Articles by Jerome V. Karpiak in JoVE
Density Gradient Multilayered Polymerization (DGMP): A Novel Technique for Creating Multi-compartment, Customizable Scaffolds for Tissue Engineering Shivanjali Joshi-Barr1, Jerome V. Karpiak2, Yogesh Ner1, Jessica H. Wen3, Adam J. Engler3, Adah Almutairi1,2 1Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, 2Biomedical Sciences Program, University of California, San Diego, 3Department of Bioengineering, University of California, San Diego Here we describe a unique strategy for creating biocompatible, layered matrices with continuous interfaces between distinct layers for tissue engineering. Such a scaffold could provide an ideal customizable environment to modulate cell behavior by various biological, chemical or mechanical cues
Other articles by Jerome V. Karpiak on PubMed
Density Gradient Multilayer Polymerization for Creating Complex Tissue Advanced Materials (Deerfield Beach, Fla.). Mar, 2012 | Pubmed ID: 22318771 An adaptable density gradient multilayer polymerization (DGMP) method facilitates simple fabrication of complex multicompartment scaffolds with structurally continuous interfaces. Solvent density liquid-liquid phase segregation compartmentalizes varied mechanical and chemical cues independently. Bulk photopolymerization produces stratified three-dimensional and two-dimensional matrices. Cells attach to patterned adhesion peptides on biomimetic 2D substrates.