Jeffrey A. Bluestone

Diabetes Center

University of California, San Francisco - UCSF

Biography
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Publications

CD4+Foxp3+ Regulatory T Cell Therapy in Transplantation
Journal of Molecular Cell Biology. Feb, 2012 | Pubmed ID: 22170955
The Yin and Yang of Interleukin-2-mediated Immunotherapy
The New England Journal of Medicine. Dec, 2011 | Pubmed ID: 22129258
A Mimic of Viral Double-stranded RNA Triggers Fulminant Type 1 Diabetes-like Syndrome in Regulatory T Cell-deficient Autoimmune Diabetic Mouse
Journal of Immunology (Baltimore, Md. : 1950). Nov, 2011 | Pubmed ID: 21967896
Pillars Article: CTLA-4 Can Function As a Negative Regulator of T Cell Activation. Immunity. 1994. 1: 405-413
Journal of Immunology (Baltimore, Md. : 1950). Oct, 2011 | Pubmed ID: 21934098
Repression of the Genome Organizer SATB1 in Regulatory T Cells is Required for Suppressive Function and Inhibition of Effector Differentiation
Nature Immunology. Sep, 2011 | Pubmed ID: 21841785
Type 1 Diabetes Immunotherapy: is the Glass Half Empty or Half Full?
Science Translational Medicine. Aug, 2011 | Pubmed ID: 21832236
Control of TH17 Cells Occurs in the Small Intestine
Nature. Jul, 2011 | Pubmed ID: 21765430
Anti-CD3 Therapy Promotes Tolerance by Selectively Depleting Pathogenic Cells While Preserving Regulatory T Cells
Journal of Immunology (Baltimore, Md. : 1950). Aug, 2011 | Pubmed ID: 21742976
Regulatory T Cells: Stability Revisited
Trends in Immunology. Jul, 2011 | Pubmed ID: 21620768
Evidence That Cd101 is an Autoimmune Diabetes Gene in Nonobese Diabetic Mice
Journal of Immunology (Baltimore, Md. : 1950). Jul, 2011 | Pubmed ID: 21613616
Requirements for Prolongation of Allograft Survival with Regulatory T Cell Infusion in Lymphosufficient Hosts
The Journal of Surgical Research. Jul, 2011 | Pubmed ID: 21571317
How Does Type 1 Diabetes Develop?: the Notion of Homicide or Î²-cell Suicide Revisited
Diabetes. May, 2011 | Pubmed ID: 21525508
Intrinsic and Extrinsic Control of Peripheral T-cell Tolerance by Costimulatory Molecules of the CD28/â€ŠB7 Family
Immunological Reviews. May, 2011 | Pubmed ID: 21488898
Mechanisms of Tolerance
Immunological Reviews. May, 2011 | Pubmed ID: 21488886
Plasticity of Human Regulatory T Cells in Healthy Subjects and Patients with Type 1 Diabetes
Journal of Immunology (Baltimore, Md. : 1950). Apr, 2011 | Pubmed ID: 21368230
Cutting Edge: Vasostatin-1-derived Peptide ChgA29-42 is an Antigenic Epitope of Diabetogenic BDC2.5 T Cells in Nonobese Diabetic Mice
Journal of Immunology (Baltimore, Md. : 1950). Apr, 2011 | Pubmed ID: 21357258
Retinoic Acid and Rapamycin Differentially Affect and Synergistically Promote the Ex Vivo Expansion of Natural Human T Regulatory Cells
PloS One. 2011 | Pubmed ID: 21253593
Expression of Î±vÎ²8 Integrin on Dendritic Cells Regulates Th17 Cell Development and Experimental Autoimmune Encephalomyelitis in Mice
The Journal of Clinical Investigation. Dec, 2010 | Pubmed ID: 21099117
Islet Transplantation in Type 1 Diabetic Patients Using Calcineurin Inhibitor-free Immunosuppressive Protocols Based on T-cell Adhesion or Costimulation Blockade
Transplantation. Dec, 2010 | Pubmed ID: 20978464
The Immune Tolerance Network at 10 Years: Tolerance Research at the Bedside
Nature Reviews. Immunology. Nov, 2010 | Pubmed ID: 20972473
Clusterin Synergizes with IL-2 for the Expansion and IFN-Î³ Production of Natural Killer Cells
Journal of Leukocyte Biology. Nov, 2010 | Pubmed ID: 20729304
FK506 Causes Cellular and Functional Defects in Human Natural Killer Cells
Journal of Leukocyte Biology. Dec, 2010 | Pubmed ID: 20671192
Human Antigen-specific Regulatory T Cells Generated by T Cell Receptor Gene Transfer
PloS One. 2010 | Pubmed ID: 20668510
Bringing Transplantation Tolerance into the Clinic: Lessons from the ITN and RISET for the Establishment of Tolerance Consortia
Current Opinion in Organ Transplantation. Aug, 2010 | Pubmed ID: 20631613
Genetics, Pathogenesis and Clinical Interventions in Type 1 Diabetes
Nature. Apr, 2010 | Pubmed ID: 20432533
Suppression of Human Anti-porcine Natural Killer Cell Xenogeneic Responses by Combinations of Monoclonal Antibodies Specific to CD2 and NKG2D and Extracellular Signal-regulated Kinase Kinase Inhibitor
Immunology. Aug, 2010 | Pubmed ID: 20406306
Small RNA Regulators of T Cell-mediated Autoimmunity
Journal of Clinical Immunology. May, 2010 | Pubmed ID: 20393792
Ten Years of the Immune Tolerance Network: an Integrated Clinical Research Organization
Science Translational Medicine. Feb, 2010 | Pubmed ID: 20371484
Prevention of Diabetes by FTY720-mediated Stabilization of Peri-islet Tertiary Lymphoid Organs
Diabetes. Jun, 2010 | Pubmed ID: 20299465
Regulatory T Cells Directed to the Site of the Action
Proceedings of the National Academy of Sciences of the United States of America. Dec, 2009 | Pubmed ID: 19955436
Autoimmunity
Current Opinion in Immunology. Dec, 2009 | Pubmed ID: 19879742
Is Antigen Specificity of Autoreactive T Cells the Key to Islet Entry?
Immunity. Oct, 2009 | Pubmed ID: 19833083
The Functional Plasticity of T Cell Subsets
Nature Reviews. Immunology. Nov, 2009 | Pubmed ID: 19809471
Regulatory T Cells As Therapeutic Targets in Rheumatoid Arthritis
Nature Reviews. Rheumatology. Oct, 2009 | Pubmed ID: 19798031
Interactions Between PD-1 and PD-L1 Promote Tolerance by Blocking the TCR-induced Stop Signal
Nature Immunology. Nov, 2009 | Pubmed ID: 19783989
Instability of the Transcription Factor Foxp3 Leads to the Generation of Pathogenic Memory T Cells in Vivo
Nature Immunology. Sep, 2009 | Pubmed ID: 19633673
Insulin Receptor Substrate-2 in Beta-cells Decreases Diabetes in Nonobese Diabetic Mice
Endocrinology. Oct, 2009 | Pubmed ID: 19574401
Lethal Effect of CD3-specific Antibody in Mice Deficient in TGF-beta1 by Uncontrolled Flu-like Syndrome
Journal of Immunology (Baltimore, Md. : 1950). Jul, 2009 | Pubmed ID: 19561097
T-bet-deficient NOD Mice Are Protected from Diabetes Due to Defects in Both T Cell and Innate Immune System Function
Journal of Immunology (Baltimore, Md. : 1950). Jul, 2009 | Pubmed ID: 19535634
Plasticity of CD4(+) FoxP3(+) T Cells
Current Opinion in Immunology. Jun, 2009 | Pubmed ID: 19500966
Treatment of Patients with New Onset Type 1 Diabetes with a Single Course of Anti-CD3 MAb Teplizumab Preserves Insulin Production for Up to 5 Years
Clinical Immunology (Orlando, Fla.). Aug, 2009 | Pubmed ID: 19443276
Regulating the Regulators: Costimulatory Signals Control the Homeostasis and Function of Regulatory T Cells
Immunological Reviews. May, 2009 | Pubmed ID: 19426214
A Novel Myelin P0-specific T Cell Receptor Transgenic Mouse Develops a Fulminant Autoimmune Peripheral Neuropathy
The Journal of Experimental Medicine. Mar, 2009 | Pubmed ID: 19221395
The Role of X-linked FOXP3 in the Autoimmune Susceptibility of Turner Syndrome Patients
Clinical Immunology (Orlando, Fla.). Apr, 2009 | Pubmed ID: 19150256
Expansion of Human Regulatory T-cells from Patients with Type 1 Diabetes
Diabetes. Mar, 2009 | Pubmed ID: 19074986
Tyrosine Kinase Inhibitors Reverse Type 1 Diabetes in Nonobese Diabetic Mice
Proceedings of the National Academy of Sciences of the United States of America. Dec, 2008 | Pubmed ID: 19015530
Innate Immunity and Intestinal Microbiota in the Development of Type 1 Diabetes
Nature. Oct, 2008 | Pubmed ID: 18806780
Control of Peripheral T-cell Tolerance and Autoimmunity Via the CTLA-4 and PD-1 Pathways
Immunological Reviews. Aug, 2008 | Pubmed ID: 18759926
Selective MiRNA Disruption in T Reg Cells Leads to Uncontrolled Autoimmunity
The Journal of Experimental Medicine. Sep, 2008 | Pubmed ID: 18725525
T Regulatory Cells in Autoimmune Diabetes: Past Challenges, Future Prospects
Journal of Clinical Immunology. Nov, 2008 | Pubmed ID: 18716861
Human Regulatory T Cells: Role in Autoimmune Disease and Therapeutic Opportunities
Immunological Reviews. Jun, 2008 | Pubmed ID: 18613848
Spontaneous Development of a Pancreatic Exocrine Disease in CD28-deficient NOD Mice
Journal of Immunology (Baltimore, Md. : 1950). Jun, 2008 | Pubmed ID: 18523243
Central Role of Defective Interleukin-2 Production in the Triggering of Islet Autoimmune Destruction
Immunity. May, 2008 | Pubmed ID: 18468463
CD3-specific Antibody-induced Immune Tolerance Involves Transforming Growth Factor-beta from Phagocytes Digesting Apoptotic T Cells
Nature Medicine. May, 2008 | Pubmed ID: 18438416
The Foxp3+ Regulatory T Cell: a Jack of All Trades, Master of Regulation
Nature Immunology. Mar, 2008 | Pubmed ID: 18285775
Safer, Longer-lasting Regulatory T Cells with Beta-catenin
Nature Medicine. Feb, 2008 | Pubmed ID: 18256611
Regulated Beta-cell Regeneration in the Adult Mouse Pancreas
Diabetes. Apr, 2008 | Pubmed ID: 18083786
B Cell Depletion: a Novel Therapy for Autoimmune Diabetes?
The Journal of Clinical Investigation. Dec, 2007 | Pubmed ID: 18060022
Nature. Sep, 2007 | Pubmed ID: 17694047
Exendin-4 Improves Reversal of Diabetes in NOD Mice Treated with Anti-CD3 Monoclonal Antibody by Enhancing Recovery of Beta-cells
Endocrinology. Nov, 2007 | Pubmed ID: 17673522
What Does the Future Hold for Cell-based Tolerogenic Therapy?
Nature Reviews. Immunology. Aug, 2007 | Pubmed ID: 17653127
CD3-specific Antibodies: a Portal to the Treatment of Autoimmunity
Nature Reviews. Immunology. Aug, 2007 | Pubmed ID: 17641665
Mechanisms of PDL1-mediated Regulation of Autoimmune Diabetes
Clinical Immunology (Orlando, Fla.). Oct, 2007 | Pubmed ID: 17627890
Constitutive Expression of B7-1 on B Cells Uncovers Autoimmunity Toward the B Cell Compartment in the Nonobese Diabetic Mouse
Journal of Immunology (Baltimore, Md. : 1950). Jul, 2007 | Pubmed ID: 17617592
Expression of CTLA-4 and FOXP3 in Cis Protects from Lethal Lymphoproliferative Disease
European Journal of Immunology. May, 2007 | Pubmed ID: 17429849
Adaptive TGF-beta-dependent Regulatory T Cells Control Autoimmune Diabetes and Are a Privileged Target of Anti-CD3 Antibody Treatment
Proceedings of the National Academy of Sciences of the United States of America. Apr, 2007 | Pubmed ID: 17389382
Sensory Neurons Link the Nervous System and Autoimmune Diabetes
Cell. Dec, 2006 | Pubmed ID: 17174888
Insulin-induced Remission in New-onset NOD Mice is Maintained by the PD-1-PD-L1 Pathway
The Journal of Experimental Medicine. Nov, 2006 | Pubmed ID: 17116737
Analysis of T-cell Assays to Measure Autoimmune Responses in Subjects with Type 1 Diabetes: Results of a Blinded Controlled Study
Diabetes. Sep, 2006 | Pubmed ID: 16936208
Regulatory T-cell Physiology and Application to Treat Autoimmunity
Immunological Reviews. Aug, 2006 | Pubmed ID: 16903917
Inhibition of T Cell Activation and Autoimmune Diabetes Using a B Cell Surface-linked CTLA-4 Agonist
The Journal of Clinical Investigation. Aug, 2006 | Pubmed ID: 16886063
Suppression of Disease in New Zealand Black/New Zealand White Lupus-prone Mice by Adoptive Transfer of Ex Vivo Expanded Regulatory T Cells
Journal of Immunology (Baltimore, Md. : 1950). Aug, 2006 | Pubmed ID: 16849451
CD127 Expression Inversely Correlates with FoxP3 and Suppressive Function of Human CD4+ T Reg Cells
The Journal of Experimental Medicine. Jul, 2006 | Pubmed ID: 16818678
Plasmacytoid DCs and T(reg) Cells: Casual Acquaintance or Monogamous Relationship?
Nature Immunology. Jun, 2006 | Pubmed ID: 16715063
Anti-CD3 and Nasal Proinsulin Combination Therapy Enhances Remission from Recent-onset Autoimmune Diabetes by Inducing Tregs
The Journal of Clinical Investigation. May, 2006 | Pubmed ID: 16628253
CTLA4Ig: Bridging the Basic Immunology with Clinical Application
Immunity. Mar, 2006 | Pubmed ID: 16546089
Antigen-specific Regulatory T Cells--ex Vivo Expansion and Therapeutic Potential
Seminars in Immunology. Apr, 2006 | Pubmed ID: 16458533
Visualizing Regulatory T Cell Control of Autoimmune Responses in Nonobese Diabetic Mice
Nature Immunology. Jan, 2006 | Pubmed ID: 16311599
Achieving Antigen-specific Tolerance in Diabetes: Regulating Specifically
International Reviews of Immunology. Sep-Dec, 2005 | Pubmed ID: 16318983
Sequential Development of Interleukin 2-dependent Effector and Regulatory T Cells in Response to Endogenous Systemic Antigen
The Journal of Experimental Medicine. Nov, 2005 | Pubmed ID: 16287710
Distinct Effector Mechanisms in the Development of Autoimmune Neuropathy Versus Diabetes in Nonobese Diabetic Mice
Journal of Immunology (Baltimore, Md. : 1950). Nov, 2005 | Pubmed ID: 16237054
How Do CD4+CD25+ Regulatory T Cells Control Autoimmunity?
Current Opinion in Immunology. Dec, 2005 | Pubmed ID: 16209918
TCR Stimulation with Modified Anti-CD3 MAb Expands CD8+ T Cell Population and Induces CD8+CD25+ Tregs
The Journal of Clinical Investigation. Oct, 2005 | Pubmed ID: 16167085
A Peptide of Glutamic Acid Decarboxylase 65 Can Recruit and Expand a Diabetogenic T Cell Clone, BDC2.5, in the Pancreas
Journal of Immunology (Baltimore, Md. : 1950). Sep, 2005 | Pubmed ID: 16148106
Expansion of Functional Endogenous Antigen-specific CD4+CD25+ Regulatory T Cells from Nonobese Diabetic Mice
Journal of Immunology (Baltimore, Md. : 1950). Sep, 2005 | Pubmed ID: 16116193
A Comprehensive Review of Interventions in the NOD Mouse and Implications for Translation
Immunity. Aug, 2005 | Pubmed ID: 16111631
B7-independent Inhibition of T Cells by CTLA-4
Journal of Immunology (Baltimore, Md. : 1950). Jul, 2005 | Pubmed ID: 15972645
A Single Course of Anti-CD3 Monoclonal Antibody HOKT3gamma1(Ala-Ala) Results in Improvement in C-peptide Responses and Clinical Parameters for at Least 2 Years After Onset of Type 1 Diabetes
Diabetes. Jun, 2005 | Pubmed ID: 15919798
An Important Role of CD80/CD86-CTLA-4 Signaling During Photocarcinogenesis in Mice
Journal of Immunology (Baltimore, Md. : 1950). May, 2005 | Pubmed ID: 15843526
Distinct Roles of Dendritic Cells and B Cells in Va14Ja18 Natural T Cell Activation in Vivo
Journal of Immunology (Baltimore, Md. : 1950). Apr, 2005 | Pubmed ID: 15814694
Treatment with Nonmitogenic Anti-CD3 Monoclonal Antibody Induces CD4+ T Cell Unresponsiveness and Functional Reversal of Established Experimental Autoimmune Encephalomyelitis
Journal of Immunology (Baltimore, Md. : 1950). Apr, 2005 | Pubmed ID: 15814673
Regulatory T-cell Therapy: is It Ready for the Clinic?
Nature Reviews. Immunology. Apr, 2005 | Pubmed ID: 15775994
The NOD Mouse: a Model of Immune Dysregulation
Annual Review of Immunology. 2005 | Pubmed ID: 15771578
CTLA-4Ig is Finally Making It: a Personal Perspective
American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons. Mar, 2005 | Pubmed ID: 15707394
Differential Roles of Costimulatory Signaling Pathways in Type 1 Diabetes Mellitus
The Review of Diabetic Studies : RDS. 2004 | Pubmed ID: 17491700
Distinct Roles of CTLA-4 and TGF-beta in CD4+CD25+ Regulatory T Cell Function
European Journal of Immunology. Nov, 2004 | Pubmed ID: 15468055
Costimulation Controls Diabetes by Altering the Balance of Pathogenic and Regulatory T Cells
The Journal of Clinical Investigation. Oct, 2004 | Pubmed ID: 15467837
Peptide Specific Amelioration of T Cell Mediated Pathogenesis in Murine Type 1 Diabetes
Clinical Immunology (Orlando, Fla.). Oct, 2004 | Pubmed ID: 15380527
Therapeutic Vaccination Using CD4+CD25+ Antigen-specific Regulatory T Cells
Proceedings of the National Academy of Sciences of the United States of America. Oct, 2004 | Pubmed ID: 15322272
NKG2D Blockade Prevents Autoimmune Diabetes in NOD Mice
Immunity. Jun, 2004 | Pubmed ID: 15189740
CTLA-4 Regulates Expansion and Differentiation of Th1 Cells Following Induction of Peripheral T Cell Tolerance
Journal of Immunology (Baltimore, Md. : 1950). Jun, 2004 | Pubmed ID: 15187122
In Vitro-expanded Antigen-specific Regulatory T Cells Suppress Autoimmune Diabetes
The Journal of Experimental Medicine. Jun, 2004 | Pubmed ID: 15184499
Notch 1 Signaling Regulates Peripheral T Cell Activation
Immunity. Apr, 2004 | Pubmed ID: 15084270
Transplantation of Cultured Islets from Two-layer Preserved Pancreases in Type 1 Diabetes with Anti-CD3 Antibody
American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons. Mar, 2004 | Pubmed ID: 14961992
Beta-cell Replacement for Type I Diabetes
Annual Review of Medicine. 2004 | Pubmed ID: 14746513
Importance of IL-10 for CTLA-4-mediated Inhibition of Tumor-eradicating Immunity
Journal of Immunology (Baltimore, Md. : 1950). Feb, 2004 | Pubmed ID: 14734721
CTLA-4 and Tolerance: the Biochemical Point of View
Immunologic Research. 2003 | Pubmed ID: 14713717
The Role of CD28 and CTLA4 in the Function and Homeostasis of CD4+CD25+ Regulatory T Cells
Novartis Foundation Symposium. 2003 | Pubmed ID: 14609212
Peptide-MHC Class II Dimers As Therapeutics to Modulate Antigen-specific T Cell Responses in Autoimmune Diabetes
Journal of Immunology (Baltimore, Md. : 1950). Nov, 2003 | Pubmed ID: 14607967
Cutting Edge: CD28 Controls Peripheral Homeostasis of CD4+CD25+ Regulatory T Cells
Journal of Immunology (Baltimore, Md. : 1950). Oct, 2003 | Pubmed ID: 14500627
TGF-beta-dependent Mechanisms Mediate Restoration of Self-tolerance Induced by Antibodies to CD3 in Overt Autoimmune Diabetes
Nature Medicine. Sep, 2003 | Pubmed ID: 12937416
Clinical Trials of Transplant Tolerance: Slow but Steady Progress
American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons. Jul, 2003 | Pubmed ID: 12814471
Altered Cutaneous Immune Parameters in Transgenic Mice Overexpressing Viral IL-10 in the Epidermis
The Journal of Clinical Investigation. Jun, 2003 | Pubmed ID: 12813028
Directed Evolution of a Single-chain Class II MHC Product by Yeast Display
Protein Engineering. Feb, 2003 | Pubmed ID: 12676983
Natural Versus Adaptive Regulatory T Cells
Nature Reviews. Immunology. Mar, 2003 | Pubmed ID: 12658273
Activation of Human T Cells by FcR Nonbinding Anti-CD3 MAb, HOKT3gamma1(Ala-Ala)
The Journal of Clinical Investigation. Feb, 2003 | Pubmed ID: 12569167
CD28/B7 Regulation of Anti-CD3-mediated Immunosuppression in Vivo
Journal of Immunology (Baltimore, Md. : 1950). Feb, 2003 | Pubmed ID: 12538715
Impairment of NK Cell Function by NKG2D Modulation in NOD Mice
Immunity. Jan, 2003 | Pubmed ID: 12530974
CTLA-4 Regulates the Requirement for Cytokine-induced Signals in T(H)2 Lineage Commitment
Nature Immunology. Feb, 2003 | Pubmed ID: 12524538
Negative Regulation of T Cell Receptor-lipid Raft Interaction by Cytotoxic T Lymphocyte-associated Antigen 4
The Journal of Experimental Medicine. Jan, 2003 | Pubmed ID: 12515820
CTLA-4: Acting at the Synapse
Molecular Interventions. Jul, 2002 | Pubmed ID: 14993389
When Ligand Becomes Receptor--tolerance Via B7 Signaling on DCs
Nature Immunology. Nov, 2002 | Pubmed ID: 12407416
Modified Anti-CD3 Therapy in Psoriatic Arthritis: a Phase I/II Clinical Trial
The Journal of Rheumatology. Sep, 2002 | Pubmed ID: 12233885
Immunotherapy of Insulin-dependent Diabetes Mellitus
Current Opinion in Immunology. Oct, 2002 | Pubmed ID: 12183168
Inability to Induce Tolerance Through Direct Antigen Presentation
American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons. Jul, 2002 | Pubmed ID: 12118894
The Immune Tolerance Network: a New Paradigm for Developing Tolerance-inducing Therapies
The Journal of Allergy and Clinical Immunology. Jul, 2002 | Pubmed ID: 12110811
Cutting Edge: Targeted Ligation of CTLA-4 in Vivo by Membrane-bound Anti-CTLA-4 Antibody Prevents Rejection of Allogeneic Cells
Journal of Immunology (Baltimore, Md. : 1950). Jul, 2002 | Pubmed ID: 12097362
Anti-CD3 Monoclonal Antibody in New-onset Type 1 Diabetes Mellitus
The New England Journal of Medicine. May, 2002 | Pubmed ID: 12037148
The Src Family Kinase Fyn Mediates Signals Induced by TCR Antagonists
Journal of Immunology (Baltimore, Md. : 1950). May, 2002 | Pubmed ID: 11970992
The Role of CTLA-4 in Induction and Maintenance of Peripheral T Cell Tolerance
European Journal of Immunology. Apr, 2002 | Pubmed ID: 11920563

Dr. Jeffrey A. Bluestone has not added a biography.

Publications

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