Jens Lykkesfeldt Department of Veterinary Disease Biology, Faculty of Health and Medical Sciences University of Copenhagen Biography Publications Institution JoVE Articles Jens Lykkesfeldt has not added a biography. If you are Jens Lykkesfeldt and would like to personalize this page please email our Author Liaison for assistance. Publications Positive Charge, Negative Effect: the Impact of Cationic Nanoparticles in the Brain Nanomedicine (London, England). Jul, 2014 | Pubmed ID: 25253492 Does Vitamin C Deficiency Affect Cognitive Development and Function? Nutrients. 2014 | Pubmed ID: 25244370 Elimination of Ascorbic Acid After High-Dose Infusion in Prostate Cancer Patients: A Pharmacokinetic Evaluation Basic & Clinical Pharmacology & Toxicology. Sep, 2014 | Pubmed ID: 25220574 In Vivo Toxicity of Cationic Micelles and Liposomes Nanomedicine : Nanotechnology, Biology, and Medicine. Aug, 2014 | Pubmed ID: 25168934 In Vivo Vitamin C Deficiency in Guinea Pigs Increases Ascorbate Transporters in Liver but Not Kidney and Brain Nutrition Research (New York, N.Y.). Jul, 2014 | Pubmed ID: 25150123 Antioxidant Supplementation for Lung Disease in Cystic Fibrosis The Cochrane Database of Systematic Reviews. 2014 | Pubmed ID: 25102015 Melatonin Does Not Affect Oxidative/inflammatory Biomarkers in a Closed-chest Porcine Model of Acute Myocardial Infarction In Vivo (Athens, Greece). Jul-Aug, 2014 | Pubmed ID: 24982213 Chronic Vitamin C Deficiency Promotes Redox Imbalance in the Brain but Does Not Alter Sodium-dependent Vitamin C Transporter 2 Expression Nutrients. May, 2014 | Pubmed ID: 24787032 The Kidneys Play an Important Role in the Clearance of RFVIIa in Rats Thrombosis Research. Jun, 2014 | Pubmed ID: 24731563 High-fat Feeding Increases Hepatic Vitamin C Synthesis and Its Circulatory Mobilization in Mice European Journal of Nutrition. Sep, 2014 | Pubmed ID: 24700376 Functional Network Analysis of Obese and Lean Göttingen Minipigs Elucidates Changes in Oxidative and Inflammatory Networks in Obese Pigs Pflugers Archiv : European Journal of Physiology. Mar, 2014 | Pubmed ID: 24590510 Prenatal Vitamin C Deficiency Results in Differential Levels of Oxidative Stress During Late Gestation in Foetal Guinea Pig Brains Redox Biology. 2014 | Pubmed ID: 24563854 Pronounced Inflammatory Response to Endotoxaemia During Nighttime: a Randomised Cross-over Trial PloS One. 2014 | Pubmed ID: 24475284 Vitamin C Advances in Nutrition (Bethesda, Md.). Jan, 2014 | Pubmed ID: 24425716 Does Vitamin C Enhance Nitric Oxide Bioavailability in a Tetrahydrobiopterin-dependent Manner? In Vitro, in Vivo and Clinical Studies Nitric Oxide : Biology and Chemistry / Official Journal of the Nitric Oxide Society. Jan, 2014 | Pubmed ID: 24333161 Melatonin Suppresses Markers of Inflammation and Oxidative Damage in a Human Daytime Endotoxemia Model Journal of Critical Care. Feb, 2014 | Pubmed ID: 24140166 Differential Toxicological Response to Positively and Negatively Charged Nanoparticles in the Rat Brain Nanotoxicology. Nov, 2014 | Pubmed ID: 23889261 Guinea Pig Ascorbate Status Predicts Tetrahydrobiopterin Plasma Concentration and Oxidation Ratio in Vivo Nutrition Research (New York, N.Y.). Oct, 2013 | Pubmed ID: 24074744 Circadian Variation in the Response to Experimental Endotoxemia and Modulatory Effects of Exogenous Melatonin Chronobiology International. Nov, 2013 | Pubmed ID: 23998285 Whey Protein Reduces Early Life Weight Gain in Mice Fed a High-fat Diet PloS One. 2013 | Pubmed ID: 23940754 Regulation of Vitamin C Homeostasis During Deficiency Nutrients. Aug, 2013 | Pubmed ID: 23892714 Translational Aspects of Rectal Evoked Potentials: a Comparative Study in Rats and Humans American Journal of Physiology. Gastrointestinal and Liver Physiology. Jul, 2013 | Pubmed ID: 23703652 Does Vitamin C Deficiency Increase Lifestyle-associated Vascular Disease Progression? Evidence Based on Experimental and Clinical Studies Antioxidants & Redox Signaling. Dec, 2013 | Pubmed ID: 23642093 Prolonged Maternal Vitamin C Deficiency Overrides Preferential Fetal Ascorbate Transport but Does Not Influence Perinatal Survival in Guinea Pigs The British Journal of Nutrition. Nov, 2013 | Pubmed ID: 23591139 Nephrectomized and Hepatectomized Animal Models As Tools in Preclinical Pharmacokinetics Basic & Clinical Pharmacology & Toxicology. Aug, 2013 | Pubmed ID: 23586405 Increased Systemic Oxidatively Generated DNA and RNA Damage in Schizophrenia Psychiatry Research. Oct, 2013 | Pubmed ID: 23465294 Kinetics of Acid-induced Degradation of Tetra- and Dihydrobiopterin in Relation to Their Relevance As Biomarkers of Endothelial Function Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals. Feb, 2013 | Pubmed ID: 23066920 Maternal Vitamin C Deficiency During Pregnancy Persistently Impairs Hippocampal Neurogenesis in Offspring of Guinea Pigs PloS One. 2012 | Pubmed ID: 23119033 Ascorbate Status Modulates Reticuloendothelial Iron Stores and Response to Deferasirox Iron Chelation in Ascorbate-deficient Rats Experimental Hematology. Oct, 2012 | Pubmed ID: 22713799 Authors' Perspective: What is the Optimum Intake of Vitamin C in Humans? Critical Reviews in Food Science and Nutrition. 2012 | Pubmed ID: 22698272 Oxidative Stress Response After Laparoscopic Versus Conventional Sigmoid Resection: a Randomized, Double-blind Clinical Trial Surgical Laparoscopy, Endoscopy & Percutaneous Techniques. Jun, 2012 | Pubmed ID: 22678316 Ascorbate and Dehydroascorbic Acid As Biomarkers of Oxidative Stress: Validity of Clinical Data Depends on Vacutainer System Used Nutrition Research (New York, N.Y.). Jan, 2012 | Pubmed ID: 22260866 Chronic Vitamin C Deficiency Does Not Accelerate Oxidative Stress in Ageing Brains of Guinea Pigs Basic & Clinical Pharmacology & Toxicology. Jun, 2012 | Pubmed ID: 22212866 Role of Vitamin C and E Supplementation on IL-6 in Response to Training Journal of Applied Physiology (Bethesda, Md. : 1985). Mar, 2012 | Pubmed ID: 22207723 Poor Antioxidant Status Exacerbates Oxidative Stress and Inflammatory Response to Pseudomonas Aeruginosa Lung Infection in Guinea Pigs Basic & Clinical Pharmacology & Toxicology. Apr, 2012 | Pubmed ID: 22008605 Fluctuating Hyperglycaemia Increases Oxidative Stress Response in Lean Rats Compared to Sustained Hyperglycaemia Despite Lower Glycaemic Exposure Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease. Oct, 2011 | Pubmed ID: 21933843 Effect of Vitamin C and Iron Chelation on Diesel Exhaust Particle and Carbon Black Induced Oxidative Damage and Cell Adhesion Molecule Expression in Human Endothelial Cells Toxicology Letters. Jun, 2011 | Pubmed ID: 21421028 Storage-induced Increase in Biomarkers of Oxidative Stress and Inflammation in Red Blood Cell Components Scandinavian Journal of Clinical and Laboratory Investigation. Jul, 2011 | Pubmed ID: 21385017 Effect of Antioxidant Supplementation on Insulin Sensitivity in Response to Endurance Exercise Training American Journal of Physiology. Endocrinology and Metabolism. May, 2011 | Pubmed ID: 21325105 High Dietary Fat and Cholesterol Exacerbates Chronic Vitamin C Deficiency in Guinea Pigs The British Journal of Nutrition. Jan, 2011 | Pubmed ID: 20875184 Antioxidant Supplementation Does Not Alter Endurance Training Adaptation Medicine and Science in Sports and Exercise. Jul, 2010 | Pubmed ID: 20019626 Is Vitamin C Supplementation Beneficial? Lessons Learned from Randomised Controlled Trials The British Journal of Nutrition. May, 2010 | Pubmed ID: 20003627 Keeping the Intracellular Vitamin C at a Physiologically Relevant Level in Endothelial Cell Culture Analytical Biochemistry. Feb, 2010 | Pubmed ID: 19782654 Vitamin C Deficiency in Early Postnatal Life Impairs Spatial Memory and Reduces the Number of Hippocampal Neurons in Guinea Pigs The American Journal of Clinical Nutrition. Sep, 2009 | Pubmed ID: 19640959 Poor Vitamin C Status is Associated with Increased Carotid Intima-media Thickness, Decreased Microvascular Function, and Delayed Myocardial Repolarization in Young Patients with Type 1 Diabetes The American Journal of Clinical Nutrition. Aug, 2009 | Pubmed ID: 19553299 Role of Marginal Vitamin C Deficiency in Atherogenesis: in Vivo Models and Clinical Studies Basic & Clinical Pharmacology & Toxicology. Jun, 2009 | Pubmed ID: 19489786 Does Vitamin C Deficiency Result in Impaired Brain Development in Infants? Redox Report : Communications in Free Radical Research. 2009 | Pubmed ID: 19161672 Utility of Melatonin to Treat Surgical Stress After Major Vascular Surgery--a Safety Study Journal of Pineal Research. May, 2008 | Pubmed ID: 18205732 Vitamin C Deficiency in Weanling Guinea Pigs: Differential Expression of Oxidative Stress and DNA Repair in Liver and Brain The British Journal of Nutrition. Dec, 2007 | Pubmed ID: 18309548 Ascorbate and Dehydroascorbic Acid As Reliable Biomarkers of Oxidative Stress: Analytical Reproducibility and Long-term Stability of Plasma Samples Subjected to Acidic Deproteinization Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology. Nov, 2007 | Pubmed ID: 18006947 Oxidative Stress and Damage in Liver, but Not in Brain, of Fischer 344 Rats Subjected to Dietary Iron Supplementation with Lipid-soluble [(3,5,5-trimethylhexanoyl)ferrocene] Journal of Biochemical and Molecular Toxicology. 2007 | Pubmed ID: 17623885 Antioxidant Supplementation Enhances the Exercise-induced Increase in Mitochondrial Uncoupling Protein 3 and Endothelial Nitric Oxide Synthase MRNA Content in Human Skeletal Muscle Free Radical Biology & Medicine. Aug, 2007 | Pubmed ID: 17602951 Malondialdehyde As Biomarker of Oxidative Damage to Lipids Caused by Smoking Clinica Chimica Acta; International Journal of Clinical Chemistry. May, 2007 | Pubmed ID: 17336279 Oxidants and Antioxidants in Disease: Oxidative Stress in Farm Animals Veterinary Journal (London, England : 1997). May, 2007 | Pubmed ID: 16914330 Pharmacokinetics of Amoxicillin Administered in Drinking Water to Recently Weaned 3- to 4-week-old Pigs with Diarrhea Experimentally Induced by Escherichia Coli O149:F4 American Journal of Veterinary Research. Apr, 2006 | Pubmed ID: 16579758 Electroencephalographic Changes After Pediatric Cardiac Surgery with Cardiopulmonary Bypass: is Slow Wave Activity Unfavorable? Pediatric Research. Oct, 2005 | Pubmed ID: 16189208 Age-dependent Change in Vitamin C Status: a Phenomenon of Maturation Rather Than of Ageing Mechanisms of Ageing and Development. Aug, 2005 | Pubmed ID: 15992612 Oxidative Stress Precedes Peak Systemic Inflammatory Response in Pediatric Patients Undergoing Cardiopulmonary Bypass Operation Free Radical Biology & Medicine. May, 2005 | Pubmed ID: 15855050 Effects of Heparin-binding Protein (CAP37/azurocidin) in a Porcine Model of Actinobacillus Pleuropneumoniae-induced Pneumonia Pharmacological Research : the Official Journal of the Italian Pharmacological Society. Jun, 2005 | Pubmed ID: 15829430 Clindamycin is Neuroprotective in Experimental Streptococcus Pneumoniae Meningitis Compared with Ceftriaxone Journal of Neurochemistry. Dec, 2004 | Pubmed ID: 15584921 Vitamin C Pharmacokinetics of Plain and Slow Release Formulations in Smokers Clinical Nutrition (Edinburgh, Scotland). Oct, 2004 | Pubmed ID: 15380894 Plasma Malondialdehyde is Induced by Smoking: a Study with Balanced Antioxidant Profiles The British Journal of Nutrition. Aug, 2004 | Pubmed ID: 15333149 Vitamin C Supplementation Decreases Oxidative DNA Damage in Mononuclear Blood Cells of Smokers European Journal of Nutrition. Oct, 2004 | Pubmed ID: 15309445 Pharmacokinetics of Amoxicillin After Oral Administration in Recently Weaned Piglets with Experimentally Induced Escherichia Coli Subtype O149:F4 Diarrhea American Journal of Veterinary Research. Jul, 2004 | Pubmed ID: 15281660 Long-term High Copper Intake: Effects on Indexes of Copper Status, Antioxidant Status, and Immune Function in Young Men The American Journal of Clinical Nutrition. Jun, 2004 | Pubmed ID: 15159234 Ascorbic Acid Recycling in Human Erythrocytes is Induced by Smoking in Vivo Free Radical Biology & Medicine. Dec, 2003 | Pubmed ID: 14642391 Evaluation of a Single Dose Versus a Divided Dose Regimen of Danofloxacin in Treatment of Actinobacillus Pleuropneumoniae Infection in Pigs Research in Veterinary Science. Jun, 2003 | Pubmed ID: 12726746 Effect of Smoking on Erythorbic Acid Pharmacokinetics The British Journal of Nutrition. May, 2003 | Pubmed ID: 12720586 Measurement of Ascorbic Acid and Dehydroascorbic Acid in Biological Samples Current Protocols in Toxicology / Editorial Board, Mahin D. Maines (editor-in-chief) ... [et Al.]. Aug, 2002 | Pubmed ID: 20954159 Gamma-tocopherol Supplementation Inhibits Protein Nitration and Ascorbate Oxidation in Rats with Inflammation Free Radical Biology & Medicine. Dec, 2002 | Pubmed ID: 12446211 Increased Oxidative Damage in Vitamin C Deficiency is Accompanied by Induction of Ascorbic Acid Recycling Capacity in Young but Not Mature Guinea Pigs Free Radical Research. May, 2002 | Pubmed ID: 12150544 Cerebral Vasculature is the Major Target of Oxidative Protein Alterations in Bacterial Meningitis Journal of Neuropathology and Experimental Neurology. Jul, 2002 | Pubmed ID: 12125739 Feeding Acetyl-L-carnitine and Lipoic Acid to Old Rats Significantly Improves Metabolic Function While Decreasing Oxidative Stress Proceedings of the National Academy of Sciences of the United States of America. Feb, 2002 | Pubmed ID: 11854487 गिनी सूअरों में गैर टर्मिनल रक्त नमूना तकनीक Malene M. Birck1, Pernille Tveden-Nyborg1, Maiken M. Lindblad1, Jens Lykkesfeldt1 1Department of Veterinary Disease Biology, Faculty of Health and Medical Sciences, University of Copenhagen JoVE 51982 Biology
गिनी सूअरों में गैर टर्मिनल रक्त नमूना तकनीक Malene M. Birck1, Pernille Tveden-Nyborg1, Maiken M. Lindblad1, Jens Lykkesfeldt1 1Department of Veterinary Disease Biology, Faculty of Health and Medical Sciences, University of Copenhagen JoVE 51982 Biology