6 Regulates Pathological Cardiac Hypertrophy
  Circulation Research. Oct, 2010  |   Pubmed ID: 20705924
• CIB1 is a Regulator of Pathological Cardiac Hypertrophy
  Nature Medicine. Aug, 2010  |   Pubmed ID: 20639889
• Debio-025 is More Effective Than Prednisone in Reducing Muscular Pathology in Mdx Mice
  Neuromuscular Disorders : NMD. Nov, 2010  |   Pubmed ID: 20637615
• The IP3 Receptor Regulates Cardiac Hypertrophy in Response to Select Stimuli
  Circulation Research. Sep, 2010  |   Pubmed ID: 20616315
• Proteasome Functional Insufficiency Activates the Calcineurin-NFAT Pathway in Cardiomyocytes and Promotes Maladaptive Remodelling of Stressed Mouse Hearts
  Cardiovascular Research. Dec, 2010  |   Pubmed ID: 20601385
• Enhanced Basal Contractility but Reduced Excitation-contraction Coupling Efficiency and Beta-adrenergic Reserve of Hearts with Increased Cav1.2 Activity
  American Journal of Physiology. Heart and Circulatory Physiology. Aug, 2010  |   Pubmed ID: 20543081
• Functional Divergence of Platelet Protein Kinase C (PKC) Isoforms in Thrombus Formation on Collagen
  The Journal of Biological Chemistry. Jul, 2010  |   Pubmed ID: 20479008
• Apoptotic Cell Death "Nixed" by an ER-mitochondrial Necrotic Pathway
  Proceedings of the National Academy of Sciences of the United States of America. May, 2010  |   Pubmed ID: 20448198
• TRPC Channels Are Necessary Mediators of Pathologic Cardiac Hypertrophy
  Proceedings of the National Academy of Sciences of the United States of America. Apr, 2010  |   Pubmed ID: 20351294
• Extracellular Signal-regulated Kinase 1/2 (ERK1/2) Signaling in Cardiac Hypertrophy
  Annals of the New York Academy of Sciences. Feb, 2010  |   Pubmed ID: 20201891
• Genetic Deletion of Myostatin from the Heart Prevents Skeletal Muscle Atrophy in Heart Failure
  Circulation. Jan, 2010  |   Pubmed ID: 20065166
• Heart-specific Deletion of CnB1 Reveals Multiple Mechanisms Whereby Calcineurin Regulates Cardiac Growth and Function
  The Journal of Biological Chemistry. Feb, 2010  |   Pubmed ID: 20037164
• Calcineurin Protects the Heart in a Murine Model of Dilated Cardiomyopathy
  Journal of Molecular and Cellular Cardiology. Jun, 2010  |   Pubmed ID: 19854199
• Alpha1G-dependent T-type Ca2+ Current Antagonizes Cardiac Hypertrophy Through a NOS3-dependent Mechanism in Mice
  The Journal of Clinical Investigation. Dec, 2009  |   Pubmed ID: 19920353
• Calcium Influx is Sufficient to Induce Muscular Dystrophy Through a TRPC-dependent Mechanism
  Proceedings of the National Academy of Sciences of the United States of America. Nov, 2009  |   Pubmed ID: 19864620
• Blockade of Hsp20 Phosphorylation Exacerbates Cardiac Ischemia/reperfusion Injury by Suppressed Autophagy and Increased Cell Death
  Circulation Research. Dec, 2009  |   Pubmed ID: 19850943
• ジスフェリン式骨格筋での遺伝子操作: 小説洞察筋ジストロフィー。
  The American Journal of Pathology. Nov, 2009  |   Pubmed ID: 19834057
• ASK1 Regulates Cardiomyocyte Death but Not Hypertrophy in Transgenic Mice
  Circulation Research. Nov, 2009  |   Pubmed ID: 19815822
• Cdc42 is an Antihypertrophic Molecular Switch in the Mouse Heart
  The Journal of Clinical Investigation. Oct, 2009  |   Pubmed ID: 19741299
• Lack of Periostin Leads to Suppression of Notch1 Signaling and Calcific Aortic Valve Disease
  Physiological Genomics. Nov, 2009  |   Pubmed ID: 19723774
• CaMKII Negatively Regulates Calcineurin-NFAT Signaling in Cardiac Myocytes
  Circulation Research. Aug, 2009  |   Pubmed ID: 19608982
• Protein Kinase C{alpha}, but Not PKC{beta} or PKC{gamma}, Regulates Contractility and Heart Failure Susceptibility: Implications for Ruboxistaurin As a Novel Therapeutic Approach
  Circulation Research. Jul, 2009  |   Pubmed ID: 19556521
• Adenine Nucleotide Translocase-1 Induces Cardiomyocyte Death Through Upregulation of the Pro-apoptotic Protein Bax
  Journal of Molecular and Cellular Cardiology. Jun, 2009  |   Pubmed ID: 19452617
• Plasma Membrane Ca2+-ATPase Isoform 4 Antagonizes Cardiac Hypertrophy in Association with Calcineurin Inhibition in Rodents
  The Journal of Clinical Investigation. Apr, 2009  |   Pubmed ID: 19287093
• The Mitochondrial Permeability Transition Pore in Motor Neurons: Involvement in the Pathobiology of ALS Mice
  Experimental Neurology. Aug, 2009  |   Pubmed ID: 19272377
• Cardiac Myosin Binding Protein-C Phosphorylation in a {beta}-myosin Heavy Chain Background
  Circulation. Mar, 2009  |   Pubmed ID: 19237661
• PKCalpha Regulates Platelet Granule Secretion and Thrombus Formation in Mice
  The Journal of Clinical Investigation. Feb, 2009  |   Pubmed ID: 19147982
• Interaction Between TAK1-TAB1-TAB2 and RCAN1-calcineurin Defines a Signalling Nodal Control Point
  Nature Cell Biology. Feb, 2009  |   Pubmed ID: 19136967
• Rcan1 Negatively Regulates Fc EpsilonRI-mediated Signaling and Mast Cell Function
  The Journal of Experimental Medicine. Jan, 2009  |   Pubmed ID: 19124655
• Genetic Manipulation of Periostin Expression in the Heart Does Not Affect Myocyte Content, Cell Cycle Activity, or Cardiac Repair
  Circulation Research. Jan, 2009  |   Pubmed ID: 19038863
• With Great Power Comes Great Responsibility: Using Mouse Genetics to Study Cardiac Hypertrophy and Failure
  Journal of Molecular and Cellular Cardiology. Feb, 2009  |   Pubmed ID: 18845155
• Periostin As a Heterofunctional Regulator of Cardiac Development and Disease
  Current Genomics. Dec, 2008  |   Pubmed ID: 19516962
• Role of ERK1/2 Signaling in Congenital Valve Malformations in Noonan Syndrome
  Proceedings of the National Academy of Sciences of the United States of America. Dec, 2008  |   Pubmed ID: 19017799
• Ca2+ Influx Through T- and L-type Ca2+ Channels Have Different Effects on Myocyte Contractility and Induce Unique Cardiac Phenotypes
  Circulation Research. Nov, 2008  |   Pubmed ID: 18832749
• DUSP6 (MKP3) Null Mice Show Enhanced ERK1/2 Phosphorylation at Baseline and Increased Myocyte Proliferation in the Heart Affecting Disease Susceptibility
  The Journal of Biological Chemistry. Nov, 2008  |   Pubmed ID: 18753132
• Does Contractile Ca2+ Control Calcineurin-NFAT Signaling and Pathological Hypertrophy in Cardiac Myocytes?
  Science Signaling. Jun, 2008  |   Pubmed ID: 18577756
• ミトコンドリアに依存する遺伝的および薬理学的阻害筋ジストロフィーを減衰させます。
  Nature Medicine. Apr, 2008  |   Pubmed ID: 18345011
• Cardiomyocyte GATA4 Functions As a Stress-responsive Regulator of Angiogenesis in the Murine Heart
  The Journal of Clinical Investigation. Nov, 2007  |   Pubmed ID: 17975667
• Inducible and Myocyte-specific Inhibition of PKCalpha Enhances Cardiac Contractility and Protects Against Infarction-induced Heart Failure
  American Journal of Physiology. Heart and Circulatory Physiology. Dec, 2007  |   Pubmed ID: 17921332
• Genetic Inhibition of Cardiac ERK1/2 Promotes Stress-induced Apoptosis and Heart Failure but Has No Effect on Hypertrophy in Vivo
  Proceedings of the National Academy of Sciences of the United States of America. Aug, 2007  |   Pubmed ID: 17709754
• Ca2+- and Mitochondrial-dependent Cardiomyocyte Necrosis As a Primary Mediator of Heart Failure
  The Journal of Clinical Investigation. Sep, 2007  |   Pubmed ID: 17694179
• Mediating ERK 1/2 Signaling Rescues Congenital Heart Defects in a Mouse Model of Noonan Syndrome
  The Journal of Clinical Investigation. Aug, 2007  |   Pubmed ID: 17641779
• Voltage-dependent Anion Channels Are Dispensable for Mitochondrial-dependent Cell Death
  Nature Cell Biology. May, 2007  |   Pubmed ID: 17417626
• Genetic Disruption of Calcineurin Improves Skeletal Muscle Pathology and Cardiac Disease in a Mouse Model of Limb-girdle Muscular Dystrophy
  The Journal of Biological Chemistry. Mar, 2007  |   Pubmed ID: 17289669
• Pharmacological- and Gene Therapy-based Inhibition of Protein Kinase Calpha/beta Enhances Cardiac Contractility and Attenuates Heart Failure
  Circulation. Aug, 2006  |   Pubmed ID: 16880328
• Calcineurin-dependent Cardiomyopathy is Activated by TRPC in the Adult Mouse Heart
  FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Aug, 2006  |   Pubmed ID: 16873889
• Age-dependent Effect of Myostatin Blockade on Disease Severity in a Murine Model of Limb-girdle Muscular Dystrophy
  The American Journal of Pathology. Jun, 2006  |   Pubmed ID: 16723712
• Direct Interaction and Reciprocal Regulation Between ASK1 and Calcineurin-NFAT Control Cardiomyocyte Death and Growth
  Molecular and Cellular Biology. May, 2006  |   Pubmed ID: 16648474
• Modulatory Calcineurin-interacting Proteins 1 and 2 Function As Calcineurin Facilitators in Vivo
  Proceedings of the National Academy of Sciences of the United States of America. May, 2006  |   Pubmed ID: 16648267
• Dichotomy of Ca2+ in the Heart: Contraction Versus Intracellular Signaling
  The Journal of Clinical Investigation. Mar, 2006  |   Pubmed ID: 16511595
• Myocyte Enhancer Factors 2A and 2C Induce Dilated Cardiomyopathy in Transgenic Mice
  The Journal of Biological Chemistry. Apr, 2006  |   Pubmed ID: 16469744
• The DnaJ-related Factor Mrj Interacts with Nuclear Factor of Activated T Cells C3 and Mediates Transcriptional Repression Through Class II Histone Deacetylase Recruitment
  Molecular and Cellular Biology. Nov, 2005  |   Pubmed ID: 16260608
• Inhibition of P38 Reduces Myocardial Infarction Injury in the Mouse but Not Pig After Ischemia-reperfusion
  American Journal of Physiology. Heart and Circulatory Physiology. Dec, 2005  |   Pubmed ID: 16143643
• Regulation of Calcineurin Through Transcriptional Induction of the Calcineurin A Beta Promoter in Vitro and in Vivo
  Molecular and Cellular Biology. Aug, 2005  |   Pubmed ID: 16024800
• Direct and Indirect Interactions Between Calcineurin-NFAT and MEK1-extracellular Signal-regulated Kinase 1/2 Signaling Pathways Regulate Cardiac Gene Expression and Cellular Growth
  Molecular and Cellular Biology. Feb, 2005  |   Pubmed ID: 15657416
• Identification of a Cooperative Mechanism Involving Interleukin-13 and Eotaxin-2 in Experimental Allergic Lung Inflammation
  The Journal of Biological Chemistry. Apr, 2005  |   Pubmed ID: 15647285
• STRESS Signaling Pathways That Modulate Cardiac Myocyte Apoptosis
  Journal of Molecular and Cellular Cardiology. Jan, 2005  |   Pubmed ID: 15623421
• Cardiomyocytes Fuse with Surrounding Noncardiomyocytes and Reenter the Cell Cycle
  The Journal of Cell Biology. Oct, 2004  |   Pubmed ID: 15492039
• Calcium-calcineurin Signaling in the Regulation of Cardiac Hypertrophy
  Biochemical and Biophysical Research Communications. Oct, 2004  |   Pubmed ID: 15336966
• Calcineurin-NFAT Signaling Regulates the Cardiac Hypertrophic Response in Coordination with the MAPKs
  Cardiovascular Research. Aug, 2004  |   Pubmed ID: 15276472
• Genetic Loss of Calcineurin Blocks Mechanical Overload-induced Skeletal Muscle Fiber Type Switching but Not Hypertrophy
  The Journal of Biological Chemistry. Jun, 2004  |   Pubmed ID: 15082723
• Redefining the Roles of P38 and JNK Signaling in Cardiac Hypertrophy: Dichotomy Between Cultured Myocytes and Animal Models
  Journal of Molecular and Cellular Cardiology. Dec, 2003  |   Pubmed ID: 14654364