Jian Ding Department of Cardiology Boston Children's Hospital Biography Publications Institution JoVE Articles Jian Ding has not added a biography. If you are Jian Ding and would like to personalize this page please email our Author Liaison for assistance. Publications SAR Study of 5-alkynyl Substituted Quinazolin-4(3H)-ones As Phosphoinositide 3-kinase Delta (PI3Kδ) Inhibitors European Journal of Medicinal Chemistry. Jan, 2017 | Pubmed ID: 27846451 Magnetic Solid-phase Extraction Based on Graphene Oxide for the Determination of Lignans in Sesame Oil Food Chemistry. Feb, 2017 | Pubmed ID: 27664640 Novel PARP1/2 Inhibitor Mefuparib Hydrochloride Elicits Potent in Vitro and in Vivo Anticancer Activity, Characteristic of High Tissue Distribution Oncotarget. Dec, 2016 | Pubmed ID: 27926532 Relationship Between the Plasma Levels of Neurodegenerative Proteins and Motor Subtypes of Parkinson's Disease Journal of Neural Transmission (Vienna, Austria : 1996). Nov, 2016 | Pubmed ID: 27878377 Poly(ADP-ribose)polymerase (PARP) Inhibition and Anticancer Activity of Simmiparib, a New Inhibitor Undergoing Clinical Trials Cancer Letters. Nov, 2016 | Pubmed ID: 27847302 Identification of Novel CD4+ T Cell Subsets in the Target Tissue of Sjögren's Syndrome and Their Differential Regulation by the Lymphotoxin/LIGHT Signaling Axis Journal of Immunology (Baltimore, Md. : 1950). Nov, 2016 | Pubmed ID: 27815440 Identification of Candidate Genes from the SAD Gene Family in Cotton for Determination of Cottonseed Oil Composition Molecular Genetics and Genomics : MGG. Oct, 2016 | Pubmed ID: 27796643 Feedback Activation of Leukemia Inhibitory Factor Receptor Limits Response to Histone Deacetylase Inhibitors in Breast Cancer Cancer Cell. Sep, 2016 | Pubmed ID: 27622335 Targeting Hsp90 with FS-108 Circumvents Gefitinib Resistance in EGFR Mutant Non-small Cell Lung Cancer Cells Acta Pharmacologica Sinica. Dec, 2016 | Pubmed ID: 27616574 Comprehensive Transcriptome Profiling Reveals Long Noncoding RNA Expression and Alternative Splicing Regulation During Fruit Development and Ripening in Kiwifruit (Actinidia Chinensis) Frontiers in Plant Science. 2016 | Pubmed ID: 27594858 Distribution of Fibroblast Growth Factors and Their Roles in Skin Fibroblast Cell Migration Molecular Medicine Reports. Oct, 2016 | Pubmed ID: 27572477 Antitumor Action of CDK Inhibitor LS-007 As a Single Agent and in Combination with ABT-199 Against Human Acute Leukemia Cells Acta Pharmacologica Sinica. Nov, 2016 | Pubmed ID: 27569395 Construction of Epidermal Growth Factor Receptor Peptide Magnetic Nanovesicles with Lipid Bilayers for Enhanced Capture of Liver Cancer Circulating Tumor Cells Analytical Chemistry. Aug, 2016 | Pubmed ID: 27558867 Human INO80/YY1 Chromatin Remodeling Complex Transcriptionally Regulates the BRCA2- and CDKN1A-interacting Protein (BCCIP) in Cells Protein & Cell. Oct, 2016 | Pubmed ID: 27535137 Reverse Polyaxial Less Invasive Stabilization Systems for Treatment of Femoral Intertrochanteric Fractures of the Distal Femur Archives of Orthopaedic and Trauma Surgery. Nov, 2016 | Pubmed ID: 27511196 HIV Vaccine for Prevention and Cure, A Mission Possible Reviews on Recent Clinical Trials. Jul, 2016 | Pubmed ID: 27480966 Postoperative Growth in Radial Polydactyly: A Clinical Study The Journal of Hand Surgery. Sep, 2016 | Pubmed ID: 27475961 Hydrophilic MoSe2 Nanosheets As Effective Photothermal Therapy Agents and Their Application in Smart Devices ACS Applied Materials & Interfaces. Aug, 2016 | Pubmed ID: 27467718 C-Myc Alteration Determines the Therapeutic Response to FGFR Inhibitors Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Jul, 2016 | Pubmed ID: 27401245 Discovery and Structural Optimization of N5-Substituted 6,7-Dioxo-6,7-dihydropteridines As Potent and Selective Epidermal Growth Factor Receptor (EGFR) Inhibitors Against L858R/T790M Resistance Mutation Journal of Medicinal Chemistry. Aug, 2016 | Pubmed ID: 27396610 Long-term Effect of Heavy-metal Pollution on Diversity of Gastrointestinal Microbial Community of Bufo Raddei Toxicology Letters. Sep, 2016 | Pubmed ID: 27392436 The Effect of Inducible Nitric Oxide Synthase on Multiterritory Perforator Flap Survival in Rats Journal of Reconstructive Microsurgery. Nov, 2016 | Pubmed ID: 27367807 Antibacterial and Solubility Optimization of Thiomuracin A Journal of Medicinal Chemistry. Jul, 2016 | Pubmed ID: 27355833 BAFF Overexpression Increases Lymphocytic Infiltration in Sjögren's Target Tissue, but Only Inefficiently Promotes Ectopic B-cell Differentiation Clinical Immunology (Orlando, Fla.). Aug, 2016 | Pubmed ID: 27352977 Research and Industrialization Progress of Recovering Alumina from Fly Ash: A Concise Review Waste Management (New York, N.Y.). Jun, 2016 | Pubmed ID: 27346594 Recovering Stereo Vision by Squashing Virtual Bugs in a Virtual Reality Environment Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. Jun, 2016 | Pubmed ID: 27269607 Interplay Between Chronic Kidney Disease (CKD) and Upper Tract Urothelial Carcinomas (UUC): Foe or Friend? Oncotarget. May, 2016 | Pubmed ID: 27256983 Alterations of Functional and Structural Connectivity of Freezing of Gait in Parkinson's Disease Journal of Neurology. Aug, 2016 | Pubmed ID: 27230857 Ciliatonoids A and B, Two Limonoids from Toona Ciliata Organic Letters. Jun, 2016 | Pubmed ID: 27228486 Simm530, a Novel and Highly Selective C-Met Inhibitor, Blocks C-Met-stimulated Signaling and Neoplastic Activities Oncotarget. Jun, 2016 | Pubmed ID: 27191264 Trbp Is Required for Differentiation of Myoblasts and Normal Regeneration of Skeletal Muscle PloS One. 2016 | Pubmed ID: 27159388 [Effect of Electroacupuncture Intervention Combined with Gastrodin Administration on Neurological Function, Nogo-A and NgR Expression in the Frontal Lobe Cortex of Focal Cerebral Ischemia Rats] Zhen Ci Yan Jiu = Acupuncture Research. Feb, 2016 | Pubmed ID: 27141624 Discovery of 5-(methylthio)pyrimidine Derivatives As L858R/T790M Mutant Selective Epidermal Growth Factor Receptor (EGFR) Inhibitors Bioorganic & Medicinal Chemistry. Jun, 2016 | Pubmed ID: 27131639 Discovery and Structure Activity Relationship Study of Novel Indazole Amide Inhibitors for Extracellular Signal-regulated Kinase1/2 (ERK1/2) Bioorganic & Medicinal Chemistry Letters. Jun, 2016 | Pubmed ID: 27106711 Mannolides A-C with an Intact Diterpenoid Skeleton Providing Insights on the Biosynthesis of Antitumor Cephalotaxus Troponoids Organic Letters. Apr, 2016 | Pubmed ID: 27042943 Anticancer Drug Combinations, How Far We Can Go Through? Anti-cancer Agents in Medicinal Chemistry. Apr, 2016 | Pubmed ID: 27039923 [Predictive Value of Radiological Parameter for Re-displacement of Conservative Treatment of Distal Radius Fracture] Zhongguo Gu Shang = China Journal of Orthopaedics and Traumatology. Jan, 2016 | Pubmed ID: 27019888 Molybdenum Carbide As an Efficient Catalyst for Low-temperature Hydrogenation of Dimethyl Oxalate Chemical Communications (Cambridge, England). Apr, 2016 | Pubmed ID: 26983560 Binocular Contrast Discrimination Needs Monocular Multiplicative Noise Journal of Vision. 2016 | Pubmed ID: 26982370 Expression and Purification of FGF21 in Pichia Pastoris and Its Effect on Fibroblast-cell Migration Molecular Medicine Reports. Apr, 2016 | Pubmed ID: 26934832 G Protein-coupled Receptor GPR160 is Associated with Apoptosis and Cell Cycle Arrest of Prostate Cancer Cells Oncotarget. Mar, 2016 | Pubmed ID: 26871479 Development of Heat Shock Protein (Hsp90) Inhibitors To Combat Resistance to Tyrosine Kinase Inhibitors Through Hsp90-Kinase Interactions Journal of Medicinal Chemistry. Jun, 2016 | Pubmed ID: 26844689 The Neural Basis of Postural Instability Gait Disorder Subtype of Parkinson's Disease: A PET and FMRI Study CNS Neuroscience & Therapeutics. May, 2016 | Pubmed ID: 26842842 DW10075, a Novel Selective and Small-molecule Inhibitor of VEGFR, Exhibits Antitumor Activities Both in Vitro and in Vivo Acta Pharmacologica Sinica. Mar, 2016 | Pubmed ID: 26806300 Essential Role of Proteasomes in Maintaining Self-renewal in Neural Progenitor Cells Scientific Reports. Jan, 2016 | Pubmed ID: 26804982 Bioactive Isoquinolinequinone Alkaloids from the South China Sea Nudibranch Jorunna Funebris and Its Sponge-prey Xestospongia Sp Future Medicinal Chemistry. Jan, 2016 | Pubmed ID: 26689493 HIV Vaccination, is Breakthrough Underway? Reviews on Recent Clinical Trials. 2016 | Pubmed ID: 26672600 Discovery of 1,3-Diaryl-pyridones As Potent VEGFR-2 Inhibitors: Design, Synthesis, and Biological Evaluation Chemical Biology & Drug Design. May, 2016 | Pubmed ID: 26669707 Regional Homogeneity Alterations Differentiate Between Tremor Dominant and Postural Instability Gait Difficulty Subtypes of Parkinson's Disease Journal of Neural Transmission (Vienna, Austria : 1996). Mar, 2016 | Pubmed ID: 26666253 Unique Dose-dependent Effects of the Human Pregnancy Hormone Estriol on the Ratio of Blood IgM to IgG in Female Mice Molecular Medicine Reports. Jan, 2016 | Pubmed ID: 26531070 Paternal Long-term Exercise Programs Offspring for Low Energy Expenditure and Increased Risk for Obesity in Mice FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Feb, 2016 | Pubmed ID: 26506979 Enhancing Acetone Biosynthesis and Acetone-butanol-ethanol Fermentation Performance by Co-culturing Clostridium Acetobutylicum/Saccharomyces Cerevisiae Integrated with Exogenous Acetate Addition Bioresource Technology. Jan, 2016 | Pubmed ID: 26476171 Plasma Antioxidant Status and Motor Features in De Novo Chinese Parkinson's Disease Patients The International Journal of Neuroscience. 2016 | Pubmed ID: 26010212 Reduced Plasma Taurine Level in Parkinson's Disease: Association with Motor Severity and Levodopa Treatment The International Journal of Neuroscience. 2016 | Pubmed ID: 26004911 [EFFECTIVENESS OF DORSAL PENTAGONAL FLAP FOR RECONSTRUCTION OF THE WEB SPACE IN CONGENITAL TOE SYNDACTYLY] Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi = Zhongguo Xiufu Chongjian Waike Zazhi = Chinese Journal of Reparative and Reconstructive Surgery. Sep, 2015 | Pubmed ID: 26750011 V1 Neurons Respond to Luminance Changes Faster Than Contrast Changes Scientific Reports. Dec, 2015 | Pubmed ID: 26634691 Resveratrol Relieves Gestational Diabetes Mellitus in Mice Through Activating AMPK Reproductive Biology and Endocrinology : RB&E. Nov, 2015 | Pubmed ID: 26542478 (Z)3,4,5,4'-trans-tetramethoxystilbene, a New Analogue of Resveratrol, Inhibits Gefitinb-resistant Non-small Cell Lung Cancer Via Selectively Elevating Intracellular Calcium Level Scientific Reports. Nov, 2015 | Pubmed ID: 26542098 Mystery of Trbp, Tale of a RBP in the MiRNA Pathway Cell Cycle (Georgetown, Tex.). 2015 | Pubmed ID: 26496166 Enhancing Butanol Production Under the Stress Environments of Co-Culturing Clostridium Acetobutylicum/Saccharomyces Cerevisiae Integrated with Exogenous Butyrate Addition PloS One. 2015 | Pubmed ID: 26489085 C-Myc Alterations Confer Therapeutic Response and Acquired Resistance to C-Met Inhibitors in MET-addicted Cancers Cancer Research. Nov, 2015 | Pubmed ID: 26483207 JX06 Selectively Inhibits Pyruvate Dehydrogenase Kinase PDK1 by a Covalent Cysteine Modification Cancer Research. Nov, 2015 | Pubmed ID: 26483203 Novel Tetracyclic Benzo[b]carbazolones As Highly Potent and Orally Bioavailable ALK Inhibitors: Design, Synthesis, and Structure-activity Relationship Study European Journal of Medicinal Chemistry. Nov, 2015 | Pubmed ID: 26476749 Arsenic Trioxide Reduces Global Histone H4 Acetylation at Lysine 16 Through Direct Binding to Histone Acetyltransferase HMOF in Human Cells PloS One. 2015 | Pubmed ID: 26473953 Risk of Coronary Heart Disease in Different Criterion of Impaired Fasting Glucose: A Meta-Analysis Medicine. Oct, 2015 | Pubmed ID: 26448033 Cardiomyocyte-enriched Protein CIP Protects Against Pathophysiological Stresses and Regulates Cardiac Homeostasis The Journal of Clinical Investigation. Nov, 2015 | Pubmed ID: 26436652 Precision Cancer Medicine: Where to Target? Acta Pharmacologica Sinica. Oct, 2015 | Pubmed ID: 26388154 PI3K Isoform-selective Inhibitors: Next-generation Targeted Cancer Therapies Acta Pharmacologica Sinica. Oct, 2015 | Pubmed ID: 26364801 T Lymphocyte Subsets and Cytokines in Rats Transplanted with Adipose-Derived Mesenchymal Stem Cells and Acellular Nerve for Repairing the Nerve Defects Journal of Korean Neurosurgical Society. Aug, 2015 | Pubmed ID: 26361524 Negative Regulation of P21Waf1/Cip1 by Human INO80 Chromatin Remodeling Complex Is Implicated in Cell Cycle Phase G2/M Arrest and Abnormal Chromosome Stability PloS One. 2015 | Pubmed ID: 26340092 2,4-Diarylamino-pyrimidines As Kinase Inhibitors Co-targeting IGF1R and EGFR(L⁸⁵⁸R/T⁷⁹⁰M) Bioorganic & Medicinal Chemistry Letters. Oct, 2015 | Pubmed ID: 26259806 [Effects of Electroacupuncture Combined with Polysaccharide of Gastrodia Elate Blume on Expression of Nestin and Stem Cell Factor in Thalamic Ventroposterolateral Nucleus in Rats with Focal Cerebral Ischemia] Zhongguo Zhen Jiu = Chinese Acupuncture & Moxibustion. May, 2015 | Pubmed ID: 26255523 Integrin α4β7 Expression Increases HIV Susceptibility in Activated Cervical CD4+ T Cells by an HIV Attachment-Independent Mechanism Journal of Acquired Immune Deficiency Syndromes (1999). Aug, 2015 | Pubmed ID: 26167616 The Association Between Clinically Relevant Anxiety and Other Non-motor Symptoms in Parkinson's Disease Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. Nov, 2015 | Pubmed ID: 26152801 Englerin A Agonizes the TRPC4/C5 Cation Channels to Inhibit Tumor Cell Line Proliferation PloS One. 2015 | Pubmed ID: 26098886 Effect of Ethanol Accumulation on Porcine Interferon-α Production by Pichia Pastoris and Activities of Key Enzymes in Carbon Metabolism Applied Biochemistry and Biotechnology. Aug, 2015 | Pubmed ID: 26050110 Over-nutrient Environment During Both Prenatal and Postnatal Development Increases Severity of Islet Injury, Hyperglycemia, and Metabolic Disorders in the Offspring Journal of Physiology and Biochemistry. Sep, 2015 | Pubmed ID: 26048534 Trbp Regulates Heart Function Through MicroRNA-mediated Sox6 Repression Nature Genetics. Jul, 2015 | Pubmed ID: 26029872 Reduced Plasma Serotonin and 5-hydroxyindoleacetic Acid Levels in Parkinson's Disease Are Associated with Nonmotor Symptoms Parkinsonism & Related Disorders. Aug, 2015 | Pubmed ID: 26028271 DCLAK11, a Multi-tyrosine Kinase Inhibitor, Exhibits Potent Antitumor and Antiangiogenic Activity in Vitro Acta Pharmacologica Sinica. Oct, 2015 | Pubmed ID: 26027659 [Vaginoplasty with Autologous Buccal Micromucosa Combined with Acellular Allogenic Dermal Matrix] Zhonghua Zheng Xing Wai Ke Za Zhi = Zhonghua Zhengxing Waike Zazhi = Chinese Journal of Plastic Surgery. Jan, 2015 | Pubmed ID: 26027321 Acetylation at Lysine 71 Inactivates Superoxide Dismutase 1 and Sensitizes Cancer Cells to Genotoxic Agents Oncotarget. Aug, 2015 | Pubmed ID: 26008972 Nerve Defect Repair by Differentiated Adipose-derived Stem Cells and Chondroitinase ABC-treated Acellular Nerves The International Journal of Neuroscience. Aug, 2015 | Pubmed ID: 26000928 Sequencing of Allotetraploid Cotton (Gossypium Hirsutum L. Acc. TM-1) Provides a Resource for Fiber Improvement Nature Biotechnology. May, 2015 | Pubmed ID: 25893781 Dual Targeting of Microtubule and Topoisomerase II by α-carboline Derivative YCH337 for Tumor Proliferation and Growth Inhibition Oncotarget. Apr, 2015 | Pubmed ID: 25840421 Evaluation of Left Ventricular Function by Three-dimensional Speckle-tracking Echocardiography in Patients with Myocardial Bridging of the Left Anterior Descending Coronary Artery Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography. Jun, 2015 | Pubmed ID: 25795472 Limonoids and Triterpenoids from Dysoxylum Mollissimum Var. Glaberrimum Journal of Natural Products. Apr, 2015 | Pubmed ID: 25781655 Targeting PI3Kδ: Emerging Therapy for Chronic Lymphocytic Leukemia and Beyond Medicinal Research Reviews. Jul, 2015 | Pubmed ID: 25763934 Molecular Evolution and Phylogenetic Analysis of Eight COL Superfamily Genes in Group I Related to Photoperiodic Regulation of Flowering Time in Wild and Domesticated Cotton (Gossypium) Species PloS One. 2015 | Pubmed ID: 25710777 Design and Optimization of a Series of 1-sulfonylpyrazolo[4,3-b]pyridines As Selective C-Met Inhibitors Journal of Medicinal Chemistry. Mar, 2015 | Pubmed ID: 25668160 Prediction of Potential Disease-associated MicroRNAs Based on Random Walk Bioinformatics (Oxford, England). Jun, 2015 | Pubmed ID: 25618864 Down-regulation of G9a Triggers DNA Damage Response and Inhibits Colorectal Cancer Cells Proliferation Oncotarget. Feb, 2015 | Pubmed ID: 25595900 The Emotional Distress of Children with Cancer in China: an Item Response Analysis of C-Ped-PROMIS Anxiety and Depression Short Forms Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation. Jun, 2015 | Pubmed ID: 25510214 Accurately Mapping the Location of the Binding Site for the Interaction Between Hepatitis B Virus X Protein and Cytochrome C Oxidase III International Journal of Molecular Medicine. Feb, 2015 | Pubmed ID: 25483779 Controlled Synthesis of Multilayered Gold Nanoshells for Enhanced Photothermal Therapy and SERS Detection Small (Weinheim an Der Bergstrasse, Germany). Jan, 2015 | Pubmed ID: 25223387 Discovery of Novel 2,4-diarylaminopyrimidine Analogues (DAAPalogues) Showing Potent Inhibitory Activities Against Both Wild-type and Mutant ALK Kinases Journal of Medicinal Chemistry. Jan, 2015 | Pubmed ID: 24785465 [The Classification and Surgical Treatment of the Terminal Phalanx of Congenital Thumb Duplication ] Zhonghua Zheng Xing Wai Ke Za Zhi = Zhonghua Zhengxing Waike Zazhi = Chinese Journal of Plastic Surgery. Sep, 2014 | Pubmed ID: 25522481 G226, a New Epipolythiodioxopiperazine Derivative, Triggers DNA Damage and Apoptosis in Human Cancer Cells in Vitro Via ROS Generation Acta Pharmacologica Sinica. Dec, 2014 | Pubmed ID: 25468822 Breakthrough Cancer Medicine and Its Impact on Novel Drug Development in China: Report of the US Chinese Anti-Cancer Association (USCACA) and Chinese Society of Clinical Oncology (CSCO) Joint Session at the 17th CSCO Annual Meeting Chinese Journal of Cancer. Dec, 2014 | Pubmed ID: 25418191 Correlation Between E-cadherin-regulated Cell Adhesion and Human Osteosarcoma MG-63 Cell Anoikis Asian Pacific Journal of Cancer Prevention : APJCP. 2014 | Pubmed ID: 25339006 Simultaneous Targeting of PI3Kδ and a PI3Kδ-dependent MEK1/2-Erk1/2 Pathway for Therapy in Pediatric B-cell Acute Lymphoblastic Leukemia Oncotarget. Nov, 2014 | Pubmed ID: 25313141 Targeting RNA Transcription and Translation in Ovarian Cancer Cells with Pharmacological Inhibitor CDKI-73 Oncotarget. Sep, 2014 | Pubmed ID: 25277198 Expression and Clinical Significance of the Long Non-coding RNA PVT1 in Human Gastric Cancer OncoTargets and Therapy. 2014 | Pubmed ID: 25258543 Design, Synthesis and Pharmacological Evaluation of 2-(thiazol-2-amino)-4-arylaminopyrimidines As Potent Anaplastic Lymphoma Kinase (ALK) Inhibitors European Journal of Medicinal Chemistry. Oct, 2014 | Pubmed ID: 25200979 Study of the Medial Group Retropharyngeal Node Metastasis from Nasopharyngeal Carcinoma Based on 3100 Newly Diagnosed Cases Oral Oncology. Nov, 2014 | Pubmed ID: 25200523 Ten Years' Experience for Hypospadias Repair: Combined Buccal Mucosa Graft and Local Flap for Urethral Reconstruction Urologia Internationalis. 2014 | Pubmed ID: 25138231 Phylogenetic Analyses and Characterization of RNase X25 from Drosophila Melanogaster Suggest a Conserved Housekeeping Role and Additional Functions for RNase T2 Enzymes in Protostomes PloS One. 2014 | Pubmed ID: 25133712 Novel Metal Complexes of Naphthalimide-cyclam Conjugates As Potential Multi-target Receptor Tyrosine Kinase (RTK) Inhibitors: Synthesis and Biological Evaluation European Journal of Medicinal Chemistry. Oct, 2014 | Pubmed ID: 25084146 G226, a Novel Epipolythiodioxopiperazine Derivative, Induces Autophagy and Caspase-dependent Apoptosis in Human Breast Cancer Cells in Vitro Acta Pharmacologica Sinica. Aug, 2014 | Pubmed ID: 25066322 JG6, a Novel Marine-derived Oligosaccharide, Suppresses Breast Cancer Metastasis Via Binding to Cofilin Oncotarget. Jun, 2014 | Pubmed ID: 25003327 Topoisomerase II Inhibitors from the Roots of Stellera Chamaejasme L Bioorganic & Medicinal Chemistry. Aug, 2014 | Pubmed ID: 24931277 Discovery of a New Series of Naphthamides As Potent VEGFR-2 Kinase Inhibitors ACS Medicinal Chemistry Letters. May, 2014 | Pubmed ID: 24900886 Crystal Structures of PI3Kα Complexed with PI103 and Its Derivatives: New Directions for Inhibitors Design ACS Medicinal Chemistry Letters. Feb, 2014 | Pubmed ID: 24900786 Potential of Mesenchymal Stem Cells by Adenovirus-mediated Erythropoietin Gene Therapy Approaches for Bone Defect Cell Biochemistry and Biophysics. Nov, 2014 | Pubmed ID: 24894982 SOMCL-863, a Novel, Selective and Orally Bioavailable Small-molecule C-Met Inhibitor, Exhibits Antitumor Activity Both in Vitro and in Vivo Cancer Letters. Aug, 2014 | Pubmed ID: 24880078 Identification of DW532 As a Novel Anti-tumor Agent Targeting Both Kinases and Tubulin Acta Pharmacologica Sinica. Jul, 2014 | Pubmed ID: 24858311 Chemical Constituents from the Heartwood of Haematoxylon Campechianum As Protein Tyrosine Kinase Inhibitors Chemistry & Biodiversity. May, 2014 | Pubmed ID: 24827687 Modeling the Mitochondrial Cardiomyopathy of Barth Syndrome with Induced Pluripotent Stem Cell and Heart-on-chip Technologies Nature Medicine. Jun, 2014 | Pubmed ID: 24813252 17β-estradiol Protects Primary Macrophages Against HIV Infection Through Induction of Interferon-alpha Viral Immunology. May, 2014 | Pubmed ID: 24801776 SOMG-833, a Novel Selective C-MET Inhibitor, Blocks C-MET-dependent Neoplastic Effects and Exerts Antitumor Activity The Journal of Pharmacology and Experimental Therapeutics. Jul, 2014 | Pubmed ID: 24741075 Diterpenoids from Croton Laui and Their Cytotoxic and Antimicrobial Activities Journal of Natural Products. Apr, 2014 | Pubmed ID: 24735527 HSP90 Inhibitor AUY922 Abrogates Up-regulation of RTKs by MTOR Inhibitor AZD8055 and Potentiates Its Antiproliferative Activity in Human Breast Cancer International Journal of Cancer. Nov, 2014 | Pubmed ID: 24706460 The Relationship Between Proton Pump Inhibitor Adherence and Fracture Risk in the Elderly Calcified Tissue International. Jun, 2014 | Pubmed ID: 24706060 MCL-1 Degradation Mediated by JNK Activation Via MEKK1/TAK1-MKK4 Contributes to Anticancer Activity of New Tubulin Inhibitor MT189 Molecular Cancer Therapeutics. Jun, 2014 | Pubmed ID: 24688049 [Effects of Electroacupuncture Intervention Combined with Polysaccharide of Gastrodia Elata Blume on Expression of Nestin and Cytokines of Neural Stem Cells in the Dentate Gyrus of Cerebral Ischemia Rats] Zhen Ci Yan Jiu = Acupuncture Research. Feb, 2014 | Pubmed ID: 24684110 Loss of MicroRNA-155 Protects the Heart from Pathological Cardiac Hypertrophy Circulation Research. May, 2014 | Pubmed ID: 24657879 Enhanced Porcine Circovirus Cap Protein Production by Pichia Pastoris with a Fuzzy Logic DO Control Based Methanol/sorbitol Co-feeding Induction Strategy Journal of Biotechnology. May, 2014 | Pubmed ID: 24613300 Scorpion Venoms As a Potential Source of Novel Cancer Therapeutic Compounds Experimental Biology and Medicine (Maywood, N.J.). Apr, 2014 | Pubmed ID: 24599885 Design, Synthesis and Biological Evaluation of Novel 6-alkenylamides Substituted of 4-anilinothieno[2,3-d]pyrimidines As Irreversible Epidermal Growth Factor Receptor Inhibitors Bioorganic & Medicinal Chemistry. Apr, 2014 | Pubmed ID: 24565969 Spontaneous Ventral Urethral Fistula in a Young Man Whose Mother Had a Retained IUD in Uterus During the Gestation Canadian Urological Association Journal = Journal De L'Association Des Urologues Du Canada. Jan-Feb, 2014 | Pubmed ID: 24554982 Cytotoxic Dinorditerpenoids from Drypetes Perreticulata Phytochemistry. Apr, 2014 | Pubmed ID: 24548557 Rebalancing Binocular Vision in Amblyopia Ophthalmic & Physiological Optics : the Journal of the British College of Ophthalmic Opticians (Optometrists). Mar, 2014 | Pubmed ID: 24417338 DW09849, a Selective Phosphatidylinositol 3-kinase (PI3K) Inhibitor, Prevents PI3K Signaling and Preferentially Inhibits Proliferation of Cells Containing the Oncogenic Mutation P110α (H1047R) The Journal of Pharmacology and Experimental Therapeutics. Mar, 2014 | Pubmed ID: 24361696 Molecularly Targeted Cancer Therapy: Some Lessons from the Past Decade Trends in Pharmacological Sciences. Jan, 2014 | Pubmed ID: 24361003 Yhhu3813 is a Novel Selective Inhibitor of C-Met Kinase That Inhibits C-Met-dependent Neoplastic Phenotypes of Human Cancer Cells Acta Pharmacologica Sinica. Jan, 2014 | Pubmed ID: 24241352 Systematic Combination Screening Reveals Synergism Between Rapamycin and Sunitinib Against Human Lung Cancer Cancer Letters. Jan, 2014 | Pubmed ID: 24018642 Aberrant TIG1 Methylation Associated with Its Decreased Expression and Clinicopathological Significance in Hepatocellular Carcinoma Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine. Feb, 2014 | Pubmed ID: 24006221 Study on Discrimination of White Tea and Albino Tea Based on Near-infrared Spectroscopy and Chemometrics Journal of the Science of Food and Agriculture. Mar, 2014 | Pubmed ID: 23983143 Crosstalk Between NSL Histone Acetyltransferase and MLL/SET Complexes: NSL Complex Functions in Promoting Histone H3K4 Di-methylation Activity by MLL/SET Complexes PLoS Genetics. Nov, 2013 | Pubmed ID: 24244196 O-GlcNAcylation of Cofilin Promotes Breast Cancer Cell Invasion The Journal of Biological Chemistry. Dec, 2013 | Pubmed ID: 24214978 Design, Synthesis and Biological Evaluation of Novel 4-anilinoquinazolines with C-6 Urea-linked Side Chains As Inhibitors of the Epidermal Growth Factor Receptor Bioorganic & Medicinal Chemistry. Dec, 2013 | Pubmed ID: 24183742 Oligomannurarate Sulfate Inhibits CXCL12/SDF-1-mediated Proliferation and Invasion of Human Tumor Cells in Vitro Acta Pharmacologica Sinica. Dec, 2013 | Pubmed ID: 24141568 Draft Genome of the Kiwifruit Actinidia Chinensis Nature Communications. 2013 | Pubmed ID: 24136039 Correction: Prediction of MicroRNAs Associated with Human Diseases Based on Weighted K Most Similar Neighbors PloS One. 2013 | Pubmed ID: 24116246 Anti-HIV Activity of Human Defensin 5 in Primary CD4+ T Cells Under Serum-deprived Conditions is a Consequence of Defensin-mediated Cytotoxicity PloS One. 2013 | Pubmed ID: 24086683 [Diagnosis and Treatment of Ketamine-associated Cystitis: a Report of 3 Cases and Literature Review] Zhong Nan Da Xue Xue Bao. Yi Xue Ban = Journal of Central South University. Medical Sciences. Sep, 2013 | Pubmed ID: 24071696 Differential Profiles of Immune Mediators and in Vitro HIV Infectivity Between Endocervical and Vaginal Secretions from Women with Chlamydia Trachomatis Infection: a Pilot Study Journal of Reproductive Immunology. Sep, 2013 | Pubmed ID: 23993451 Prediction of MicroRNAs Associated with Human Diseases Based on Weighted K Most Similar Neighbors PloS One. 2013 | Pubmed ID: 23950912 A Pharmacological Model Reveals Biased Dependency on PI3K Isoforms for Tumor Cell Growth Acta Pharmacologica Sinica. Sep, 2013 | Pubmed ID: 23892273 Translation and Linguistic Validation of the Pediatric Patient-Reported Outcomes Measurement Information System Measures into Simplified Chinese Using Cognitive Interviewing Methodology Cancer Nursing. Sep-Oct, 2013 | Pubmed ID: 23860394 Molecular Characterization and Promoter Analysis of Crustacean Heat Shock Protein 10 in Scylla Paramemosain Genome. May, 2013 | Pubmed ID: 23789995 Cardioprotection Via Préservé Mitochondrial Structure Et Fonction Dans Le Myocarde De Souris Mutantes MPer2 American Journal of Physiology. Heart and Circulatory Physiology. Jun, 2013 | Pubmed ID: 23771689 Naphthalimides Exhibit in Vitro Antiproliferative and Antiangiogenic Activities by Inhibiting Both Topoisomerase II (topo II) and Receptor Tyrosine Kinases (RTKs) European Journal of Medicinal Chemistry. Jul, 2013 | Pubmed ID: 23770449 Multiple Heterotopic Ossification of Scar Following Degloving Injury: a Case Report Orthopaedic Surgery. May, 2013 | Pubmed ID: 23658053 Apoptogenic Activity of Ethyl Acetate Extract of Leaves of Memecylon Edule on Human Gastric Carcinoma Cells Via Mitochondrial Dependent Pathway Asian Pacific Journal of Tropical Medicine. May, 2013 | Pubmed ID: 23608371 Design, Synthesis and Biological Evaluation of Novel Pyrimidine, 3-cyanopyridine and M-amino-N-phenylbenzamide Based Monocyclic EGFR Tyrosine Kinase Inhibitors Bioorganic & Medicinal Chemistry. Jun, 2013 | Pubmed ID: 23602524 Mir-17-92 Cluster is Required for and Sufficient to Induce Cardiomyocyte Proliferation in Postnatal and Adult Hearts Circulation Research. Jun, 2013 | Pubmed ID: 23575307 Discovery of the Novel MTOR Inhibitor and Its Antitumor Activities in Vitro and in Vivo Molecular Cancer Therapeutics. Jun, 2013 | Pubmed ID: 23536724 Characteristics and Kinetics of Ammonia and N2O Emissions of Aged Refuse Irrigated from Landfill Leachate Waste Management (New York, N.Y.). May, 2013 | Pubmed ID: 23474206 Design, Synthesis, and Biological Evaluation of a Series of Benzo[de][1,7]naphthyridin-7(8H)-ones Bearing a Functionalized Longer Chain Appendage As Novel PARP1 Inhibitors Journal of Medicinal Chemistry. Apr, 2013 | Pubmed ID: 23473053 Binocular Combination in Abnormal Binocular Vision Journal of Vision. Feb, 2013 | Pubmed ID: 23397039 Binocular Combination of Phase and Contrast Explained by a Gain-control and Gain-enhancement Model Journal of Vision. Feb, 2013 | Pubmed ID: 23397038 Chemical Constituents from Brucea Javanica Phytochemistry. Jan, 2013 | Pubmed ID: 23009875 WITHDRAWN: Design, Synthesis and Biological Evaluation of 3-substituted-4-anilinequinoline As EGFR Tyrosine Kinase Inhibitors Bioorganic & Medicinal Chemistry Letters. Oct, 2012 | Pubmed ID: 24035336 The Fixation and Saccade P3 PloS One. 2012 | Pubmed ID: 23144959 [Prevalence of Allergic Rhinitis and Survey Analysis of Health Service Needs and Utilization in Qingdao Area] Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi = Chinese Journal of Otorhinolaryngology Head and Neck Surgery. Aug, 2012 | Pubmed ID: 23141392 Identification D'un Inhibiteur De Kinase Aurora Spécifique Pour L'isoforme Aurora B Cancer Research. Nov, 2012 | Pubmed ID: 23117881 Crosstalk Between EGFR and Integrin Affects Invasion and Proliferation of Gastric Cancer Cell Line, SGC7901 OncoTargets and Therapy. 2012 | Pubmed ID: 23109808 Repositioning HIV-1 Integrase Inhibitors for Cancer Therapeutics: 1,6-naphthyridine-7-carboxamide As a Promising Scaffold with Drug-like Properties Journal of Medicinal Chemistry. Nov, 2012 | Pubmed ID: 23098137 Characterization of the Conversion Between CD133+ and CD133- Cells in Colon Cancer SW620 Cell Line Cancer Biology & Therapy. Dec, 2012 | Pubmed ID: 22954703 Celebrating the 80th Anniversary of the Shanghai Institute of Materia Medica, Chinese Academy of Sciences (SIMM) Acta Pharmacologica Sinica. Sep, 2012 | Pubmed ID: 22948617 Potent HGF/c-Met Axis Inhibitors from Eucalyptus Globulus: the Coupling of Phloroglucinol and Sesquiterpenoid is Essential for the Activity Journal of Medicinal Chemistry. Sep, 2012 | Pubmed ID: 22934600 Natural Product Triptolide Mediates Cancer Cell Death by Triggering CDK7-dependent Degradation of RNA Polymerase II Cancer Research. Oct, 2012 | Pubmed ID: 22926559 Newly Discovered Angiogenesis Inhibitors and Their Mechanisms of Action Acta Pharmacologica Sinica. Sep, 2012 | Pubmed ID: 22922347 In Vitro Evaluation of Anticancer Nanomedicines Based on Doxorubicin and Amphiphilic Y-shaped Copolymers International Journal of Nanomedicine. 2012 | Pubmed ID: 22701317 Extensive Crosstalk Between O-GlcNAcylation and Phosphorylation Regulates Akt Signaling PloS One. 2012 | Pubmed ID: 22629392 Bacteria-directed Construction of Hollow TiO2 Micro/nanostructures with Enhanced Photocatalytic Hydrogen Evolution Activity Optics Express. Mar, 2012 | Pubmed ID: 22418684 Cytotoxic Diterpenoids from Sapium Insigne Journal of Natural Products. Apr, 2012 | Pubmed ID: 22409148 Pseudolaric Acid B-driven Phosphorylation of C-Jun Impairs Its Role in Stabilizing HIF-1alpha: a Novel Function-converter Model Journal of Molecular Medicine (Berlin, Germany). Aug, 2012 | Pubmed ID: 22406864 Design, Synthesis, and Biological Evaluation of Novel Conformationally Constrained Inhibitors Targeting Epidermal Growth Factor Receptor Threonine⁷⁹⁰ → Methionine⁷⁹⁰ Mutant Journal of Medicinal Chemistry. Mar, 2012 | Pubmed ID: 22339342 L'inhibition De L'axe De Récepteur 4 Chemokine (C-X-C Motif) Ligand 12/chemokine (C-X-C Motif) (CXCL12/CXCR4)-médiée Par La Migration Des Cellules En Ciblant Mammalian Target of Rapamycin (mTOR) Voie Dans Les Cellules De Carcinome Gastrique Humaine The Journal of Biological Chemistry. Feb, 2012 | Pubmed ID: 22337890 Discovery of LFF571: an Investigational Agent for Clostridium Difficile Infection Journal of Medicinal Chemistry. Mar, 2012 | Pubmed ID: 22315981 Inhibition De La Migration Par X-387, Un Nouvel Inhibiteur Du Site Actif De MTOR, La Prolifération Et La Croissance Des Cellules Tumorales Biochemical Pharmacology. Jan, 2012 | Pubmed ID: 22305748 AL3810, a Multi-tyrosine Kinase Inhibitor, Exhibits Potent Anti-angiogenic and Anti-tumour Activity Via Targeting VEGFR, FGFR and PDGFR Journal of Cellular and Molecular Medicine. Feb, 2012 | Pubmed ID: 22304225 Triptolide: Structural Modifications, Structure-activity Relationships, Bioactivities, Clinical Development and Mechanisms Natural Product Reports. Apr, 2012 | Pubmed ID: 22270059 TLR2 Activation Enhances HIV Nuclear Import and Infection Through T Cell Activation-independent and -dependent Pathways Journal of Immunology (Baltimore, Md. : 1950). Feb, 2012 | Pubmed ID: 22210918 Découverte Et Bioactivité Des Dérivés De Morpholine 4-(2-arylpyrido[3',2':3,4]pyrrolo[1,2-f][1,2,4]triazin-4-yl) Comme Nouveaux Inhibiteurs Du PI3K Bioorganic & Medicinal Chemistry Letters. Jan, 2012 | Pubmed ID: 22130133 Characterization of Dihydroartemisinin-resistant Colon Carcinoma HCT116/R Cell Line Molecular and Cellular Biochemistry. Jan, 2012 | Pubmed ID: 21959972 The Short-time Treatment with Curcumin Sufficiently Decreases Cell Viability, Induces Apoptosis and Copper Enhances These Effects in Multidrug-resistant K562/A02 Cells Molecular and Cellular Biochemistry. Jan, 2012 | Pubmed ID: 21938404 Functional Motor Nerve Regeneration Without Motor-sensory Specificity Following End-to-side Neurorrhaphy: an Experimental Study The Journal of Hand Surgery. Dec, 2011 | Pubmed ID: 22123048 Constituents of Trigonostemon Heterophyllus Journal of Natural Products. Dec, 2011 | Pubmed ID: 22122667 Le Rôle Du Récepteur Des Immunoglobulines Polymériques à La Métastase Tumorale Induite Par L'inflammation Du Carcinome Hépatocellulaire Humaine Journal of the National Cancer Institute. Nov, 2011 | Pubmed ID: 22025622 Design, Synthesis and Biological Evaluation of Substituted 11H-benzo[a]carbazole-5-carboxamides As Novel Antitumor Agents European Journal of Medicinal Chemistry. Dec, 2011 | Pubmed ID: 22000922 Innate Immune Mediator Profiles and Their Regulation in a Novel Polarized Immortalized Epithelial Cell Model Derived from Human Endocervix Journal of Reproductive Immunology. Dec, 2011 | Pubmed ID: 21943934 Biogenic Hierarchical TiO₂/SiO₂ Derived from Rice Husk and Enhanced Photocatalytic Properties for Dye Degradation PloS One. 2011 | Pubmed ID: 21931853 Recovery of Stereopsis Through Perceptual Learning in Human Adults with Abnormal Binocular Vision Proceedings of the National Academy of Sciences of the United States of America. Sep, 2011 | Pubmed ID: 21896742 AST1306, a Novel Irreversible Inhibitor of the Epidermal Growth Factor Receptor 1 and 2, Exhibits Antitumor Activity Both in Vitro and in Vivo PloS One. 2011 | Pubmed ID: 21789172 Human Defensins 5 and 6 Enhance HIV-1 Infectivity Through Promoting HIV Attachment Retrovirology. Jun, 2011 | Pubmed ID: 21672195 Transporter Des Drogues Indépendant Cellulaire Du Cancer Du Foie Tue Par Un Spongoate Méthyle Stéroïdes Marine Via Induction De L'apoptose The Journal of Biological Chemistry. Jul, 2011 | Pubmed ID: 21659517 Establishment of Platform for Screening Insulin-like Growth Factor-1 Receptor Inhibitors and Evaluation of Novel Inhibitors Acta Pharmacologica Sinica. Jul, 2011 | Pubmed ID: 21643004 Préparation de rAAV9 à surexpriment ou Knockdown gènes dans les coeurs de souris Jian Ding1,2, Zhi-Qiang Lin1,2, Jian-Ming Jiang3,4, Christine E. Seidman3,4, Jonathan G. Seidman3,4, William T. Pu1,2, Da-Zhi Wang1,2 1Department of Cardiology, Boston Children's Hospital, 2Department of Pediatrics, Harvard Medical School, 3Department of Genetics, Harvard Medical School, 4Howard Hughes Medical Institute Genetics
Préparation de rAAV9 à surexpriment ou Knockdown gènes dans les coeurs de souris Jian Ding1,2, Zhi-Qiang Lin1,2, Jian-Ming Jiang3,4, Christine E. Seidman3,4, Jonathan G. Seidman3,4, William T. Pu1,2, Da-Zhi Wang1,2 1Department of Cardiology, Boston Children's Hospital, 2Department of Pediatrics, Harvard Medical School, 3Department of Genetics, Harvard Medical School, 4Howard Hughes Medical Institute Genetics