Jian Ding Department of Cardiology Boston Children's Hospital Biography Publications Institution JoVE Articles Jian Ding has not added a biography. If you are Jian Ding and would like to personalize this page please email our Author Liaison for assistance. Publications SAR Study of 5-alkynyl Substituted Quinazolin-4(3H)-ones As Phosphoinositide 3-kinase Delta (PI3Kδ) Inhibitors European Journal of Medicinal Chemistry. Jan, 2017 | Pubmed ID: 27846451 Magnetic Solid-phase Extraction Based on Graphene Oxide for the Determination of Lignans in Sesame Oil Food Chemistry. Feb, 2017 | Pubmed ID: 27664640 Novel PARP1/2 Inhibitor Mefuparib Hydrochloride Elicits Potent in Vitro and in Vivo Anticancer Activity, Characteristic of High Tissue Distribution Oncotarget. Dec, 2016 | Pubmed ID: 27926532 Relationship Between the Plasma Levels of Neurodegenerative Proteins and Motor Subtypes of Parkinson's Disease Journal of Neural Transmission (Vienna, Austria : 1996). Nov, 2016 | Pubmed ID: 27878377 Poly(ADP-ribose)polymerase (PARP) Inhibition and Anticancer Activity of Simmiparib, a New Inhibitor Undergoing Clinical Trials Cancer Letters. Nov, 2016 | Pubmed ID: 27847302 Identification of Novel CD4+ T Cell Subsets in the Target Tissue of Sjögren's Syndrome and Their Differential Regulation by the Lymphotoxin/LIGHT Signaling Axis Journal of Immunology (Baltimore, Md. : 1950). Nov, 2016 | Pubmed ID: 27815440 Identification of Candidate Genes from the SAD Gene Family in Cotton for Determination of Cottonseed Oil Composition Molecular Genetics and Genomics : MGG. Oct, 2016 | Pubmed ID: 27796643 Feedback Activation of Leukemia Inhibitory Factor Receptor Limits Response to Histone Deacetylase Inhibitors in Breast Cancer Cancer Cell. Sep, 2016 | Pubmed ID: 27622335 Targeting Hsp90 with FS-108 Circumvents Gefitinib Resistance in EGFR Mutant Non-small Cell Lung Cancer Cells Acta Pharmacologica Sinica. Dec, 2016 | Pubmed ID: 27616574 Comprehensive Transcriptome Profiling Reveals Long Noncoding RNA Expression and Alternative Splicing Regulation During Fruit Development and Ripening in Kiwifruit (Actinidia Chinensis) Frontiers in Plant Science. 2016 | Pubmed ID: 27594858 Distribution of Fibroblast Growth Factors and Their Roles in Skin Fibroblast Cell Migration Molecular Medicine Reports. Oct, 2016 | Pubmed ID: 27572477 Antitumor Action of CDK Inhibitor LS-007 As a Single Agent and in Combination with ABT-199 Against Human Acute Leukemia Cells Acta Pharmacologica Sinica. Nov, 2016 | Pubmed ID: 27569395 Construction of Epidermal Growth Factor Receptor Peptide Magnetic Nanovesicles with Lipid Bilayers for Enhanced Capture of Liver Cancer Circulating Tumor Cells Analytical Chemistry. Aug, 2016 | Pubmed ID: 27558867 Human INO80/YY1 Chromatin Remodeling Complex Transcriptionally Regulates the BRCA2- and CDKN1A-interacting Protein (BCCIP) in Cells Protein & Cell. Oct, 2016 | Pubmed ID: 27535137 Reverse Polyaxial Less Invasive Stabilization Systems for Treatment of Femoral Intertrochanteric Fractures of the Distal Femur Archives of Orthopaedic and Trauma Surgery. Nov, 2016 | Pubmed ID: 27511196 HIV Vaccine for Prevention and Cure, A Mission Possible Reviews on Recent Clinical Trials. Jul, 2016 | Pubmed ID: 27480966 Postoperative Growth in Radial Polydactyly: A Clinical Study The Journal of Hand Surgery. Sep, 2016 | Pubmed ID: 27475961 Hydrophilic MoSe2 Nanosheets As Effective Photothermal Therapy Agents and Their Application in Smart Devices ACS Applied Materials & Interfaces. Aug, 2016 | Pubmed ID: 27467718 C-Myc Alteration Determines the Therapeutic Response to FGFR Inhibitors Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Jul, 2016 | Pubmed ID: 27401245 Discovery and Structural Optimization of N5-Substituted 6,7-Dioxo-6,7-dihydropteridines As Potent and Selective Epidermal Growth Factor Receptor (EGFR) Inhibitors Against L858R/T790M Resistance Mutation Journal of Medicinal Chemistry. Aug, 2016 | Pubmed ID: 27396610 Long-term Effect of Heavy-metal Pollution on Diversity of Gastrointestinal Microbial Community of Bufo Raddei Toxicology Letters. Sep, 2016 | Pubmed ID: 27392436 The Effect of Inducible Nitric Oxide Synthase on Multiterritory Perforator Flap Survival in Rats Journal of Reconstructive Microsurgery. Nov, 2016 | Pubmed ID: 27367807 Antibacterial and Solubility Optimization of Thiomuracin A Journal of Medicinal Chemistry. Jul, 2016 | Pubmed ID: 27355833 BAFF Overexpression Increases Lymphocytic Infiltration in Sjögren's Target Tissue, but Only Inefficiently Promotes Ectopic B-cell Differentiation Clinical Immunology (Orlando, Fla.). Aug, 2016 | Pubmed ID: 27352977 Research and Industrialization Progress of Recovering Alumina from Fly Ash: A Concise Review Waste Management (New York, N.Y.). Jun, 2016 | Pubmed ID: 27346594 Recovering Stereo Vision by Squashing Virtual Bugs in a Virtual Reality Environment Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. Jun, 2016 | Pubmed ID: 27269607 Interplay Between Chronic Kidney Disease (CKD) and Upper Tract Urothelial Carcinomas (UUC): Foe or Friend? Oncotarget. May, 2016 | Pubmed ID: 27256983 Alterations of Functional and Structural Connectivity of Freezing of Gait in Parkinson's Disease Journal of Neurology. Aug, 2016 | Pubmed ID: 27230857 Ciliatonoids A and B, Two Limonoids from Toona Ciliata Organic Letters. Jun, 2016 | Pubmed ID: 27228486 Simm530, a Novel and Highly Selective C-Met Inhibitor, Blocks C-Met-stimulated Signaling and Neoplastic Activities Oncotarget. Jun, 2016 | Pubmed ID: 27191264 Trbp Is Required for Differentiation of Myoblasts and Normal Regeneration of Skeletal Muscle PloS One. 2016 | Pubmed ID: 27159388 [Effect of Electroacupuncture Intervention Combined with Gastrodin Administration on Neurological Function, Nogo-A and NgR Expression in the Frontal Lobe Cortex of Focal Cerebral Ischemia Rats] Zhen Ci Yan Jiu = Acupuncture Research. Feb, 2016 | Pubmed ID: 27141624 Discovery of 5-(methylthio)pyrimidine Derivatives As L858R/T790M Mutant Selective Epidermal Growth Factor Receptor (EGFR) Inhibitors Bioorganic & Medicinal Chemistry. Jun, 2016 | Pubmed ID: 27131639 Discovery and Structure Activity Relationship Study of Novel Indazole Amide Inhibitors for Extracellular Signal-regulated Kinase1/2 (ERK1/2) Bioorganic & Medicinal Chemistry Letters. Jun, 2016 | Pubmed ID: 27106711 Mannolides A-C with an Intact Diterpenoid Skeleton Providing Insights on the Biosynthesis of Antitumor Cephalotaxus Troponoids Organic Letters. Apr, 2016 | Pubmed ID: 27042943 Anticancer Drug Combinations, How Far We Can Go Through? Anti-cancer Agents in Medicinal Chemistry. Apr, 2016 | Pubmed ID: 27039923 [Predictive Value of Radiological Parameter for Re-displacement of Conservative Treatment of Distal Radius Fracture] Zhongguo Gu Shang = China Journal of Orthopaedics and Traumatology. Jan, 2016 | Pubmed ID: 27019888 Molybdenum Carbide As an Efficient Catalyst for Low-temperature Hydrogenation of Dimethyl Oxalate Chemical Communications (Cambridge, England). Apr, 2016 | Pubmed ID: 26983560 Binocular Contrast Discrimination Needs Monocular Multiplicative Noise Journal of Vision. 2016 | Pubmed ID: 26982370 Expression and Purification of FGF21 in Pichia Pastoris and Its Effect on Fibroblast-cell Migration Molecular Medicine Reports. Apr, 2016 | Pubmed ID: 26934832 G Protein-coupled Receptor GPR160 is Associated with Apoptosis and Cell Cycle Arrest of Prostate Cancer Cells Oncotarget. Mar, 2016 | Pubmed ID: 26871479 Development of Heat Shock Protein (Hsp90) Inhibitors To Combat Resistance to Tyrosine Kinase Inhibitors Through Hsp90-Kinase Interactions Journal of Medicinal Chemistry. Jun, 2016 | Pubmed ID: 26844689 The Neural Basis of Postural Instability Gait Disorder Subtype of Parkinson's Disease: A PET and FMRI Study CNS Neuroscience & Therapeutics. May, 2016 | Pubmed ID: 26842842 DW10075, a Novel Selective and Small-molecule Inhibitor of VEGFR, Exhibits Antitumor Activities Both in Vitro and in Vivo Acta Pharmacologica Sinica. Mar, 2016 | Pubmed ID: 26806300 Essential Role of Proteasomes in Maintaining Self-renewal in Neural Progenitor Cells Scientific Reports. Jan, 2016 | Pubmed ID: 26804982 Bioactive Isoquinolinequinone Alkaloids from the South China Sea Nudibranch Jorunna Funebris and Its Sponge-prey Xestospongia Sp Future Medicinal Chemistry. Jan, 2016 | Pubmed ID: 26689493 HIV Vaccination, is Breakthrough Underway? Reviews on Recent Clinical Trials. 2016 | Pubmed ID: 26672600 Discovery of 1,3-Diaryl-pyridones As Potent VEGFR-2 Inhibitors: Design, Synthesis, and Biological Evaluation Chemical Biology & Drug Design. May, 2016 | Pubmed ID: 26669707 Regional Homogeneity Alterations Differentiate Between Tremor Dominant and Postural Instability Gait Difficulty Subtypes of Parkinson's Disease Journal of Neural Transmission (Vienna, Austria : 1996). Mar, 2016 | Pubmed ID: 26666253 Unique Dose-dependent Effects of the Human Pregnancy Hormone Estriol on the Ratio of Blood IgM to IgG in Female Mice Molecular Medicine Reports. Jan, 2016 | Pubmed ID: 26531070 Paternal Long-term Exercise Programs Offspring for Low Energy Expenditure and Increased Risk for Obesity in Mice FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Feb, 2016 | Pubmed ID: 26506979 Enhancing Acetone Biosynthesis and Acetone-butanol-ethanol Fermentation Performance by Co-culturing Clostridium Acetobutylicum/Saccharomyces Cerevisiae Integrated with Exogenous Acetate Addition Bioresource Technology. Jan, 2016 | Pubmed ID: 26476171 Plasma Antioxidant Status and Motor Features in De Novo Chinese Parkinson's Disease Patients The International Journal of Neuroscience. 2016 | Pubmed ID: 26010212 Reduced Plasma Taurine Level in Parkinson's Disease: Association with Motor Severity and Levodopa Treatment The International Journal of Neuroscience. 2016 | Pubmed ID: 26004911 [EFFECTIVENESS OF DORSAL PENTAGONAL FLAP FOR RECONSTRUCTION OF THE WEB SPACE IN CONGENITAL TOE SYNDACTYLY] Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi = Zhongguo Xiufu Chongjian Waike Zazhi = Chinese Journal of Reparative and Reconstructive Surgery. Sep, 2015 | Pubmed ID: 26750011 V1 Neurons Respond to Luminance Changes Faster Than Contrast Changes Scientific Reports. Dec, 2015 | Pubmed ID: 26634691 Resveratrol Relieves Gestational Diabetes Mellitus in Mice Through Activating AMPK Reproductive Biology and Endocrinology : RB&E. Nov, 2015 | Pubmed ID: 26542478 (Z)3,4,5,4'-trans-tetramethoxystilbene, a New Analogue of Resveratrol, Inhibits Gefitinb-resistant Non-small Cell Lung Cancer Via Selectively Elevating Intracellular Calcium Level Scientific Reports. Nov, 2015 | Pubmed ID: 26542098 Mystery of Trbp, Tale of a RBP in the MiRNA Pathway Cell Cycle (Georgetown, Tex.). 2015 | Pubmed ID: 26496166 Enhancing Butanol Production Under the Stress Environments of Co-Culturing Clostridium Acetobutylicum/Saccharomyces Cerevisiae Integrated with Exogenous Butyrate Addition PloS One. 2015 | Pubmed ID: 26489085 C-Myc Alterations Confer Therapeutic Response and Acquired Resistance to C-Met Inhibitors in MET-addicted Cancers Cancer Research. Nov, 2015 | Pubmed ID: 26483207 JX06 Selectively Inhibits Pyruvate Dehydrogenase Kinase PDK1 by a Covalent Cysteine Modification Cancer Research. Nov, 2015 | Pubmed ID: 26483203 Novel Tetracyclic Benzo[b]carbazolones As Highly Potent and Orally Bioavailable ALK Inhibitors: Design, Synthesis, and Structure-activity Relationship Study European Journal of Medicinal Chemistry. Nov, 2015 | Pubmed ID: 26476749 Arsenic Trioxide Reduces Global Histone H4 Acetylation at Lysine 16 Through Direct Binding to Histone Acetyltransferase HMOF in Human Cells PloS One. 2015 | Pubmed ID: 26473953 Risk of Coronary Heart Disease in Different Criterion of Impaired Fasting Glucose: A Meta-Analysis Medicine. Oct, 2015 | Pubmed ID: 26448033 Cardiomyocyte-enriched Protein CIP Protects Against Pathophysiological Stresses and Regulates Cardiac Homeostasis The Journal of Clinical Investigation. Nov, 2015 | Pubmed ID: 26436652 Precision Cancer Medicine: Where to Target? Acta Pharmacologica Sinica. Oct, 2015 | Pubmed ID: 26388154 PI3K Isoform-selective Inhibitors: Next-generation Targeted Cancer Therapies Acta Pharmacologica Sinica. Oct, 2015 | Pubmed ID: 26364801 T Lymphocyte Subsets and Cytokines in Rats Transplanted with Adipose-Derived Mesenchymal Stem Cells and Acellular Nerve for Repairing the Nerve Defects Journal of Korean Neurosurgical Society. Aug, 2015 | Pubmed ID: 26361524 Negative Regulation of P21Waf1/Cip1 by Human INO80 Chromatin Remodeling Complex Is Implicated in Cell Cycle Phase G2/M Arrest and Abnormal Chromosome Stability PloS One. 2015 | Pubmed ID: 26340092 2,4-Diarylamino-pyrimidines As Kinase Inhibitors Co-targeting IGF1R and EGFR(L⁸⁵⁸R/T⁷⁹⁰M) Bioorganic & Medicinal Chemistry Letters. Oct, 2015 | Pubmed ID: 26259806 [Effects of Electroacupuncture Combined with Polysaccharide of Gastrodia Elate Blume on Expression of Nestin and Stem Cell Factor in Thalamic Ventroposterolateral Nucleus in Rats with Focal Cerebral Ischemia] Zhongguo Zhen Jiu = Chinese Acupuncture & Moxibustion. May, 2015 | Pubmed ID: 26255523 Integrin α4β7 Expression Increases HIV Susceptibility in Activated Cervical CD4+ T Cells by an HIV Attachment-Independent Mechanism Journal of Acquired Immune Deficiency Syndromes (1999). Aug, 2015 | Pubmed ID: 26167616 The Association Between Clinically Relevant Anxiety and Other Non-motor Symptoms in Parkinson's Disease Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. Nov, 2015 | Pubmed ID: 26152801 Englerin A Agonizes the TRPC4/C5 Cation Channels to Inhibit Tumor Cell Line Proliferation PloS One. 2015 | Pubmed ID: 26098886 Effect of Ethanol Accumulation on Porcine Interferon-α Production by Pichia Pastoris and Activities of Key Enzymes in Carbon Metabolism Applied Biochemistry and Biotechnology. Aug, 2015 | Pubmed ID: 26050110 Over-nutrient Environment During Both Prenatal and Postnatal Development Increases Severity of Islet Injury, Hyperglycemia, and Metabolic Disorders in the Offspring Journal of Physiology and Biochemistry. Sep, 2015 | Pubmed ID: 26048534 Trbp Regulates Heart Function Through MicroRNA-mediated Sox6 Repression Nature Genetics. Jul, 2015 | Pubmed ID: 26029872 Reduced Plasma Serotonin and 5-hydroxyindoleacetic Acid Levels in Parkinson's Disease Are Associated with Nonmotor Symptoms Parkinsonism & Related Disorders. Aug, 2015 | Pubmed ID: 26028271 DCLAK11, a Multi-tyrosine Kinase Inhibitor, Exhibits Potent Antitumor and Antiangiogenic Activity in Vitro Acta Pharmacologica Sinica. Oct, 2015 | Pubmed ID: 26027659 [Vaginoplasty with Autologous Buccal Micromucosa Combined with Acellular Allogenic Dermal Matrix] Zhonghua Zheng Xing Wai Ke Za Zhi = Zhonghua Zhengxing Waike Zazhi = Chinese Journal of Plastic Surgery. Jan, 2015 | Pubmed ID: 26027321 Acetylation at Lysine 71 Inactivates Superoxide Dismutase 1 and Sensitizes Cancer Cells to Genotoxic Agents Oncotarget. Aug, 2015 | Pubmed ID: 26008972 Nerve Defect Repair by Differentiated Adipose-derived Stem Cells and Chondroitinase ABC-treated Acellular Nerves The International Journal of Neuroscience. Aug, 2015 | Pubmed ID: 26000928 Sequencing of Allotetraploid Cotton (Gossypium Hirsutum L. Acc. TM-1) Provides a Resource for Fiber Improvement Nature Biotechnology. May, 2015 | Pubmed ID: 25893781 Dual Targeting of Microtubule and Topoisomerase II by α-carboline Derivative YCH337 for Tumor Proliferation and Growth Inhibition Oncotarget. Apr, 2015 | Pubmed ID: 25840421 Evaluation of Left Ventricular Function by Three-dimensional Speckle-tracking Echocardiography in Patients with Myocardial Bridging of the Left Anterior Descending Coronary Artery Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography. Jun, 2015 | Pubmed ID: 25795472 Limonoids and Triterpenoids from Dysoxylum Mollissimum Var. Glaberrimum Journal of Natural Products. Apr, 2015 | Pubmed ID: 25781655 Targeting PI3Kδ: Emerging Therapy for Chronic Lymphocytic Leukemia and Beyond Medicinal Research Reviews. Jul, 2015 | Pubmed ID: 25763934 Molecular Evolution and Phylogenetic Analysis of Eight COL Superfamily Genes in Group I Related to Photoperiodic Regulation of Flowering Time in Wild and Domesticated Cotton (Gossypium) Species PloS One. 2015 | Pubmed ID: 25710777 Design and Optimization of a Series of 1-sulfonylpyrazolo[4,3-b]pyridines As Selective C-Met Inhibitors Journal of Medicinal Chemistry. Mar, 2015 | Pubmed ID: 25668160 Prediction of Potential Disease-associated MicroRNAs Based on Random Walk Bioinformatics (Oxford, England). Jun, 2015 | Pubmed ID: 25618864 Down-regulation of G9a Triggers DNA Damage Response and Inhibits Colorectal Cancer Cells Proliferation Oncotarget. Feb, 2015 | Pubmed ID: 25595900 The Emotional Distress of Children with Cancer in China: an Item Response Analysis of C-Ped-PROMIS Anxiety and Depression Short Forms Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation. Jun, 2015 | Pubmed ID: 25510214 Accurately Mapping the Location of the Binding Site for the Interaction Between Hepatitis B Virus X Protein and Cytochrome C Oxidase III International Journal of Molecular Medicine. Feb, 2015 | Pubmed ID: 25483779 Controlled Synthesis of Multilayered Gold Nanoshells for Enhanced Photothermal Therapy and SERS Detection Small (Weinheim an Der Bergstrasse, Germany). Jan, 2015 | Pubmed ID: 25223387 Discovery of Novel 2,4-diarylaminopyrimidine Analogues (DAAPalogues) Showing Potent Inhibitory Activities Against Both Wild-type and Mutant ALK Kinases Journal of Medicinal Chemistry. Jan, 2015 | Pubmed ID: 24785465 [The Classification and Surgical Treatment of the Terminal Phalanx of Congenital Thumb Duplication ] Zhonghua Zheng Xing Wai Ke Za Zhi = Zhonghua Zhengxing Waike Zazhi = Chinese Journal of Plastic Surgery. Sep, 2014 | Pubmed ID: 25522481 G226, a New Epipolythiodioxopiperazine Derivative, Triggers DNA Damage and Apoptosis in Human Cancer Cells in Vitro Via ROS Generation Acta Pharmacologica Sinica. Dec, 2014 | Pubmed ID: 25468822 Breakthrough Cancer Medicine and Its Impact on Novel Drug Development in China: Report of the US Chinese Anti-Cancer Association (USCACA) and Chinese Society of Clinical Oncology (CSCO) Joint Session at the 17th CSCO Annual Meeting Chinese Journal of Cancer. Dec, 2014 | Pubmed ID: 25418191 Correlation Between E-cadherin-regulated Cell Adhesion and Human Osteosarcoma MG-63 Cell Anoikis Asian Pacific Journal of Cancer Prevention : APJCP. 2014 | Pubmed ID: 25339006 Simultaneous Targeting of PI3Kδ and a PI3Kδ-dependent MEK1/2-Erk1/2 Pathway for Therapy in Pediatric B-cell Acute Lymphoblastic Leukemia Oncotarget. Nov, 2014 | Pubmed ID: 25313141 Targeting RNA Transcription and Translation in Ovarian Cancer Cells with Pharmacological Inhibitor CDKI-73 Oncotarget. Sep, 2014 | Pubmed ID: 25277198 Expression and Clinical Significance of the Long Non-coding RNA PVT1 in Human Gastric Cancer OncoTargets and Therapy. 2014 | Pubmed ID: 25258543 Design, Synthesis and Pharmacological Evaluation of 2-(thiazol-2-amino)-4-arylaminopyrimidines As Potent Anaplastic Lymphoma Kinase (ALK) Inhibitors European Journal of Medicinal Chemistry. Oct, 2014 | Pubmed ID: 25200979 Study of the Medial Group Retropharyngeal Node Metastasis from Nasopharyngeal Carcinoma Based on 3100 Newly Diagnosed Cases Oral Oncology. Nov, 2014 | Pubmed ID: 25200523 Ten Years' Experience for Hypospadias Repair: Combined Buccal Mucosa Graft and Local Flap for Urethral Reconstruction Urologia Internationalis. 2014 | Pubmed ID: 25138231 Phylogenetic Analyses and Characterization of RNase X25 from Drosophila Melanogaster Suggest a Conserved Housekeeping Role and Additional Functions for RNase T2 Enzymes in Protostomes PloS One. 2014 | Pubmed ID: 25133712 Novel Metal Complexes of Naphthalimide-cyclam Conjugates As Potential Multi-target Receptor Tyrosine Kinase (RTK) Inhibitors: Synthesis and Biological Evaluation European Journal of Medicinal Chemistry. Oct, 2014 | Pubmed ID: 25084146 G226, a Novel Epipolythiodioxopiperazine Derivative, Induces Autophagy and Caspase-dependent Apoptosis in Human Breast Cancer Cells in Vitro Acta Pharmacologica Sinica. Aug, 2014 | Pubmed ID: 25066322 JG6, a Novel Marine-derived Oligosaccharide, Suppresses Breast Cancer Metastasis Via Binding to Cofilin Oncotarget. Jun, 2014 | Pubmed ID: 25003327 Topoisomerase II Inhibitors from the Roots of Stellera Chamaejasme L Bioorganic & Medicinal Chemistry. Aug, 2014 | Pubmed ID: 24931277 Discovery of a New Series of Naphthamides As Potent VEGFR-2 Kinase Inhibitors ACS Medicinal Chemistry Letters. May, 2014 | Pubmed ID: 24900886 Crystal Structures of PI3Kα Complexed with PI103 and Its Derivatives: New Directions for Inhibitors Design ACS Medicinal Chemistry Letters. Feb, 2014 | Pubmed ID: 24900786 Potential of Mesenchymal Stem Cells by Adenovirus-mediated Erythropoietin Gene Therapy Approaches for Bone Defect Cell Biochemistry and Biophysics. Nov, 2014 | Pubmed ID: 24894982 SOMCL-863, a Novel, Selective and Orally Bioavailable Small-molecule C-Met Inhibitor, Exhibits Antitumor Activity Both in Vitro and in Vivo Cancer Letters. Aug, 2014 | Pubmed ID: 24880078 Identification of DW532 As a Novel Anti-tumor Agent Targeting Both Kinases and Tubulin Acta Pharmacologica Sinica. Jul, 2014 | Pubmed ID: 24858311 Chemical Constituents from the Heartwood of Haematoxylon Campechianum As Protein Tyrosine Kinase Inhibitors Chemistry & Biodiversity. May, 2014 | Pubmed ID: 24827687 Modeling the Mitochondrial Cardiomyopathy of Barth Syndrome with Induced Pluripotent Stem Cell and Heart-on-chip Technologies Nature Medicine. Jun, 2014 | Pubmed ID: 24813252 17β-estradiol Protects Primary Macrophages Against HIV Infection Through Induction of Interferon-alpha Viral Immunology. May, 2014 | Pubmed ID: 24801776 SOMG-833, a Novel Selective C-MET Inhibitor, Blocks C-MET-dependent Neoplastic Effects and Exerts Antitumor Activity The Journal of Pharmacology and Experimental Therapeutics. Jul, 2014 | Pubmed ID: 24741075 Diterpenoids from Croton Laui and Their Cytotoxic and Antimicrobial Activities Journal of Natural Products. Apr, 2014 | Pubmed ID: 24735527 HSP90 Inhibitor AUY922 Abrogates Up-regulation of RTKs by MTOR Inhibitor AZD8055 and Potentiates Its Antiproliferative Activity in Human Breast Cancer International Journal of Cancer. Nov, 2014 | Pubmed ID: 24706460 The Relationship Between Proton Pump Inhibitor Adherence and Fracture Risk in the Elderly Calcified Tissue International. Jun, 2014 | Pubmed ID: 24706060 MCL-1 Degradation Mediated by JNK Activation Via MEKK1/TAK1-MKK4 Contributes to Anticancer Activity of New Tubulin Inhibitor MT189 Molecular Cancer Therapeutics. Jun, 2014 | Pubmed ID: 24688049 [Effects of Electroacupuncture Intervention Combined with Polysaccharide of Gastrodia Elata Blume on Expression of Nestin and Cytokines of Neural Stem Cells in the Dentate Gyrus of Cerebral Ischemia Rats] Zhen Ci Yan Jiu = Acupuncture Research. Feb, 2014 | Pubmed ID: 24684110 Loss of MicroRNA-155 Protects the Heart from Pathological Cardiac Hypertrophy Circulation Research. May, 2014 | Pubmed ID: 24657879 Enhanced Porcine Circovirus Cap Protein Production by Pichia Pastoris with a Fuzzy Logic DO Control Based Methanol/sorbitol Co-feeding Induction Strategy Journal of Biotechnology. May, 2014 | Pubmed ID: 24613300 Scorpion Venoms As a Potential Source of Novel Cancer Therapeutic Compounds Experimental Biology and Medicine (Maywood, N.J.). Apr, 2014 | Pubmed ID: 24599885 Design, Synthesis and Biological Evaluation of Novel 6-alkenylamides Substituted of 4-anilinothieno[2,3-d]pyrimidines As Irreversible Epidermal Growth Factor Receptor Inhibitors Bioorganic & Medicinal Chemistry. Apr, 2014 | Pubmed ID: 24565969 Spontaneous Ventral Urethral Fistula in a Young Man Whose Mother Had a Retained IUD in Uterus During the Gestation Canadian Urological Association Journal = Journal De L'Association Des Urologues Du Canada. Jan-Feb, 2014 | Pubmed ID: 24554982 Cytotoxic Dinorditerpenoids from Drypetes Perreticulata Phytochemistry. Apr, 2014 | Pubmed ID: 24548557 Rebalancing Binocular Vision in Amblyopia Ophthalmic & Physiological Optics : the Journal of the British College of Ophthalmic Opticians (Optometrists). Mar, 2014 | Pubmed ID: 24417338 DW09849, a Selective Phosphatidylinositol 3-kinase (PI3K) Inhibitor, Prevents PI3K Signaling and Preferentially Inhibits Proliferation of Cells Containing the Oncogenic Mutation P110α (H1047R) The Journal of Pharmacology and Experimental Therapeutics. Mar, 2014 | Pubmed ID: 24361696 Molecularly Targeted Cancer Therapy: Some Lessons from the Past Decade Trends in Pharmacological Sciences. Jan, 2014 | Pubmed ID: 24361003 Yhhu3813 is a Novel Selective Inhibitor of C-Met Kinase That Inhibits C-Met-dependent Neoplastic Phenotypes of Human Cancer Cells Acta Pharmacologica Sinica. Jan, 2014 | Pubmed ID: 24241352 Systematic Combination Screening Reveals Synergism Between Rapamycin and Sunitinib Against Human Lung Cancer Cancer Letters. Jan, 2014 | Pubmed ID: 24018642 Aberrant TIG1 Methylation Associated with Its Decreased Expression and Clinicopathological Significance in Hepatocellular Carcinoma Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine. Feb, 2014 | Pubmed ID: 24006221 Study on Discrimination of White Tea and Albino Tea Based on Near-infrared Spectroscopy and Chemometrics Journal of the Science of Food and Agriculture. Mar, 2014 | Pubmed ID: 23983143 Crosstalk Between NSL Histone Acetyltransferase and MLL/SET Complexes: NSL Complex Functions in Promoting Histone H3K4 Di-methylation Activity by MLL/SET Complexes PLoS Genetics. Nov, 2013 | Pubmed ID: 24244196 O-GlcNAcylation of Cofilin Promotes Breast Cancer Cell Invasion The Journal of Biological Chemistry. Dec, 2013 | Pubmed ID: 24214978 Design, Synthesis and Biological Evaluation of Novel 4-anilinoquinazolines with C-6 Urea-linked Side Chains As Inhibitors of the Epidermal Growth Factor Receptor Bioorganic & Medicinal Chemistry. Dec, 2013 | Pubmed ID: 24183742 Oligomannurarate Sulfate Inhibits CXCL12/SDF-1-mediated Proliferation and Invasion of Human Tumor Cells in Vitro Acta Pharmacologica Sinica. Dec, 2013 | Pubmed ID: 24141568 Draft Genome of the Kiwifruit Actinidia Chinensis Nature Communications. 2013 | Pubmed ID: 24136039 Correction: Prediction of MicroRNAs Associated with Human Diseases Based on Weighted K Most Similar Neighbors PloS One. 2013 | Pubmed ID: 24116246 Anti-HIV Activity of Human Defensin 5 in Primary CD4+ T Cells Under Serum-deprived Conditions is a Consequence of Defensin-mediated Cytotoxicity PloS One. 2013 | Pubmed ID: 24086683 [Diagnosis and Treatment of Ketamine-associated Cystitis: a Report of 3 Cases and Literature Review] Zhong Nan Da Xue Xue Bao. Yi Xue Ban = Journal of Central South University. Medical Sciences. Sep, 2013 | Pubmed ID: 24071696 Differential Profiles of Immune Mediators and in Vitro HIV Infectivity Between Endocervical and Vaginal Secretions from Women with Chlamydia Trachomatis Infection: a Pilot Study Journal of Reproductive Immunology. Sep, 2013 | Pubmed ID: 23993451 Prediction of MicroRNAs Associated with Human Diseases Based on Weighted K Most Similar Neighbors PloS One. 2013 | Pubmed ID: 23950912 A Pharmacological Model Reveals Biased Dependency on PI3K Isoforms for Tumor Cell Growth Acta Pharmacologica Sinica. Sep, 2013 | Pubmed ID: 23892273 Translation and Linguistic Validation of the Pediatric Patient-Reported Outcomes Measurement Information System Measures into Simplified Chinese Using Cognitive Interviewing Methodology Cancer Nursing. Sep-Oct, 2013 | Pubmed ID: 23860394 Molecular Characterization and Promoter Analysis of Crustacean Heat Shock Protein 10 in Scylla Paramemosain Genome. May, 2013 | Pubmed ID: 23789995 Cardioprotection Via Preserved Mitochondrial Structure and Function in the MPer2-mutant Mouse Myocardium American Journal of Physiology. Heart and Circulatory Physiology. Jun, 2013 | Pubmed ID: 23771689 Naphthalimides Exhibit in Vitro Antiproliferative and Antiangiogenic Activities by Inhibiting Both Topoisomerase II (topo II) and Receptor Tyrosine Kinases (RTKs) European Journal of Medicinal Chemistry. Jul, 2013 | Pubmed ID: 23770449 Multiple Heterotopic Ossification of Scar Following Degloving Injury: a Case Report Orthopaedic Surgery. May, 2013 | Pubmed ID: 23658053 Apoptogenic Activity of Ethyl Acetate Extract of Leaves of Memecylon Edule on Human Gastric Carcinoma Cells Via Mitochondrial Dependent Pathway Asian Pacific Journal of Tropical Medicine. May, 2013 | Pubmed ID: 23608371 Design, Synthesis and Biological Evaluation of Novel Pyrimidine, 3-cyanopyridine and M-amino-N-phenylbenzamide Based Monocyclic EGFR Tyrosine Kinase Inhibitors Bioorganic & Medicinal Chemistry. Jun, 2013 | Pubmed ID: 23602524 Mir-17-92 Cluster is Required for and Sufficient to Induce Cardiomyocyte Proliferation in Postnatal and Adult Hearts Circulation Research. Jun, 2013 | Pubmed ID: 23575307 Discovery of the Novel MTOR Inhibitor and Its Antitumor Activities in Vitro and in Vivo Molecular Cancer Therapeutics. Jun, 2013 | Pubmed ID: 23536724 Characteristics and Kinetics of Ammonia and N2O Emissions of Aged Refuse Irrigated from Landfill Leachate Waste Management (New York, N.Y.). May, 2013 | Pubmed ID: 23474206 Design, Synthesis, and Biological Evaluation of a Series of Benzo[de][1,7]naphthyridin-7(8H)-ones Bearing a Functionalized Longer Chain Appendage As Novel PARP1 Inhibitors Journal of Medicinal Chemistry. Apr, 2013 | Pubmed ID: 23473053 Binocular Combination in Abnormal Binocular Vision Journal of Vision. Feb, 2013 | Pubmed ID: 23397039 Binocular Combination of Phase and Contrast Explained by a Gain-control and Gain-enhancement Model Journal of Vision. Feb, 2013 | Pubmed ID: 23397038 Chemical Constituents from Brucea Javanica Phytochemistry. Jan, 2013 | Pubmed ID: 23009875 WITHDRAWN: Design, Synthesis and Biological Evaluation of 3-substituted-4-anilinequinoline As EGFR Tyrosine Kinase Inhibitors Bioorganic & Medicinal Chemistry Letters. Oct, 2012 | Pubmed ID: 24035336 The Fixation and Saccade P3 PloS One. 2012 | Pubmed ID: 23144959 [Prevalence of Allergic Rhinitis and Survey Analysis of Health Service Needs and Utilization in Qingdao Area] Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi = Chinese Journal of Otorhinolaryngology Head and Neck Surgery. Aug, 2012 | Pubmed ID: 23141392 Identification of an Aurora Kinase Inhibitor Specific for the Aurora B Isoform Cancer Research. Nov, 2012 | Pubmed ID: 23117881 Crosstalk Between EGFR and Integrin Affects Invasion and Proliferation of Gastric Cancer Cell Line, SGC7901 OncoTargets and Therapy. 2012 | Pubmed ID: 23109808 Repositioning HIV-1 Integrase Inhibitors for Cancer Therapeutics: 1,6-naphthyridine-7-carboxamide As a Promising Scaffold with Drug-like Properties Journal of Medicinal Chemistry. Nov, 2012 | Pubmed ID: 23098137 Characterization of the Conversion Between CD133+ and CD133- Cells in Colon Cancer SW620 Cell Line Cancer Biology & Therapy. Dec, 2012 | Pubmed ID: 22954703 Celebrating the 80th Anniversary of the Shanghai Institute of Materia Medica, Chinese Academy of Sciences (SIMM) Acta Pharmacologica Sinica. Sep, 2012 | Pubmed ID: 22948617 Potent HGF/c-Met Axis Inhibitors from Eucalyptus Globulus: the Coupling of Phloroglucinol and Sesquiterpenoid is Essential for the Activity Journal of Medicinal Chemistry. Sep, 2012 | Pubmed ID: 22934600 Natural Product Triptolide Mediates Cancer Cell Death by Triggering CDK7-dependent Degradation of RNA Polymerase II Cancer Research. Oct, 2012 | Pubmed ID: 22926559 Newly Discovered Angiogenesis Inhibitors and Their Mechanisms of Action Acta Pharmacologica Sinica. Sep, 2012 | Pubmed ID: 22922347 In Vitro Evaluation of Anticancer Nanomedicines Based on Doxorubicin and Amphiphilic Y-shaped Copolymers International Journal of Nanomedicine. 2012 | Pubmed ID: 22701317 Extensive Crosstalk Between O-GlcNAcylation and Phosphorylation Regulates Akt Signaling PloS One. 2012 | Pubmed ID: 22629392 Bacteria-directed Construction of Hollow TiO2 Micro/nanostructures with Enhanced Photocatalytic Hydrogen Evolution Activity Optics Express. Mar, 2012 | Pubmed ID: 22418684 Cytotoxic Diterpenoids from Sapium Insigne Journal of Natural Products. Apr, 2012 | Pubmed ID: 22409148 Pseudolaric Acid B-driven Phosphorylation of C-Jun Impairs Its Role in Stabilizing HIF-1alpha: a Novel Function-converter Model Journal of Molecular Medicine (Berlin, Germany). Aug, 2012 | Pubmed ID: 22406864 Design, Synthesis, and Biological Evaluation of Novel Conformationally Constrained Inhibitors Targeting Epidermal Growth Factor Receptor Threonine⁷⁹⁰ → Methionine⁷⁹⁰ Mutant Journal of Medicinal Chemistry. Mar, 2012 | Pubmed ID: 22339342 Inhibition of Chemokine (C-X-C Motif) Ligand 12/chemokine (C-X-C Motif) Receptor 4 Axis (CXCL12/CXCR4)-mediated Cell Migration by Targeting Mammalian Target of Rapamycin (mTOR) Pathway in Human Gastric Carcinoma Cells The Journal of Biological Chemistry. Feb, 2012 | Pubmed ID: 22337890 Discovery of LFF571: an Investigational Agent for Clostridium Difficile Infection Journal of Medicinal Chemistry. Mar, 2012 | Pubmed ID: 22315981 Inhibition of Tumor Cell Growth, Proliferation and Migration by X-387, a Novel Active-site Inhibitor of MTOR Biochemical Pharmacology. Jan, 2012 | Pubmed ID: 22305748 AL3810, a Multi-tyrosine Kinase Inhibitor, Exhibits Potent Anti-angiogenic and Anti-tumour Activity Via Targeting VEGFR, FGFR and PDGFR Journal of Cellular and Molecular Medicine. Feb, 2012 | Pubmed ID: 22304225 Triptolide: Structural Modifications, Structure-activity Relationships, Bioactivities, Clinical Development and Mechanisms Natural Product Reports. Apr, 2012 | Pubmed ID: 22270059 TLR2 Activation Enhances HIV Nuclear Import and Infection Through T Cell Activation-independent and -dependent Pathways Journal of Immunology (Baltimore, Md. : 1950). Feb, 2012 | Pubmed ID: 22210918 Discovery and Bioactivity of 4-(2-arylpyrido[3',2':3,4]pyrrolo[1,2-f][1,2,4]triazin-4-yl) Morpholine Derivatives As Novel PI3K Inhibitors Bioorganic & Medicinal Chemistry Letters. Jan, 2012 | Pubmed ID: 22130133 Characterization of Dihydroartemisinin-resistant Colon Carcinoma HCT116/R Cell Line Molecular and Cellular Biochemistry. Jan, 2012 | Pubmed ID: 21959972 The Short-time Treatment with Curcumin Sufficiently Decreases Cell Viability, Induces Apoptosis and Copper Enhances These Effects in Multidrug-resistant K562/A02 Cells Molecular and Cellular Biochemistry. Jan, 2012 | Pubmed ID: 21938404 Functional Motor Nerve Regeneration Without Motor-sensory Specificity Following End-to-side Neurorrhaphy: an Experimental Study The Journal of Hand Surgery. Dec, 2011 | Pubmed ID: 22123048 Constituents of Trigonostemon Heterophyllus Journal of Natural Products. Dec, 2011 | Pubmed ID: 22122667 The Role of Polymeric Immunoglobulin Receptor in Inflammation-induced Tumor Metastasis of Human Hepatocellular Carcinoma Journal of the National Cancer Institute. Nov, 2011 | Pubmed ID: 22025622 Design, Synthesis and Biological Evaluation of Substituted 11H-benzo[a]carbazole-5-carboxamides As Novel Antitumor Agents European Journal of Medicinal Chemistry. Dec, 2011 | Pubmed ID: 22000922 Innate Immune Mediator Profiles and Their Regulation in a Novel Polarized Immortalized Epithelial Cell Model Derived from Human Endocervix Journal of Reproductive Immunology. Dec, 2011 | Pubmed ID: 21943934 Biogenic Hierarchical TiO₂/SiO₂ Derived from Rice Husk and Enhanced Photocatalytic Properties for Dye Degradation PloS One. 2011 | Pubmed ID: 21931853 Recovery of Stereopsis Through Perceptual Learning in Human Adults with Abnormal Binocular Vision Proceedings of the National Academy of Sciences of the United States of America. Sep, 2011 | Pubmed ID: 21896742 AST1306, a Novel Irreversible Inhibitor of the Epidermal Growth Factor Receptor 1 and 2, Exhibits Antitumor Activity Both in Vitro and in Vivo PloS One. 2011 | Pubmed ID: 21789172 Human Defensins 5 and 6 Enhance HIV-1 Infectivity Through Promoting HIV Attachment Retrovirology. Jun, 2011 | Pubmed ID: 21672195 Drug Transporter-independent Liver Cancer Cell Killing by a Marine Steroid Methyl Spongoate Via Apoptosis Induction The Journal of Biological Chemistry. Jul, 2011 | Pubmed ID: 21659517 Establishment of Platform for Screening Insulin-like Growth Factor-1 Receptor Inhibitors and Evaluation of Novel Inhibitors Acta Pharmacologica Sinica. Jul, 2011 | Pubmed ID: 21643004 माउस दिलों में overexpress को rAAV9 की तैयारी या पछाड़ना जीन Jian Ding1,2, Zhi-Qiang Lin1,2, Jian-Ming Jiang3,4, Christine E. Seidman3,4, Jonathan G. Seidman3,4, William T. Pu1,2, Da-Zhi Wang1,2 1Department of Cardiology, Boston Children's Hospital, 2Department of Pediatrics, Harvard Medical School, 3Department of Genetics, Harvard Medical School, 4Howard Hughes Medical Institute Genetics
माउस दिलों में overexpress को rAAV9 की तैयारी या पछाड़ना जीन Jian Ding1,2, Zhi-Qiang Lin1,2, Jian-Ming Jiang3,4, Christine E. Seidman3,4, Jonathan G. Seidman3,4, William T. Pu1,2, Da-Zhi Wang1,2 1Department of Cardiology, Boston Children's Hospital, 2Department of Pediatrics, Harvard Medical School, 3Department of Genetics, Harvard Medical School, 4Howard Hughes Medical Institute Genetics