In JoVE (1)
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Articles by Jiaxian Lin in JoVE
A Rapid and Quantitative Fluorimetric Method for Protein-Targeting Small Molecule Drug Screening Yong Yu1, Siu Yee New1, Jiaxian Lin2, Xiaodi Su1, Yen Nee Tan1 1Institute of Materials Research and Engineering, Agency for Science, Technology and Research (A*STAR), 2School of Chemical & Biomedical Engineering, Nanyang Technological University A protocol for small molecular drug screening based on in-situ synthesis of ultrasmall fluorescent gold nanoclusters (Au NCs) using drug-loaded protein as template is presented. This method is simple to determine the binding affinity of drugs to a target protein by a visible fluorescent signal emitted from the protein-templated Au NCs.