Jeroen Demmers Proteomics Center Erasmus University Medical Center Biography Publications Institution JoVE Articles Jeroen DemmersAssociate Professor Jeroen Demmers is the director of the Erasmus MC Proteomics core facility and an associate professor at the department of Biochemistry. He received an MSc degree in Chemistry with honors from Utrecht University and a PhD from the same institution (Albert Heck and Antoinette Killian labs). As a postdoctoral fellow in the lab of Brain Chait at The Rockefeller University he used proteomics methodology to study protein-DNA interactions in yeast. In 2006 he moved to Erasmus University Medical Center in Rotterdam, where he started his own lab. His research program comprises the development of mass spectrometry based methodologies for qualitative and quantitative proteomics analysis, with a focus on the analysis of post-translational modifications, in particular ubiquitin. In addition, as a core facility head he collaborates with many researchers in the Netherlands and abroad. Lab website: www.proteomicscenter.nl Publications Recovery in the Myogenic Program of Congenital Myotonic Dystrophy Myoblasts After Excision of the Expanded (CTG) Repeat International Journal of Molecular Sciences. Nov, 2019 | Pubmed ID: 31766224 HSF2BP Interacts with a Conserved Domain of BRCA2 and Is Required for Mouse Spermatogenesis Cell Reports. 06, 2019 | Pubmed ID: 31242413 Global Proteome and Ubiquitinome Changes in the Soluble and Insoluble Fractions of Q175 Huntington Mice Brains Molecular & Cellular Proteomics : MCP. 09, 2019 | Pubmed ID: 31138642 Heterogeneous Clinical Phenotypes and Cerebral Malformations Reflected by Rotatin Cellular Dynamics Brain : a Journal of Neurology. 04, 2019 | Pubmed ID: 30879067 FACT Subunit Spt16 Controls UVSSA Recruitment to Lesion-stalled RNA Pol II and Stimulates TC-NER Nucleic Acids Research. 05, 2019 | Pubmed ID: 30715484 On the Mechanism of Hyperthermia-Induced BRCA2 Protein Degradation Cancers. Jan, 2019 | Pubmed ID: 30650591 Human Osteoblast-Derived Extracellular Matrix with High Homology to Bone Proteome Is Osteopromotive Tissue Engineering. Part A. 09, 2018 | Pubmed ID: 29667532 Improvement of Ubiquitylation Site Detection by Orbitrap Mass Spectrometry Journal of Proteomics. 02, 2018 | Pubmed ID: 29122726 Quantitative Proteomics Reveals Extensive Changes in the Ubiquitinome After Perturbation of the Proteasome by Targeted DsRNA-Mediated Subunit Knockdown in Drosophila Journal of Proteome Research. 08, 2017 | Pubmed ID: 28665616 BRCA1185delAG Tumors May Acquire Therapy Resistance Through Expression of RING-less BRCA1 The Journal of Clinical Investigation. 08, 2016 | Pubmed ID: 27454287 Comparative Interactomics Analysis of Different ALS-associated Proteins Identifies Converging Molecular Pathways Acta Neuropathologica. 08, 2016 | Pubmed ID: 27164932 Combgap Contributes to Recruitment of Polycomb Group Proteins in Drosophila Proceedings of the National Academy of Sciences of the United States of America. Apr, 2016 | Pubmed ID: 27001825 The Core Spliceosome As Target and Effector of Non-canonical ATM Signalling Nature. Jul, 2015 | Pubmed ID: 26106861 Global Quantitative Proteomics Reveals Novel Factors in the Ecdysone Signaling Pathway in Drosophila Melanogaster Proteomics. Feb, 2015 | Pubmed ID: 25403936 Proteomic Signatures of Extracellular Vesicles Secreted by Nonmineralizing and Mineralizing Human Osteoblasts and Stimulation of Tumor Cell Growth FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Jan, 2015 | Pubmed ID: 25359493 NLS-tagging: an Alternative Strategy to Tag Nuclear Proteins Nucleic Acids Research. Dec, 2014 | Pubmed ID: 25260593 Identification of Fibrin Clot-bound Plasma Proteins PloS One. 2012 | Pubmed ID: 22870270 Proteomic Analysis of the Microenvironment of Developing Oocytes Proteomics. May, 2012 | Pubmed ID: 22589193 VEGFR2 Translocates to the Nucleus to Regulate Its Own Transcription PloS One. 2011 | Pubmed ID: 21980525 Drosophila Transcription Factor Tramtrack69 Binds MEP1 to Recruit the Chromatin Remodeler NuRD Molecular and Cellular Biology. Nov, 2010 | Pubmed ID: 20733004 Differential Proteomics Based on 18O Labeling to Determine the Cyclin Dependent Kinase 9 Interactome Journal of Proteome Research. Sep, 2010 | Pubmed ID: 20593818 Histone Chaperones ASF1 and NAP1 Differentially Modulate Removal of Active Histone Marks by LID-RPD3 Complexes During NOTCH Silencing Molecular Cell. Sep, 2009 | Pubmed ID: 19782028 DKDM2 Couples Histone H2A Ubiquitylation to Histone H3 Demethylation During Polycomb Group Silencing Genes & Development. Oct, 2008 | Pubmed ID: 18923078 The Transcriptional Coactivator SAYP is a Trithorax Group Signature Subunit of the PBAP Chromatin Remodeling Complex Molecular and Cellular Biology. May, 2008 | Pubmed ID: 18299390 Deubiquitylating Enzyme UBP64 Controls Cell Fate Through Stabilization of the Transcriptional Repressor Tramtrack Molecular and Cellular Biology. Mar, 2008 | Pubmed ID: 18160715 Rilevamento di siti di Ubiquitinazione proteica mediante arricchimento dei peptidi e spettrometria di massa Karel Bezstarosti1, Lennart van der Wal1, Jeroen A. A. Demmers1 1Proteomics Center, Erasmus University Medical Center JoVE 59079 Biochemistry
Rilevamento di siti di Ubiquitinazione proteica mediante arricchimento dei peptidi e spettrometria di massa Karel Bezstarosti1, Lennart van der Wal1, Jeroen A. A. Demmers1 1Proteomics Center, Erasmus University Medical Center JoVE 59079 Biochemistry
